German Foreign Minister Heiko Maas said in a newspaper interview on Saturday there was a growing risk of a hard Brexit in the midst of the coronavirus crisis as negotiations between Britain and the European Union so far on the future trade relationship had yielded hardly any progress. Britain left...

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Gigi Hadid was seen snubbing Harry Styles while embracing other bandmates after Zayn Malik’s ‘One Direction’ exit

Prince Harry and Meghan Markle are now going to have a film based on their life as well

Madrid and Barcelona will not progress to the next phase of Spain's exit from one of Europe’s strictest lockdowns that will allow bars, restaurants and places of worship to reopen in some areas from Monday, the government announced.

Megafloods, broken backstops and retreating ice sheets combine in a geological epic: the dramatic story of Britain's protracted original exit from Europe

Brexit may seem important right now, but whoever wins the election will be in charge halfway to 2030 – a crucial time in efforts to limit dangerous warming, says Jacob Aron

Ryanair Group CEO Michael O’Leary sits down with Reuters Tim Hepher to discuss challenges including industry-wide consolidation, environmental taxes, Brexit, the grounding of the Boeing 737 MAX and his 5-year, 100 million euro bonus package. Watch here the full event.

Former British Primer Minister Tony Blair cast doubt on that timetable for Brexit negotiations and said there was still a risk that Britain could exit the EU in a year's time without having struck a deal with its biggest trading partner.

The UK’s exit from the EU has had a mixed effect on scientists’ assessment of their international mobility and future job market prospects, according to the 2020 STEM Survey

ABSTRACT

Pneumocystis, a major opportunistic pathogen in patients with a broad range of immunodeficiencies, contains abundant surface proteins encoded by a multicopy gene family, termed the major surface glycoprotein (Msg) gene superfamily. This superfamily has been identified in all Pneumocystis species characterized to date, highlighting its important role in Pneumocystis biology. In this report, through a comprehensive and in-depth characterization of 459 msg genes from 7 Pneumocystis species, we demonstrate, for the first time, the phylogeny and evolution of conserved domains in Msg proteins and provide a detailed description of the classification, unique characteristics, and phylogenetic relatedness of five Msg families. We further describe, for the first time, the relative expression levels of individual msg families in two rodent Pneumocystis species, the substantial variability of the msg repertoires in P. carinii from laboratory and wild rats, and the distinct features of the expression site for the classic msg genes in Pneumocystis from 8 mammalian host species. Our analysis suggests multiple functions for this superfamily rather than just conferring antigenic variation to allow immune evasion as previously believed. This study provides a rich source of information that lays the foundation for the continued experimental exploration of the functions of the Msg superfamily in Pneumocystis biology.

IMPORTANCE Pneumocystis continues to be a major cause of disease in humans with immunodeficiency, especially those with HIV/AIDS and organ transplants, and is being seen with increasing frequency worldwide in patients treated with immunodepleting monoclonal antibodies. Annual health care associated with Pneumocystis pneumonia costs ~$475 million dollars in the United States alone. In addition to causing overt disease in immunodeficient individuals, Pneumocystis can cause subclinical infection or colonization in healthy individuals, which may play an important role in species preservation and disease transmission. Our work sheds new light on the diversity and complexity of the msg superfamily and strongly suggests that the versatility of this superfamily reflects multiple functions, including antigenic variation to allow immune evasion and optimal adaptation to host environmental conditions to promote efficient infection and transmission. These findings are essential to consider in developing new diagnostic and therapeutic strategies.

The first-ever interstellar comet is showing signs of brightening, suggesting it may have been heated up as it passed near to the sun

There are three main strategies for leaving coronavirus lockdown, but each risks a dangerous second wave and further lockdowns if things don't go as planned

The Italian is reportedly set to leave Stamford Bridge at the end of his contract..

In her first on-camera interview since the former vice president “unequivocally” denied the sexual assault allegation, Reade says she's willing to be questioned under oath.

Investors pulled $16.2 billion from stocks in the past week in the largest weekly redemption since the March stock market slump, according to the Bank of America's weekly flows data.

Follow our live coronavirus updates here Coronavirus: the symptoms

Follow our live coronavirus updates here

MPs are calling for 'strategic clarity' from the Government

Michael Gove insisted the Government "should not be thinking of lifting" lockdown restrictions yet as he launched a staunch defence of Boris Johnson's management of the coronavirus crisis.

Brits could be allowed to meet up with small "bubbles" of up to 10 of their closest family or friends in an effort to wind down the coronavirus lockdown.

Labour leader Sir Keir Starmer has called for a coronavirus lockdown "exit strategy" with the Government facing increasing pressure to reveal its next steps.

Italians were today looking forward to a gradual easing of their coronavirus lockdown after the unveiling of a detailed exit strategy by prime minister Giuseppe Conte.

People headed to the beach and fast food outlets after New Zealand lifted its strict lockdown rules that were put in place to limit the spread of coronavirus.

Boris Johnson is preparing a plan for the UK's escape from lockdown after declaring the nation has "past the peak" of its coronavirus outbreak.

Primary schools are set to reopen as soon as June 1 as part of Boris Johnson's coronavirus lockdown exit strategy, The Sunday Telegraph reports.

Brits will be left in the lurch unless ministers set out a clear path for lifting the Covid-19 lockdown, a former prime minister's think tank said.

Deputy Irish Premier Simon Coveney has said the Covid-19 pandemic has made the timeline for a UK-EU trade deal "virtually impossible".

Police have dropped an investigation into two prominent Brexit campaigners accused of breaching spending rules during the referendum campaign. In 2018 the Electoral commission said that Alan Halsall, of Vote Leave, and Darren Grimes, founder of pro-Brexit youth group BeLeave, failed to declare a payment related to the campaign. The watchdog said that BeLeave "spent more than £675,000 with (Canadian data firm) Aggregate IQ under a common plan with Vote Leave". This spending took Vote Leave over its £7 million legal spending limit by almost £500,000. Vote Leave paid a £61,000 fine, but denied wrongdoing, while Mr Grimes won an appeal against his £20,000 fine in July. The Commission also referred the pair to the Metropolitan Police but on Friday it was revealed that the investigations had now been dropped. A spokesman for the Leave campaigners said: "The Metropolitan Police has written to Vote Leave board member Alan Halsall and BeLeave founder Darren Grimes to confirm that it will not be acting on allegations made against them by the Electoral Commission and various Remain campaigners. "This marks the end of a two-year ordeal for both individuals." Mr Grimes, 26, said the development called into question whether the Electoral Commission was "fit for purpose". He had insisted since the allegations were first made that he was "completely innocent" of making false declarations in relation to the £680,000 donation. In a statement, Mr Grimes, a former fashion student originally from County Durham, said: "The Metropolitan Police has found, after investigation and consultation with the Crown Prosecution Service, that there is no case to be answered. "Once again the Electoral Commission has been found to be part of the mob, a quango out of control that isn't policing elections so much as punishing Leavers who have the temerity to win them. "My ordeal at the hands of the kangaroo court that is the Electoral Commission is now over, but questions must now be asked of whether that body is fit for purpose." Mr Halsall, the responsible person for Vote Leave, said he was "delighted to have been exonerated" and thanked the police for their "professional" investigation. "I was very disappointed that my colleagues at Vote Leave and myself were never given the opportunity of making our case in person to the Electoral Commission before being fined and reported to the police," he added. "It seems a rather unusual way of conducting an inquiry into such matters that only the so-called whistleblowers who made these allegations are interviewed by the regulator." A spokesman for the Met said an investigation into the Electoral Commission's allegations against Vote Leave and BeLeave, submitted on July 17 2018, was handed over in October to the Crown Prosecution Service (CPS). "On Tuesday, March 3 preliminary advice was received from the CPS," said the force spokesman. "This advice has now been duly considered and no further action will be taken."

A hard Brexit is more likely due to the coronavirus crisis because Britain and the European Union have made so little progress in talks, Germany's foreign minister has said. Heiko Maas said that negotiations between Britain and the EU so far on the future trade relationship had yielded few gains with the UK disregarding the political declaration, which he said was "simply not on". Britain left the EU in January, and talks with the bloc are now focused on setting new trading terms from 2021, when London's status-quo transition period ends. However, the talks quickly hit an impasse when negotiations resumed last month, according to diplomats and officials. "It's worrying that Britain is moving further away from our jointly agreed political declaration on key issues in the negotiations," Mr Maas told the Augsburger Allgemeine newspaper. "It's simply not on, because the negotiations are a complete package as it's laid out in the political declaration." Mr Maas said there was currently neither common ground on how to shape a comprehensive trade deal or on whether to extend the negotiation period beyond the end of the year. "The British government is still refusing to extend the deadline," Mr Maas said. "If it stays that way, we will have to deal with Brexit in addition to the coronavirus at the turn of the year." Simon Coveney, Ireland's foreign minister, said on Friday that the coronavirus pandemic had made an already difficult timeline for a British-European Union trade deal "virtually impossible" and that it would make sense to seek more time.

Celebrity TV chef from MKR has been repeatedly criticised by scientific and medical groups over his views on health and nutrition

The controversial reality TV chef Pete Evans will exit My Kitchen Rules, Seven’s defining show of the decade which slumped badly in the ratings this year.

Evans, a self-styled health guru held one of the most lucrative jobs in television despite a series of controversies related to his views on health and nutrition.

Follow our live Covid-19 updates here

We were too slow to implement lockdown and make sure it was policed, Labour leader tells Tories Follow our live coronavirus updates HERE Coronavirus: the symptoms

Follow our live coronavirus updates HERE Coronavirus: The symptoms

The EU's chief negotiator has branded progress in post-Brexit talks disappointing and warned the "clock was ticking".

Sir Keir Starmer has urged the Government to publish an exit strategy for the coronavirus lockdown amid warnings the country could "fall behind" without one.

The UK will begin the first round of post-Brexit trade deal talks with the US this week.

Cabinet Office minister says Government does not want the UK to continue with its 'European Union-lite membership' beyond December 2020

Britain and the US are set to begin negotiations on an "ambitious" post-Brexit free trade agreement.

Ivan Rakitic has warned Barcelona he wants to be "where he is valued" amid growing transfer speculation.

Gary Neville claims Tottenham star Harry Kane has 'deliberately opened the door' for a move away from north London.

Ivan Rakitic has made 299 appearances for Barcelona in all competitions and remains the only midfielder to score for the Catalan club in a European Cup final. At Camp Nou, his name is still cheered by fans.

Steve Sidwell has revealed a number of Chelsea players were crying on the floor after learning of Jose Mourinho's departure from the club in 2007.

Harry Kane's departure from Tottenham is "inevitable", according to former West Ham player Tony Cottee.

Tottenham defender Jan Vertonghen has hinted that he will look to leave the club once his contract expires this summer.

Liverpool star Mohamed Salah has - quite literally - laughed off suggestions of a move away from Anfield.

Mikel Arteta has admitted he felt the energy was not right at Arsenal when he first arrived at the club.

Aston Villa chief executive Christian Purslow has compared the Premier League's 'Project Restart' planning to the Brexit process.