ies Predicting the Phillies' Opening Day roster By mlb.mlb.com Published On :: Sun, 10 Feb 2019 16:19:58 EDT Phillies pitchers and catchers have their first workout Wednesday morning at Carpenter Complex. Almost anything can happen between Wednesday and Opening Day. That said, here is a very early prediction of the Phillies' Opening Day roster, knowing the Phillies remain in the hunt to sign Bryce Harper or Manny Machado. Full Article
ies Phillies can still win the offseason By mlb.mlb.com Published On :: Thu, 14 Feb 2019 23:00:00 EDT We're reluctant to finalize our list of offseason winners because, as you may have heard, there are some prominent unsigned free agents. Not just Bryce Harper and Manny Machado, either. Full Article
ies Who will hit second and third for Phillies? By mlb.mlb.com Published On :: Sat, 16 Feb 2019 16:54:46 EDT Phillies manager Gabe Kapler believes the two most important spots in a lineup are the Nos. 2 and 4 holes. Rhys Hoskins and Carlos Santana hit there most of last season. But with J.T. Realmuto, Andrew McCutchen and Jean Segura joining the Phillies in the offseason, Kapler has more options. Full Article
ies Segura moving forward with contending Phillies By mlb.mlb.com Published On :: Sat, 16 Feb 2019 18:17:05 EDT Jean Segura became one of the Phillies' most notable offseason acquisitions, a two-time All-Star expected to give the organization its best overall production at shortstop since Jimmy Rollins left town, in part because of a little brawl he had late last season with Mariners teammate Dee Gordon. Full Article
ies Phillies' Top 30 Prospects list By m.mlb.com Published On :: Fri, 17 Feb 2017 21:01:24 EDT Who do the Phillies have in the pipeline? Get scouting reports, video, stats, projected ETAs and more for Philly's Top 30 Prospects on MLBPipeline.com's Prospect Watch. Full Article
ies The Phillies' Spring Training battle to watch By mlb.mlb.com Published On :: Mon, 18 Feb 2019 18:20:16 EDT The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs. Full Article
ies Talks 'intensifying' between Harper, Phillies By mlb.mlb.com Published On :: Mon, 18 Feb 2019 11:26:49 EDT The Phillies have been the favorites in the Bryce Harper sweepstakes for months, and that speculation heated up over the weekend. Full Article
ies Here are the Phillies' Top 30 Prospects By mlb.mlb.com Published On :: Tue, 19 Feb 2019 10:38:51 EDT The Phillies list isn't quite as strong as it once was because of the Realmuto deal, but there's still some very good talent at the top and some exciting players on the rise. Full Article
ies Whooping cough: Health officials urge pregnant women to get vaccinated as another infant dies By www.bmj.com Published On :: Friday, August 9, 2024 - 12:56 Full Article
ies Low molecular weight heparin does not prevent VTE after knee arthroscopy, studies show By www.bmj.com Published On :: Tuesday, December 6, 2016 - 06:31 Full Article
ies POSTPONED: Zimbabwe Futures 2025: Financial Sector Expansion and Policy Priorities By www.chathamhouse.org Published On :: Mon, 06 Nov 2017 15:00:00 +0000 POSTPONED: Zimbabwe Futures 2025: Financial Sector Expansion and Policy Priorities 15 November 2017 — 9:00AM TO 11:30AM Anonymous (not verified) 6 November 2017 Harare, Zimbabwe This roundtable will draw on current best practice and senior level expertise to identify policy options for financial stability and sector growth. A depoliticized analysis of the development agenda will highlight requisite conditions and prospective policies for a business-driven roadmap to the economic recovery of Zimbabwe, with a specific focus on the financial sector.Participants will discuss macro-economic policy and stability, retail banking products and services, fintech, mobilizing domestic finance for national infrastructure and balancing consumer price index and inflation. This event is being held in partnership with the Zimbabwe Business Club.PLEASE NOTE, THIS EVENT HAS BEEN POSTPONED UNTIL FURTHER NOTICE. Full Article
ies Rebuilding Zimbabwe's Economy: Emmerson Mnangagwa’s Immediate Priorities By www.chathamhouse.org Published On :: Wed, 13 Dec 2017 14:41:18 +0000 Rebuilding Zimbabwe's Economy: Emmerson Mnangagwa’s Immediate Priorities Expert comment sysadmin 13 December 2017 Zimbabwe cannot expect to rebuild in the same economic model that brought previous prosperity. — Emmerson Mnangagwa is sworn in as president on 24 November. Photo: Getty Images. Returning to Harare as Zimbabwe’s president-designate Emmerson Mnangagwa declared, ‘We want to grow our economy, we want peace, we want jobs, jobs, jobs.’ Robert Mugabe leaves a legacy of an independent Zimbabwe in a deep economic crisis. Much remains uncertain as to what a new government in Zimbabwe will look like, and there is sure to be continuity as well as considerable change. What is clear is that a new administration under Mnangagwa will need to turn the economy around to garner support and legitimacy from the Zimbabwean people. Zimbabwe’s economic output halved over the period 1997–2008, and it has not recovered. With more than 80 per cent of Zimbabweans in the informal economy, and with social and economic resilience undermined by previous crises and decades of mismanagement, the stakes for the new leader are very high. Reform will be difficult particularly because politically connected elites have acquired businesses through uncompetitive means. They will be reluctant to see significantly more competition. But they will also want an improved economic environment. And there is scope for the people of Zimbabwe to benefit from this. An important change will be in the prioritization of economic stability. Mugabe demonstrated that he was willing to make political decisions irrespective of the economic consequences. Mnangagwa is thought to be less ideological and more of a pragmatist. For him, delivering economic recovery will be crucial to building political support. The most pressing fiscal priority is the public wage bill. Employment costs account for over 80 per cent of government expenditure, crowding out spending on social programmes, health and education. But the fragility of the economy means that reform cannot be fast-tracked. The public wage bill accounts for over 20 per cent of GDP and is an essential driver of demand. Public sector workers are also politically influential. Another further priority is the reform of state-owned enterprises that are pressuring the fiscus. A new administration will need to rebuild confidence. Policymakers have been operating in a low-confidence environment for a long time, but for any meaningful change to take root there has to be trust between the government, businesses and the people of Zimbabwe. Businesses and citizens will want to see a plan of action for remonetizing the economy. Zimbabwe faces an acute liquidity crisis. A shortage of US dollars and a lack of confidence in government-issued bond notes are testing resilience. The financial system has recovered from a crisis of nonperforming loans – triggered by high debt amassed during the post-dollarization boom, and weak corporate governance. But the system remains highly fragile and swamped with government debt. Hard cash US dollar deposits fell from 49 per cent ($582 million) in 2009 to just six per cent ($269 million) in 2016. In 2015, industrial utilization stood at just 34.3 per cent of installed capacity, and it was estimated that just five per cent of the country’s businesses were viable. The crux of the Zimbabwean economy is the linkage between agriculture and manufacturing. Commercial agriculture contributes approximately 12 per cent of the country’s GDP, and more than 60 per cent of inputs into the manufacturing sector. Tobacco in particular is a vital earner of much needed foreign exchange. Policies to support mid-scale farmers will have multiplier effects. They drive agricultural growth and generate jobs throughout the supply chain. Zimbabwe also has world-class natural resource endowments including ferrochrome, gold, copper, iron ore, lithium, diamonds and platinum group metals. But longer investment-gestation periods and industry risk adversity will mean that payoffs from fresh investments in this sector will take longer to materialize. Domestic finance will need to be mobilized to generate recovery, and this will need to be supported by international investment. But international investors entering the country must be cognizant of Zimbabwean’s expectations and also historical perceptions – especially around the scepticism of neoliberal economics as a result of failed structural adjustment programmes in the 1990s. Zimbabweans have high social expectations for international investors. Educated, tech-savvy, internationally connected youth are at the core of the consumer class that investors will be targeting, to both sell products to but also to staff offices in country. But this cohort also has a greater expectation of international companies to adhere to the norms and standards that they abide by at home and not take advantage of weak governance or poor regulation to exploit citizens. Investors in Zimbabwe must also recognize that behind the controversial Mugabe policies of land reform and indigenization – the empowerment of local citizens through shared ownership – was a popular desire for postcolonial economic transformation. This sentiment remains. Working in partnership with local entities and communicating the economic contribution made to society will be necessary to build a long-term presence in Zimbabwe, and reap the dividend of what many hope to be a new start for the country. Fresh thinking is required from domestic policymakers and international partners. A skilled population and estimated 3-5 million-strong diaspora will bring international experience and make a considerable contribution to this process. Some of this thinking has been done. The Lima process of re-engagement with international financial institutions that was agreed at the end of 2015 has laid some of the groundwork, especially around international expectations regarding both economic and governance reform – the substance of which was analysed in a 2016 Chatham House paper. The implementation of recommendations of the well-regarded auditor-general’s report on SOE reform will also be a key prerequisite for long-term reform. Zimbabweans are not alone in processing what has happened and how to react. Investors have long been poised to capitalize on what is perceived to be one of the continent’s best long-term prospects. A lot will remain unchanged following the transition. But significantly, for the first time in decades, there is a real opportunity to effect positive change and improve the livelihoods of millions of Zimbabweans. This article was originally published at the Huffington Post. Full Article
ies Political Reform in Angola: Challenges and Priorities for Elected Officials By www.chathamhouse.org Published On :: Fri, 26 Oct 2018 14:05:01 +0000 Political Reform in Angola: Challenges and Priorities for Elected Officials 31 October 2018 — 4:00PM TO 5:00PM Anonymous (not verified) 26 October 2018 Chatham House, London Angola’s reformulated National Assembly has passed a series of legislative reforms since elections in August 2017, in which the ruling MPLA won a majority of 150 seats to the 51 held by the UNITA leading opposition party.Many of the changes have targeted the revitalization of an underperforming economy and improved governance: in June 2018 parliament approved a new private investment law aimed at diversifying Angola’s fiscal base beyond oil revenues while new legislation in May mandated the return of illicitly exported capital of over $100,000.As the appetite for measurable progress across all sectors of society remains high, and with newly constituted municipal elections scheduled for 2020, inclusive and accountable political debate will remain critical to Angola’s future.At the event, a cross-party delegation discuss the role of the National Assembly in affecting political change and the importance of maintaining open dialogue among opposing voices to address the challenges facing Angola. Full Article
ies Zimbabwe Futures 2030: Policy Priorities for Economic Expansion By www.chathamhouse.org Published On :: Thu, 07 Feb 2019 12:36:52 +0000 Zimbabwe Futures 2030: Policy Priorities for Economic Expansion 28 February 2019 — 9:00AM TO 1:00PM Anonymous (not verified) 7 February 2019 Harare, Zimbabwe This roundtable draws on current best practice and senior level expertise to identify policy options for long term economic expansion in Zimbabwe and pathways for inclusive development.Participants discuss the necessary policies and business strategies to enable and support the effective implementation of the Transitional Stabilization Programme and longer term national development plans.The discussions highlight requisite conditions for a business-driven and inclusive process towards Zimbabwe’s long-term economic recovery.This event was held in partnership with the Zimbabwe Business Club and Konrad Adenauer Stiftung. Full Article
ies South Africa After the Elections: Balancing Domestic and International Policy Priorities By www.chathamhouse.org Published On :: Thu, 09 May 2019 14:35:01 +0000 South Africa After the Elections: Balancing Domestic and International Policy Priorities 16 May 2019 — 1:30PM TO 2:30PM Anonymous (not verified) 9 May 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE The government that emerges from the 8 May election in South Africa faces immediate domestic and international foreign policy demands. Attracting Foreign Direct Investment to stimulate job growth, accelerating anti-corruption and good governance efforts are at the forefront of the new government’s agenda. International ambitions will be upgraded such as UN security council reform, maximizing South Africa’s G20, BRICS and IBSA membership and preparing for South Africa’s chairmanship of the African Union (AU) in 2020. At this meeting, the speakers – Moeletsi Mbeki, deputy chairman of SAIIA and author with Nobantu Mbeki of A Manifesto for Social Change: How to Save South Africa, and Elizabeth Sidiropoulos, chief executive of SAIIA and currently co-editing a volume on A South African Foreign Policy for the 2020s which will be published in 2019 – will reflect on the election and discuss the new government’s domestic and international policy agenda. The meeting will be chaired by Ann Grant, former British High Commissioner to South Africa (2000-05) with past experience working for Oxfam, Standard Chartered Bank and Tullow Oil. Full Article
ies Mine Action in Angola: Clearing the Legacies of Conflict to Harness the Potential of Peace By www.chathamhouse.org Published On :: Fri, 14 Jun 2019 14:40:27 +0000 Mine Action in Angola: Clearing the Legacies of Conflict to Harness the Potential of Peace Other resource sysadmin 14 June 2019 This publication draws on and updates the briefing note published following a meeting of the All- Party Parliamentary Group (APPG) on Angola on 26 April 2017. It also incorporates insights from a Chatham House Africa Programme conference session on the legacies of the Angolan Civil War, held on 23 March 2018; and draws on the Africa Programme’s research into conservation-driven development models in Southern Africa. — A mine clearance specialist in Angola preparing equipment used to look for unexploded ordnance, May 2012. Photo: Eye Ubiquitous/Contributor/Getty Images. Almost two decades after the end of its civil war, Angola remains one of the most heavily landmine-contaminated countries in the world. The Angolan government has committed to clearing its landmines by 2025, and there is constructive collaboration between the government and mine clearing agencies in this endeavour, but the target will be achievable only if a decline in funding from international donors is reversed. International funding for mine clearance in Angola fell by more than 80 per cent between 2005 and 2017, and this sharp drop in external support has compounded the impact on domestic funding for national clearance efforts as a result of the downturn in prices for Angola’s main export commodities. The national mine action agency, the Comissão Nacional Intersectorial de Desminagem e Assistência Humanitária (CNIDAH), is supported by the Mines Advisory Group (MAG), Norwegian People’s Aid (NPA) and the HALO Trust. By 2017, 15 years after the end of the civil war, these organizations had collectively helped clear 56 per cent of known landmine-contaminated land. State-led demining has focused principally on clearing areas designated for infrastructure projects. Now, it is critical that humanitarian demining in largely agricultural and conservation areas is prioritized to bring to an end the daily threat to Angola’s rural poor – as well as to the country’s livestock and wildlife – of injury or death as a result of landmine accidents. Angola has some of the world’s most important remaining wilderness, including the tributary system for the unique Okavango Delta, and the country has the potential to host one of the most diverse wildlife populations on the continent. However, the presence of landmines and other remnants of the civil war render large areas of the country unsafe both for wildlife and for the local people, whose ability to derive a sustainable livelihood from their natural environment is fundamental to its protection. Wildlife and tourism provide important economic opportunities for diversification beyond an oil-dominated economy. Critically, Angola’s economic diversification and development objectives can only be achieved if the landmines that prohibit access to land for agriculture, mining, tourism and wildlife are cleared. There are economic opportunities for released land in the most heavily mined provinces of Cuando Cubango and Moxico. Already, some new funding for mine action in Angola, if upscaled or matched by international donors, could be transformative for its people, and for the conservation of the region’s vital biodiversity. 2019-06-17-Angola (PDF) Full Article
ies Zimbabwe Futures 2030: Sector Priorities for Policy Implementation By www.chathamhouse.org Published On :: Fri, 21 Jun 2019 13:45:01 +0000 Zimbabwe Futures 2030: Sector Priorities for Policy Implementation 4 June 2019 — 9:00AM TO 5:15PM Anonymous (not verified) 21 June 2019 Harare, Zimbabwe This roundtable will draw on current best practice and senior level expertise to identify sector specific policy options to support inclusive long-term economic growth in Zimbabwe. Representatives from both large firms and SMEs, as well as government technocrats and industry bodies, will consider policy recommendations and business strategies to support the implementation of the Transitional Stabilisation Plan and National Development Plan. This roundtable is part of an ongoing research process that aims to draw on senior private sector expertise to develop policy recommendations to support inclusive economic growth in Zimbabwe. A summary of the first roundtable can be found here.Attendance at this event is by invitation only. Full Article
ies Zimbabwe Futures 2030: Policy Priorities for Industrialization, Agri-Business and Tourism By www.chathamhouse.org Published On :: Fri, 21 Jun 2019 13:45:01 +0000 Zimbabwe Futures 2030: Policy Priorities for Industrialization, Agri-Business and Tourism 6 June 2019 — 9:30AM TO 1:15PM Anonymous (not verified) 21 June 2019 Bulawayo, Zimbabwe The government of Zimbabwe has committed itself to facilitating an open-market economy and industrialization including through the Transitional Stabilisation Programme (TSP) and new industrialization policy. To achieve industrialization and economic expansion, government will need to underpin markets with provision of public goods, entrepreneurial incentives and protect contract enforcement and dispute resolution mechanisms. The private sector also has a role to play in working with government to create an environment conducive to inclusive and job creating economic growth. Discussions at this invitation only event will help to identify specific policy options to support inclusive long-term economic growth in Zimbabwe. This roundtable is part of an ongoing research process that aims to draw on senior private sector expertise to develop policy recommendations to support inclusive economic growth in Zimbabwe. A summary of the first roundtable can be found here. Attendance at this event is by invitation only. Full Article
ies Diabetes: Once weekly insulin could be as effective as daily injections, studies indicate By www.bmj.com Published On :: Thursday, September 12, 2024 - 14:36 Full Article
ies Advanced technologies in the face of war By www.chathamhouse.org Published On :: Wed, 05 Oct 2022 13:22:14 +0000 Advanced technologies in the face of war 24 October 2022 — 1:00PM TO 2:00PM Anonymous (not verified) 5 October 2022 Online How is NATO strengthening its technological edge? Russia’s invasion of Ukraine has brought with it a heavy focus on technology and weaponry, particularly as casualties mount and large numbers of equipment are lost on both sides. The conflict has highlighted how states and their militaries seek technological superiority and how access to advanced capabilities can help shape the course of the war. Aiming to sharpen the Alliance’s technological edge, NATO is working to support the development of emerging and potentially disruptive technologies such as artificial intelligence (AI), autonomous systems, biotechnologies and quantum technologies that are seen as presenting both risks and opportunities for the Alliance. As part of this work, NATO’s newly formed Defence Innovation Accelerator for the North Atlantic (DIANA), hosted by both the UK and Estonia, brings together academia, industry and government to support the development of critical technologies to deter and defend against existing and future threats. Key questions to be considered by the panel include: How will the technologies that form the focus of DIANA’s efforts strengthen the Alliance and prepare it to better deal with threats to peace and security across the region? How will these technologies be applied and used in war? To what extent can a war be won by technology? Is Ukraine, and other future conflict zones, in danger of becoming a testing ground for emerging technologies? What has the war in Ukraine taught NATO about modern warfare and how should the Alliance respond to this? After the commotion of AUKUS, how will the Alliance manage the sharing of technologies and IP among member states? As with all members events, questions from the audience drive the conversation. Read the transcript. Full Article
ies Disruptive technologies by nation states and malign cyber actors – the US response By www.chathamhouse.org Published On :: Thu, 02 Feb 2023 12:32:13 +0000 Disruptive technologies by nation states and malign cyber actors – the US response 16 February 2023 — 1:00PM TO 2:00PM Anonymous (not verified) 2 February 2023 Chatham House and Online Lisa Monaco, the US deputy attorney general, discusses how autocratic governments and malign cyber actors use disruptive technologies to project power and engage in illicit activity. Weaponizing data, ransomware attacks and other illicit cyber activity represent significant threats to national security. Governments and malicious cyber actors around the world exploit disruptive technology to engage in criminal activity, track citizens and coerce other countries thereby weakening the rules-based order and fundamental principles of democracy. Lisa Monaco discusses how the world is at an inflection point when it comes to meeting this challenge and describes how the US and partner nations are responding to protect their citizens and the broader international community. Key questions to discuss include: What steps does the US government need to take to properly address this threat? How are countries coordinating policies to confront the problem? To what extent does this challenge go beyond US-China competition? As with all member events, questions from the audience drive the conversation. Read the transcript. Full Article
ies How do Eurasian kleptocracies earn and use their money? By www.chathamhouse.org Published On :: Fri, 22 Oct 2021 15:54:24 +0000 How do Eurasian kleptocracies earn and use their money? 9 November 2021 — 1:00PM TO 2:30PM Anonymous (not verified) 22 October 2021 Chatham House and Online This event explores the presence of corrupt funds from Eurasia in Western democracies, what they are used for, and how they can be constrained. The Pandora Papers once again shone the spotlight on the UK being home to corrupt funds from kleptocracies, where the ruling elite abuse their political power for private gain. In recent years much focus has been placed on this term, and the possible effects such money could have on Western democracies. How do such states create this wealth in the first place? How do these funds make their way to the UK? Is the term kleptocracy appropriate for the majority of countries in Eurasia? What evidence is there that such funds are ‘weaponized’ to achieve foreign policy goals? This event discusses the term, how it can be applied, and the differences between how ’grey’ funds are used by various countries. It also highlights how the UK and the wider international community can counteract these flows, both from a legal point of view, and via other methods. Full Article
ies Africa and Europe: Cooperation on digital transitions and new technologies By www.chathamhouse.org Published On :: Thu, 12 May 2022 09:02:13 +0000 Africa and Europe: Cooperation on digital transitions and new technologies 26 May 2022 — 8:00AM TO 12:30PM Anonymous (not verified) 12 May 2022 Online The 11th Africa Day International Conference takes place under the auspices of the president of the Republic of Slovenia, HE Mr Borut Pahor, and within the framework of the Bled Strategic Forum. Slovenia’s annual high-level Africa event seeks to improve policy outcomes for citizens in Europe and Africa as a result of a mutual understanding and strengthened cooperation between the two regions. The event is co-hosted by the Ministry of Foreign Affairs of the Republic of Slovenia, the Chatham House Africa Programme and the European Commission. Expert discussions at this year’s edition will examine collaborative links between Africa and Europe in promoting responsible innovation and governance of emerging technologies, as well as the role of technology in shaping creative and cultural economies. The conference will be broadcast live on this website, on the Slovenian Ministry of Foreign Affairs website and on the Africa Programme Facebook page. 11th Africa Day International Conference Agenda (PDF) Full Article
ies [68Ga]Ga-RAYZ-8009: A Glypican-3-Targeted Diagnostic Radiopharmaceutical for Hepatocellular Carcinoma Molecular Imaging--A First-in-Human Case Series By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 To date, the imaging and diagnosis of hepatocellular carcinoma (HCC) rely on CT/MRI, which have well-known limitations. Glypican-3 (GPC3) is a cell surface receptor highly expressed by HCC but not by normal or cirrhotic liver tissue. Here we report initial clinical results of GPC3-targeted PET imaging with [68Ga]Ga-DOTA-RYZ-GPC3 (RAYZ-8009), a peptide-based GPC3 ligand in patients with known or suspected HCC. Methods: [68Ga]Ga-RAYZ-8009 was obtained after labeling the peptide precursor with 68Ga from a 68Ge/68Ga generator and heating at 90°C for 10 min followed by sterile filtration. After administration of [68Ga]Ga-RAYZ-8009, a dynamic or static PET/CT scan was acquired between 45 min and 4 h after administration. Radiotracer uptake was measured by SUVs for the following tissues: suspected or actual HCC or hepatoblastoma lesions, non–tumor-bearing liver, renal cortex, blood pool in the left ventricle, and gastric fundus. Additionally, tumor–to–healthy-liver ratios (TLRs) were calculated. Results: Twenty-four patients (5 patients in the dynamic protocol; 19 patients in the static protocol) were scanned. No adverse events occurred. Two patients had no lesion detected and did not have HCC during follow-up. In total, 50 lesions were detected and analyzed. The mean SUVmax of these lesions was 19.6 (range, 2.7–95.3), and the mean SUVmean was 10.1 (range, 1.0–49.2) at approximately 60 min after administration. Uptake in non–tumor-bearing liver and blood pool rapidly decreased over time and became negligible 45 min after administration (mean SUVmean, <1.6), with a continuous decline to 4 h after administration (mean SUVmean, 1.0). The opposite was observed for HCC lesions, for which SUVs and TLRs continuously increased for up to 4 h after administration. In individual lesion analysis, TLR was the highest between 60 and 120 min after administration. Uptake in the gastric fundus gradually increased for up to 45 min (to an SUVmax of 31.3) and decreased gradually afterward. Conclusion: [68Ga]Ga-RAYZ-8009 is safe and allows for high-contrast imaging of GPC3-positive HCC, with rapid clearance from most normal organs. Thereby, [68Ga]Ga-RAYZ-8009 is promising for HCC diagnosis and staging. Further research is warranted. Full Article
ies Nuclear Imaging of Bispecific Antibodies on the Rise By jnm.snmjournals.org Published On :: 2024-10-01T04:08:08-07:00 Bispecific antibodies (bsAbs) are engineered to target 2 different epitopes simultaneously. About 75% of the 16 clinically approved bsAbs have entered the clinic internationally since 2022. Hence, research on biomedical imaging of various radiolabeled bsAb scaffolds may serve to improve patient selection for bsAb therapy. Here, we provide a comprehensive overview of recent advances in radiolabeled bsAbs for imaging via PET or SPECT. We compare direct targeting and pretargeting approaches in preclinical and clinical studies in oncologic research. Furthermore, we show preclinical applications of imaging bsAbs in neurodegenerative diseases. Finally, we offer perspectives on the future directions of imaging bsAbs based on their challenges and opportunities. Full Article
ies Turkey in 2020 and Beyond: What Lies Ahead for Turkish Politics? By www.chathamhouse.org Published On :: Wed, 06 Nov 2019 11:10:01 +0000 Turkey in 2020 and Beyond: What Lies Ahead for Turkish Politics? 25 November 2019 — 12:30PM TO 1:30PM Anonymous (not verified) 6 November 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE Turkey witnessed some major developments over the last year. In August 2018, the dramatic Lira devaluation caused the Turkish economy to go into recession. In the 2019 local elections, which took place during the economic downturn, the Republican Peoples’ Party (CHP) mayoral candidates took control of Ankara and Istanbul after 25 years of dominance by the ruling Justice and Development Party (AKP).The election results might lead to a rethink of the AKP leadership and consequences on Turkish politics will depend on Erdoğan’s interpretation of this reversal of his political fortune.Will this affect the long-standing alliance between AKP and MHP that has characterised Turkish foreign policy for the past few years? What impact will this have on both the domestic and international level? Finally, will Turkey’s recent incursion into Syria have lasting effect on the country’s alliances with other powers and its standing?In this context, the speaker will analyse the significance of these changes and the future trajectory of Turkish politics, economics and foreign policy. Full Article
ies Amazon starts air drone deliveries near Phoenix By www.upi.com Published On :: Tue, 05 Nov 2024 14:08:24 -0500 Amazon Prime Air drone deliveries are underway and delivering small packages within an hour in the West Valley of the Phoenix metro area. Full Article
ies ‘Loopholes’ let warring parties use incendiary weapons in Ukraine, Middle East: HRW By www.upi.com Published On :: Sun, 10 Nov 2024 11:43:33 -0500 Loopholes in international laws governing the use of incendiary weapons in warfare are allowing warring parties in Ukraine and the Middle East to exploit the use of such weapons without adequately protecting civilians. Full Article
ies North Korea ratifies landmark defense pact with Russia By www.upi.com Published On :: Tue, 12 Nov 2024 04:18:20 -0500 North Korea ratified a defense treaty with Russia, state media reported Tuesday, formally deepening military cooperation that has seen Pyongyang send thousands of troops to help Moscow in its war against Ukraine. Full Article
ies Former Notre Dame football coach Gerry Faust dies at 89 By www.upi.com Published On :: Tue, 12 Nov 2024 09:33:39 -0500 Gerry Faust, who won five Ohio high school football state titles before taking over as coach at Notre Dame in the early 1980s, has died, his family announced. He was 89. Full Article
ies FC Cincinnati's Marco Angulo dies after car crash in Ecuador By www.upi.com Published On :: Tue, 12 Nov 2024 10:35:23 -0500 FC Cincinnati midfielder Marco Angulo has died from injuries he sustained from a car crash, the MLS franchise and Ecuadorian Football Association announced Tuesday. He was 22. Full Article
ies Cornelis Networks Partners with SURF to Enhance HPC Cluster Networking Capabilities By www.hpcwire.com Published On :: Mon, 19 Aug 2024 15:09:53 +0000 Aug. 19, 2024 — SURF’s innovation department recently collaborated with Cornelis Networks to advance networking capabilities for high-performance computing (HPC) clusters. The collaboration marks a new step forward for SURF […] The post Cornelis Networks Partners with SURF to Enhance HPC Cluster Networking Capabilities appeared first on HPCwire. Full Article
ies Harness Insights with Cutting-edge AI Capabilities from HPE By www.hpcwire.com Published On :: Thu, 17 Dec 2020 13:00:45 +0000 The demand for high-performance computing (HPC) and artificial intelligence (AI) is rising dramatically as organizations rush to put their data to work. Several industries see a significant increase in HPC […] The post Harness Insights with Cutting-edge AI Capabilities from HPE appeared first on HPCwire. Full Article
ies US Treasury Issues Final Rule Addressing Investments in Certain National Security Technologies and Products By www.hpcwire.com Published On :: Wed, 30 Oct 2024 21:41:06 +0000 WASHINGTON, Oct. 30, 2024 — The U.S. Department of the Treasury (Treasury) today issued a final rule (Final Rule) to implement Executive Order 14105 of August 9, 2023, “Addressing United […] The post US Treasury Issues Final Rule Addressing Investments in Certain National Security Technologies and Products appeared first on HPCwire. Full Article
ies AMAX Expands Server Portfolio with New AMD EPYC 9005 Series Processors for AI and HPC Workloads By www.hpcwire.com Published On :: Wed, 06 Nov 2024 15:12:47 +0000 FREMONT, Calif., Nov. 6, 2024 — AMAX, an AMD Elite Partner and a global leader in end-to-end GPU cluster solutions and advanced cooling technologies, announced its latest lineup of servers powered […] The post AMAX Expands Server Portfolio with New AMD EPYC 9005 Series Processors for AI and HPC Workloads appeared first on HPCwire. Full Article
ies U.S. Navy, Lebanese military begin partnership to improve construction, humanitarian capabilities By www.upi.com Published On :: Tue, 21 Sep 2021 15:25:57 -0400 The USNS Choctaw County has arrived in Beirut, Lebanon, to participate in a first-of-its-kind mission intended to strengthen military ties between the countries, the U.S. Navy said Tuesday. Full Article
ies Renewable Power Unlock New Efficiencies for High-Performance Computing By www.hpcwire.com Published On :: Thu, 14 Mar 2024 13:00:44 +0000 The surge in digital transformation across industries has led to exponential data growth, driving a heightened demand for computing power. However, this growth also intensifies concerns about energy consumption and […] The post Renewable Power Unlock New Efficiencies for High-Performance Computing appeared first on HPCwire. Full Article
ies The Secret to Accomplishing Big Goals Lies in Breaking Them into Flexible, Bite-Size Chunks By www.scientificamerican.com Published On :: Mon, 29 Jan 2024 13:00:00 GMT Subgoals can make all the difference when ambitious targets seem too daunting Full Article Mind & Brain Psychology
ies D-Wave Readies 4,400-plus-qubit Advantage2 System for Use By www.hpcwire.com Published On :: Wed, 06 Nov 2024 16:41:14 +0000 Quantum computing pioneer D-Wave today announced it had completed calibration and benchmarking the latest latest version of its Advantage2 quantum processor, a 4,400-plus-qubit device. D-Wave said that compared with the […] The post D-Wave Readies 4,400-plus-qubit Advantage2 System for Use appeared first on HPCwire. Full Article Short Takes
ies Blake Shelton, Taylor Sheridan working on a singing competition series for CBS By www.upi.com Published On :: Mon, 11 Nov 2024 16:57:20 -0500 Country music star Blake Shelton and writer-producer Taylor Sheridan are working on a new reality competition series for CBS called "The Road." Full Article
ies NASA identifies nine possible landing regions for Artemis III moon mission By www.upi.com Published On :: Mon, 28 Oct 2024 19:02:34 -0400 NASA has identified nine possible landing sites for its Artemis III mission in September 2026 that will return astronauts to the moon for the first time in more than 50 years, the space agency announced Monday. Full Article
ies The Hobbies That Halt Cognitive Decline In Seniors (M) By www.spring.org.uk Published On :: Tue, 22 Oct 2024 17:00:53 +0000 Your brain could stay sharp for years just by doing these simple activities. Full Article Dementia subscribers-only
ies The Best Exercise For Brain Health Revealed By 98 Studies By www.spring.org.uk Published On :: Sun, 10 Nov 2024 17:00:25 +0000 Which types of exercise can help keep the brain healthy? Full Article Boost Brain Power
ies The otters of Singapore — and other unexpected wildlife thriving in cities | Philip Johns By www.ted.com Published On :: Thu, 19 Sep 2024 14:40:19 +0000 Animal behavior expert Philip Johns introduces us to the vibrant urban environments of Singapore, where city dwellers and skyscrapers coexist with a rich array of other species, including otters, hornbills and lizards — prompting the question: Can we design cities to be wildlife refuges? Full Article Higher Education
ies Can AI preserve your most precious memories? | Pau Aleikum Garcia By www.ted.com Published On :: Thu, 26 Sep 2024 14:57:15 +0000 "Memories are the architects of our identity," says technologist Pau Aleikum Garcia, but they're not permanent. Photos can be lost amid political unrest or natural disaster, while illnesses like Alzhemier's can rob people of their past. He puts forward a novel solution — "synthetic memories," or dreamlike visualizations of long-gone moments created through generative AI — and explores how it could reconnect families or even enhance cognitive abilities. Full Article Higher Education
ies The magical, mesmerizing migration of monarch butterflies | Jaime Rojo By www.ted.com Published On :: Wed, 09 Oct 2024 14:49:36 +0000 When monarch butterflies migrate, they produce one of the most iconic wildlife spectacles in the world — and provide us with an important indicator of ecological health, says photographer Jaime Rojo. Telling a story about our relationship to the natural world, he shares his experience photographing these mesmerizing insects deep in their remote mountain habitats in Mexico, diving into the latest research into the mysteries of their multi-thousand-mile journey and sharing how each of us can join the growing movement to protect them. Full Article Higher Education
ies Why do some bodies respond differently to disease? | Erika Moore By www.ted.com Published On :: Tue, 15 Oct 2024 19:51:55 +0000 TED Fellow and equity bioengineer Erika Moore investigates how cells controlling inflammation behave differently depending on a patient's background. By focusing on the "who" behind the disease, Moore is uncovering why certain diseases disproportionately affect certain ethnicities, paving the way for more inclusive and effective health care. Full Article Higher Education
ies Democracy is being tested. Citizen assemblies can help | Ketakandriana Rafitoson By www.ted.com Published On :: Tue, 05 Nov 2024 15:49:03 +0000 How can everyday people help foster and protect democracy? Detailing her work fighting for people power as an activist in Madagascar, Ketakandriana Rafitoson discusses how citizen assemblies — meetings where ordinary citizens get educated about democracy — empower communities to protect their rights, debate important civic questions and take action to create a brighter future. Full Article Higher Education
ies Educational Opportunities and Performance in Montana By www.edweek.org Published On :: Wed, 16 Jan 2019 00:00:00 +0000 This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes. Full Article Montana
ies What Are Trump's Next K-12 Priorities? Don't Look to a GOP Platform for Answers By blogs.edweek.org Published On :: Mon, 24 Aug 2020 00:00:00 +0000 President Donald Trumps list of priorities for his second term includes just two bullet points related to K-12 education. Full Article Montana