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[ASAP] Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c00768




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[ASAP] Kinetics of the <italic toggle="yes">Trans</italic> Effect in Ruthenium Complexes Provide Insight into the Factors That Control Activity and Stability in CO<sub>2</sub> Electroreduction

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c02912




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Product :: Data at Work: Best practices for creating effective charts and information graphics in Microsoft Excel




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Product :: Data at Work: Best practices for creating effective charts and information graphics in Microsoft Excel




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Substrate analysis for effective biofuels production Neha Srivastava, Manish Srivastava, P. K. Mishra, Vijai Kumar Gupta, editors

Online Resource




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The Johannine footwashing as the sign of perfect love : an exegetical study of John 13:1-20 / Bincy Mathew

Mathew, Bincy, 1979- author




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Infections of the Central Nervous System: Pathology and Genetics


 
Highly commended at the British Medical Association (BMA) Awards 2019, this new volume from the International Society of Neuropathology series addresses infections of the nervous system, written by expert editors. An expansive and inclusive contents list including rare disorders presented in easily referable chapters, containing; definitions, microbiological characteristics, epidemiology, clinical features, lab tests, pathology, genetics and treatment

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A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry

RSC Adv., 2020, 10,17101-17113
DOI: 10.1039/D0RA00049C, Paper
Open Access
Ying-peng Li, Cong-ying Wang, Hong-tao Shang, Rui-rui Hu, Hui Fu, Xue-feng Xiao
High-throughput lipidomics provides the possibility for the development of new therapeutic drugs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Retraction: Effect of temperature and large guest molecules on the C–H symmetric stretching vibrational frequencies of methane in structure H and I clathrate hydrates

RSC Adv., 2020, 10,16904-16904
DOI: 10.1039/D0RA90048F, Retraction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Go Fuseya, Satoshi Takeya, Akihiro Hachikubo
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cost-effective smart microfluidic device with immobilized silver nanoparticles and embedded UV-light sources for synergistic water disinfection effects

RSC Adv., 2020, 10,17479-17485
DOI: 10.1039/D0RA00076K, Paper
Open Access
Amit Prabhakar, Mehul Agrawal, Neha Mishra, Nimisha Roy, Ankur Jaiswar, Amar Dhwaj, Deepti Verma
A novel microfluidic-device for water disinfection via diverse physiochemical effects has been demonstrated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effects of ozone treatment on SOD activity and genes in postharvest cantaloupe

RSC Adv., 2020, 10,17452-17460
DOI: 10.1039/D0RA00976H, Paper
Open Access
Huijie Zhang, Xiaojun Zhang, Chenghu Dong, Na Zhang, Zhaojun Ban, Li Li, Jinze Yu, Yunfeng Hu, Cunkun Chen
Ozone has been shown to play a positive role in the storage and preservation of agricultural products.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effect of temperature and large guest molecules on the C–H symmetric stretching vibrational frequencies of methane in structure H and I clathrate hydrates

RSC Adv., 2020, 10,17473-17478
DOI: 10.1039/D0RA02748K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Go Fuseya, Satoshi Takeya, Akihiro Hachikubo
Temperature effect on C–H symmetric stretching frequencies of CH4 in water cages of sI and sH clathrate hydrates were clarified.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

RSC Adv., 2020, 10,17593-17601
DOI: 10.1039/D0RA02688C, Paper
Open Access
Andrea Barragán-Cárdenas, Maribel Urrea-Pelayo, Víctor Alfonso Niño-Ramírez, Adriana Umaña-Pérez, Jean Paul Vernot, Claudia Marcela Parra-Giraldo, Ricardo Fierro-Medina, Zuly Rivera-Monroy, Javier García-Castañeda
The cytotoxic effect against the breast cancer cell line MDA-MB-468 of the palindromic peptide LfcinB (21–25)Pal: 1RWQWRWQWR9 and its analogous peptides, obtained via alanine scanning, was evaluated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effect of Zn doping on phase transition and electronic structures of Heusler-type Pd2Cr-based alloys: from normal to all-d-metal Heusler

RSC Adv., 2020, 10,17829-17835
DOI: 10.1039/D0RA02951C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xiaotian Wang, Mengxin Wu, Tie Yang, Rabah Khenata
By first-principles calculations, for Heusler alloys Pd2CrZ (Z = Al, Ga, In, Tl, Si, Sn, P, As, Sb, Bi, Se, Te, Zn), the effect of Zn doping on their phase transition and electronic structure has been studied in this work.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effect of new carbonyl cyanide aromatic hydrazones on biofilm inhibition against methicillin resistant Staphylococcus aureus

RSC Adv., 2020, 10,17854-17861
DOI: 10.1039/D0RA03124K, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xueer Lu, Ziwen Zhang, Yingying Xu, Jun Lu, Wenjian Tang, Jing Zhang
2e and 2j with strong p-NO2 and p-CF3 at phenyl ring had the lowest MICs against S. aureus and MRSA. 2e displayed unaided or synergistic efficacy against MRSA, especially combined with ofloxacin. EM revealed that 2e destroys biofilms and cell membranes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pure CSS folded-corner effect

Create a simple CSS folded-corner effect without images or extra markup. It works well in all modern browsers and is best suited to designs with simple colour backgrounds.

Demo: Pure CSS folded-corner effect

Known support: Firefox 3.5+, Chrome 4+, Safari 4+, Opera 10+, IE 8+

This post is going to expand on the technique used to create the folded-corner effect that is part of the demo page for Multiple Backgrounds and Borders with CSS 2.1. As a starting point it will look to recreate the appearance of the note style used on the Yiibu‘s fantastic web site. Where Yiibu uses images, this will use pseudo-elements.

Nothing complicated. Any element will do and there’s no need for extra markup. It’s just a simple coloured box to start with. Browsers with no support for pseudo-elements, such as IE6 and IE7, will only be capable of displaying this.

Adding position:relative makes it possible to absolutely position the pseudo-element.

.note {
  position: relative;
  width: 30%;
  padding: 1em 1.5em;
  margin: 2em auto;
  color: #fff;
  background: #97C02F;
}

The folded-corner

The folded-corner is created from a pseudo-element that is positioned in the top corner of the box. The pseudo-element has no width or height but is given a thick border. Varying the size of the border will vary the size of the folded-corner.

In this example, the top and right borders are set to colours that match the background colour of the box’s parent. The left and bottom border are then given a slightly darker or lighter shade of the box’s background colour.

.note:before {
  content: "";
  position: absolute;
  top: 0;
  right: 0;
  border-width: 0 16px 16px 0;
  border-style: solid;
  border-color: #658E15 #fff;
}

This is all that’s needed to create a simple folded-corner effect like that found on Yiibu.

Firefox 3.0 doesn’t allow for the positioning of pseudo-elements. You can throw in a couple of extra styles to help tidy things up in that browser.

.note:before {
  ...
  display: block;
  width: 0;
}

Adding a subtle shadow

The appearance of a fold can be slightly enhanced by adding a box-shadow (for browsers that support it) to the pseudo-element. Setting overflow:hidden on the note itself will help hide parts of the shadow that would disrupt the folded-corner effect.

.note:before {
  ...
  -webkit-box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
  -moz-box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
  box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
}

Rounded corners

It’s also relatively simple to make this work with rounded corners if desired. Unfortunately, every modern browser has some form of border-radius bug – including those using the non-prefixed property – which means a slight work around is needed.

Webkit browsers are the only browsers that can come anywhere close to rounding the corner of the pseudo-element if it only has 2 borders. Opera 11 and Firefox 3.6 make a mess of it. Opera 11 makes the biggest mess.

Using 4 borders avoids the problems in Opera 11 and Firefox 3.6. But it will trigger a bug in Safari 5 that leaves the diagonal looking a little jaggy. We can get around this problem by setting at least one border colour to be transparent.

When a background colour is applied to the pseudo-element it will show through the transparent border. Ideally, this approach would form the basis of the entire effect because we could reduce the amount of code needed. But Opera 11 will not show the background colour through the transparent borders unless a border-radius has been set.

.note-rounded:before {
  content: "";
  position: absolute;
  top: 0;
  right: 0;
  border-width: 8px;
  border-color: #fff #fff transparent transparent;
  background: #658E15;
  -moz-border-radius: 0 0 0 5px;
  border-radius: 0 0 0 5px;
  display: block;
  width: 0;
}

The CSS file on the demo page has more comments on the work arounds. Every browser has its own peculiarities when it comes to using border-radius or borders on elements with no width or height. This is the merely simplest solution I’ve found to deal with those browser inconsistencies.

The final code

This is all the CSS needed to create a simple folded-corner effect, with a subtle shadow, from a single HTML element. To include a variant with rounded corners, the “note” object can be extended with the modifications described previously.

.note {
  position: relative;
  width: 30%;
  padding: 1em 1.5em;
  margin: 2em auto;
  color: #fff;
  background: #97C02F;
  overflow: hidden;
}

.note:before {
  content: "";
  position: absolute;
  top: 0;
  right: 0;
  border-width: 0 16px 16px 0;
  border-style: solid;
  border-color: #fff #fff #658E15 #658E15;
  background: #658E15;
  -webkit-box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
  -moz-box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
  box-shadow: 0 1px 1px rgba(0,0,0,0.3), -1px 1px 1px rgba(0,0,0,0.2);
  /* Firefox 3.0 damage limitation */
  display: block; width: 0;
}

.note.rounded {
  -moz-border-radius: 5px 0 5px 5px;
  border-radius: 5px 0 5px 5px;
}

.note.rounded:before {
  border-width: 8px;
  border-color: #fff #fff transparent transparent;
  -moz-border-radius: 0 0 0 5px;
  border-radius: 0 0 0 5px;
}

The demo page shows the final effect, an example with rounded corners, and how different coloured notes are easy to create from this base.

This technique works less well when the element receiving the folded-corner effect is sitting on top of a background image rather than a simple background colour. However, the same limitation exists for image-based methods of creating this effect.




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Coronavirus | Tripura State Rifles men risk infection from BSF soldiers

State health officials are planning extensive tests




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CRPF officer dies of COVID19 infection




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Three keys to effective feedback [electronic resource] / Sloan R. Weitzel

Weitzel, Sloan R., author




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Total quality management and just-in-time purchasing [electronic resource] : their effects on performance of firms operating in the U.S. / Hale Kaynak

Kaynak, Hale, 1956-




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The truth about managing effectively (collection) [electronic resource] / Cathy Fyock [and three others]

Fyock, Catherine D., author




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Perfect phrases for virtual teamwork [electronic resource] : hundreds of ready-to-use phrases for fostering collaboration at a distance / Meryl Runion with Lynda McDermott

Runion, Meryl




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Visuals matter! [electronic resource] : designing and using effective visual representations to support project and portfolio decisions / Joana Geraldi, Mario Arlt

Geraldi, Joana G., 1979- author




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What every leader should know about expatriate effectiveness [electronic resource] / Meena S. Wilson, Maxine A. Dalton

Wilson, Meena S., author




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A year with Peter Drucker [electronic resource] : 52 weeks of coaching for leadership effectiveness / based on the work of Peter F. Drucker ; Joseph A. Maciariello

Maciariello, Joseph A., author




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The you of leadership [electronic resource] : an intuitive approach to effective business leadership / Twan van de Kerkhof

Kerkhof, Twan van de, author






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JAMA Otolaryngology–Head & Neck Surgery : Effect of a Change in Papillary Thyroid Cancer Terminology on Anxiety Levels and Treatment Preferences

Interview with Brooke Nickel and Juan Brito, MD, MSc, authors of Effect of a Change in Papillary Thyroid Cancer Terminology on Anxiety Levels and Treatment Preferences: A Randomized Crossover Trial




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JAMA Neurology : Effect of Dextroamphetamine on Poststroke Motor Recovery

Interview with Larry B. Goldstein, MD, author of Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial






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JAMA Internal Medicine : Effect of Exercise Intervention on Functional Decline in Very Elderly Patients

Interview with Mikel Izquierdo, Ph.D, and Nicolás Martínez-Velilla, PhD, authors of Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial, and William J. Hall, MD, author of A Novel Exercise Intervention and Functional Status in Very Elderly Patients During Acute Hospitalization







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JAMA Neurology : Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke

Interview with Adrian F. Hernandez, MD, MHS, author of Clinical Effectiveness of Direct Oral Anticoagulants vs Warfarin in Older Patients With Atrial Fibrillation and Ischemic Stroke: Findings From the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study




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JAMA Cardiology : Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels

Interview with Kausik K. Ray, MD, author of Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial, and Maarten JG. Leening, MD, PhD, author of Safety and Tolerability of Sustained Lipid-Lowering Therapy: Trial Data and Public Perception in a World Where Vaccines and Statins Are About to Collide




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JAMA Internal Medicine : Effect of Collaborative Dementia Care on Quality of Life, Caregiver Well-being, and Health Care Use

Interview with Katherine L. Possin, PhD, author of Effect of Collaborative Dementia Care via Telephone and Internet on Quality of Life, Caregiver Well-being, and Health Care Use: The Care Ecosystem Randomized Clinical Trial, and Jennifer Tjia, MD, MSCE, FAAHPM, author of A Telephone-Based Dementia Care Management Intervention—Finding the Time to Listen










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Focus on effective surveillance of COVID-19, contact-tracing and early diagnosis: Harsh Vardhan tells Tamil Nadu, Telangana and Karnataka

The Minister also asked the States to ensure adoption of infection, prevention and control (IPC) practices in all health-care settings to avoid and reduce chances of infections to health-care workers.




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Product :: Adobe After Effects Classroom in a Book (2020 release) (Web Edition)




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Product :: Adobe After Effects Classroom in a Book (2020 release)




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Product :: Adobe After Effects Classroom in a Book (2020 release)




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Environmental Toxicants: Human Exposures and Their Health Effects, 4th Edition


 

An Updated Reference on Human Exposure to Environmental Toxicants and A Study of Their Impact on Public Health

With the 4th edition of Environmental Toxicants: Human Exposures and Their Health Effects, readers have access to up-to-date information on the study and science of environmental toxicology and public health worldwide. Practitioners and professionals can use this resource to understand newly discovered information on the adverse health effects



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