We know that there is at least one planet orbiting Proxima Centauri, the nearest star to our solar system, and now astronomers may have taken the first picture of a second world

Getting less sleep for five nights in a row can make you view other people’s expressions more negatively, including facial reactions seen over video calls

Rocks from a 3.2-billion-year-old formation in Australia show changes in the direction of their magnetism over time that suggest plate tectonics started earlier than we thought

A bunch of asteroids near Jupiter and Neptune with orbits perpendicular to the plane of the solar system may have come here from a different star system

Some dogs and cats may be passing gut microbes to their owners that withstand last-resort antibiotics, which can be needed to fight off pneumonia from a coronavirus infection

In a small trial, implanting electrodes into the brain helped women with severe anorexia gain weight and feel less anxious and depressed

The ongoing spread of bluetongue virus among European farm animals may have started when a cow was inseminated with infected bull semen stored from an earlier outbreak

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app

Healthcare systems need to prepare for the extensive physiotherapy and mental rehabilitation that people put on ventilators for covid-19 will need as they recover

Stars that are similar to the sun in every way we can measure are mostly more active than the sun, which hints that the sun’s activity may ramp up someday, risking solar eruptions

The Tully Monster is a famously odd 300-million-year-old fossil that looks like an alien, but a new analysis suggests it was a backboned animal like a hagfish or lamprey

We’ve found a 200-metre cliff in Mars's Hellas basin, the first evidence of a river that flowed on the planet for more than 100,000 years

Mercury is much denser than the other rocky planets in the solar system, and that may be because a collision vaporised its surface and the debris was blown away by the sun

This story is a bit on the nose. Hello, Peter Ludlow here, CEO of InGen, the company behind the wildly successful dinosaur-themed amusement park, Jurassic Park. As you’re all aware, after an unprecedented storm hit the park, we lost power and the velociraptors escaped their enclosure and killed hundreds of park visitors, prompting a two-month […]

Up and to the office, where sat all the morning, among other things a great conflict I had with Sir W. Warren, he bringing a letter to the Board, flatly in words charging them with their delays in passing his accounts, which have been with them these...

(Lord's day). Up, and going down to the water side, I met Sir John Robinson, and so with him by coach to White Hall, still a vain, prating, boasting man as any I know, as if the whole City and Kingdom had all its work done by him. He tells me he hath...

Up and angry with my mayds for letting in watermen, and I know not who, anybody that they are acquainted with, into my kitchen to talk and prate with them, which I will not endure. Then out and by coach to my Lord Treasurer's, who continues still...

Up betimes, and by coach to St. James's; but there find Sir W. Coventry gone out betimes this morning, on horseback, with the King and Duke of York, to Putney-heath, -- to run some horses, and so back again to the office, where some witnesses from...

Up pretty betimes and out of doors, and in Fen Church street met Mr. Lovett going with a picture to me, but I could not stand to discourse or see it, but on to the next hackney coach and so to Sir W. Coventry, where he and I alone a while discoursing...

An Indianapolis man was fatally shot by police after a high-speed chase in an incident that appeared to have been broadcast on Facebook Live, sparking outcry and protests throughout the night.More than 100 people from the community gathered at the scene of the shooting to express their outrage Wednesday night, chanting “No justice, no peace!” as they demanded answers from police about the latest officer-involved death. Protestors continued demonstrating Thursday, with dozens marching through the streets before congregating outside of the Indianapolis Metropolitan Police Department headquarters. “We deserve better,” one community activist told The Indianapolis Star. “I am disgusted, horrified, tired, and angry.”‘You’re Gonna Kill Me’: Body-Cam Footage Shows Cops Mocking Dallas Man as He DiesThe Indianapolis Metropolitan Police Department said the incident began around 6 p.m. when officers began pursuing a man who they observed to be driving recklessly. After the driver exited the car, an officer chased him on foot before gunfire was “exchanged” at around 6:14 p.m., police said in a press release, without revealing who fired first. In the unconfirmed Facebook video of the incident, at least 13 or 14 gunshots can be heard. In another video obtained by The Indianapolis Star, a detective who arrived after the shooting can be heard saying: “Looks like it’s going to be a closed casket, homie.” “We are aware of inappropriate comments made by an IMPD detective” on the live stream, Indianapolis MPD Chief Randal Taylor said at a Thursday press conference. “Let me be clear: These comments are unacceptable and unbecoming of our police department.” While Taylor did not confirm the authenticity of the Facebook live stream, he did stress he was “concerned with the things on social media,” stating he thinks that some comments online “lack trust as to what occurred.” Authorities have not yet identified the name of the driver but said he and the officer who shot him were both black men. Family members identified the driver to local media outlets as 21-year-old Dreasjon “Sean” Reed. The officer who fired the fatal shot has been placed on administrative leave pending further investigation.“I feel like to lose a life, especially at a young age, there’s never going to be justice,” Jazmine Reed, the 21-year-old’s sister, told WISH, adding that her family watched the pursuit and shooting on Facebook as it happened. “Cause he’s gone—there’s never justice for that. Even if somebody was to get time or whatever for it, it’s never going to be justice because he’s never coming back.” The sister said she drove to the scene after watching the video, not knowing whether her brother was still alive. “I shouldn’t have to bury my little brother,” she added.The Indianapolis MPD said the incident began after two officers saw a Toyota Corolla being driven “recklessly.” They followed the driver in unmarked cars and asked for assistance as they said the vehicle continued “at a high rate of speed” and the operator was “disobeying all traffic signals” and nearly hit another car. In the Facebook video, titled “High-speed case lol,” Reed, who is shirtless, appears nervous as he speaks to his 2,000 viewers and points his camera to show the moving police cars behind him.“Almost lost him y’all!” he says. “Almost got rid of his ass!”Video Shows Florida Deputy Violently Yanking Middle Schooler’s Hair During ArrestAt one point, he appears to pull over and stop his car. Authorities say the driver disregarded “the officers’ verbal commands to stop” and ran out of the car, prompting an officer to chase him on foot.“I’m on 62nd and Michigan,” Reed says in the video, just before exiting the vehicle. “I just parked... I’m gone.” He added: “Please come get me! Please come get me! Please come get me!”Reed can then be heard running for approximately 30 seconds, as a voice behind him yells: “Stop! Stop!”“Fuck you,” Reed replies. Indianapolis Metropolitan Police Department Assistant Chief Chris Bailey said during a Wednesday news conference that the officer first used his taser, but it’s unclear if it worked and is not seen on the purported video from the scene.“It is believed at this time that shots were fired by both the officer and the suspect,” Bailey said.In the video, Reed appears to start screaming before collapsing on the ground. About eight seconds later, 11 or 12 gunshots can be heard in rapid succession. The live stream did not show Reed talking about a gun or firing a weapon. After a brief pause, two more shots can be heard as the camera faces the sky while the opening lyrics of Young Dolph’s “16 Zips” appears to be playing off the phone. By the end of the gunfire, more than 4,000 people had tuned in to watch the live stream, according to the Star.Bailey said Indianapolis Emergency Medical Services arrived shortly after and pronounced the driver dead at the scene. The officer was uninjured.Taylor on Thursday stated that a “loaded gun” was recovered at the scene that appeared to have been fired twice and that it belonged to the driver. He added that disciplinary action will be taken against the detective who made the “casket” comment.After the incident, the Facebook Live video, which has been widely shared on social media, was removed from the victim’s account, Bailey said. Bailey added that authorities are aware of Facebook videos.Cop Charged With Assault After Video Shows Him Slamming Suspect’s Head Into Pavement“Both the officers and the detectives have done their due diligence in preserving that evidence through the proper legal channels, and if it’s associated that there’s information on there that’s appropriate for the investigation, they’ll utilize it,” he said.Taylor added Thursday the police officers involved in the shooting were not wearing body cameras, but he has no reason to believe they acted inappropriately. But after the press conference, dozens of protesters took to the streets demanding more police action, shouting “all lives matter,” as drivers stopped their cars and put their fists out their windows in solidarity.About eight hours after that shooting, Indianapolis police fatally shot another man during an investigation into a burglary at an apartment complex. Authorities said that around 1:30 a.m. Thursday, four officers responded to the apartment and were immediately fired upon by a man with a rifle. All four officers “returned fire” and hit the man, who was pronounced dead at the scene, police said in a news release. In response to both incidents, Taylor stressed at a Thursday press conference that he will provide residents with “the truth whether we are right or wrong.”“We have long talked about the kind of police department we want to be—one that serves with the community, that's not policed at—a police department that is trusted, one where every resident feels a comfortable calling,” Taylor said. “We recognize and are saddened that this mutual trust that is so valued has been eroded over the last 24 hours.”Investigators are now conducting a separate investigation into that shooting, and police said there’s evidence the victim called 911 with the intent of ambushing the responding officers. “Our hearts this morning are with the families who lost loved ones during these tragic events. All of us are trying to make a new normal in an un-normal time. Incidents like these do not help restore normalcy to our community,” Chrystal Ratcliffe, the president of the NAACP branch in Indianapolis said in a statement.The American Civil Liberties Union of Indiana on Thursday called for a “prompt, thorough, and transparent investigation” into Reed’s death.“Whether someone is unarmed or armed, compliant or resistant, police officers should be properly trained in de-escalation tactics and turn to the use of force only as a last resort, not a first option,” the statement read. Read more at The Daily Beast.Got a tip? Send it to The Daily Beast hereGet our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

Three sisters who worked in Mexico's government hospital system were found murdered by strangling, authorities in the northern border state of Coahuila announced Friday, stirring new alarm in a country where attacks on health care workers have occurred across the nation amid the coronavirus outbreak. Two of the sisters were nurses for the Mexican Social Security Institute and the third was a hospital administrator, but there was no immediate evidence the attack was related to their work. The National Union of Social Security Employees called the killings “outrageous and incomprehensible.”

The former cabinet minister says he cannot ask campaign volunteers to work for another year.

Countries have "gone their own way" rather than working together, the ex-prime minister says.

The controversial concept of B teams may be back on the agenda as football tries to navigate a way through Covid-19, Brighton technical director Dan Ashworth says.

A selection of the week's best photos from across the continent and beyond.

A selection of news photographs taken around the world this week.

Thousands of nurseries and childminders may shut permanently due to the pandemic, research suggests.

The entire nation is currently locked down due to the Coronavirus outbreak and the lockdown has now been extended till May 3. However, Salman Khan's father and veteran writer Salim Khan was recently spotted taking a walk on the Bandra Promenade by one of the area's residents. This was reported by Pinkvilla. The resident said, "Initially, we thought maybe it's a one off thing but over the last 3 weeks, we have seen him walk for half an hour every alternate day. He comes by 8.30 am and is around till 9 am."

And talking about the reason behind the same, Khan spoke at length and said, "I have been adviced by the doctors to continue my walks as I have lower back issues. I have been walking for the last 40 years and the doctor has told me if I stop suddenly, it might affect my back more. Moreover, I have the pass issued by the government till April 30, and I am following all the norms possible."

He added, "It is only on medical grounds, that I am allowed to take a walk outside. I am a law-abiding citizen but people tend to pick on us given that we are celebrities. I am not the only one who walks around. There are so many people I see who are strolling with their pets. But no one reports them! Anyway, I am ensuring I take all safety measures and also, I hope everyone else does too."

We hope Salim Khan stays safe and healthy and takes care of himself!

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The makers of Kangana Ranaut's Thalaivi are resigned to the fact that the film, like many other Bollywood offerings, will be delayed. However, they have a more pressing problem on their hands — two elaborate sets that were built in Hyderabad and Chennai have been standing unused over the past six weeks, leading to losses. If the lockdown extends to June, the makers fear the sets may be destroyed in the rains.

"We need to wrap up the film before the rains hit. Since they are outdoor set-up, they will be ruined in the monsoon. Reconstructing the set will be an expensive affair," laments producer Shailesh R Singh.

J Jayalalithaa

The shoot of the biopic on J Jayalalithaa, the late chief minister of Tamil Nadu, was running like clockwork until March. With a 45-day shooting stint slated to kick off on March 10, the AL Vijay-led team had constructed a set of the Parliament House at the Ramakrishna Cine Studios in Hyderabad. After the shoot would be wrapped up by the third week of April, their next pit-stop was Chennai.

"We have recreated Mount Road at the AVM Studio in Chennai, and had planned a patchwork shoot there. Almost 40 per cent of the movie is left to be filmed," says producer Vishnu Vardhan Induri, adding that they pre-emptively cancelled the Hyderabad shoot in the wake of the pandemic.

Sources say that the makers, who are bearing the maintenance cost of the sets and the studio rent, have incurred losses of R5 crore so far due to the lockdown. While Singh is unwilling to put a number to the damages, he adds, "Our team's safety is our priority. We had paid [the studio] for March, but were unable to shoot for a single day in Hyderabad. It's uncertain when the lockdown will be lifted. Even if we get a 10-day window, we will finish shooting the outdoor portions."

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A potentially fatal viral infection that affects pigs can readily find its way into human cells, say scientists, raising concerns about the potential for outbreaks that threaten our health. Researchers at Ohio State University in the US and Utrecht University in the Netherlands collaborated to better understand the new virus and its potential reach.

The study, published in the in the journal PNAS, is the first to point to possible transmission of this virus between species. Porcine deltacoronavirus was first identified in 2012 in pigs in China, but it was not associated with disease. It was first detected in the US in 2014 during a diarrhea outbreak in Ohio pigs and has since been detected in various countries. Young, infected pigs experience acute diarrhea and vomiting. The disease can be fatal.

As of yet, no human cases have been documented, but scientists are concerned about the possibility. "Before it was found in pigs ¿ including in the Ohio outbreak ¿ it had only been found in various birds," said Linda Saif, a professor in Ohio State University in the US. "We're very concerned about emerging coronaviruses and worry about the harm they can do to animals and their potential to jump to humans," said Saif.

Emergence of the new virus is especially worrisome to veterinary and public-health experts because of its similarity to the life-threating viruses responsible for SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) outbreaks. The potential for a virus to jump from one species to another is highly dependent on its ability to bind to receptors on the cells of the animal or human, said Scott Kenney, an assistant professor at Ohio State University.

"A receptor is like a lock in the door. If the virus can pick the lock, it can get into the cell and potentially infect the host," he said. The study looked at a particular cellular receptor called aminopeptidase N that the researchers suspected might be involved. "We know from other coronaviruses that these receptors on the cells are used and that they're found in the respiratory and digestive tracts of a number of different animals," Kenney said.

"Now we know that this new virus could go into cells of different species, including humans," he added. For now, the only known infection in humans and other species is in the laboratory, using cultured cells. The study confirmed that the virus could bind to human cells, and to cells from cats and chickens. "This doesn't prove that this virus can infect and cause disease in these other species, but that's something we obviously want to know," Saif said.

The next step in understanding this virus and its potential for human infection will be a study looking for antibodies in the blood that would serve as evidence that the pig virus has already infected people.

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Eating yogurt may help reduce chronic inflammation, a factor in bowel disease, arthritis and asthma, according to a study. The research, published in the Journal of Nutrition, explored the hypothesis that yogurt may help reduce inflammation by improving the integrity of the intestinal lining. This could help prevent endotoxins - pro-inflammatory molecules produced by gut microbes - from crossing into the blood stream.

"I wanted to look at the mechanism more closely and look specifically at yogurt," said Brad Bolling, an assistant professor at the University of Wisconsin-Madison in the US. While anti-inflammatory medications like aspirin, naproxen, hydrocortisone and prednisone can help mitigate the effects of chronic inflammation, each comes with its own risks and side effects.

The study enrolled 120 premenopausal women, half obese and half non-obese. Half of the participants were assigned to eat 12 ounces of low-fat yogurt every day for nine weeks; a control group ate non-dairy pudding for nine weeks. Bolling and his team took fasting blood samples from participants and evaluated an assortment of biomarkers that scientists have used over the years to measure endotoxin exposure and inflammation.

The results showed that while some of the biomarkers remained steady over time, the yogurt-eaters experienced significant improvements in certain key markers, such as TNF, an important inflammation-activating protein. "The results indicate that ongoing consumption of yogurt may be having a general anti-inflammatory effect," said Bolling.

The research focuses on a different aspect of the study. Participants were also involved in a high-calorie meal challenge at the beginning and end of their nine-week dietary intervention. The challenge, meant to stress an individual's metabolism, started with either a serving of yogurt or non-dairy pudding followed by a large high-fat, high-carb breakfast meal. "It was two sausage muffins and two hash browns, for a total of 900 calories. But everybody managed it. They'd been fasting, and they were pretty hungry," Bolling said.

For both challenges, blood work showed that the yogurt "appetizer" helped improve some key biomarkers of endotoxin exposure and inflammation as participants digested the meal over the ensuing hours. It also helped improve glucose metabolism in obese participants, by speeding the reduction of post-meal blood glucose levels.

"Eating eight ounces of low-fat yogurt before a meal is a feasible strategy to improve post-meal metabolism and thus may help reduce the risk of cardiovascular and metabolic diseases," said Ruisong Pei, a postdoctoral researcher at UW-Madison.

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If your workplace is supporting its employees by reducing their job strain, it may boost in preventing new cases of common mental illness from occurring up to 14 per cent, a new study suggests.

The findings, published in the journal Lancet Psychiatry, confirm that high job strain is associated with an increased risk of developing common mental disorders such as depression and anxiety amongst middle-aged workers.

Job strain is a term used to describe the combination of high work pace, intensity, and conflicting demands, coupled with low control or decision-making capacity.

"The results indicate that if we were able to eliminate job strain situations in the workplace, up to 14 per cent of cases of common mental illness could be avoided," said lead author Samuel Harvey, Associate Professor at the Black Dog Institute in Australia.

"These findings serve as a wake-up call for the role workplace initiatives should play in our efforts to curb the rising costs of mental disorders," Harvey added.

To determine levels of job strain, 6,870 participants completed questionnaires at age 45 testing for factors including decision authority, skill discretion and questions about job pace, intensity and conflicting demands.

The researchers also accounted for non-workplace factors including divorce, financial problems, housing instability, and other stressful life events like death or illness.

The models developed in this study controlled for individual workers' temperament and personality, their IQ, level of education, prior mental health problems and a range of other factors from across their early lives.

The final modelling suggested that those experiencing higher job demands, lower job control and higher job strain were at greater odds of developing mental illness by age 50, regardless of sex or occupational class.

"Workplaces can adopt a range of measures to reduce job strain, and finding ways to increase workers' perceived control of their work is often a good practical first step. This can be achieved through initiatives that involve workers in as many decisions as possible," Harvey, who is also affiliated with the University of New South Wales in Australia, noted.

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Pic courtesy/YouTube

Consuming a ketogenic diet not only helps to lose weight but also helps maintain vision in patients with glaucoma, a study conducted over mice has found. Ketogenic diet is a diet which has high fat, low protein and low carbohydrates.

Glaucoma is a progressive disease in which damage to the cells that transmit visual information to the brain leads to vision loss and, in some cases, blindness. Higher rates of glaucoma in people with diabetes suggests a potential connection between this eye disease and metabolic stress.

The findings led by Denise Inman from the Northeast Ohio Medical University in the US showed that a low carb and high-fat diet protects retina cells and their connections to the brain from degeneration.

Switching mice destined to develop glaucoma to a low carbohydrate, high fat diet protects the cells of the retina and their connections to the brain from degeneration.

The results, published in the journal JNeurosci, found that feeding mice, genetically modified to develop glaucoma, a ketogenic diet composed of nearly 90 per cent fat for two months protected retinal cells from degeneration by increasing energy availability.

Although further research into this intervention is required, these findings suggest that a ketogenic diet may help to maintain vision in patients with glaucoma, the researchers said.

(Edited by mid-day online desk, with inputs from IANS)

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Acupuncture may not boost chances of IVF success

Undergoing acupuncture treatment during in vitro fertilisation (IVF) might not increase a woman's chances of conceiving, finds a study. The study, however, showed that acupuncture is no better than placebo for improving IVF success.

Acupuncture, a traditional Chinese medicine in which thin needles are inserted into the body, has become a widely used treatment prior to and during IVF.

It showed no significant benefit from IVF when compared with a short course of acupuncture using dummy needles placed away from "true" acupuncture points.

"Our findings do not support acupuncture as an efficacious treatment compared to sham," lead investigator Caroline Smith, Professor at the Western Sydney University in Australia.

For the study, published in the journal JAMA, the team included over 800 Australian and New Zealand women to examine the effects of acupuncture administered prior to and following an embryo transfer (ET).

The participants were given either acupuncture or a sham acupuncture control (a non-insertive needle placed away from the true acupuncture points).

The results showed the rate of live birth was 18.3 per cent among participants who received acupuncture versus 17.8 per cent who received the sham acupuncture control, a non-significant difference.

While a short course of acupuncture may statistically be no better than sham at improving live birth and pregnancy outcomes, a psycho-social benefit from acupuncture was reported by women undergoing IVF, the researchers said.

"Some studies suggest reproductive outcomes maybe improved when acupuncture is compared with no treatment," Smith said.

"Feeling relaxed and reporting relief from stress and women feeling good about themselves is to be welcomed for women as they undergo an IVF cycle," explained co-author Michael Chapman, Professor at the University of New South Wales, Sydney.

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Are you experiencing depression, mood instability, and loneliness? Blame the disruption in your body's internal clock, researchers say.

Our 24-hour biological body clock governs the fundamental physiological and behavioural functions including from body temperature to eating habits in almost all organisms. Disruptions in that biological clock may arise from increased activity during rest periods and/or inactivity during the day. Disturbances to the body's internal clock or the circadian rhythms are also associated with lower happiness and health satisfaction, and worse cognitive function, according to a study published in The Lancet Psychiatry.

"Our findings indicate an association between altered daily circadian rhythms and mood disorders and well-being," said study author Laura Lyall, from the University of Glasgow.

"The study reinforces the idea that mood disorders are associated with disturbed circadian rhythms, and we provide evidence that altered rest-activity rhythms are also linked to worse subjective well-being and cognitive ability," Lyall added.

The study included data from 91,105 participants aged between 37-73. The researchers objectively measured the rest and activity rhythm patterns which is known as relative amplitude.

The results showed that lower relative amplitude was linked with greater odds of reporting lifetime history of major depression or bipolar disorder.

It was also associated with greater mood instability, higher neuroticism scores, more subjective loneliness, lower happiness and health satisfaction, and slower reaction time.

However, the researcher said that the findings showed observational associations rather than cause and effect, and "cannot tell us whether mood disorders and reduced well-being cause disturbed rest-activity patterns, or whether disturbed circadian rhythmicity makes people vulnerable to mood disorders and poorer well-being," Lyall said.

She also noted that rest-activity rhythms differ between younger and older adults which may cause difference in the daily clock and mental health link based on their age.

(Edited by mid-day online desk, with inputs from IANS)

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People with chronic conditions like arthritis or diabetes may suffer physical repercussions if they get into a fight with their spouse, according to a new study.

The findings, published in the journal Annals of Behavioral Medicine, suggests that in two groups of older individuals -- one group with arthritis and one with diabetes -- the patients who felt more tension with their spouse also reported worse symptoms on those days.

"The findings gave us an insight into how marriage might affect health, which is important for people dealing with chronic conditions like arthritis or diabetes," said co-author Lynn Martire, Professor at Pennsylvania State University in the US.

People with osteoarthritis in their knees who experience greater pain become disabled quicker, and people with diabetes that is not controlled have a greater risk for developing complications, the researcher said.

For the study, the researchers recruited a group of 145 patients with osteoarthritis in the knee and their spouses. The other included 129 patients with Type 2 diabetes and their spouses.

The participants in both groups kept daily diaries about their mood, how severe their symptoms were, and whether their interactions with their spouse were positive or negative. The participants in the arthritis and diabetes groups kept their diaries for 22 and 24 days, respectively.

The researchers found that within both groups of participants, patients were in a worse mood on days when they felt more tension than usual with their spouse, which in turn led to greater pain or severity of symptoms.

The researchers also found that within the group with arthritis, the severity of the patient's pain also had an effect on tensions with their spouse the following day.

When they had greater pain, they were in a worse mood and had greater tension with their partner the next day, the researcher added.

Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, according to a study.

The study showed that couples in which the male partner had major depression were 60 per cent less likely to conceive and give birth than those in which the male partner did not have major depression.

On the other hand, depression in the female partner was not found to influence the rate of birth.

In addition, intake of a class of antidepressants known as non-selective serotonin reuptake inhibitors (non-SSRIs) was also linked to a higher risk of early pregnancy loss among females being treated for infertility, the study appearing in the journal Fertility and Sterility, noted.

However, SSRIs, another class of antidepressants, were not linked to pregnancy loss. Neither depression in the female partner nor the use of any other class of antidepressant were linked to lower pregnancy rates.

"Our study provides infertility patients and their physicians with new information to consider when making treatment decisions," said Esther Eisenberg, at National Institutes of Health's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in Maryland, US.

Citing previous studies, the authors noted that 41 per cent of women seeking fertility treatments have symptoms of depression.

Another study of men seeking in-vitro fertilisation (IVF) treatments reported that nearly 50 per cent experienced depression.

For the study, the team analysed data for 1,650 women and 1,608 men to evaluate the potential influence of depression in couples seeking non-IVF treatments.

Among the women, 5.96 per cent were rated as having active major depression, compared to 2.28 per cent of the men.

Women using non-SSRIs were roughly 3.5 times as likely to have a first-trimester pregnancy loss, compared to those not using antidepressants.

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Researchers have found that long term chronic isolation cause the build-up of a chemical in the brain, that increases stress, aggression and fear.

The mice isolated for two weeks showed behavioural changes like, increased aggressiveness towards unfamiliar mice, persistent fear, and hypersensitivity to threatening stimuli.

When encountering a threatening stimulus, mice that have been socially isolated remain frozen in place long after the threat has passed, whereas normal mice stop freezing soon after the threat is removed, the research said.

Although the study was done in mice, it has potential implications for understanding how chronic stress affects humans and has potential applications for treating mental health disorders, said lead author Moriel Zelikowsky, postdoctoral scholar at the California Institute of Technology in the US.

Previous studies have determined that social isolation for two weeks in mice resulted in the upregulation of the signalling molecule neuropeptide, tachykinin 2 (Tac2)/neurokinin B (NkB) -- a short protein molecule.

In the new study, published in the journal Cell, the team found that chronic isolation leads to an increase in Tac2 gene expression and the production of a neuropeptide called neurokinin B (NkB) throughout the brain.

But, administration of a drug that chemically blocks NkB-specific receptors enabled the stressed mice to behave normally, eliminating the negative effects of social isolation.

On the other hand, artificially increasing Tac2 levels and activating the corresponding neurons in normal, animals led them to behave like isolated and stressed, the research showed.

Suppressing the Tac2 gene in certain different brain parts, increased fear behaviours, or aggression accordingly, implying that it must increase in different brain regions to produce the various effects of social isolation, the researchers said.

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This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

Researchers have found that a common antibacterial substance found in toothpaste may combat life-threatening diseases such as cystic fibrosis (CF) when combined with a drug.

The study, published in the journal Antimicrobial Agents and Chemotherapy, found that when triclosan -- a substance that reduces or prevents bacteria from growing -- is combined with an antibiotic called tobramycin, it kills the cells that protect the CF bacteria, known as Pseudomonas aeruginosa, by up to 99.9 per cent.

CF is a common genetic disease with one in every 2,500 to 3,500 people diagnosed with it at an early age. It results in a thick mucus in the lungs, which becomes a magnet for bacteria.

These bacteria are notoriously difficult to kill because they are protected by a slimy barrier known as a biofilm, which allows the disease to thrive even when treated with antibiotics, the researcher said.

"The problem that we're really tackling is finding ways to kill these biofilms," said lead author Chris Waters, Professor at the Michigan State University.

According to the researcher, there are many common biofilm-related infections that people get such as ear infections and swollen, painful gums caused by gingivitis.

But more serious, potentially fatal diseases join the ranks of CF including endocarditis, or inflammation of the heart, as well as infections from artificial hip and pacemaker implants, the researcher added.

For the study, the researchers grew 6,000 biofilms in petri dishes, added in tobramycin along with many different compounds, to see what worked better at killing the bacteria.

Twenty-five potential compounds were effective, but one stood out, the researcher said.

"It's well known that triclosan, when used by itself, isn't effective at killing Pseudomonas aeruginosa. But when I saw it listed as a possible compound to use with tobramycin, I was intrigued. We found triclosan was the one that worked every time," said Alessandra Hunt from the Michigan State University.

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Representational Image

Exposure to ozone (O3) -- a common air pollutant -- at birth may increase the risk of developing asthma by age three, a new study suggests.

The study, presented at the 2018 American Thoracic Society International Conference, showed that 31 per cent of the participants developed asthma, 42 per cent had allergic rhinitis and 76 per cent had eczema.

"Our findings show that the hazard ratios for ozone measured at birth as a single pollutant showed statistically significant higher risks for development of asthma, allergic rhinitis and eczema," said lead author Teresa To from The Hospital for Sick Children (SickKids) in Canada.

The study also found that 82 per cent higher risk of developing asthma was associated with each 10 parts per billion (ppb), or ppb increase in exposure to ozone at birth.

For the study, 1,881 children were recruited who were followed from birth to 17 years of age, on average.

According to the researchers, children are at a higher risk because their lungs and other respiratory organs are smaller, and they spend more time in outdoor physical activities that make them breathe faster and more deeply.

The research team took annual average concentrations of pollutants from fixed monitoring stations.

Development of asthma, allergic rhinitis and eczema were determined based on any records of health services used for these conditions.

The researchers adjusted for variables such as parental history of asthma and early home exposure to pollutants.

Earlier, some studies have shown that ozone depletes antioxidant activity and increases indications of inflammation in the respiratory tract fluid lining and affects lung growth.

"Air pollution isn't only one or a few countries' problems, but rather a global public health concern," said To, also a professor at the University of Toronto.

"While there are individual actions one can consider to reduce exposure to air pollutants, it also requires action by public authorities at the national, regional and international levels," she noted.

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Representational Image

Surgeons are developing a new smartphone-based tool that can detect urethral or urine blockage, potentially making it easier for patients to test themselves for the condition from the comfort of their own homes.

The novel technique could take high-speed photography which could capture subtle differences between a normal steady stream of liquid and a stream of liquid with an obstruction.

Urethral strictures are a slowing or blocking of the natural flow of urine due to an injury or infection. It is normally diagnosed by uroflowmetry, a test administered at a physician's office.

"The problem is that patient follow-up after we treat this condition is very poor," said Matthew Gretzer, Associate Professor at the University of Arizona in the US.

"But we need patients to come back to our clinic for a uroflow test to determine if the obstruction is still present," he added.

In order to test Gretzer's hypothesis on high-speed photography, the team created a model of a urethral structure using tubing hooked to a saline bag that could drain through.

Saline fluid was passed through the tubing with and without blockages, created using 3D printed strictures,placed within the tubing. High-speed photography captured both the regular and blocked stream of liquid exiting the tube.

Gretzer contended that photos can be a medium to diagnose blockages and he hopes that patients could send him these images to analyse and make the diagnosis. He plans to create a mobile app which can be downloaded by the patients.

"All patients would need to do is take high-speed images of their urine flow using a strobe light," Gretzer said.

"Strobe light apps are readily available right now for people to use on their phones".

According to the researchers, as fluid exits an opening, a natural breakpoint occurs where the liquid stream forms droplets, but with obstructions in place, it changes.

The results showed that by analysing photos, they could measure the length to this point of droplet formation. This length then directly related to the presence of an obstruction in the tube.

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A still from Marvel Studio's Avengers: Infinity War

Maybe because they thought I was some angrez-type, dissing one after another loads of films being dished out in the early 2000s - inevitably, a film producer or the other would proudly remind me back then, about how India (in this case, Bollywood) was absolutely the only movie market in the world where Hollywood, or the appearance of a Spielberg or George Lucas film in theatres, made no difference to the lives of local filmmakers, Subhash Ghai, Yash Chopra, if you may.

This was true for India, up until a decade ago; and yes, not true for anywhere else. Still, since the names mentioned to me were of filmmakers (no doubt, well-known/mainstream), I argued, this had a lot more to do with the reliably desi, nearly mythological star-system, that movies pivoted around and audiences lined up in cinemas for. You need a face to build a following (for anything). Any branding intern will tell you that. Hollywood had its own star-system. Few filmmaking cultures, apart from India and the US, did.

So sure, the handsomely paid Tom Cruise or Julia Roberts, or for that matter Superman/Batman, were huge in India as well. But, their films merely ran at exclusive cinemas for English films in bigger cities (say Chanakya, Sterling in South Delhi/Bombay).

Did the cash-rich Hollywood not wish to partake in the desi star, plus song, mainstream movies that enchanted millions? By late 2000s, American studios began setting up offices in Mumbai, cheekily over-paying Bollywood's lead cast, getting into lopsided deals favouring local producers, to make a direct entry into Indian markets, at last.

Bollywood films, more or less, remained the same, in terms of scale. For they weren't here to change the status quo. It suited them. The budgets (for them) were pocket-change, anyway. Major Indian filmmakers continued to feel safe in the face of a captive audience. In about a decade though, one region, small-town at a time, the American studios, having deepened a desi distribution network, began to spread out the release of their own global blockbusters that none in India could potentially compete with. The economics simply wouldn't match.

Spiderman first spoke to its audience in Bhojpuri in 2007. Ronald Emmerich's 2012 (2009), with the Taj Mahal in a shambles in the promo, with no such scene in the picture, had curious villagers walk over to nearest theatres to catch the end of the world. By 2012, even Ang Lee's deeply meditative, Life Of Pie, collecting R90 crore, had thumped the Akshay Kumar masala picture, Khiladi 786 (releasing around the same time), by a R20 crore margin!

Woah. Did desis stop loving their super-stars? Nope. They still do. Here's what happened. Hollywood altogether destroyed its own, entire 'star-system' instead - making films not about actors (or even directors, for that matter), but relentlessly concentrating their massive might/resources/energy on propping up super-heroes (several for the price of one), gigantic disasters, and dazzling 3D/IMAX special effect, to effectively conquer the earth while, sometimes, saving it on the big screen.

Perhaps 2015 was a turning point, when up until mid-year, three out of India's top five hits had emerged from Hollywood (rightly subtitled in English, even in their English versions). Fast & Furious 7 (basically racing cars) was the first film to hit R100 crore mark. Avengers: Age of the Ultron, and Jurassic World, had wholly crowded out domestic competition on the opening weekend.

These movies may have lacked a singular creative voice/vision, but they were fail-safe in the boardroom's understanding of markets, and shares. As is expectedly the case with the latest, stupendous success of Marvel's Avengers: Infinity War (having grossed over a record-breaking R200 crore, already) - where nothing exceeds like excess!

The global fan-boy pressure to get off on this pic (like many others), made critic-proof by critics themselves, is such that you simply don't want to be that guy pooping on everyone's parade. It's like being the first fellow to suggest the whisky being served from a Blue Label bottle at the boss's house-party tastes suspiciously like Aristocrat Premium: "Kya baat kar raha hai?" Naah, don't wanna be that guy!

Curiosity is irresistible. There's nothing to call out. Conditioning is complete. Indians can probably see in Thanos's quest for 'infinity stones' their own uncles, who wear similar rings for inter-planetary changes! Balance of the universe sounds a lot like 'srishti ka santulan' from Abhishek Bachchan's Drona.

The film itself being a Bollywood multi-multi-starrer, where in the end, Amrish Puri wins, and if you wonder how dead superheroes might stage a comeback-hey, Ekta Kapoor's been spinning this for decades. The premise of so many avengers, guardians, and devils, all in one, is lost on no one who devours Hindu mythology, with 330 million gods anyway. Yeah, this is desi entertainment. I say this listening to actor Ranveer Singh's voice in the Hindi trailer of Marvel's forthcoming Deadpool 2 go: "Kitna traas dega, Thanos." Sach mein, bro!

Mayank Shekhar attempts to make sense of mass culture. He tweets @mayankw14 Send your feedback to mailbag@mid-day.com

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QSQT - perhaps the first Hindi film to be referred to by its abbreviated title - finished 30 years of its release this week

If you think about it, the reason the girl (Juhi Chawla) can't be with the boy (Aamir Khan) in Mansoor Khan's directorial debut Qayamat Se Qayamat Tak (1988) - path-breaking romance for its time - is rather simple. Years ago, the boy's father had killed the girl's uncle. This is because the uncle had impregnated the boy's aunt, but forced to marry someone else - abetting her suicide.

Now, why this uncle and aunt couldn't get together isn't quite clear in this adaptation of Romeo And Juliet. Unlike the couple in Sairat (2016), both belonged to rich, neighbouring families, from the same (Rajput) caste. The thorn in their backsides was the khadoos patriarch (Goga Kapoor). He enjoyed the sole right to decide who his son (and later his grand-daughter) would marry. Also, that girl had slept with his son out of wedlock.

For a movie mirroring such rigid, patriarchal values, it's amazing that it remains, up until 2018, a rare occasion where the heroine (Juhi) falls for first, and actively chases the hero (Aamir) - a sign of ultimate gender equality (to my mind), making it one of the most feministic films I know. QSQT - perhaps the first Hindi film to be referred to by its abbreviated title - finished 30 years of its release this week. Aamir, who also shared writing credit for the movie, organised a special screening with cast and crew to mark and discuss the moment.

I just saw QSQT myself, after several years, to observe with much relief that the film hasn't aged much (certainly not as much as humans have, since), although it's not as young as the all-time favourite, Mansoor's Jo Jeeta Wahi Sikander (1992), which still looks as fresh as last Friday's catch.

One of the things that Mansoor revealed after the QSQT screening, which is rather ironic given the film's subject, were the constant creative differences/fights he would have with his late father, producer-writer Nasir Husain, during the making, making others worry if they could ever move on. That way, QSQT is full of ironies.

To begin with, for a 2-hour, 43-minute movie, there are only four-and-a-half songs. This, coming from Nasir, king of Bollywood musicals, who produced, among other great soundtracks, the 10-minute-plus medley in Hum Kisise Kum Naheen (1977; best piece of music ever).

Once, being told that a track in QSQT had been composed, while it hadn't been, Nasir decided to hop over to the studio of music composer sons of Chitragupta, Anand-Milind, giving them only a 15-minute heads up. In that interim, Anand-Milind came up with the song, Aye Mere Hum Safar.

Don't know if the pressures were equally high throughout, for I recently discovered the track, Return To Alamo (1977) by The Shadows, which even by Bollywood's liberal standards for 'inspiration', seems shockingly lifted, note for note, even tempo intact, for the number Akele Hain Toh Kya Gham Hai. The only stroke of genius being that a war-cry has been turned into a romantic melody!

In 1995, Mansoor and Aamir teamed up to unofficially remake Kramer Vs Kramer (1979), even picking up scenes from the original, while one of the main songs was copied from The Godfather score. I once asked Aamir if he thought this was a complete, creative low. He didn't agree.

What young Mansoor, and indeed Aamir, did with one foot firmly on traditions and family customs/values, and the other on relatively modern sensibilities/outlook with QSQT, is take baby steps out of the shadows of the veteran Nasir Husain. This is very similar to how the Barjatyas' reticent scion Sooraj, 25, made his directorial debut with Salman Khan in Maine Pyar Kiya (MPK, 1989), and Yash Chopra's son Aditya, 24, smartly, gently pushed the mainstream bar with Shah Rukh Khan in his first film, Dilwale Dulhania Le Jayenge (DDLJ, 1995).

Together, with soft romances involving hardened parents, the three newbie Khans invaded Bollywood, gradually extricating it from the '80s 'Angry Young Man' hangover, rape-avenger actioners, and family melodramas driven by baffling sensibilities of the money-making, assembly line movies, adapted from the South. QSQT, originally titled Nafrat Ke Waaris, was as much 10 years ahead of its time, as comforting for mainstream audiences from 20 years before. I remember older family members (and teenage girls alike) being struck by Aamir and Juhi, who were formally "introduced" in the film, although Aamir had earlier already starred in Ketan Mehta's Holi (1984).

Leading up to QSQT's release, a hoarding teaser campaign had been launched across Mumbai (and perhaps other cities), with just the question, "Who's Aamir Khan? Ask the girl next door!" The billboards turned into QSQT's posters upon the film's release. Yup, it's been 30 frickin' years. Of course, we know who's Aamir Khan. What film-buffs have always been curious about ever since, and for good reason, is what's he up to next! We always inevitably remember his last film. Which is why, I suspect, QSQT, unlike MPK, DDLJ, if you think about it, hasn't actually got its due.

Mayank Shekhar attempts to make sense of mass culture. He tweets @mayankw14 Send your feedback to mailbag@mid-day.com

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The most erudite can be swayed by numbers alone. Representation pic

The only reason a semi-circle of well-connected writers, and well-paid editors seemed to loathe Chetan Bhagat so vehemently is because he is so widely read, perhaps even loved, and they aren't, I (rightly) thought — standing in the periphery of that semi-circle at a literary fest after-party, over half a decade ago. With that bitchy conversation over-valuing Bhagat's national impact going nowhere, I stepped out to grab a drink.

Bhagat was at the corner of the bar at Indigo, where a big-shot industrialist, now I forget if it was Anand Mahindra or Ness Wadia (and that's not even the point), somberly walked up to him to check on what's going on in Indian politics. His vishesh tippani followed. Now, where to go?

The most erudite can be swayed by numbers alone, in this case the number of Bhagat's English young-lit readers. Do these numbers always signify democracy? It could produce the opposite effect. Let's look at politics in a bit, but we do know a little about mass news, entertainment, although it's hard to tell one from the other.

They're crafted around second-guessing audience's supposed tastes, often where one thing works, automatically everybody else follows, and therefore an entire industry, over time, step by step, splicing out everything that doesn't fit into the larger, determined hole, produces a mainstream media that looks the same —across. Pick up the most popular radio, television stations, websites, newspapers, or even movies (creating stars, or special effects), and you'll know. One size must fit all. Your circus, my monkeys. It's a numbers' game. And numbers can be gamed.

Is politics that aims for more complicated arithmetic, and much larger audiences, another field that defies free-market, with greater competition only inhibiting choice, and progressively screwing up quality? Survey the national scene. Examine its broad product categories that, weeding out the highest common multiple over time, every political party has conveniently fit into, in order to appeal to the lowest common denominator: Nehru/Gandhi, Sangh, Ambedkar, Lohia, Left (and those opposing them, of course). Grand promises of abolishing poverty (1971), 'acche din' (2014) etc, although well-meaning, are merely side-shows, and tag-lines.

Every politician, ideally, must check one or the other box, holding uniformly same and sometimes inter-changeable opinions on a variety of complex issues. That's what you need/scream to lord over vast public resources/institutions. Target in place. Hit-job ordered. Distraction complete. Groups vote en masse. Design is set.

Educational qualifications, past experience, passing tough exams/interviews that test competence, are for minions entrusted with growing/protecting a small company's pocket change. If you're part of none of the above cult groups, the newbie Aam Aadmi Party, for instance, you do appear like an "anarchist". It's easy to be portrayed as one. This is basically show-business, albeit of relatively not such good-looking people.

How did we get here? Because Ambedkar, the father of Indian Constitution, said we would. If, for one, he ironically stated, we fell prey to 'personality cults', or quoting John Stuart Mill, "lay liberties at the feet of even a great man, trusting him with powers, which enable him to subvert institutions." Two, if political democracy did not follow actual social democracy on the ground (unqualified liberty, equality, fraternity, for all). It didn't. So where do the regular folk stand? Between a rock, and a hard place. But you must pick a side. It makes life simpler.

And you must vote. Have to vote. It's your right. Your privilege. You must vote. This is democracy. They go to vote — for one, or perhaps, against the other. As they did in Karnataka. In a tri-partite fight, the party with the lowest number of seats, steps in to form a government, with the help of the party they fought against. The one with the highest number of seats looks at how they could "poach" from the other two, whose MLAs were locked up! It didn't matter what they fought for, or against.
The popular television anchor with the second highest English news ratings asks the gentleman from the scavenging team how they would manage the numbers. Arrey! He names his captain; and winks, pretty much. They both laugh out loud, in public, on TV, simultaneously. This is supposed to be "horse-trading" to form a "stable" government.

The highest read Indian English writer, Bhagat, weighs in with a pragmatic tweet, that must be seen as our form of public intellectualism — calling horse-trading an "art form". Yes, the election is over. Another will follow. The voter looks puzzled. Or maybe doesn't. Now let's just frickin' move on, right. No, you wanna question this? Oh.

Mayank Shekhar attempts to make sense of mass culture. He tweets @mayankw14 Send your feedback to mailbag@mid-day.com

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Order of the day
Start your week with Before Sunset
8 pm – 11 pm: Some films one can never watch enough. If you call yourself a die-hard Richard Linklater fan then you wouldn’t want to miss the chance of watching this film. Join Ethan Hawke and Julie Delpy as they meet nine years after they first found each other serendipitously, on the streets of Vienna. One of the finest performances from the lead pair, this one never gets old.
14 Monday
WHERE: Drishyam VFX, Andheri West
Entry: R200
log on to: www.1018mb.com

Enjoy some spontaneous laughter
7.30 pm: Tired of the same old rehearsed lines? Then this act is for you. Mosey on to Bandra this evening where you will be treated to some improv comedy. There’s no pre-written material and your stand-up for the day, Max Fernandes, will pick up from you to bring humour on the go. You can be a participant (recommended) or a passive audience. Take your pick.
15 Tuesday
where: The Cuckoo Club, Bandra
Entry: Rs 200
Call: 9619962969

Give in to some waffle pleasure
1 PM onwards: You’ve managed to make it through Monday and Tuesday. So, you need a little treat. Celebrate the day at The Waffle Factory and avail their offers on shakes and iced teas. The offer is on every Wednesday right up until August 29. So, if you have a friend you meet only mid-week, this can become a standing date. Sweet idea? We think so, too.
16 Wednesday
where: The Waffle Factory (across outlets)

Hear the women out
9.30 PM: It’s not often that you hear women take the stage in India’s Indie music scene. Which is why #ladiesfirst is an initiative that needs your support. This evening, Social Offline x nrtya will host the Nush Lewis band and Ladies Compartment. Your ears, tonight, will be treated to jazz, blues, American folk, indie, and Carnatic Indian classical traditions.
17 Thursday
Where: Todi Mill Social, Near Viva Center, Lower Parel West
Entry: Rs 400
Call: 65110361

Relive Bollywood’s golden melodies
6.30 pm: Why should every evening out be about Western music? Relive some good old Bollywood memories as a host of playback singers along with live musicians bring to the stage, the tunes of Laxmikant-Pyarelal. And, if you are a fan, then one more reason to not give this a miss: Pyarelal Sharma Ji himself will conduct the whole 40 piece orchestra team and singers.
18 Friday
Where: Shanmukhananda Hall, Sion
Entry: Rs 250-Rs 3,000
Call: 24078888

Make your own organic make-up
2 PM to 5 PM: This is what we have always wanted. Make-up that’s organic, not tested on animals and perfectly suitable for our own skin. The Mumbai Fashion Academy is hosting this workshop where you will learn how to make your own concealer stick, liquid foundation, powder cake, make up remover and more. All material will be provided.
19 Saturday
Where: Mumbai Fashion Academy, Parel
Entry: Rs 2500
Call: 9769671960

Take it slow this time
If you think speed dating is not quite your thing, there’s the option to try this. Life of Line, a speed-dating company is slowing things down with this unique event. Participants will get to spend 30 minutes with the eligible singles of their choice, as opposed to the regular eight minutes. The custom category has been created following feedback from over a 1,000 people. The idea is to give more time to the right person. Life of Line verifies the profiles, both professional and social. The profiles of your date is shared ahead of the meet.
When: 3 pm, May 26 
Where: Hoppipola, 5th Lane, Ramkrishna Nagar, Khar West
Entry: Rs 3,999
Log on to: bookmyshow.com

See flowers in all their arty glory
Bas Meeuws is a Dutch photographer known for his photographic still life series. This exhibition titled Spring In The Wintertime is being presented in India for the first time. It’s a selection of 43 photographs that also includes a previously unseen work.
When: 11 am to 6.30 pm, 
till May 31 
Where: Tarq, Colaba 
Call: 66150424

Enjoy handcrafted cocktails
Here are the drinks that promise to take you through the heat. The summer-themed drinks at Nara are inspired from those in Thailand. Sip on cocktails like Chiang Rai (Mango and Galliano), Chiang Mai (Mango mojito), Mae Sot (pineapple and Bacardi). For a fruity mix, try the Kerff Rot Spritz and the raspberry and cranberry drink. There’s also the Thai Monk and the Fangs Tonic, which is a spin on the gin and tonic.
When: 12 pm to 1 am 
Where: Nara, Raheja Towers, BKC 
Call: 61378080

Catch the Boyzlife
The two-member band Boyzlife featuring Keith Duffy and Brian McFadden, formerly of Boyzone and Westlife respectively, are in India for the first time. Their concert titled Boyzlife Live will feature a blend of the greatest hits for their former bands. The Boyzlife show has been performed several times since 2016 and Mumbai will get to see it finally. For 90s kids especially, this concert would make for an ideal trip down memory lane.
When: 7 pm onwards, May 19
Where: Dublin Square, Phoenix Marketcity, Kurla
Entry: Rs 1,000-Rs 1,750
Log on to: bookmyshow.com

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Watch a Panchatantra tale
4 PM: Take your kid for a play, based on a story from the Panchatantra. Written by Vishnu Sharma, Hil Mil Kar, is about how a crow, rat, tortoise and a deer become really good friends and stick together against all problems. This play employs both traditional and modern musical instruments to tell the story.
WHERE: Harkat Studio, Bungalow No. 75,
JP Road, Versova, Andheri West
ENTRY: Rs 200
TO BOOK: insider.in

Dig into nihari gosht
12 PM – 3 PM: Transport yourself to the Royal Era of the Nawabs, with The Sahib Room & Kipling Bar's all-new Dawat-e-Khaas thali, which will allow guests to experience the aromas and taste of Awadhi cuisine. The delicacies include tunday kebab and dum biryanis.
WHERE: The Sahib Room & Kipling Bar, Level 9M, The St. Regis, Lower Parel
PRICE: Non-veg: Rs 3,500; veg: Rs 2,500
FOR RESERVATION: 8291926985

Catch a nature exhibition
11 AM – 7 PM: See how fashion photographer Sunder Ramu romances with nature in one-of-a-kind exhibition, The Last Dance of the Leaves. The series of prints of pictures of dry leaves showcases a world that's both real and surreal. At the core of this exhibition lies the simple belief that we must live like a leaf and to remember that if the leaves go extinct, so will we.
WHERE: Tao Art Gallery, 165, The View, Dr Annie Besant Road, Worli
CALL: 24918585

Go shopping for your dream wedding
10 AM – 10 PM: Have a dream wedding in mind, but need help? The Wedding Story might just be what you're looking for. In its very first edition, the pop-up marketplace will offer a unique shopping experience with the most renowned names in the wedding industry under one roof. There will be a wide range of apparel, beauty and grooming, trousseau essentials, lifestyle products to choose from.
WHERE: 18.99 Latitude, 4th Floor, Kamala Mills, Lower Parel
CALL: 9967130313

Discover Bandra of yore
May 27, 8 AM: Witness how the neighbourhood of Bandra is preserving its rich culture at a heritage walk, Bandra's Past and Present. The walk explores the unique physical spaces, character and cultures of contemporary Bandra; it spotlights the neighbourhood's particular history and legacies, and attempts by its communities to preserve the same.
MEETING POINT: Bandra Fort
ENTRY: Rs 850
TO BOOK: eventshigh.com

Enjoy a fruity sangria
7 AM – 1 AM: Sip on some refreshing sangrias at Smoke House Deli and deter away from the sweltering heat. One can choose from three uplifting options such as the rosso, melon and bianco. The sangrias come infused with tropical fruits like apples and pomegranate.
WHERE: Smoke House Deli, 33rd Road, Pali Hill, Bandra West
PRICE: Rs 699
CALL: 65287800

Draw a flamenco dancer on canvas
4 PM: Explore your creativity, by painting a flamenco dancer. This will be a guided session, shedding light on the strokes, sketches and techniques to help you paint better.
WHERE: SodaBottleOpenerWala, Sentinel, Powai
ENTRY: Rs 1,850
TO BOOK: insider.in

Paint a mug
1 PM – 4 PM: Beer and coffee lovers, this one is for you. At a fun workshop, you will learn how to paint your beer/coffee mug in five easy steps. You will first pick your mug, after which you'll choose a design or create your own, colour it and give it a name. You will get to take it back home after seven days.
WHERE: Doolally Taproom, 1st Floor,
135 Kwality House, Kemps Corner
ENTRY: R1,500
TO BOOK: eventshigh.com

Order of the day
Set the tone for the week
8 pm onwards: There's no rule that says you must let the Monday morning blues carry on till way after sundown. How about starting the week on a musical note then? Gather your gang and head to this karaoke night, where you can unleash your inner Madonna or Enrique or whoever is your crooning idol.
21 Monday
Where: Tipsy Gypsy, Level 1, Fun Republic,
Link Road, Andheri West
Call: 7021857037

Listen to acoustic fusion
7.30 pm: Bhrigu Sahni is a singer-songwriter known for his acoustic compositions. Based in Brooklyn, New York, Sahni is a graduate from Berklee College of Music. He uses altered tunings and flamenco techniques on the acoustic guitar to create a very different kind of soundscape. Give him a listen.
22 Tuesday
Where: The Cuckoo Club, Pali Hill, Bandra West
Entry: Rs 350
Log on to: bookmyshow.com

Get your mid-week break
8 pm onwards: If the words "unlimited sangria" is music to your ears, you would not want to give this a miss. Forget about the long work day and unwind with your poison, along with a buffet. What's more, you can actually dive into this DIY sangria and stir up a fancy concoction according to your taste.
23 Wednesday
Where: BKC Dive, Pinnacle Corporate Part, Bandra Kurla Complex, Bandra East
Entry: Rs 299 onwards
Call: 8655077330

Watch them fight it out
7.30 pm to 9.30 pm: Burqa Boxers is a documentary about Muslim women boxers in Kolkata. These youngsters who face the grim reality of abuse and rape daily, dream of a better future by learning boxing from Razia Shabnam, one of India's first female boxing coaches.
24 Thursday
Where: The Bagel Shop, Anand Vila,
Pali Mala Road, Bandra West
Entry: Rs 250
Log on to: www.instamojo.com

Attend a pro talk
4 pm to 6 pm: Get your dose of wisdom this week from global icon Niladri Kumar, who is a fifth-generation sitar player, and inventor of the zitar. Hear Kumar speak of his musical journey, his understanding of genres and the challenges he managed to conquer.
25 Friday
Where: Soundideaz Academy, Shah Industrial Estate, Andheri West
FREE entry
Call: 7045781807

Dance with your child
11 am to 12.30 pm: This one's for the mothers in the house. If you've wanted your little one to learn how to dance, here's a novel way of getting them started. Instead of sending them to a school, which could be a long-term option, you can actually match your own steps with them.
26 Saturday
Where: Impulse Studio, Tej Gaurav House, Matunga East
Entry: Rs 500
Call: 9987157242

Sample prints from Bengal
Prints from Bengal is an exhibition that features works that date back to the early 20th century by artists of Bengal, who lived through tumultuous periods in history. Think Partition of Bengal, Swadeshi movement, and the subsequent reunion of the state in 1911. The artists whose works will be featured are Gaganendranath Tagore, Mukul Dey, Ramendra Nath Chakraborty, Ramkinkar Baij and Rani Chanda. The prints range from lino-cuts to lithographs that reflect the history of the print-making process, while focusing on forms, structure, texture and use of negative and positive space. Interestingly, many of the works exhibited in Mumbai for the first time, recall the history of the venue of Project 88 that was once a century-old metal printing press.
When: 11 am to 7 pm,
till June 16
Where: Project 88, Colaba
Call: 22810066

Bite into cherry blossom specials
If Japan seems too far at the moment, this could be a close second, at least, food wise. Partake in a sushi-sake festival wherein the menu includes popular Japanese delicacies like a vegetarian miso soup, a sashimi sampler with varieties of salmon, tuna, scallops and hamachi paired with the Hakushika Honjozo Namachozo sake. You can also savour modern spin-offs like sushi burgers. The sake serving is of 60ml per course.
When: 12 pm to 1 am
Where: Pa Pa Ya, all outlets
Entry: Rs 2,199 for veg and Rs 2,999 for non-veg

Get started on Haiku
You've heard and read about haiku, and perhaps have been contemplating trying it out too. This workshop, conducted by Neha Bahuguna is good to get you started. Bahuguna, who is a NID graduate, has a multi-disciplinary approach and has, over the years, worked as a lyricist, writer and conducted storytelling and poetry workshops.
When: 3 pm, May 25
Where: ARTISANS' Gallery, Kala Ghoda
Entry: Rs 1,500
Log on to: insider.in

Watch a film on Pushkar
In Pushkar Puran, filmmaker Kamal Swarup explores the ancient myths and politicking of Indian gods, as the water in the Pushkar lake turns holy. The director has captured the exuberant goings on of this quaint lake town during the Pushkar Mela, revisiting its sacred stories and myths. The film has been beautifully shot by Ashok Meena and Kumar Avyaya.
When: 8.30 to 10.30 pm,
May 26
Where: Harkat Studios, Aram Nagar 2, JP Road, Versova, Andheri West
Entry: Rs 349
Log on to: insider.in

Hear music from the roots
Catch the duo Maati Baani, comprising vocalist Nirali Kartik and composer Kartik Shah. They are known for creating music rooted in traditions but set in a contemporary sound.
When: 8.30 pm, May 24
Where: Sharyans Audeus, Andheri West
Entry: R1,000
call: 26735115

Sign up for this app
Shilpa is an attractive, interactive, user-friendly phone app, touted to be the most popular app of 2018. It can sing, dance, and follow all your commands.
C Sharp B Blunt is a solo performance by Pallavi Arun, that takes a satirical look at the extent to which the female form is objectified. The app, Shilpa, ticks all the boxes in how women should behave with men. Until, of course, the next update is due.
When: 9 pm, May 24 to May 25
Where: Prithvi Theatre, Janki Kutir, Juhu Tara Road, Juhu
Log on to: www.bookmyshow.com

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Luka Chuppi
U/A: Romance, comedy
Dir: Laxman Utekar
Cast: Kriti Sanon, Kartik Aaryan, Pankaj Tripathi
Ratings: 

If you ever needed a better proof of the fact that most 'star-actors' (especially the new-age ones) are inevitably over-rated, given that the success of their characters, or indeed their films, depends so much on the script: Well, here is one.

This picture stars Kartik Aaryan, lately anointed the rising star among millennials, largely on the back of three super-hit rom-coms in a row - Pyaar Ka Punchnama (2011), its sequel (2015), and Sonu Ke Titu Ki Sweety (2018) - by the same director (Luv Ranjan).

Social media, and of course the usual entertainment portals, have been fired up ever since, capturing his newly captive mass-base. He walks into a picture of a similar genre, with hardly a story, let alone a screenplay, and you can watch the same actor, looking dumbfounded, fumbling all over the frickin' place - much like his film.
Which is about a girl, with a stock-expression (Kriti Sanon), taking stock of her young-adult life. She isn't quite ready to get married. But doesn't mind being with the guy she's just about met. She decides to live-in. For? 20-odd days, pretending to be married, in another town - sounds like a long vacation to me!

Either way, it's a logical step for a modern couple to take. Not for the characters in this movie, who live in seriously moronic times. Local news channels have gone berserk over, "Desh mein naya system aaya hai" - referring to an epidemic called live-in relationships! Goons, with the heroine's dad lording over them, are at every nook and corner, whacking/harassing couples over an inescapable pandemic. A top Khan Bollywood superstar has been boycotted/trolled nationwide for moving in with his girlfriend!

The hero-heroine in this pic play news reporters - continuously covering this earth-shattering story. Those behind the writing of this ultra-filmy picture were obviously born in PVR/Fun Republic. What happens next? Honestly, absolutely nothing. Or rather nothing that you may like to know, since the couple is still very much together, and their families seem okay with them being so forever. Eh?

This is supposed to be a comedy, exploring a perceived taboo, set in small-town India. Which, as a movie, is just the reverse from a decade and half ago, when Bollywood films just had to be set abroad, in order to do well - think Salaam Namaste (2005), also about a couple (Saif Ali Khan, Preity Zinta) living in, but in Melbourne!

Writer Javed Akhtar, astute cultural observer, ascribes this shift towards small towns as a fairly settled, secure, migrant Indian middle-class finding solace in its roots or where it came from. Given a massive string of commercial successes, emanating from stories from Meerut, Agra, Kota, Lucknow, Kanpur and the like, a formula is bound to set in.

This picture is placed in Mathura and Gwalior. An ensemble cast of rustic faces, dressed down, attempt some semi-rural humour, with odd, local mannerisms, and 'horny uncle' sex jokes. There is mention of caste and religion for the realism.

In walks Pankaj Tripathi, giving you a glimpse of how a performer can still rise above poor material - but only that much. Forget the audience, just wondering why/how they managed to chipkao this non-script on an actor, who's seriously in top form right now. Anyhoo, that's probably another story.

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Hellboy
U/A: Action, Adventure, Fantasy
Director: Neil Marshall
Cast: David Harbour, Ian McShane, Milla Jovovich, Sasha Lane, Daniel Dae Kim
Rating: 

This latest adaptation of the Mike Mignola comic book is a reboot and not a sequel. Most of the sequences and plot points take for granted that- the viewer is familiar with the story. This film has a rather peculiar blend of history, myth, supernatural and occult playing peekaboo in a narrative that opens up in the past and flashes forward to the post-modern present with rather too much haste. We see a time when everything is acceptable including the paranormal, the other-worldly, different dimensions and the freak. We see Hellboy with horns, crimson skin, and thorny attitude passed out in a Mexican bar or observing a wrestling match and he doesn't raise any eyebrows. And just as we get familiar with the characters and interested in the theme we are subjected to a flashback and that's the pattern we are exposed to throughout this rather jerky, coarse re-imagining of the Hellboy universe. The real problem here is that there's just too much back story and not much of going forward.

Hellboy of course looks more or less the same. The overall look is replicated from the original – this one though looks more worn and unkempt. Hellboy (David Harbour) works with his adoptive father Professor Broom (Ian McShane) at the B.P.R.D, an organization devoted to investigating and generally exterminating paranormal threats. The gruff Superhero heads to England when called upon by the Osiris club to help nullify the Blood Queen's(Milla Jovovich) demonic plot to resurrect herself and bring ruin upon the world.

Check out the trailer here:

The narrative jumps from one plot point to another without acquiring much coherence. We get it that the Blood Queen is part of the main conflict here but by the time she gets into her stride the narrative gets all rushed up and the ensuing melee doesn't have much engagement. Andrew Cosby's screenplay writes in some inner conflict for Hellboy but it doesn't translate all that well on screen. Even the other main characters don't have smooth enough arcs. Neil Marshall is no Guillermo Del Toro and his vision for the action here is also not consistent enough- even though there are a few flashes of brilliance. David Harbour's performance, lacks the confident stamp of authority that Ron Perlman's did. Some of the CGI effects are good but there are moments when they look conspicuous and patched on. Too many characters, too many plot threads and just as many merges between the unimaginable, plagues this tale of a superhero winding his way through tales of legends and destiny - ending it with cataclysmic bedlam that works out to be a rather chaotic gory mess!

Also Read: Milla Jovovich said yes to Hellboy for this reason

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Brihanmumbai Municipal Corporation (BMC) Mayor Kishori Pednekar on Monday informed that the total number of containment zones in the city is now 1036.

"There has been a significant drop in the number of containment zones in Mumbai," Pednekar said. The Mayor said that many zones are out of the list as they reported zero COVID19 cases in the last two weeks. "231 zones are out of the containment zone list after they didn't record a single COVID-19 positive patient for the last 14 days," she added.

According to the Union Ministry of Health and Family Welfare, the total number of positive COVID-19 cases in Maharashtra is 8,068. Till now, 1,076 people have either been cured and discharged, while 342 deaths have been reported in the state.

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