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Blood Oxygen Test Finds Heart Defects in Newborns

Title: Blood Oxygen Test Finds Heart Defects in Newborns
Category: Health News
Created: 8/22/2011 11:00:00 AM
Last Editorial Review: 8/22/2011 12:00:00 AM




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New Blood Thinner Effient No Better Than Plavix at Preventing Heart Trouble: Study

Title: New Blood Thinner Effient No Better Than Plavix at Preventing Heart Trouble: Study
Category: Health News
Created: 8/26/2012 10:05:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM




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Kids Benefit From Doctors' Antismoking Counseling: Experts

Title: Kids Benefit From Doctors' Antismoking Counseling: Experts
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM




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Readmission Rates for Children May Not Reflect Hospital Performance

Title: Readmission Rates for Children May Not Reflect Hospital Performance
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM




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New Defibrillator Works Without Wires Touching Heart

Title: New Defibrillator Works Without Wires Touching Heart
Category: Health News
Created: 8/26/2013 4:36:00 PM
Last Editorial Review: 8/27/2013 12:00:00 AM




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Babies May Remember Words Heard Before Birth

Title: Babies May Remember Words Heard Before Birth
Category: Health News
Created: 8/26/2013 4:36:00 PM
Last Editorial Review: 8/27/2013 12:00:00 AM




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Anti-Fungal Drug Not Tied to Most Birth Defects: Study

Title: Anti-Fungal Drug Not Tied to Most Birth Defects: Study
Category: Health News
Created: 8/28/2013 5:36:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM




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Drinking Before First Pregnancy Raises Risk of Breast Cancer: Study

Title: Drinking Before First Pregnancy Raises Risk of Breast Cancer: Study
Category: Health News
Created: 8/28/2013 4:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM




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Bullying Starts Before School Years Begin, Study Finds

Title: Bullying Starts Before School Years Begin, Study Finds
Category: Health News
Created: 8/25/2014 12:36:00 PM
Last Editorial Review: 8/26/2014 12:00:00 AM




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Heart Studies Don't Reflect Real-World Patients, Study Finds

Title: Heart Studies Don't Reflect Real-World Patients, Study Finds
Category: Health News
Created: 8/26/2014 4:36:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM




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Brief Drop in Blood Sugar at Birth Tied to Poorer School Performance

Title: Brief Drop in Blood Sugar at Birth Tied to Poorer School Performance
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM




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No Mental Benefits Seen for Elderly Who Stop Blood Pressure Meds

Title: No Mental Benefits Seen for Elderly Who Stop Blood Pressure Meds
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM




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Mom's Healthy Diet Linked to Lower Heart Defect Risk at Birth

Title: Mom's Healthy Diet Linked to Lower Heart Defect Risk at Birth
Category: Health News
Created: 8/25/2015 12:00:00 AM
Last Editorial Review: 8/26/2015 12:00:00 AM




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Awareness of Memory Problems Fades a Few Years Before Dementia: Study

Title: Awareness of Memory Problems Fades a Few Years Before Dementia: Study
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM




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Mixed Findings on Pot's Effect on the Developing Brain

Title: Mixed Findings on Pot's Effect on the Developing Brain
Category: Health News
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM




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Health Tip: Early to Bed Before Back to School

Title: Health Tip: Early to Bed Before Back to School
Category: Health News
Created: 8/22/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM




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Twitter Broadening Discussions About Death, Grief: Study

Title: Twitter Broadening Discussions About Death, Grief: Study
Category: Health News
Created: 8/20/2016 12:00:00 AM
Last Editorial Review: 8/22/2016 12:00:00 AM




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Kids' Mild Brain Injury Can Have Long-Term Effects

Title: Kids' Mild Brain Injury Can Have Long-Term Effects
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM




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Scans Show Range of Zika-Linked Infant Brain Defects

Title: Scans Show Range of Zika-Linked Infant Brain Defects
Category: Health News
Created: 8/23/2016 12:00:00 AM
Last Editorial Review: 8/24/2016 12:00:00 AM




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Medical Marijuana's Pain Relief May Work Better for Men

Title: Medical Marijuana's Pain Relief May Work Better for Men
Category: Health News
Created: 8/24/2016 12:00:00 AM
Last Editorial Review: 8/25/2016 12:00:00 AM




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The Benefits of a Weekly Diet Plan

Title: The Benefits of a Weekly Diet Plan
Category: Health News
Created: 8/28/2017 12:00:00 AM
Last Editorial Review: 8/28/2017 12:00:00 AM




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Some Newborns Don't Get Heart Defect, Hearing Loss Tests

Title: Some Newborns Don't Get Heart Defect, Hearing Loss Tests
Category: Health News
Created: 8/25/2017 12:00:00 AM
Last Editorial Review: 8/28/2017 12:00:00 AM




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Health Tip: Avoid Juice Before Age 1

Title: Health Tip: Avoid Juice Before Age 1
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM




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Before Volcano Buried Pompeii, Toxic Water May Have Plagued Residents

Title: Before Volcano Buried Pompeii, Toxic Water May Have Plagued Residents
Category: Health News
Created: 8/29/2017 12:00:00 AM
Last Editorial Review: 8/30/2017 12:00:00 AM




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The Health Benefits of Eating Earlier

Title: The Health Benefits of Eating Earlier
Category: Health News
Created: 8/27/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM




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Goats Can Read Human Emotions, Prefer Happy Faces

Title: Goats Can Read Human Emotions, Prefer Happy Faces
Category: Health News
Created: 8/31/2018 12:00:00 AM
Last Editorial Review: 8/31/2018 12:00:00 AM




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CDC Boosts Efforts to Fight Congo Ebola Outbreak

Title: CDC Boosts Efforts to Fight Congo Ebola Outbreak
Category: Health News
Created: 8/30/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM




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The Benefits of Strength Training During Pregnancy

Title: The Benefits of Strength Training During Pregnancy
Category: Health News
Created: 8/30/2019 12:00:00 AM
Last Editorial Review: 8/30/2019 12:00:00 AM




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Whether From Diet or Surgery, Weight Loss Has Same Benefits: Study

Title: Whether From Diet or Surgery, Weight Loss Has Same Benefits: Study
Category: Health News
Created: 8/21/2020 12:00:00 AM
Last Editorial Review: 8/24/2020 12:00:00 AM




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Not So Sudden: Many Seek Medical Help 2 Weeks Before Cardiac Arrest

Title: Not So Sudden: Many Seek Medical Help 2 Weeks Before Cardiac Arrest
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM




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President Trump Promises a COVID Vaccine Before the End of the Year

Title: President Trump Promises a COVID Vaccine Before the End of the Year
Category: Health News
Created: 8/28/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM




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After a Heart Attack, a Joint Effort to Lose Weight Works Best

Title: After a Heart Attack, a Joint Effort to Lose Weight Works Best
Category: Health News
Created: 8/27/2020 12:00:00 AM
Last Editorial Review: 8/28/2020 12:00:00 AM




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One Benefit of Online Learning: Better Sleep for Kids

Title: One Benefit of Online Learning: Better Sleep for Kids
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM




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Don't Forget to Apply Sunscreen Before & After Water Fun

Title: Don't Forget to Apply Sunscreen Before & After Water Fun
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM




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Taking a Shot at Pain Relief After Knee Replacement

Title: Taking a Shot at Pain Relief After Knee Replacement
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM




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AHA News: Obstacles Didn't Stop This Heart Defect Survivor From Competing on 'American Ninja Warrior

Title: AHA News: Obstacles Didn't Stop This Heart Defect Survivor From Competing on 'American Ninja Warrior
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM




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What Are the Benefits of Drinking Tea With Milk?

Title: What Are the Benefits of Drinking Tea With Milk?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM




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Qigong Meditation for Beginners: Techniques, Benefits, and More

Title: Qigong Meditation for Beginners: Techniques, Benefits, and More
Category: Health and Living
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM




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Banded Squats: Benefits and 11 Ways to Do Them

Title: Banded Squats: Benefits and 11 Ways to Do Them
Category: Health and Living
Created: 8/8/2022 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM




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7 Surprising Goat Milk Soap Benefits

Title: 7 Surprising Goat Milk Soap Benefits
Category: Health and Living
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM




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Why Do Men Often Die Before Women?

Title: Why Do Men Often Die Before Women?
Category: Health News
Created: 7/14/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM




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Here Is Why Men Should Take Vitamin B12: 10 Health Benefits

Title: Here Is Why Men Should Take Vitamin B12: 10 Health Benefits
Category: Health and Living
Created: 7/27/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM




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Do You Use Mouthwash Before or After Brushing?

Title: Do You Use Mouthwash Before or After Brushing?
Category: Health and Living
Created: 8/5/2022 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM




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GERD (Acid Reflux) in Infants and Children

Title: GERD (Acid Reflux) in Infants and Children
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM




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The effect of graded exercise therapy on fatigue in people with serious respiratory illness: a systematic review

Background

In adults with serious respiratory illness, fatigue is prevalent and under-recognised, with few treatment options. The aim of this review was to assess the impact of graded exercise therapy (GET) on fatigue in adults with serious respiratory illness.

Methods

Electronic databases were searched to identify randomised controlled trials (RCTs) testing GET (involving incremental increases in exercise from an established baseline) in adults with serious respiratory illness. The primary outcome was fatigue and secondary outcomes were health-related quality of life (HRQoL) and adverse events. Two authors independently screened for inclusion, evaluated risk of bias and extracted data.

Results

76 RCTs were included with 3309 participants, most with a diagnosis of COPD or asthma. Reductions in fatigue measured by the Chronic Respiratory Disease Questionnaire fatigue domain score were demonstrated following GET consisting of aerobic with/without resistance training (mean difference (MD) 0.53 points, 95% CI 0.41–0.65, 11 RCTs, 624 participants) and GET using resistance training alone (MD 0.58 points, 95% CI 0.21–0.96, two RCTs, 82 participants) compared with usual care. Although the mean effect exceeded the minimal important difference, the lower end of the confidence intervals did not always exceed this threshold so the clinical significance could not be confirmed. GET consistently improved HRQoL in people with a range of chronic respiratory diseases on multiple HRQoL measures. No serious adverse events related to GET were reported.

Conclusion

GET may improve fatigue alongside consistent improvements in HRQoL in people with serious respiratory illness. These findings support the use of GET in the care of people with serious respiratory illness.




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Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain [RESEARCH]

The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.




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Wonca Europe 2023 Definition of General Practice/Family Medicine: New Needs New Content




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Reply to Letter to Editor Concerning “Nocturnal Pressure Controlled Ventilation Improves Sleep Efficiency in Patients Receiving Mechanical Ventilation”




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The Challenge of Implementing Race-Neutral PFT Reference Equations




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Simulation in Mechanical Ventilation Training: Integrating Best Practices for Effective Education