Title: Experts Cast Doubt on Notion That New Strain of Coronavirus Is More Infectious
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Title: Trump Says Obamacare Must Go as U.S. Coronavirus Cases Climb Past 1.2 Million
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Between the first seven days of January 2020 and the last seven days of March, mean daily controller inhaler use rose 14.5%.

A roundup of the latest news about COVID-19

A roundup of the latest news about COVID-19

A roundup of the latest news about COVID-19

Two new reports suggest that the warm summer months will not significantly slow the novel coronavirus as it spreads around the globe.

Title: Trump Signs Massive Relief Package Into Law as U.S. Coronavirus Cases Reach 9,000
Category: Health News
Created: 3/19/2020 12:00:00 AM
Last Editorial Review: 3/19/2020 12:00:00 AM

Title: Remdesivir (RDV): Experimental Antiviral for Coronavirus (COVID-19)
Category: Medications
Created: 3/26/2020 12:00:00 AM
Last Editorial Review: 5/5/2020 12:00:00 AM

Title: Long Periods in Space Alter Astronauts' Brains
Category: Health News
Created: 4/14/2020 12:00:00 AM
Last Editorial Review: 4/15/2020 12:00:00 AM

ABSTRACT

Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe and fatal acute respiratory disease in humans and remains endemic in the Middle East since first being identified in 2012. There are currently no approved vaccines or therapies available for MERS-CoV. In this study, we evaluated parainfluenza virus 5 (PIV5)-based vaccine expressing the MERS-CoV envelope spike protein (PIV5/MERS-S) in a human DPP4 knockin C57BL/6 congenic mouse model (hDPP4 KI). Following a single-dose intranasal immunization, PIV5-MERS-S induced neutralizing antibody and robust T cell responses in hDPP4 KI mice. A single intranasal administration of 10⁴ PFU PIV5-MERS-S provided complete protection against a lethal challenge with mouse-adapted MERS-CoV (MERS_MA6.1.2) and improved virus clearance in the lung. In comparison, single-dose intramuscular immunization with 10⁶ PFU UV-inactivated MERS_MA6.1.2 mixed with Imject alum provided protection to only 25% of immunized mice. Intriguingly, an influx of eosinophils was observed only in the lungs of mice immunized with inactivated MERS-CoV, suggestive of a hypersensitivity-type response. Overall, our study indicated that PIV5-MERS-S is a promising effective vaccine candidate against MERS-CoV infection.

IMPORTANCE MERS-CoV causes lethal infection in humans, and there is no vaccine. Our work demonstrates that PIV5 is a promising vector for developing a MERS vaccine. Furthermore, success of PIV5-based MERS vaccine can be employed to develop a vaccine for emerging CoVs such as SARS-CoV-2, which causes COVID-19.

The polysaccharide pectin is a major component of the plant cell wall. The pectic glycan homogalacturonan (HG) is a proportionally small but important component of a specialized seed cell wall called mucilage. HG is synthesized in a highly methylesterified form, and, following secretion, is de-methylesterified by pectin methylesterases (PMEs). The degree of methylesterification of HG determines the structural and functional properties of pectin, but how methylesterification is regulated remains largely unknown. Here, we identified two BEL1-Like homeodomain (BLH) transcription factors, BLH2 and BLH4, as positive regulators of HG de-methylesterification in Arabidopsis (Arabidopsis thaliana) seed coat mucilage. BLH2 and BLH4 were significantly expressed in mucilage secretory cells during seed mucilage production. BLH2 and BLH4 single mutants exhibited no obvious mucilage phenotype, but the blh2 blh4 double mutant displayed significantly reduced mucilage adherence to the seed. Reduced mucilage adherence in blh2 blh4 was caused by decreased PME activity in the seed coat, which increased the degree of methylesterification of HG in mucilage. The expression of several PME metabolism-related genes, including PME58, PECTIN METHYLESTERASE INHIBITOR6, SEEDSTICK, and MYB52 was significantly altered in blh2 blh4 seeds. BLH2 and BLH4 directly activated PME58 expression by binding to its TGACAGGT cis-element. Moreover, pme58 mutants exhibited reduced mucilage adherence similar to that of blh2 blh4, and the blh2 blh4 pme58 triple mutant exhibited no additional mucilage adherence defects. Furthermore, overexpression of PME58 in blh2 blh4 rescued the mucilage adherence defect. Together, these results demonstrate that BLH2 and BLH4 redundantly regulate de-methylesterification of HG in seed mucilage by directly activating PME58.

Reactive oxygen and nitrogen species have been implicated in many biological processes and diseases, including immune responses, cardiovascular dysfunction, neurodegeneration, and cancer. These chemical species are short-lived in biological settings, and detecting them in these conditions and diseases requires the use of molecular probes that form stable, easily detectable, products. The chemical mechanisms and limitations of many of the currently used probes are not well-understood, hampering their effective applications. Boronates have emerged as a class of probes for the detection of nucleophilic two-electron oxidants. Here, we report the results of an oxygen-18–labeling MS study to identify the origin of oxygen atoms in the oxidation products of phenylboronate targeted to mitochondria. We demonstrate that boronate oxidation by hydrogen peroxide, peroxymonocarbonate, hypochlorite, or peroxynitrite involves the incorporation of oxygen atoms from these oxidants. We therefore conclude that boronates can be used as probes to track isotopically labeled oxidants. This suggests that the detection of specific products formed from these redox probes could enable precise identification of oxidants formed in biological systems. We discuss the implications of these results for understanding the mechanism of conversion of the boronate-based redox probes to oxidant-specific products.

The new decade of the 21^st century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission to humans, and mechanisms associated with the pathogenicity of SARS-CoV-2 are not yet clear, however, its resemblance to SARS-CoV and several other bat coronaviruses was recently confirmed through genome sequencing-related studies. The development of therapeutic strategies is necessary in order to prevent further epidemics and cure infections. In this review, we summarize current information about the emergence, origin, diversity, and epidemiology of three pathogenic coronaviruses with a specific focus on the current outbreak in Wuhan, China. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2.

ABSTRACT

Members of family Coronaviridae cause a variety of diseases in birds and mammals. Porcine hemagglutinating encephalomyelitis virus (PHEV), a lesser-researched coronavirus, can infect naive pigs of any age, but clinical disease is observed in pigs ≤4 weeks of age. No commercial PHEV vaccines are available, and neonatal protection from PHEV-associated disease is presumably dependent on lactogenic immunity. Although subclinical PHEV infections are thought to be common, PHEV ecology in commercial swine herds is unknown. To begin to address this gap in knowledge, a serum IgG antibody enzyme-linked immunosorbent assay (ELISA) based on the S1 protein was developed and evaluated on known-status samples and then used to estimate PHEV seroprevalence in U.S. sow herds. Assessment of the diagnostic performance of the PHEV S1 ELISA using serum samples (n = 924) collected from 7-week-old pigs (n = 84; 12 pigs per group) inoculated with PHEV, porcine epidemic diarrhea virus, transmissible gastroenteritis virus, porcine respiratory coronavirus, or porcine deltacoronavirus showed that a sample-to-positive cutoff value of ≥0.6 was both sensitive and specific, i.e., all PHEV-inoculated pigs were seropositive from days postinoculation 10 to 42, and no cross-reactivity was observed in samples from other groups. The PHEV S1 ELISA was then used to estimate PHEV seroprevalence in U.S. sow herds (19 states) using 2,756 serum samples from breeding females (>28 weeks old) on commercial farms (n = 104) with no history of PHEV-associated disease. The overall seroprevalence was 53.35% (confidence interval [CI], ±1.86%) and herd seroprevalence was 96.15% (CI, ±3.70%).

IMPORTANCE There is a paucity of information concerning the ecology of porcine hemagglutinating encephalomyelitis virus (PHEV) in commercial swine herds. This study provided evidence that PHEV infection is endemic and highly prevalent in U.S. swine herds. These results raised questions for future studies regarding the impact of endemic PHEV on swine health and the mechanisms by which this virus circulates in endemically infected populations. Regardless, the availability of the validated PHEV S1 enzyme-linked immunosorbent assay (ELISA) provides the means for swine producers to detect and monitor PHEV infections, confirm prior exposure to the virus, and to evaluate the immune status of breeding herds.

OBJECTIVE

Incident type 2 diabetes is common among patients with recent acute coronary syndrome and is associated with an adverse prognosis. Some data suggest that cholesteryl ester transfer protein (CETP) inhibitors reduce incident type 2 diabetes. We compared the effect of treatment with the CETP inhibitor dalcetrapib or placebo on incident diabetes in patients with recent acute coronary syndrome.

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of ¹⁸F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

Currently, the expansion of the novel human respiratory coronavirus (known as SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2], COVID-2019 [coronavirus disease 2019], or 2019-nCoV [2019 novel coronavirus]) has stressed the need for therapeutic alternatives to alleviate and stop this new epidemic. The previous epidemics of infections by high-morbidity human coronaviruses, such as SARS-CoV in 2003 and the Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, prompted the characterization of compounds that could be potentially active against the currently emerging novel coronavirus, SARS-CoV-2. The most promising compound is remdesivir (GS-5734), a nucleotide analog prodrug currently in clinical trials for treating Ebola virus infections. Remdesivir inhibited the replication of SARS-CoV and MERS-CoV in tissue cultures, and it displayed efficacy in nonhuman animal models. In addition, a combination of the human immunodeficiency virus type 1 (HIV-1) protease inhibitors lopinavir/ritonavir and interferon beta (LPV/RTV–IFN-β) was shown to be effective in patients infected with SARS-CoV. LPV/RTV–IFN-β also improved clinical parameters in marmosets and mice infected with MERS-CoV. Remarkably, the therapeutic efficacy of remdesivir appeared to be superior to that of LPV/RTV–IFN-β against MERS-CoV in a transgenic humanized mouse model. The relatively high mortality rates associated with these three novel human coronavirus infections, SARS-CoV, MERS-CoV, and SARS-CoV-2, have suggested that proinflammatory responses might play a role in the pathogenesis. It remains unknown whether the generated inflammatory state should be targeted. Therapeutics that target the coronavirus alone might not be able to reverse highly pathogenic infections. This minireview aims to provide a summary of therapeutic compounds that have shown potential in fighting SARS-CoV-2 infections.

Understanding how coronary blood vessels form and regenerate during development and progression of cardiac diseases will shed light on the development of new treatment options targeting coronary artery diseases. Recent studies with the state-of-the-art technologies have identified novel origins of, as well as new, cellular and molecular mechanisms underlying the formation of coronary vessels in the postnatal heart, including collateral artery formation, endocardial-to-endothelial differentiation and mesenchymal-to-endothelial transition. These new mechanisms of coronary vessel formation and regeneration open up new possibilities targeting neovascularization for promoting cardiac repair and regeneration. Here, we highlight some recent studies on cellular mechanisms of coronary vessel formation, and discuss the potential impact and significance of the findings on basic research and clinical application for treating ischemic heart disease.

Trước tình trạng bùng phát dịch corona ở nhiều nước trên thế giới, mỗi gia đình cần phải thường xuyên vệ sinh, khử trùng nhà cửa sạch sẽ như một phần của các biện pháp phòng ngừa dịch bệnh.

Thị trường BĐS ở Mỹ vốn đang phục hồi và chuẩn bị có một khởi đầu mạnh mẽ trong mùa Xuân này, cho tới khi virus Corona bùng phát và gây ra những ảnh hưởng không nhỏ.

पंजाब में कोरोना महामारी से बुधवार को दो और लोगों ने दम तोड़ दिया। इसके साथ ही प्रदेश में संक्रमण से मरने वालों की संख्या 27 हो गई।

राजस्थान में शुक्रवार को कोरोना वायरस संक्रमण के 64 नए मामले सामने आए और एक बीमार व्यक्ति की मौत हो गई। अब राज्य में कोरोना की वजह से मौतों का आंकड़ा 100 हो गया है और कुल संक्रमितों की संख्या 3491 हो गई है।

राजस्थान में कोरोना संक्रमण के 57 नए मामले सामने आए, जिससे राज्य में कोरोना वायरस संक्रमितों की कुल संख्या बढ़कर 3,636 हो गई।

देश सेवा हर नागरिक का पहला कर्तव्य होना चाहिए। बहुत कम लोगों को यह मौका मिलता है। देश सेवा में योगदान देकर अच्छा महसूस कर रही हूं।

कश्मीर में शुक्रवार को कोरोना के 30 नए मामले सामने आए। अब प्रदेश में संक्रमितों का आंकड़ा 823 हो चुका है। वहीं 29 मरीजों को ठीक होने पर अस्पताल से छुट्टी दे दी गई।

कोरोना वायरस से लोगों को बचाने के लिए योद्धा के रूप में डेढ़ महीने से कंडी के बीएमओ डॉ. इकबाल मलिक सेवाएं दे रहे हैं। उन्होंने बताया कि उनके परिवार से ज्यादा महत्व उन लोगों का है जिनके लिए वह ड्यूटी देकर सरकार से वेतन लेते हैं।

पंजाब में शनिवार को कोरोना संक्रमण से पीड़ित एक और मरीज की मौत हो गई। इसके साथ ही प्रदेश में महामारी से मृतकों की संख्या 30 पहुंच गई है।

चंडीगढ़ में सेक्टर 32 स्थित जीएमसीएच में शानिवार दोपहर को बापूधाम निवासी कोरोना के संदिग्ध मरीज की मौत हो गई।

छत्तीसगढ़ के कोरबा जिले में तीन और कोरोना संक्रमित मिले हैं। इसी के साथ राज्य में संक्रमितों की संख्या बढ़कर 36 हो गई।

लॉक डाउन का तीसरा चरण शहरियों पर संक्रमण के लिहाज से भारी पड़ा है। महाराष्ट्र और दिल्ली से आए लोग कोरोना संक्रमितों की संख्या बढ़ने का कारण बने। एक मई से सात मई तक सिर्फ पांच दिन में संक्रमितों की संख्या पांच से 17 हो गई।

जिले में बढ़ते कोरोना संक्रमण के बीच राहत की खबर है। शंकरगढ़ के कपारी गांव के दोनों कोरोना पॉजिटिव युवकों की तीसरी बार कराई गई जांच की रिपोर्ट शुक्रवार को निगेटिव आई है। वहीं तेलियरगंज के शंकरघाट निवासी संक्रमित युवक की रिपोर्ट अभी आनी बाकी है...

दिल्ली-एनसीआर समेत पूरे देश में लॉकडाउन का दूसरा चरण 3 मई को खत्म हो जाएगा और 4 मई से इसका तीसरा चरण शुरू हो जाएगा। लेकिन लॉकडाउन के लंबे दौर के बाद भी कोरोना संक्रमितों के आंकड़े लगातार बढ़ रहे हैंं, पढ़ें दिनभर के अपडेट्स...

गुरुग्राम जिला प्रशासन ने कोरोना वायरस के प्रसार को रोकने के लिए छह और इलाकों को कंटेनमेंट जोन घोषित कर दिया है।

भारतीय महिला हॉकी टीम ने कोविड-19 महामारी के खिलाफ लड़ाई में मदद के लिए 20 लाख रुपये की राशि जुटाई है..

जानलेवा महामारी कोरोना वायरस से संक्रमित बिहार के बिहार शरीफ के रहने वाले महताब आलम संक्रमण से मुक्त हो गए हैं।

बिहार के पूर्णिया जिले में बुधवार को कोरोना संक्रमण का एक नया मामला प्रकाश में आने के साथ प्रदेश में कोविड-19 के मामले अब बढकर 536 हो गए हैं।

बिहार के समस्तीपुर जिले में शुक्रवार को कोरोना वायरस संक्रमण के छह नये मामले सामने आने के बाद प्रदेश में कोविड-19 से संक्रमित लोगों की संख्या बढ़कर 556 हो गई है।

बिहार मिलिट्री पुलिस (बीएमपी) के पांच कर्मी कोरोना वायरस से संक्रमित पाए गए हैं जिसके बाद राज्य में संक्रमितों की कुल संख्या बढ़कर 579 हो गई है।

उत्तराखंड में छह और कोरोना पॉजिटिव मरीज ठीक हो चुके हैं। अब राज्य में 45 मरीज ठीक हो चुके हैं। वहीं राज्य में कुल पॉजिटिव मरीजों की संख्या 61 है।

ऋषिकेश एम्स में भर्ती रुड़की के खाताखेड़ी गांव के एक युवक में कोरोना की पुष्टि के बाद पुलिस-प्रशासन ने पांच हजार की आबादी वाले गांव को पाबंद कर सभी रास्ते बंद कर दिए हैं।

उत्तराखंड के ऊधमसिंह नगर जिले में शनिवार को चार नए मामले सामने आए हैं। अब राज्य में कुछ मरीजों की संख्या 67 हो गई है।

वैश्विक महामारी कोरोना वायरस से निपटने के लिए लगाया गया लॉकडाउन जारी है। आज लॉकडाउन 3.0 का छठा दिन है। वहीं, देशभर में संक्रमित मरीजों की संख्या में लगातार बढ़ोतरी हो रही है

Paris Games Week 2020 organizer SELL announced it has cancelled this years event due to concerns over the ongoing coronavirus (COVID-19) pandemic. The event was set to run from October 23 to 27. 

Read the message from SELL below:

Dear players,

It is with great emotion that we have made the difficult decision to cancel Paris Games Week, initially scheduled from 23rd to 27th October and which would have marked our 10th anniversary.

The current context and the necessary anticipation of both the technical and logistical complexities of an event such as Paris Games Week have led us to cancel this edition.

This year should have been special, with a line-up full of new releases, and an anniversary edition which we were thrilled to celebrate with you.

We are going to work with all the industry players to enable us all to live our passion. We are already preparing next year’s edition and are looking forward to seeing you again.

Our Very Best Regards,

The Paris Games Week Team

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443416/paris-games-week-2020-cancelled-due-to-coronavirus-pandemic/