Famous supporters flocked to social media as Sen. Bernie Sanders ended his presidential campaign.

Review of 'A Good Provider Is One Who Leaves: One Family and Migration in the 21st Century' by Jason DeParle

Immigration does touch on many other policy issues, though maybe not in the manner he suggests.

Maybe it’s irony. Or maybe it’s her latest attempt to pinkwash her father’s anti-family agenda.

A recent article from Edutopia suggested that we’re rushing young children through childhood.

strataconf: The Future Is Graph Databases http://t.co/BVxOZwtoKS A Conversation with @EmilEifrem, founder of @Neo4J #strataconf

The body of an elderly woman, who died of Covid-19, has been lying at a funeral parlour since Monday because her family, who are in another province, cannot get the necessary documents from closed Home Affairs branches in order to travel.

The Duke of Sussex recently launched a fitness online program for the military community.

Life as we knew it will definitely change after this, as firms realise that people can work from home, saving them money, the air is better without traffic and pollution and more and more courses and meetings take place online.

Around the World, Family Style

Italy - The Cinque Terra, Lake Como and Milan

The Amateur Traveler talks to Nancy Sathre-Vogel from FamilyOnBikes.com about their odyssey – a bike ride with two young boys along the length of the Pan-American highway from Alaska to the southern end of South America. Learn why they did this trip, how they have managed it and what they have learned along the way.

The Amateur Traveler talks to Jessica Spiegel of BootsNAll’s Italy blog “Why Go Italy” and the Eye on Italy podcast about one of her favorite cities in Italy: Milan. Jessica tells us about the fashion industry, the spectacular cathedral, and the first mall as well as some quiet neighborhoods and parks. She also tells us how far in advance you should get tickets to see Leonardo di Vinci’s Last Supper, what to expect when you watch soccer in Italy, and what to do when you see movie stars walking down the streets of Milan. We talk about wonderful Italian people and the joys of learning Italian.

Hear about travel to Milwaukee as the Amateur Traveler talks to Barbara Ali about her hometown on the shores of Lake Michigan.

At a cost of $7.5 million a patient, they were 16 very expensive field hospitals. Yet, according to NPR, those hospitals are now “stand[ing] down.” You probably remember them from headlines early in the pandemic: makeshift medical centers being assembled at breakneck speed by companies contracted by the Army Corps of Engineers in anticipation of…

The post After Treating Barely Any Patients for a Massive $7.5 Million Each, 16 Emergency COVID Hospitals Are Standing Down appeared first on The Western Journal.

The online gambling ring allegedly used an offshore website to help book $32 million in illegal sports wagers placed by more than 2,000 bettors in the United States.

TL;DR: Give a meaningful gift during these difficult times with a Tribute Video Montage for $64.99, a 34% saving as of May 9.

A Zoom happy hour only goes so far.

If you're looking for a way to celebrate and send affection to your loved ones, regardless of the reason, check out Tribute Video Montage as an alternative to those wonky (and sometimes awkward) video calls. 

Sending a Tribute might just be one of the best morale-boosting presents you can send during these trying times. It's a way for friends and family to share their love and appreciation for someone they want to celebrate, whether for a major milestone, like a 50th anniversary or 30th birthday or just because. The platform is super easy to use and breaks a 10-hour process down to just 10 minutes. Read more...

Prime Minister Justin Trudeau says Canada will not pay the full price for medical masks that do not live up to medical standards.

Six-time world champion Lewis Hamilton has said he feels "fresher than ever" following an unexpected break from Formula One.

AC Milan have revealed that none of their first-team footballers or staff were positive for coronavirus.

11 Million Struggling to Pay Mortgage Payments and Rent

Miles from Tomorrowland Synopsis Miles from Tomorrowland is an animated television series produced by the Disney Channel that premiered in February of 2015. Miles from Tomorrowland is an American animated TV series about the adventures of an inquisitive, if somewhat reckless boy named Miles who travels the universe with his family. Miles from Tomorrowland is […]

Family is an integral part of any person’s life. When we live with our families, it’s either we’re dependent on somebody or somebody is dependent on us. Many conflicts arise in a family due to improper finance management. When you have a family, you might often come across situations where you might feel there is […]

The post 9 Frugal Tips for Families to Save Money appeared first on Dumb Little Man.

February 20, 2020 (New York, NY) –For the first time, eMarketer is estimating the number of people who watch Twitch on a regular basis in its latest forecast.  Twitch hosts streaming […]

More than 20% of social users will use TikTok this year February 27, 2020 (New York, NY) – Since launching in the US in 2017, social video app TikTok has […]

Part of the Sport Relief promo for the BBC UK Homepage

The province is investing $1.5 million to support a housing project in Muskoka to help people with no place to call home.

The following article, BREAKING: Vice President Mike Pence’s Press Sec Katie Miller, Wife of President Trump’s Sr. Advisor, Stephen Miller, Tests Positive For COVID-19, was first published on 100PercentFedUp.com.

Only moments ago, White House Press Secretary Kayleigh McEnany confirmed that a member of Vice President Mike Pence’s team tested positive for coronavirus. Watch: White House Press Secretary Kayleigh McEnany confirms a member of Vice President Mike Pence's team tested positive for coronavirus pic.twitter.com/3VaUXbwMq7 — Bloomberg QuickTake (@QuickTake) May 8, 2020 Reuters White House Correspondent […]

Continue reading: BREAKING: Vice President Mike Pence’s Press Sec Katie Miller, Wife of President Trump’s Sr. Advisor, Stephen Miller, Tests Positive For COVID-19 ...

Research Event

Event participants

Yezid Sayigh, Senior Fellow, Carnegie Middle East Center
David Butter, Associate Fellow, Middle East and North Africa Programme, Chatham House
Chair: Lina Khatib, Head, Middle East and North Africa Programme, Chatham House

Jesper V. Olsen
Dec 1, 2005; 4:2010-2021
Technology

31 January 2020

Mammalian cytochrome P450 enzymes often metabolize many pharmaceuticals and other xenobiotics, a feature that is valuable in a biotechnology setting. However, extant P450 enzymes are typically relatively unstable, with T50 values of ∼30–40 °C. Reconstructed ancestral cytochrome P450 enzymes tend to have variable substrate selectivity compared with related extant forms, but they also have higher thermostability and therefore may be excellent tools for commercial biosynthesis of important intermediates, final drug molecules, or drug metabolites. The mammalian ancestor of the cytochrome P450 1B subfamily was herein characterized structurally and functionally, revealing differences from the extant human CYP1B1 in ligand binding, metabolism, and potential molecular contributors to its thermostability. Whereas extant human CYP1B1 has one molecule of α-naphthoflavone in a closed active site, we observed that subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open active site with four ligand copies. A structure of the ancestor with 17β-estradiol revealed only one molecule in the active site, which still had the same open conformation. Detailed comparisons between the extant and ancestor forms revealed increases in electrostatic and aromatic interactions between distinct secondary structure elements in the ancestral forms that may contribute to their thermostability. To the best of our knowledge, this represents the first structural evaluation of a reconstructed ancestral cytochrome P450, revealing key features that appear to contribute to its thermostability.

4 March 2020 , Volume 96, Number 2

7 May 2020 , Volume 96, Number 3

David A. Mitchell
Jun 1, 2006; 47:1118-1127
Thematic Reviews

Mohamad Navab
Sep 1, 2000; 41:1495-1508
Articles

Mohamad Navab
Sep 1, 2000; 41:1481-1494
Articles

Michael Dean
Jul 1, 2001; 42:1007-1017
Thematic Reviews

Dawn L. Brasaemle
Dec 1, 2007; 48:2547-2559
Thematic Reviews

The DOCK-D (dedicator of cytokinesis D) family proteins are atypical guanine nucleotide exchange factors that regulate Rho GTPase activity. The family consists of Zizimin1 (DOCK9), Zizimin2 (DOCK11), and Zizimin3 (DOCK10). Functions of the DOCK-D family proteins are presently not well-explored, and the role of the DOCK-D family in neuroinflammation is unknown. In this study, we generated three mouse lines in which DOCK9 (DOCK9−/−), DOCK10 (DOCK10−/−), or DOCK11 (DOCK11−/−) had been deleted and examined the phenotypic effects of these gene deletions in MOG35–55 peptide-induced experimental autoimmune encephalomyelitis, an animal model of the neuroinflammatory disorder multiple sclerosis. We found that all the gene knockout lines were healthy and viable. The only phenotype observed under normal conditions was a slightly smaller proportion of B cells in splenocytes in DOCK10−/− mice than in the other mouse lines. We also found that the migration ability of macrophages is impaired in DOCK10−/− and DOCK11−/− mice and that the severity of experimental autoimmune encephalomyelitis was ameliorated only in DOCK10−/− mice. No apparent phenotype was observed for DOCK9−/− mice. Further investigations indicated that lipopolysaccharide stimulation up-regulates DOCK10 expression in microglia and that microglial migration is decreased in DOCK10−/− mice. Up-regulation of C–C motif chemokine ligand 2 (CCL2) expression induced by activation of Toll-like receptor 4 or 9 signaling was reduced in DOCK10−/− astrocytes compared with WT astrocytes. Taken together, our findings suggest that DOCK10 plays a role in innate immunity and neuroinflammation and might represent a potential therapeutic target for managing multiple sclerosis.

7 May 2020 , Volume 96, Number 3

Expert

The leak exposed millions of records with full names, emails, user conversations, payment logs, and IP addresses dating back to March.

Water scarcity, a socio-environmental threat to anthropogenic activities and ecosystems alike, affects large regions of the globe. However, it is often the most vulnerable and disadvantaged populations that suffer the severest consequences, highlighting the role of economic and institutional factors in water scarcity. In this way, researchers generally consider not only the physical constraints but socio-economic determinants as well.

A new way of looking at marine evolution over the past 540 million years has shown that levels of biodiversity in our oceans have remained fairly constant, rather than increasing continuously over the last 200 million years, as scientists previously thought.