Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity towards third-generation cephalosporins, while losing its activity towards the original penicillin substrates. We describe three single-amino-acid-substitution mutations in the ArgS arginine-tRNA synthetase that confer extra antibiotic tolerance protection to ESBL-producing Burkholderia thailandensis. This pathway can be exploited to evade antibiotic tolerance induction in developing therapeutic measures against Burkholderia species, targeting their essential aminoacyl-tRNA synthetases.

France beat Croatia to earn a final tournament debut, as they joined Serbia, Romania and Poland in qualifying for UEFA Futsal EURO 2018 via the play-offs.

People travelling to the UK will be quarantined for two weeks upon arrival as part of measures to prevent a second peak of the coronavirus pandemic.

Staff from NHS England have been asked to travel hundreds of miles to Scotland to be tested for coronavirus, according to reports.

The Herald is bringing you the latest coronavirus news and updates from Scotland, the UK and the world.

England won the 2017 Maurice Burlaz Trophy, the prize awarded to the nation that achieved the best results in UEFA's men's youth competitions over the previous two seasons.

England has been selected to host the 16-team UEFA Women's EURO 2021.

The Laurel Highlands boys basketball team will be honored at the USCAA Men’s Division II Basketball National Championship Game on Wednesday, March 11, at Penn State Fayette, The Eberly Campus.

A good grip can mean the difference between life and death for lizards in a hurricane, causing populations hit more frequently by hurricanes to have larger toepads, according to researchers from Washington University and Penn State.

• English FA launches ‘Football’s staying home’ campaign
• Captains lead Premier League teams into #PlayersTogether partnership with National Health Service Charities Together
• English Football League uses relief fund to help clubs facing cashflow problems
• Numerous club initiatives to help local communities

• Football association announces financial package for struggling clubs
• Pro Junior System will reward clubs investing in home-grown talent
• Robert Lewandowski and Jakub Błaszczykowski make personal donations to Polish hospitals

Holyrood’s Economy, Energy and Fair Work Committee is to have an inquiry into the role of Scottish Development International (SDI) in developing a Scotland that competes on the international stage.

The Culture, Tourism, Europe and External Affairs Committee will on Thursday (5 March) question the Secretary of State for Scotland regarding the Withdrawal Agreement and the future relationship between the European Union and the UK.

The Scottish Parliament will next week (Tuesday 10 March) be invited to nominate Stephen Boyle to Her Majesty the Queen for appointment as the new Auditor General for Scotland.

Playing in the 2002 UEFA European Under-17 Championship finals left a lasting impression on England's record scorer Wayne Rooney - the tournament ambassador for this year's finals in England.

England senior coach Gareth Southgate speaks to UEFA.com about #U17EURO and how he works with the host nation's successful youth teams.

Seven months after England lifted the FIFA Under-17 World Cup, coach Steve Cooper is calling on his current crop to build on that success.

The Netherlands equalled Spain's record of three U17 EURO titles: the story of the finals in England at a glance.

The Netherlands came out on top after a busy fortnight of action in the Republic of Ireland.

The Netherlands beat Italy for the second final running to become the first four-time Under-17 EURO champions.

U.S. Secretary of Education Arne Duncan has been warning against a GOP NCLB rewrite bill that's slated to pass the House next week.

From the 2nd July 2020, the Danish airline DAT will fly directly from Berlin-Tegel to Rønne (Bornholm). The popular Baltic island can then be reached within an hour’s flight time on Thursdays and Sundays until the 9th August.

Finals ambassadors Erin Cuthbert and Jo Love are excited to welcome WU19 EURO to their native Scotland.

Ultimately, the payment of municipal utilities and taxes is the responsibility of the property owner, explains an attorney.

Denmark overwhelmed Ireland to claim Europe's last FIFA World Cup berth after Sweden ousted Italy to follow Switzerland and Croatia through.

Holders Germany will face Mexico, Sweden and South Korea at the World Cup finals, with all-European group contests as England meet Belgium, and Spain play Portugal.

Governor Jack Markell, Delaware State Housing Authority, and their partners are pleased to announce the launch of a free housing locator website providing information about rental housing across the First State.

Governor Markell and the Delaware State Housing Authority announced the launch of a free housing locator website providing information about rental housing across the First State.

University officials, who have discouraged visits to campus and campus landmarks due to COVID-19, are increasing signage and social distancing guidance around the sites, as visitors continue to seek photographs in those areas and appear to be ignoring health care recommendations.

Amsterdam and Groningen will stage the expanded 16-team finals from 19 January to 6 February 2022.

For the first time in European Championship history, Finns will watch the UEFA EURO 2020 finals draw wondering when their own team's name will be selected.

As currently funded, $278 million project would unfairly burden electric ratepayers on Delmarva WILMINGTON, Del. – Delaware Governor John Carney and Maryland Governor Larry Hogan on Tuesday sent a letter to members of the Federal Energy Regulatory Commission, urging commissioners to expedite their review of the $278 million Artificial Island transmission line project and consider a […]

Accreditation is the highest recognition afforded to museums in the United States.

Work will begin this spring and continue into the summer of 2018.

In India, however, this is not likely to be a separate offering — Disney titles are being made available on the homegrown Hotstar, with no change in subscription plans, as of now.

An Air India flight carrying 129 Indian nationals from Dhaka, Bangladesh, landed at Delhi airport today as part of Vande Bharat Mission to bring back stranded Indians from different countries.

"Invading Your Forest," a workshop on managing invasive species in Delaware woodlands, will be held on Friday, January 17 from 9:30 a.m. to 4 p.m. at the ACE building-Delaware State Fairgrounds, Harrington.

More than 120,000 acres of Delaware farmland are now permanently preserved for future generations, state officials announced today, marking the 20th anniversary of the state's preservation program. With 17 farms on 2,245 acres entering the latest round of the program, the new milestone means that 24 percent of First State farmland is now preserved for perpetuity.

“I am proud to announce the largest round of Delaware farmland permanently preserved through the Delaware Agricultural Lands Preservation Program in the last several years. This is a result of federal funding from the Natural Resources Conservation Service and funding from both New Castle County and Kent County,” said Delaware Secretary of Agriculture Michael Scuse. More than 124,000 acres of Delaware farmland are now permanently preserved for future generations, with 3,039 acres of easements selected into the state’s preservation program.

When a new shellfish grower recently placed his first shipment of tiny oysters in growing cages in Rehoboth Bay, it marked the physical start of Delaware’s shellfish aquaculture program administered by the Department of Natural Resources and Environmental Control’s Division of Fish & Wildlife.

More than 127,000 acres of Delaware farmland are now permanently preserved for future generations, with the purchase of the development rights of 41 farms totaling 3,534 acres. This is the 22nd consecutive year of easement selections by the Delaware Agricultural Lands Preservation Foundation.

The Delaware Agricultural Lands Preservation Foundation voted to extended district enrollment until December 31, 2018 to any agricultural landowners who want to preserve their farms and still have the opportunity to submit an application for the upcoming round. Farms must be enrolled in a preservation district before the landowner can sell an easement.

 Regarding imposing of anti-dumping duty on all imports of Recordable Digital Versatile Disc [DVD] of all kinds origina

Wilmington --

Location: Rockland Road (Bridge over Brandywine Creek) between Adams Dam Road and Rockland Falls, Wilmington.

Dates and Times: 9:00 a.m. until 2:00 p.m. on Wednesday, April 1, 2020, pending weather.

Rain Date: Thursday, April 2, 2020 from 9:00 a.m. until 2:00 p.m. [More]