This study uses mendelian randomization to estimate the associations between genetic variants related to reduced HMG-CoA reductase activity and epithelial ovarian cancer in the general population and in BRCA1/2 mutation carriers.

Barrass, Robert

Online Resource

Online Resource

Pervo, Richard I

Campbell, Joseph, 1904- author

Research into improving the cross-browser consistency of both the “clearfix” and “overflow:hidden” methods of containing floats. The aim is to work around several bugs in IE6 and IE7.

This article introduces a new hack (with caveats) that can benefit the “clearfix” methods and the new block formatting context (NBFC) methods (e.g. using overflow:hidden) of containing floats. It’s one outcome of a collaboration between Nicolas Gallagher (that’s me) and Jonathan Neal.

If you are not familiar with the history and underlying principles behind methods of containing floats, I recommend that you have a read of Easy clearing (2004), Everything you know about clearfix is wrong (2010), and Clearfix reloaded and overflow:hidden demystified (2010).

Consistent float containment methods

The code is show below and documented in this GitHub gist. Found an improvement or flaw? Please fork the gist or leave a comment.

Micro clearfix hack: Firefox 3.5+, Safari 4+, Chrome, Opera 9+, IE 6+

.cf {
  /* for IE 6/7 */
  *zoom: expression(this.runtimeStyle.zoom="1", this.appendChild(document.createElement("br")).style.cssText="clear:both;font:0/0 serif");
  /* non-JS fallback */
  *zoom: 1;
}

.cf:before,
.cf:after {
  content: "";
  display: table;
}

.cf:after {
  clear: both;
}

Overflow hack (NBFC): Firefox 2+, Safari 2+, Chrome, Opera 9+, IE 6+

.nbfc {
  overflow: hidden;
  /* for IE 6/7 */
  *zoom: expression(this.runtimeStyle.zoom="1", this.appendChild(document.createElement("br")).style.cssText="clear:both;font:0/0 serif");
  /* non-JS fallback */
  *zoom: 1;
}

The GitHub gist also contains another variant of the clearfix method for modern browsers (based on Thierry Koblentz’s work). It provides greater visual consistency (avoiding edge-case bugs) for even older versions of Firefox.

The only difference from existing float-containment methods is the inclusion of a CSS expression that inserts a clearing line-break in IE 6 and IE 7. Jonathan and I found that it helps to resolve some of the visual rendering differences that exist between these browsers and more modern ones. First I’ll explain what some of those differences are and when they occur.

Containing floats in IE 6/7

In IE 6 and IE 7, the most common and robust method of containing floats within an element is to give it “layout” (find out more: On having Layout). Triggering “layout” on an element in IE 6/7 creates a new block formatting context (NBFC). However, certain IE bugs mean that previous float containment methods don’t result in cross-browser consistency. Specifically, this is what to expect in IE 6/7 when creating a NBFC:

1. The top- and bottom-margins of non-floated child elements are contained within the ancestor element that has been given “layout”. (Also expected in other browsers when creating a NBFC)
2. The bottom-margins of any right-floated descendants are contained within the ancestor. (Also expected in other browsers when creating a NBFC)
3. The bottom-margins of any left-floated children are not contained within the ancestor. The margin has no effect on the height of the ancestor and is truncated, having no affect outside of the ancestor either. (IE 6/7 bug)
4. In IE 6, if the right edge of the margin-box of a left-floated child is within 2px of the left edge of the content-box of its NBFC ancestor, the float’s bottom margin reappears and is contained within the parent. (IE 6 bug)
5. Unwanted white-space can appear at the bottom of a float-container. (IE 6/7 bug)

There is a lack of consistency between IE 6/7 and other browsers, and between IE 6 and IE 7. Thanks to Matthew Lein for his comment that directed me to this IE 6/7 behaviour. It was also recently mentioned by “Suzy” in a comment on Perishable Press.

IE 6/7’s truncation of the bottom-margin of left-floats is not exposed in many of the test-cases used to demonstrate CSS float containment techniques. Using an IE-only CSS expression helps to correct this bug.

The CSS expression

Including the much maligned <br style="clear:both"> at the bottom of the float-container, as well as creating a NBFC, resolved all these inconsistencies in IE 6/7. Doing so prevents those browsers from collapsing (or truncating) top- and bottom-margins of descendant elements.

Jonathan suggested inserting the clearing line-break in IE 6/7 only, using CSS expressions applied to fictional CSS properties. The CSS expression is the result of many iterations, tests, and suggestions. It runs only once, the first time an element receives the associated classname.

*zoom: expression(this.runtimeStyle.zoom="1", this.appendChild(document.createElement("br")).style.cssText="clear:both;font:0/0 serif");

It is applied to zoom, which is already being used to help contain floats in IE 6/7, and the use of the runtimeStyle object ensures that the expression is replaced once it has been run. The addition of font:0/0 serif prevents the occasional appearance of white-space at the bottom of a float-container. And the * hack ensures that only IE 6 and IE 7 parse the rule.

It’s worth noting that IE 6 and IE 7 parse almost any string used as CSS property. An earlier iteration used the entirely fictitious properties “-ms-inject” or “-ie-x” property to exploit this IE behaviour.

*-ie-x: expression(this.x||(this.innerHTML+='<br style="clear:both;font:0/0">',this.x=1));

However, this expression is evaluated over and over again. Using runtimeStyle instead avoids this. Sergey Chikuyonok also pointed out that using innerHTML destroys existing HTML elements that may event handlers attached to them. By using document.createElement and appendChild you can insert the new element without removing all the events attached to other descendant elements.

Containing floats in more modern browsers

There are two popular methods to contain floats in modern browsers. Creating a new block formatting context (as is done in IE 6/7 when hasLayout is triggered) or using a variant of the “clearfix” hack.

Creating a NBFC results in an element containing any floated children, and will prevent top- and bottom-margin collapse of non-floated children. When combined with the enhanced IE 6/7 containment method, it results in consistent cross-browser float containment.

The other method, known as “clearfix”, traditionally used a single :after pseudo-element to clear floats in a similar fashion to a structural, clearing HTML line-break. However, to prevent the top-margins of non-floats from collapsing into the margins of their float-containing ancestor, you also need to use the :before pseudo-element. This is the approach taken in Thierry Koblentz’s “clearfix reloaded”. In contemporary browsers, the micro clearfix hack is also suitable.

The method presented in this article should help improve the results of cross-browser float containment, whether you predominantly use “clearfix” or the NBFC method. The specific limitations of both the “clearfix” and various NBFC methods (as outlined in Thierry’s articles) remain.

Problems

Using a CSS expression to change the DOM in IE 6/7 creates problems of its own. Obviously, the DOM in IE 6/7 is now different to the DOM in other browsers. This affects any JavaScript DOM manipulation that may depend on :last-child or appending new children.

This is still an experimental work-in-progress that is primarily research-driven rather than seeking to become a practical snippet of production code. Any feedback, further testing, and further experimentation from others would be much appreciated.

Thanks to these people for contributing improvements: Jonathan Neal, Mathias Bynens, Sergey Chikuyonok, and Thierry Koblentz.

Applying conditional classnames to the html element is a popular way to help target specific versions of IE with CSS fixes. It was first described by Paul Irish and is a feature of the HTML5 Boilerplate. Despite all its benefits, there are still a couple of niggling issues. Here are some hacky variants that side-step those issues.

An article by Paul Irish, Conditional stylesheets vs CSS hacks? Answer: Neither!, first proposed that conditional comments be used on the opening html tag to help target legacy versions of IE with CSS fixes. Since its inclusion in the HTML5 Boilerplate project, contributors have further refined the technique.

However, there are still some niggling issues with the “classic” conditional comments approach, which Mathias Bynens summarized in a recent article on safe CSS hacks.

1. The Compatibility View icon is displayed in IE8 and IE9 if you are not setting the X-UA-Compatible header in a server config.
2. The character encoding declaration might not be fully contained within the first 1024 bytes of the HTML document if you need to include several attributes on each version of the opening html tag (e.g. Facebook xmlns junk).

You can read more about the related discussions in issue #286 and issue #378 at the HTML5 Boilerplate GitHub repository.

The “bubble up” conditional comments method

Although not necessarily recommended, it looks like both of these issues can be avoided with a bit of trickery. You can create an uncommented opening html tag upon which any shared attributes (so no class attribute) can be set. The conditional classes are then assigned in a second html tag that appears after the <meta http-equiv="X-UA-Compatible"> tag in the document. The classes will “bubble up” to the uncommented tag.

<!DOCTYPE html>
<html lang="en">
  <head>
    <meta http-equiv="X-UA-Compatible"
          content="IE=edge,chrome=1">
    <meta charset="utf-8">
    <!--[if lt IE 7]><html class="no-js ie6"><![endif]-->
    <!--[if IE 7]><html class="no-js ie7"><![endif]-->
    <!--[if IE 8]><html class="no-js ie8"><![endif]-->
    <!--[if gt IE 8]><!--><html class="no-js"><!--<![endif]-->

    <title>Document</title>
  </head>
  <body>
  </body>
</html>

Fork the Gist

The result is that IE8 and IE9 won’t ignore the <meta http-equiv="X-UA-Compatible"> tag, the Compatibility View icon will not be displayed, and the amount of repeated code is reduced. Obviously, including a second html tag in the head isn’t pretty or valid HTML.

If you’re using a server-side config to set the X-UA-Compatible header (instead of the meta tag), then you can still benefit from the DRYer nature of using two opening html tags and it isn’t necessary to include the conditional comments in the head of the document. However, you might still want to do so if you risk not containing the character encoding declaration within the first 1024 bytes of the document.

<!DOCTYPE html>
<html lang="en">
<!--[if lt IE 7]><html class="no-js ie6"><![endif]-->
<!--[if IE 7]><html class="no-js ie7"><![endif]-->
<!--[if IE 8]><html class="no-js ie8"><![endif]-->
<!--[if gt IE 8]><!--><html class="no-js"><!--<![endif]-->
  <head>
    <meta charset="utf-8">
    <title>Document</title>
  </head>
  <body>
  </body>
</html>

Fork the Gist

The “preemptive” conditional comments method

Another method to prevent the Compatibility View icon from showing was found by Julien Wajsberg. It relies on including a conditional comment before the DOCTYPE. Doing this seems to help IE recognise the <meta http-equiv="X-UA-Compatible"> tag. This method isn’t as DRY and doesn’t have the character encoding declaration as high up in the document, but it also doesn’t use 2 opening html elements.

<!--[if IE]><![endif]-->
<!DOCTYPE html>
<!--[if lt IE 7]><html class="no-js ie6"><![endif]-->
<!--[if IE 7]><html class="no-js ie7"><![endif]-->
<!--[if IE 8]><html class="no-js ie8"><![endif]-->
<!--[if gt IE 8]><!--><html class="no-js"><!--<![endif]-->
  <head>
    <meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1">
    <meta charset="utf-8">
    <title>Document</title>
  </head>
  <body>
  </body>
</html>

Fork the Gist

While it’s interesting to explore these possibilities, the “classic” method is still generally the most understandable. It doesn’t create invalid HTML, doesn’t risk throwing IE into quirks mode, and you won’t have a problem with the Compatibility View icon if you use a server-side config.

If you find any other approaches, or problems with those posted here, please leave a comment but also consider adding what you’ve found to the relevant issues in the HTML5 Boilerplate GitHub repository.

Thanks to Paul Irish for feedback and suggestions.

Munson, Chuck, author

Interview with Alexander T. Sandhu, MD, MS, author of Association Between Offering Limited Left Ventricular Ejection Fraction Echocardiograms and Overall Use of Echocardiography

Interview with Amy A. Gelfand, MD, author of Potential Benefits of Migraine—What Is It Good For?, and Guy Fagherazzi, PhD, author of Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study

Interview with Charles Adrian Austin, MD, MSCR, and Jan Busby-Whitehead, MD, authors of Association Between Postoperative Delirium and Long-term Cognitive Function After Major Nonemergent Surgery

Interview with Donald A. Redelmeier, MD, FRCPC, MSHSR, FACP, author of Association Between Statin Use and Risk of Dementia After a Concussion

Interview with Sylvana M. Côté, author of Association Between Childhood Behaviors and Adult Employment Earnings in Canada

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Interview with Scott David Solomon, MD, and Stephen Yishu Wang, BS, authors of Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study, and Edward P. Havranek, MD, author of The Influence of Social and Economic Factors on Heart Disease

Interview with Ganessan Kichenadasse, MBBS, FRACP, author of Association Between Body Mass Index and Overall Survival With Immune Checkpoint Inhibitor Therapy for Advanced Non–Small Cell Lung Cancer

Interview with Arash Mostaghimi, author of Association Between Sexual Orientation and Lifetime Prevalence of Skin Cancer in the United States, and Howa Yeung, MD MSc, author of Sexual and Gender Minority Populations and Skin Cancer—New Data and Renewed Priorities

Interview with Christina Vandenbroucke-Grauls, MD, PhD, author of Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With Multidrug-Resistant Microorganisms: A Systematic Review and Meta-analysis, and Todd Campbell Lee, MD MPH, author of Deprescribing Proton Pump Inhibitors: Overcoming Resistance

Carwardine, Mark, author

Messenger of Sympathy and Love Servant of Parted Friends Consoler of the Lonely Bond of the Scattered Family Enlarger of the Common Life Carrier of News and Knowledge Instrument of Trade and Industry Promoter of Mutual Acquaintance Of Peace and of Goodwill Among Men and Nations. A business consultant once passed around copies of the

The post A Letter is Better: Love and Remembrance appeared first on Berkshire Publishing.

Dewey Library - KF6289.I49 2018

Dewey Library - KZ6515.G74 2018

Dewey Library - K758.S25 2019

Dewey Library - KZ4850.B67 2018

Dewey Library - KF2120.D38 2018

Dewey Library - K3496.M33 2019

Experts stress the need for an over-arching central law to deal with epidemics

Australia. Parliament. Joint Standing Committee on Trade and Investment Growth, author, issuing body

Lower-temperature process improves the efficiency of single-crystal solar cells

Biogen will pay the biotech firm $350 million upfront and get rights to its therapies for up to 12 neurological diseases

Lower-temperature process improves the efficiency of single-crystal solar cells

WHO does not recommend against taking the drug for fever caused by novel coronavirus infection

Berlin : Springer, 2005

Darmstadt : Steinkopff, 2005

Totowa, N.J. : Humana Press, [2007]

Hayden Library - QC174.13.S55 2018

Hayden Library - QC773.S78 2018