dna

Podcast: Where dog breeds come from, bots that build buildings, and gathering ancient human DNA from cave sediments

This week, a new family tree of dog breeds, advances in artificial wombs, and an autonomous robot that can print a building with Online News Editor David Grimm.   Viviane Slon joins Sarah Crespi to discuss a new way to seek out ancient humans—without finding fossils or bones—by screening sediments for ancient DNA.   Jen Golbeck interviews Andrew Shtulman, author of Scienceblind: Why Our Intuitive Theories About the World Are So Often Wrong for this month’s book segment.    Listen to previous podcasts.   See more book segments.     Download the show transcript. Transcripts courtesy of Scribie.com. [Image: nimis69/iStockphoto; Music: Jeffrey Cook]  




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A new taste for the tongue, ancient DNA from Egyptian mummies, and early evidence for dog breeding

This week we have stories on how we taste water, extracting ancient DNA from mummy heads, and the earliest evidence for dog breeding with Online News Editor David Grimm. Sarah Crespi talks to John Travis about postsurgical cognitive dysfunction—does surgery sap your brain power? Listen to previous podcasts. [Music: Jeffrey Cook]




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DNA and proteins from ancient books, music made from data, and the keys to poverty traps

This week we hear stories on turning data sets into symphonies for business and pleasure, why so much of the world is stuck in the poverty trap, and calls for stiffening statistical significance with Online News Editor David Grimm. Sarah Crespi talks to news writer Ann Gibbons about the biology of ancient books—what can we learn from DNA, proteins, and book worm trails about a book, its scribes, and its readers? Listen to previous podcasts. [Music: Jeffrey Cook]




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Debunking yeti DNA, and the incredibly strong arms of prehistoric female farmers

The abominable snowman, the yeti, bigfoot, and sasquatch—these long-lived myths of giant, hairy hominids depend on dropping elusive clues to stay in the popular imagination—a blurry photo here, a big footprint there—but what happens when scientists try to pin that evidence down? Online News Editor David Grimm talks with Sarah Crespi about the latest attempts to verify the yeti’s existence using DNA analysis of bones and hair and how this research has led to more than the debunking of a mythic creature. Sarah also interviews Alison Macintosh of the University of Cambridge in the United Kingdom about her investigation of bone, muscle, and behavior in prehistory female farmers—what can a new database of modern women’s bones—athletes and regular folks—tell us about the labor of women as humans took up farming?   Listen to previous podcasts. [Image: Didier Descouens/CC BY SA 3.0; Music: Jeffrey Cook]




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Folding DNA into teddy bears and getting creative about gun violence research

This week, three papers came out describing new approaches to folding DNA into large complex shapes—20 times bigger than previous DNA sculptures. Staff Writer Bob Service talks with Sarah Crespi about building microscopic teddy bears, doughnuts, and more from genetic material, and using these techniques to push forward fields from materials science to drug delivery. Sarah also interviews Philip Cook of Duke University in Durham, North Carolina, about his Policy Forum on gun regulation research. It’s long been hard to collect data on gun violence in the United States, and Cook talks about how some researchers are getting funding and hard data. He also discusses some strong early results on open-carry laws and links between gun control and intimate partner homicide. Listen to previous podcasts. [Image: : K. WAGENBAUER ET AL., NATURE, VOL. 551, 2017; Music: Jeffrey Cook]




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How DNA is revealing Latin America’s lost histories, and how to make a molecule from just two atoms

Geneticists and anthropologists studying historical records and modern-day genomes are finding traces of previously unknown migrants to Latin America in the 16th and 17th centuries, when Asians, Africans, and Europeans first met indigenous Latin Americans. Sarah Crespi talks with contributing correspondent Lizzie Wade about what she learned on the topic at the American Association of Physical Anthropologists’s annual meeting in Austin. Sarah also interviews Kang-Keun Ni about her research using optical tweezers to bring two atoms—one cesium and one sodium—together into a single molecule. Such precise control of molecule formation is allowing new observations of these basic processes and is opening the door to creating new molecules for quantum computing. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Juan Fernando Ibarra; Music: Jeffrey Cook] 




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Ancient DNA is helping find the first horse tamers, and a single gene is spawning a fierce debate in salmon conservation

Who were the first horse tamers? Online News Editor Catherine Matacic talks to Sarah Crespi about a new study that brings genomics to bear on the question. The hunt for the original equine domesticators has focused on Bronze Age people living on the Eurasian steppe. Now, an ancient DNA analysis bolsters the idea that a small group of hunter-gatherers, called the Botai, were likely the first to harness horses, not the famous Yamnaya pastoralists often thought to be the originators of the Indo-European language family. Sarah also talks with News Intern Katie Langin about her feature story on a single salmon gene that may separate spring- and fall-run salmon. Conservationists, regulators, and citizens are fiercely debating the role such a small bit of DNA plays in defining distinct populations. Is the spring run distinct enough to warrant protection? This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Jessica Piispanen/USFWS; Music: Jeffrey Cook] 




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Sketching suspects with DNA, and using light to find Zika-infected mosquitoes

DNA fingerprinting has been used to link people to crimes for decades, by matching DNA from a crime scene to DNA extracted from a suspect. Now, investigators are using other parts of the genome—such as markers for hair and eye color—to help rule people in and out as suspects. Staff Writer Gretchen Vogel talks with Sarah Crespi about whether science supports this approach and how different countries are dealing with this new type of evidence. Sarah also talks with Jill Fernandes of the University of Queensland in Brisbane, Australia, about her Science Advances paper on a light-based technique for detecting Zika in mosquitoes. Instead of grinding up the bug and extracting Zika DNA, her group shines near-infrared light through the body. Mosquitoes carrying Zika transmit this light differently from uninfected ones. If it’s successful in larger trials, this technique could make large-scale surveillance of infected mosquitoes quicker and less expensive. In our monthly books segment, Jen Golbeck talks with author Sarah-Jayne Blakemore about her new work: Inventing Ourselves: The Secret Life of the Teenage Brain. You can check out more book reviews and share your thoughts on the Books et al. blog. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: National Institute of Allergy and Infectious Diseases, National Institutes of Health; Music: Jeffrey Cook]




dna

Exploding the Cambrian and building a DNA database for forensics

First, we hear from science writer Joshua Sokol about his trip to the Cambrian—well not quite. He talks with host Megan Cantwell about his travels to a remote site in the mountains of British Columbia where some of Earth’s first animals—including a mysterious, alien-looking creature—are spilling out of Canadian rocks.   Also on this week’s show, host Sarah Crespi talks with James Hazel a postdoctoral research fellow at the Center for Genetic Privacy and Identity in Community Settings at Vanderbilt University in Nashville about a proposal for creating a universal forensic DNA database. He and his co-authors argue that current, invasive practices such as law enforcement subpoenaing medical records, commercial genetic profiles, and other sets of extremely detailed genetic information during criminal investigations, would be curtailed if a forensics-use-only universal database were created.     This week’s episode was edited by Podigy.   Read a transcript (PDF) Listen to previous podcasts.   About the Science Podcast  




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‘The Tragedy of the Commons’ turns 50, and how Neanderthal DNA could change your skull

In 1968, Science published the now-famous paper “The Tragedy of the Commons” by ecologist Garrett Hardin. In it, Hardin questioned society’s ability to manage shared resources, concluding that individuals will act in their self-interest and ultimately spoil the resource. Host Meagan Cantwell revisits this classic paper with two experts: Tine De Moor, professor of economics and social history at Utrecht University in the Netherlands, and Brett Frischmann, a professor of law, business, and economics at Villanova University in Pennsylvania. They discuss how premodern societies dealt with common resources and how our current society might apply the concept to a more abstract resource—knowledge. Not all human skulls are the same shape—and if yours is a little less round, you may have your extinct cousins, the Neanderthals, to thank. Meagan speaks with Simon Fisher, neurogeneticist and director of the Max Planck Institute for Psycholinguistics in Nijmegen, the Netherlands, about why living humans with two Neanderthal gene variants have slightly less round heads—and how studying Neanderthal DNA can help us better understand our own biology. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. About the Science Podcast [Image: Phillip Gunz; Music: Jeffrey Cook]




dna

Detection of prostate-specific antigen in semen using DNA aptamers: an application of nucleic acid aptamers in forensic body fluid identification

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00371A, Paper
Tetsuya Satoh, Seiya Kouroki, Yusuke Kitamura, Toshihiro Ihara, Kazutoshi Matsumura, Susumu Iwase
In forensics, body fluid identification plays an important role because it aids in reconstructing the crime scene. Therefore, it is essential to develop simple and reliable techniques for body fluid...
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

A rapid and colorimetric biosensor based on GR-5 DNAzyme and self-replicating catalyzed hairpin assembly for lead detection

Anal. Methods, 2020, 12,2215-2220
DOI: 10.1039/D0AY00091D, Paper
Fang Wang, Jianyuan Dai, Hongli Shi, Xiaoqian Luo, Lan Xiao, Cuisong Zhou, Yong Guo, Dan Xiao
A rapid and colorimetric biosensor for Pb2+ detection has been constructed on the basis of Pb2+-dependent GR-5 DNAzyme and the self-replicating catalyzed hairpin assembly (SRCHA) reaction.
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

Rapid and colorimetric detection of nucleic acids based on entropy-driven circuit and DNAzyme mediated autocatalytic reaction

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00341G, Paper
Hongli Shi, Jianyuan Dai, fang Wang, Yushun Xia, Dan Xiao, Cuisong Zhou
In this work, a novel, rapid and enzyme-free colorimetric biosensor for nucleic acids detection has been developed based on entropy-driven circuit (EDC) and DNAzyme mediated autocatalytic reaction. Upon sensing of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Knowledge management and engineering with decisional DNA Edward Szczerbicki, Cesar Sanin, editors

Online Resource




dna

[ASAP] “Sample-to-Answer” Detection of Rare ctDNA Mutation from 2 mL Plasma with a Fully Integrated DNA Extraction and Digital Droplet PCR Microdevice for Liquid Biopsy

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00818




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[ASAP] One-Step Surface Modification to Graft DNA Codes on Paper: The Method, Mechanism, and Its Application

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00317




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[ASAP] Probing the Mechanism of Structure-Switching Aptamer Assembly by Super-Resolution Localization of Individual DNA Molecules

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05563




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[ASAP] Excimer-FRET Cascade in Dual DNA Probes: Open Access to Large Stokes Shift, Enhanced Acceptor Light up, and Robust RNA Sensing

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00270




dna

[ASAP] Capping Ligand Size-Dependent LSPR Property Based on DNA Nanostructure-Mediated Morphological Evolution of Gold Nanorods for Ultrasensitive Visualization of Target DNA

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00321




dna

[ASAP] Sequencing of Small DNA Fragments with Aggregated-Induced-Emission Molecule-Labeled Nucleotides

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00707




dna

Reversible membrane deformations by straight DNA origami filaments

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00150C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Henri Girao Franquelim, Hendrik Dietz, Petra Schwille
Membrane-active cytoskeletal elements, such as FtsZ, septin or actin, form filamentous polymers able to induce and stabilize curvature on cellular membranes. In order to emulate the characteristic dynamic self-assembly properties...
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

As ethnic tensions rise over kidnapping of Mizos, Bru leaders send envoys to gain release

The MZP is planning a "Long March for Peace" from Aizawl to the western town of Tuipuibari.




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Mamata Banerjee’s nephew slapped at public meeting in Midnapore



  • DO NOT USE West Bengal
  • India

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Structural DNA nanotechnology / Nadrian C. Seeman (New York University)

Seeman, Nadrian C., 1945- author




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[ASAP] Cytosine Methylation Enhances DNA Condensation Revealed by Equilibrium Measurements Using Magnetic Tweezers

Journal of the American Chemical Society
DOI: 10.1021/jacs.9b11957




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DNA techniques to verify food authenticity: applications in food fraud / editors: Malcolm Burns, Lucy Foster, Michael Walker

Online Resource






dna

Jennifer Doudna's tips for new entrepreneurs

As the founder of multiple biotech firms, C&EN's guest editor has learned a thing or two about the challenges and triumphs of starting a company. We asked her to share her best advice for budding academic entrepreneurs




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A day with Jennifer Doudna: Trying to keep up with one of the world's most sought-after scientists

The gene-editing tool CRISPR-Cas9 rerouted Doudna's career path. What hasn't changed for the renowned scientist and serial entrepreneur? Living and breathing the science




dna

Will the coronavirus help mRNA and DNA vaccines prove their worth?

As gene-based vaccines are being designed and tested at unprecedented speeds to fight COVID-19, scientists wonder if this will be the technology's make-or-break moment.




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Rome Therapeutics launches to probe junk DNA for cancer drug discovery

Biotech veteran Rosana Kapeller co-founded the start-up, which raised $50 million to develop small-molecule drugs




dna

Rome Therapeutics launches to probe junk DNA for cancer drug discovery

Biotech veteran Rosana Kapeller cofounded the start-up, which raised $50 million to develop small-molecule drugs




dna

[ASAP] Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00310




dna

[ASAP] Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)

ACS Sensors
DOI: 10.1021/acssensors.0c00497




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DNA methods for the detection of Phytophthora cinnamomi from soil / by Nari Anderson

Anderson, Nari




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Molecular biotechnology : principles and applications of recombinant DNA / Bernard R. Glick and Jack J. Pasternak, Cheryl L. Patten

Glick, Bernard R




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From genes to genomes : concepts and applications of DNA technology / Jeremy W. Dale, Malcolm von Schantz, and Nick Plant

Dale, Jeremy




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DNA nanotechnology : from structure to function / Chunhai Fan, editor




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DNA technology : a reference handbook / David E. Newton

Newton, David E., author




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Plant omics and crop breeding / edited by Sajad Majeed Zargar, PhD, Vandna Rai, PhD




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Adnan Bounni (1926-2008): une vie pour l'archéologie syrienne / édité par Michel Al-Maqdissi, Frédéric Alpi ; Marcx Griesheimer et Éva Ishaq

Rotch Library - DS94.5.B855 2008




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The Arab architectural renaissance in the western part of occupied Jerusalem: a historical and current review based on documents, figures, maps and photos / by Adnan Abdelrazek (Ph. D.)

Rotch Library - NA1478.J4 A23 2017




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Aurangabad with Daulatabad, Khuldabad, and Ahmadnagar / Pushkar Sohoni ; photography, Clare Arni and Selvaprakash Lakshmanan

Rotch Library - DS485.A895 S65 2015




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Arabicity: contemporary Arab art / edited by Rose Issa and Juliet Cestar ; contributions by Rose Issa, Georges Corm, Michket Krifa, Etel Adnan

Rotch Library - N7265.3.A733 2019




dna

Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage

Toxicol. Res., 2019, 8,833-841
DOI: 10.1039/C9TX00080A, Paper
Qiaoyun Liu, Longsheng Wang, Hanwen Chen, Bo Huang, Jiawei Xu, Ying Li, Paul Héroux, Xinqiang Zhu, Yihua Wu, Dajing Xia
Prometryn induces oxidative stress-mediated DNA damage; Prometryn induces S phase of cell cycle arrest; Prometryn induces Bax-dependent apoptosis in BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells

Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

Binding patterns and dynamics of double-stranded DNA on the phosphorene surface

Nanoscale, 2020, 12,9430-9439
DOI: 10.1039/D0NR01403F, Paper
Baoyu Li, Xuejie Xie, Guangxin Duan, Serena H. Chen, Xuan-Yu Meng, Ruhong Zhou
Molecular dynamics simulations and electrophoresis experiments show that dsDNA can form a stable binding on the phosphorene surface through the terminal base pairs and adopt an upright orientation regardless of its initial configurations.
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

Dynamics of lattice defects in mixed DNA origami monolayers

Nanoscale, 2020, 12,9733-9743
DOI: 10.1039/D0NR01252A, Paper
Yang Xin, Xueyin Ji, Guido Grundmeier, Adrian Keller
DNA origami lattice formation at solid–liquid interfaces is surprisingly resilient toward the incorporation of DNA origami impurities with different shapes.
The content of this RSS Feed (c) The Royal Society of Chemistry




dna

DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo

Nanoscale, 2020, 12,9786-9799
DOI: 10.1039/D0NR00361A, Paper
Open Access
Juan Liu, Ioana Craciun, Andrea Belluati, Dalin Wu, Sandro Sieber, Tomaz Einfalt, Dominik Witzigmann, Mohamed Chami, Jörg Huwyler, Cornelia G. Palivan
Soft flexible DNA-linked polymersome clusters selectively interact with the cell membrane in vitro and in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry