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Ohio State records 40-plus point win vs Charlotte despite apparent Jaloni Cambridge injury
Early in the second half, Ohio State freshman Jaloni Cambridge went down with an apparent lower-back injury.
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Where South Carolina football ranks in latest College Football Playoff poll
South Carolina football landed 21st in the latest CFP bracket. Here’s the College Football Playoff for the newly ranked No. 23 Gamecocks.
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Blugolds men’s and women’s basketball have home opener, first games in the new Sonnentag Event Center
EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ...
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Women's basketball notebook: Gonzaga got the best from a motivated Stanford team, a sign of respect for Bulldogs
Nov. 12—The Gonzaga women's basketball team has much to learn after a challenging loss at Stanford on Sunday. Losses have a way of exposing a team's shortcomings. And there is much to learn from the worst loss (89-58) in coach Lisa Fortier's 11 seasons. Stanford, unranked in the preseason poll for the first time since 1999-2000, is unranked no more. The Cardinal (3-0) entered at No. 24 in the ...
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Markowski, Potts lead No. 21 Nebraska women to 84-56 win over road warriors Southern
Alexis Markowski scored 22 points, Natalie Potts had a double-double and No. 21 Nebraska cruised to an 84-58 win over Southern on Tuesday night. Potts had 17 points and 12 rebounds, eight on the offensive end, for the Cornhuskers (3-0). Alberte Rimdal added 12 points.
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JuJu Watkins leads No. 3 USC women to 124-39 rout of Cal State Northridge
JuJu Watkins had 21 points, nine assists and six steals to help No. 3 Southern California trounce Cal State Northridge 124-39 on Tuesday night. The Trojans (3-0) had six players in double figures, including Kiki Iriafen with 15 points and Kayleigh Heckel with 14 points off the bench. All 13 Trojans who played scored.
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New underground gallery & auditorium to open beneath historic Mitchell Library building
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Openbook’s autumn edition showcases diverse talents of Australia’s creative community
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Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
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Intracranially Administered Anti-A{beta} Antibodies Reduce {beta}-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation
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Stressed Memories: How Acute Stress Affects Memory Formation in Humans
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Multiscale Computer Model of the Spinal Dorsal Horn Reveals Changes in Network Processing Associated with Chronic Pain
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Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus
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Loss of Dopamine Transporters in Methamphetamine Abusers Recovers with Protracted Abstinence
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Human REM Sleep Delta Waves and the Blurring Distinction between NREM and REM Sleep
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Striatal Serotonin Release Signals Reward Value
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The Salience Network: A Neural System for Perceiving and Responding to Homeostatic Demands
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To See or Not to See: Prestimulus {alpha} Phase Predicts Visual Awareness
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Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
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On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex
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A Hierarchy of Temporal Receptive Windows in Human Cortex
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Targeting Cre Recombinase to Specific Neuron Populations with Bacterial Artificial Chromosome Constructs
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Topographic Mapping of a Hierarchy of Temporal Receptive Windows Using a Narrated Story
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A Recurrent Network Mechanism of Time Integration in Perceptual Decisions
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Intraneuronal beta-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
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Deep Neural Networks Reveal a Gradient in the Complexity of Neural Representations across the Ventral Stream
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Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1- and T2-Weighted MRI
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Cardiac-Sympathetic Contractility and Neural Alpha-Band Power: Cross-Modal Collaboration during Approach-Avoidance Conflict
As evidence mounts that the cardiac-sympathetic nervous system reacts to challenging cognitive settings, we ask if these responses are epiphenomenal companions or if there is evidence suggesting a more intertwined role of this system with cognitive function. Healthy male and female human participants performed an approach-avoidance paradigm, trading off monetary reward for painful electric shock, while we recorded simultaneous electroencephalographic and cardiac-sympathetic signals. Participants were reward sensitive but also experienced approach-avoidance "conflict" when the subjective appeal of the reward was near equivalent to the revulsion of the cost. Drift-diffusion model parameters suggested that participants managed conflict in part by integrating larger volumes of evidence into choices (wider decision boundaries). Late alpha-band (neural) dynamics were consistent with widening decision boundaries serving to combat reward sensitivity and spread attention more fairly to all dimensions of available information. Independently, wider boundaries were also associated with cardiac "contractility" (an index of sympathetically mediated positive inotropy). We also saw evidence of conflict-specific "collaboration" between the neural and cardiac-sympathetic signals. In states of high conflict, the alignment (i.e., product) of alpha dynamics and contractility were associated with a further widening of the boundary, independent of either signal's singular association. Cross-trial coherence analyses provided additional evidence that the autonomic systems controlling cardiac-sympathetics might influence the assessment of information streams during conflict by disrupting or overriding reward processing. We conclude that cardiac-sympathetic control might play a critical role, in collaboration with cognitive processes, during the approach-avoidance conflict in humans.
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Role of the STING->IRF3 Pathway in Ambient GABA Homeostasis and Cognitive Function
Targeting altered expression and/or activity of GABA (-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying the transcriptional regulation of GATs are unknown. In the present study, we demonstrated that the stimulator of interferon genes (STING) upregulates GAT1 and GAT3 expression in the brain, which resulted in cognitive dysfunction. Genetic and pharmacological intervention of STING suppressed the expression of both GAT1 and GAT3, increased the ambient GABA concentration, and therefore, enhanced tonic GABAA inhibition of principal hippocampal neurons, resulting in spatial learning and working memory deficits in mice in a type I interferon-independent manner. Stimulation of the STING->GAT pathway efficiently restored cognitive dysfunction in STING-deficient mice models. Our study uncovered for the first time that the STING signaling pathway regulates GAT expression in a cell autonomous manner and therefore could be a novel target for GABAergic cognitive deficits.
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Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.
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A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans
Emerging research in nonhuman animals implicates cerebellar projections to the ventral tegmental area (VTA) in appetitive behaviors, but these circuits have not been characterized in humans. Here, we mapped cerebello-VTA white matter connectivity in a cohort of men and women using probabilistic tractography on diffusion imaging data from the Human Connectome Project. We uncovered the topographical organization of these connections by separately tracking from parcels of cerebellar lobule VI, crus I/II, vermis, paravermis, and cerebrocerebellum. Results revealed that connections between the cerebellum and VTA predominantly originate in the right cerebellar hemisphere, interposed nucleus, and paravermal cortex and terminate mostly ipsilaterally. Paravermal crus I sends the most connections to the VTA compared with other lobules. We discovered a mediolateral gradient of connectivity, such that the medial cerebellum has the highest connectivity with the VTA. Individual differences in microstructure were associated with measures of negative affect and social functioning. By splitting the tracts into quarters, we found that the socioaffective effects were driven by the third quarter of the tract, corresponding to the point at which the fibers leave the deep nuclei. Taken together, we produced detailed maps of cerebello-VTA structural connectivity for the first time in humans and established their relevance for trait differences in socioaffective regulation.