Former Republican Missouri Gov. Eric Greitens appointed enough board members to have Commissioner Margie Vandeven fired last year, but now that he's gone, the state board decided to hire her back.

Trier : WVT Wissenschaftlicher Verlag Trier, 2017.

Sabrina Ionescu wins the Wooden Award for the second year in a row, becoming the fifth in the trophy's history to win in back-to-back seasons. With the honor, she completes a complete sweep of the national postseason player of the year awards. As a senior, Ionescu matched her own single-season mark with eight triple-doubles in 2019-20, and she was incredibly efficient from the field with a career-best 51.8 field goal percentage.

Pac-12 Networks' Ashley Adamson catches up with Oregon's "Big 3" of Sabrina Ionescu, Ruthy Hebard and Satou Sabally to hear how they're adjusting to the new world without sports while still preparing for the WNBA Draft on April 17. They also share how they're staying hungry for basketball during the hiatus.

After sweeping every national player of the year award, Sabrina Ionescu is off to the WNBA level where her skills will make an instant impact — not just to her new team but the league as a whole. She averaged 17.5 points, 8.6 rebounds and 9.1 assists for the Ducks in 2019-20, rewriting her own NCAA career triple-double record and becoming the first in college basketball history with at least 2,000 points, 1,000 rebounds and 1,000 assists.

Athletic forward Satou Sabally is preparing to take the leap to the WNBA level following three productive seasons at Oregon. As a junior, she averaged 16.2 points and 6.9 rebounds per game while helping the Ducks sweep the Pac-12 regular season and tournament titles. At 6-foot-4, she also drained 45 3-pointers for Oregon in 2019-20 while notching a career-best average of 2.3 assists per game.

Ruthy Hebard, who ranks 2nd in Oregon history in points (2,368) and 3rd in rebounds (1,299), prepares to play in the WNBA following four years in Eugene. Hebard is the Oregon and Pac-12 all-time leader in career field-goal percentage (65.1) and averaged 17.3 points per game and a career-high 9.6 rebounds per game as a senior.

Oregon State guard Mikayla Pivec is the epitome of a versatile player. Her 1,030 career rebounds were the most in school history, and she finished just one assist shy of becoming the first in OSU history to tally 1,500 points, 1,000 rebounds and 500 assists. She'll head to the WNBA looking to showcase her talents at the next level following the 2020 WNBA Draft.

UCLA guard Japreece Dean is primed to shine at the next level as she heads to the WNBA Draft in April. The do-it-all point-woman was an All-Pac-12 honoree last season, and one of only seven D-1 hoopers with at least 13 points and 5.5 assists per game.

The reaction on social media has been fierce.

Benjamin Meyer
Jul 3, 2019; 39:5326-5335
Systems/Circuits

Speech by Mr Agustín Carstens, General Manager of the BIS, to the Basler Bankenforum, Basel, 5 September 2019.

Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia's pathophysiology is still unclear, postmortem studies point toward a dysfunction of cortical interneurons as a central element. It has been suggested that alterations in parvalbumin-positive interneurons in schizophrenia are the consequence of a deficient signaling through NMDARs. Animal studies demonstrated that early postnatal ablation of the NMDAR in corticolimbic interneurons induces neurobiochemical, physiological, behavioral, and epidemiological phenotypes related to schizophrenia. Notably, the behavioral abnormalities emerge only after animals complete their maturation during adolescence and are absent if the NMDAR is deleted during adulthood. This suggests that interneuron dysfunction must interact with development to impact on behavior. Here, we assess in vivo how an early NMDAR ablation in corticolimbic interneurons impacts on mPFC and ventral hippocampus functional connectivity before and after adolescence. In juvenile male mice, NMDAR ablation results in several pathophysiological traits, including increased cortical activity and decreased entrainment to local gamma and distal hippocampal theta rhythms. In addition, adult male KO mice showed reduced ventral hippocampus-mPFC-evoked potentials and an augmented low-frequency stimulation LTD of the pathway, suggesting that there is a functional disconnection between both structures in adult KO mice. Our results demonstrate that early genetic abnormalities in interneurons can interact with postnatal development during adolescence, triggering pathophysiological mechanisms related to schizophrenia that exceed those caused by NMDAR interneuron hypofunction alone.

SIGNIFICANCE STATEMENT NMDAR hypofunction in cortical interneurons has been linked to schizophrenia pathophysiology. How a dysfunction of GABAergic cortical interneurons interacts with maturation during adolescence has not been clarified yet. Here, we demonstrate in vivo that early postnatal ablation of the NMDAR in corticolimbic interneurons results in an overactive but desynchronized PFC before adolescence. Final postnatal maturation during this stage outspreads the impact of the genetic manipulation toward a functional disconnection of the ventral hippocampal-prefrontal pathway, probably as a consequence of an exacerbated propensity toward hippocampal-evoked depotentiation plasticity. Our results demonstrate a complex interaction between genetic and developmental factors affecting cortical interneurons and PFC function.

Hassan Al-Hassan, a Syrian farmer known to locals as Abu Hasan, remembers how difficult it had been in the past few years in the village of al-Rabeha in the southern governorate of Homs. “Due to lack of water, we could hardly produce anything,” said Abu Hasan. FAO is helping to restore access to water for over 40 000 families – about [...]

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