f

For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as potential active substances. Treatments based on HLA-presented peptides have shown promising results in clinical application as personalized T cell-based immunotherapy. Peptide vaccination cocktails are produced as investigational medicinal products under GMP conditions. To support clinical trials based on HLA-presented tumor-associated antigens, in this study the sensitive LC-MS/MS HLA class I antigen identification pipeline was fully validated for our technical equipment according to the current US Food and Drug Administration (FDA) and European Medicines Agency (EMA) guidelines.

The immunopeptidomes of JY cells with or without spiked-in, isotope labeled peptides, of peripheral blood mononuclear cells of healthy volunteers as well as a chronic lymphocytic leukemia and a bladder cancer sample were reliably identified using a data-dependent acquisition method. As the LC-MS/MS pipeline is used for identification purposes, the validation parameters include accuracy, precision, specificity, limit of detection and robustness.

Archival materials -- Handbooks, manuals, etc.

London : J. Churchill, 1839.

Londres : Paris, 1860.

Paris : G. Steinheil, 1892.

Edinburgh : printed by James Ballantyne & Co, [1807?]

Paris : Bailliere, 1896.

Text summarization refers to the process that generates a shorter form of text from the source document preserving salient information. Recently, many models for text summarization have been proposed. Most of those models were evaluated using recall-oriented understudy for gisting evaluation (ROUGE) scores. However, as ROUGE scores are computed based on n-gram overlap, they do not reflect semantic meaning correspondences between generated and reference summaries. Because Korean is an agglutinative language that combines various morphemes into a word that express several meanings, ROUGE is not suitable for Korean summarization. In this paper, we propose evaluation metrics that reflect semantic meanings of a reference summary and the original document, Reference and Document Aware Semantic Score (RDASS). We then propose a method for improving the correlation of the metrics with human judgment. Evaluation results show that the correlation with human judgment is significantly higher for our evaluation metrics than for ROUGE scores.

French translation of the press release about the Basel Committee publishing a discussion paper on "The regulatory treatment of sovereign exposures" (7 December 2017)

The National Trust for Historic Preservation is looking for 1,000 places tied to women's history, and to share the stories of the figures behind them

During the Nazi occupation of France, many valuable works of art were stolen from the Jeu de Paume museum and relocated to Germany. One brave French woman kept detailed notes of the thefts

There are better sports documentaries than The Last Dance, but the entertaining series on the Michael Jordan-led Bulls dynasty might be a better fit for this particular time.

'Creative Music Making' Documentary to Air on Nine Network - MPress  Maryville University News

The fatherhood documentary "Dads" featuring actor Bryce Dallas Howard will be airing on Apple TV+ ahead of Father's Day, with the film set to be available to stream from the service from June 19.

Born in New Jersey, USA, to Jamaican parents, Linton Hinds Jr was acquainted with the culture of their homeland. He developed an appreciation for the country's food, music and home remedies such as the roots tonic.Those natural drinks, once shunned as backward concoctions, are the rage in Jamaica, with countless brands on the market.

A glance through Jamie Genevieve's social media pages and a fairly intimidating impression emerges.

The new analysis significantly increases the annual estimate of undocumented high school students earning diplomas that has long been used in debates about immigration and special protections for immigrant youth who were illegally brought to the U.S. as children.

The Epson WorkForce ES-500WR delivers fast and accurate scans paired with a robust software package that will appeal to data-crunching offices.

Having printer problems? Whether it's a software issue, a hardware problem, or something else, here's how to troubleshoot your printer.

The film follows three young men over six years in a rural North Carolina community as they struggle to finish high school.

"Raising Bertie," about three African-American boys in Bertie County, N.C., airs on the PBS documentary series "POV" Monday night.

Document management solutions have evolved from simple file storage engines to sophisticated workflow and data classification systems. We review and rank the top 10 players in this field.

A new documentary on the history and future of Delaware agriculture will air next weekend on WHYY-TV, in time to kick off the Delaware State Fair. “Delaware Agriculture: Farming the First State,” a 30-minute documentary, will be broadcast at 5:30 p.m. and 11 p.m. July 19, 11 a.m. July 21 and 5:30 p.m. July 22.

Agency: HSS Closing Date: 5/28/2020

A court document has surfaced showing that Tara Reade – a former Senate staffer for Joe Biden who has accused him of sexual assault – told her then-husband she was harassed while working in his office.
Read Full Article at RT.com

Pulled from YouTube, censored in internet searches, and denounced by every single mainstream media outlet, what kind of information could make everyone so mad about ‘Plandemic’? We watched it to find out.
Read Full Article at RT.com

Hello

The document I referenced is https://filebox.ece.vt.edu/~symort/rfworkshop/Mixer_workshop_instruction.pdf. (This is cadence workshop document)

While following the pxf simulation in the above article, the results are different and I have a question.

My result picture is shown below.

<my result error>

<document result>

<my direct plot>

<document direct plot>

The difference with the documentation is that in the direct plot screen after the pxf simulation,

1.output harmonics-> input sideband

2.Frequency axis: out-> frequency axis: absin

3.The results for port0 (RF port) are also different (see photo below).

4.The frequency values in the box are different.

My screen shows 5G, 10G, 1K ~ 10M, but the document is the same as 1K ~ 10M.

Ask for a solution. Thank you.

In early February, during DistribuTECH, the Smart Electric Power Alliance (SEPA) hosted a workshop to discuss what requirements are necessary for successful distributed energy resource management systems (DERMS) deployment.

In early February, during DistribuTECH, the Smart Electric Power Alliance (SEPA) hosted a workshop to discuss what requirements are necessary for successful distributed energy resource management systems (DERMS) deployment.

Sponsors of Tier 2 migrants will be aware that they are obliged to retain certain documents for every sponsored migrant for a set period of time as part of their sponsorship duties. The specific documents that sponsors are required to retain and the...

On 6 January 2016, the European Commission published an implementing regulation establishing a standard form for the European Single Procurement Document (“ESPD”). The ESPD is one of the new features of EU procurement regulation introduc...

TBD (Owen Holland) Ltd v Simons & Ors [2020] EWHC 30 (Ch) Background A search order is one of the most draconian orders that the English courts can make, allowing an applicant – where there is a real possibility that a respondent may destroy o...

The decision to shelve detailed advice from the nation’s top disease control experts for reopening communities during the coronavirus pandemic came from the highest levels of the White House.

The migrants awaiting deportation climbed over the walls and escaped the repatriation centre on Sunday when EnviroMongz Projects security guards left their posts.