Most prospective cohort studies of acquired demyelinating syndromes in children have focused on the genetic, environmental, and neuroimaging predictors of multiple sclerosis. Less is known regarding the severity of the incident demyelinating event and predictors of residual attack–related physical disability.

In a national, prospective longitudinal study, incident acquired demyelinating syndromes in children were characterized in terms of physical deficits and acuity at onset, and recovery over the first 12 months. Follow-up evaluations up to 10 years’ postonset were analyzed. (Read the full article)

Gastrostomy tube placement is a difficult decision for families of children with neurologic impairment. Better understanding the impact of these tubes on the lives of children and families will help improve decision-making and support from health care providers.

Gastrostomy tube placement has broad-reaching implications for children and their families. There are physical, emotional, and relational challenges and benefits for the child, the parents, and the family unit. Exploring potential outcomes with families may improve decision-making conversations and support. (Read the full article)

Central nervous system (CNS) tuberculosis has high morbidity and mortality, and it frequently affects children aged <5 years.

In California, children who were US-born, Hispanic, and aged <5 years were at increased risk of CNS tuberculosis. Children with CNS tuberculosis were more likely to die. Specific populations of US-born infants might benefit from additional prevention measures. (Read the full article)

Systemic responses occur after burn injury that lead to widespread changes to the body, including the heart. Elevated levels of catecholamines and stress hormones have been found up to 3 years after severe burns. Little is known about the longer-term effects.

Children with burns had 1.3 times as many admissions and 2.3 times the number of days in hospital for circulatory diseases compared with uninjured children. Children with minor burns had an increased risk of incident admissions for circulatory diseases. (Read the full article)

Helen Janc Malone introduces this week's blog theme, "accountability and assessment systems." She writes that at the heart of the current accountability debate is a fundamental question, What is the purpose of all the collected assessment data? Are they an end game or a starting point to educational

The Cpx stress response is widespread among Enterobacteriaceae. We have previously reported a mutation in cpxA in a multidrug resistant strain of Klebsiella aerogenes isolated from a patient treated with imipenem. This mutation yields to a single amino acid substitution (Y144N) located in the periplasmic sensor domain of CpxA. In this work, we sought to characterize this mutation in Escherichia coli by using genetic and biochemical approaches. Here, we show that cpxA^Y144N is an activated allele that confers resistance to β-lactams and aminoglycosides in a CpxR-dependent manner, by regulating the expression of the OmpF porin and the AcrD efflux pump, respectively. We also demonstrate the intimate interconnection between Cpx system and peptidoglycan integrity on the expression of an exogenous AmpC β-lactamase by using imipenem as a cell wall active antibiotic or inactivation of penicillin-binding proteins. Moreover, our data indicate that the Y144N substitution abrogates the interaction between CpxA and CpxP and increase phosphotransfer activity on CpxR. Because the addition of a strong AmpC inducer such as imipenem is known to causes abnormal accumulation of muropeptides (disaccharide-pentapeptide, N-acetylglucosamyl-1,6-anhydro-N-acetylmuramyl-l-alanyl-d-glutamy-meso-diaminopimelic-acid-d-alanyl-d-alanine) in the periplasmic space, we propose these molecules activate the Cpx system by displacing CpxP from the sensor domain of CpxA. Altogether, these data could explain why large perturbations to peptidoglycan caused by imipenem lead to mutational activation of the Cpx system and bacterial adaptation through multidrug resistance. These results also validate the Cpx system, in particular the interaction between CpxA and CpxP, as a promising therapeutic target.

Staphylococcus aureus osteomyelitis is a debilitating infection of bone. Treatment of osteomyelitis is impaired by the propensity of invading bacteria to induce pathologic bone remodeling that may limit antibiotic penetration to the infectious focus. The nonsteroidal anti-inflammatory drug diflunisal was previously identified as an osteoprotective adjunctive therapy for osteomyelitis, based on the ability of this compound to inhibit S. aureus quorum sensing and subsequent quorum-dependent toxin production. When delivered locally during experimental osteomyelitis, diflunisal significantly limits bone destruction without affecting bacterial burdens. However, because diflunisal's "quorum-quenching" activity could theoretically increase antibiotic recalcitrance, it is critically important to evaluate this adjunctive therapy in the context of standard of care antibiotics. The objective of this study is to evaluate the efficacy of vancomycin to treat osteomyelitis during local diflunisal treatment. We first determined that systemic vancomycin effectively reduces bacterial burdens in a murine model of osteomyelitis, and identified a dosing regimen that decreases bacterial burdens without eradicating infection. Using this dosing scheme, we found that vancomycin activity is unaffected by the presence of diflunisal in vitro and in vivo. Similarly, locally-delivered diflunisal still potently inhibits osteoblast cytotoxicity in vitro and bone destruction in vivo in the presence of sub-therapeutic vancomycin. However, we also found that the resorbable polyurethane foams used to deliver diflunisal serve as a nidus for infection. Taken together, these data demonstrate that diflunisal does not significantly impact standard of care antibiotic therapy for S. aureus osteomyelitis, but also highlight potential pitfalls encountered with local drug delivery.

Have a larger home with Wi-Fi dead zones? A multi-node system might be a better solution than a traditional wireless router with extenders. Here are the best Wi-Fi mesh network systems we've tested in our labs.

Yong Y. Han
Dec 1, 2005; 116:1506-1512
ARTICLES

In Denver, teachers will go on strike Monday to protest a performance-pay system that’s been in place for 15 years. The dispute is illustrative of a larger national shift away from differentiated pay.

Penn State researchers provide informed commentary on the impact of the coronavirus pandemic on the criminal justice system (CJS), focusing on its efforts to contain the spread of the virus through the three core components of the CJS — courts, corrections, and policing – as well as opportunities going forward. To read more, visit the "Insights from Experts" website — a partnership of Penn State's Social Science Research Institute and the Center for Health Care and Policy Research.

The Assessment for Learning Project, a partnership between Center for Innovation in Education and Next Generation Learning Challenges, granted twelve grants totaling $2 million for rethinking assessment.

We conducted a systematic review to demonstrate that tummy time was positively associated with gross motor development; prone, supine, crawling, and rolling development; reduction in BMI-z; and prevention of brachycephaly.

Schools can't even afford to hire enough teachers, so why are we surprised that teachers are turning to a website for resources? asks Kat Tipton.

Delaware’s state museum system has been accredited by the American Alliance of Museums (AAM), the highest recognition afforded to museums in the United States. Administered by the Delaware Division of Historical and Cultural Affairs, the system includes five museums as well as the archaeological and historic objects collections curated by the state.

China will reform its disease prevention and control system to address weaknesses exposed by the coronavirus outbreak, a senior health official said on Saturday.

The Telangana Police will soon rollout an Artificial Intelligence (AI)- based system through CCTVs to check face mask norm violations.

DOVER (January 3, 2020): As part of a systems-wide upgrade to State of Delaware banking processes, the Office of State Treasurer Colleen C. Davis and the Department of Labor have announced improvements to unemployment benefit payment distribution. By the end of this month, the state will move unemployment debit cards to the U.S. Bank ReliaCard®, […]

 Settlement and Default Handling Procedures in Multilateral and Deferred Net Settlement Systems under the PSS Act, 2007

Agency: NCC Closing Date: 5/22/2020

Agency: GSS Closing Date: 5/28/2020

Agency: HSS Closing Date: 5/28/2020

NEW CASTLE (July 24, 2018) – Following a 14-month review of Delaware’s opioid use disorder treatment system, a research team from the Johns Hopkins Bloomberg School of Public Health and the Bloomberg American Health Initiative today recommended four major strategies to achieve the state’s goal of a system of care that is accessible, evidence-based, individualized, […]

NEW CASTLE (April 25, 2019) – The Delaware Department of Health and Social Services (DHSS) today announced that Delaware is one of five states selected to partner with the national nonprofit Shatterproof in the development of a new pilot rating system designed to measure quality in addiction treatment programs. Delaware was selected due to the […]

DEPARTMENT OF HEALTH AND SOCIAL SERVICES: Division of Management Services

DEPARTMENT OF HEALTH AND SOCIAL SERVICES: Division of Public Health

DOVER, Del. – Governor John Carney, along with the Delaware Department of Health and Social Services (DHSS), announced on Friday a coordinated statewide plan to ensure individuals with symptoms consistent with coronavirus disease 2019 (COVID-19) have access to safe and efficient testing in Delaware. Tests will be administered at no cost to the patients. Through […]

Wilmington – Today, May 04, 2020, the Delaware Department of Labor is announcing the launch of a new unemployment insurance benefits system that will process claims for independent contractors, self-employed individuals, and others as detailed in the CARES Act. These individuals can file benefits claims for Pandemic Unemployment Assistance beginning the week of May 11, […]

This apparatus can be used to sanitize the seats of cars, taxis, ambulances, goods vans, buses, flights, trains, and could even sanitize elevators, etc.

Road mishaps cost India 3-5% of its gross domestic product every year. India amounts to one percent of the vehicles across the world, yet it contributes almost 6% of the road fatalities on the road.

The English language abilities of an applicant are likely to get a rank based on proficiency in the new British visa regime that is getting finalized by UK after it makes an exit from the EU.UK Immigration and Need for an Evaluation The authorities…

Britain will soon accept immigrants only when they possess the right skills. An immigration system based on points is common to Canada, Australia, and New Zealand and in the immediate future, it appears that Britain will join them. The election results…

Many of the buzzy applications of AI in healthcare we hear about involve medical IoT, computer vision for radiology or disease prediction. But the fact is, many health institutions that just aren’t there yet with adoption. With limited budgets and dated systems, can public health agencies tap into the power [...]

The post Can AI in healthcare help us identify high-risk people across systems? appeared first on Government Data Connection.

The government of Denmark is having a negotiation with the industry regarding improvement of energy efficiency. The mutual agreement of 2012 has the ability to cut 12 per cent of energy usage in 2020, as compared to the same calculated in 2006. The agreement…

  While the title might set off alarm bells for some of you folks it isn’t that bad an idea to have eyes on everything and everyone all the time. Surveillance is sometimes a necessity and sometime...

  Introduction Intel®  VTune™ Amplifier 2014 for Systems is part of the Intel® System Studio suite of tools supporting both the mobile and embedded markets. This article will demon...

  Mobile applications can behave differently between emulator and device and, as an app grows more and more complex, debugging performance bottlenecks can become extremely difficult. The GPA System Anal...

In the case of Covid-19, hazardous waste is being generated in hospitals, quarantine zones or red zone areas within cities. They are potential sources of Covid-19 and can cause further spread within the locality.

Technology will play a crucial role in developing the EV ecosystem including in design, simulation, manufacturing and developing the overall vehicle cycle.

In the future application season, A new and streamlined electronic registration system, having the earlier deadline will Replace the expensive and bulky H-1B application process, as per the statement of the federal government.The Major ChangesIn place…

Addressing a gathering at Siddaganga Matha in Tumkur in Karnataka, Modi accused the Opposition of remaining silent on Pakistan’s “atrocities on Hindus, Sikhs, Jains and Christians” and said “jis tarah ki nafrat hum logon se karte hain, vaisa hi swar ab desh ki sansad ke khilaf dikh raha hai.

Budget 2019: NEP has potential to overhaul the system

Earlier, the Business Correspondent Federation of India (BCFI) had said that while the BCs were offering services of cash withdrawal, very few are depositing money in the wake of the current lockdown.

Emission of the green house at the current levels will cause catastrophe in most parts of the world with some ecosystems expected to collapse by 2030.