One of the giants of the literacy world is grappling with the recent push for the "science of reading"—and responding to critics who say her early reading program doesn't align to evidence-based practice.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

A performing arts outreach team shares Christ with crowds gathered to watch their street performances every evening during the Avignon Festival.

Discovery Health Medical Scheme's (DHMS) 2023 cancer claims payouts were almost 19% higher than the previous year though the scheme says screening rates in South Africa have mostly returned to pre-pandemic levels.

The Patch Project, an initiative between Penn State Beaver and local nonprofit Reforest Our Future, aims to restore natural elements to the local landscape. Ten small patches of forest will be planted around Beaver County. The project is being completed with funds from the inaugural Commonwealth Campus Undergraduate Community-Engaged Research Award.
 

Two graduate students in Penn State Great Valley’s data analytics program, Praneeth Sunkavalli and Jainil Kakka, won second place for their research poster at a recent symposium hosted by the Penn State Institute for Computational and Data Sciences. For their research project, they used machine learning to analyze event data from soccer games to measure the success rates of a defensive tactic called "pressing," when players pressure their opponents in an attempt to regain the ball.

Kost Tire and Auto Service has partnered with Penn State Scranton to offer campus students, faculty and staff free winter safety checks of their vehicles during a special event on Tuesday, Oct. 1. In addition, representatives from State Farm Insurance will be offering car seat safety checks.

Developed by a team in the College of Arts and Architecture's Office of Digital Learning, HAX, or Headless Authoring eXperience, is a content management system that structures content in a ubiquitous format for simple web publishing.

Scientists have spotted microplastics, tiny pieces of plastic smaller than 5 millimeters, in some of the most pristine environments on Earth, from the depths of the Mariana Trench to the snow on Mt. Everest to the mountaintop clouds of China and Japan. Microplastics have been detected in human brains, the bellies of sea turtles and the roots of plants. Now, new research led by Penn State scientists reveals that microplastics in the atmosphere could be affecting weather and climate.

Penn State Great Valley is offering a streamlined 33-credit MBA with highly flexible delivery and the opportunity to specialize by earning up to three graduate certificates as part of the program.

Sen. Kyle Evans Gay, in partnership with the Delaware State Housing Authority (DSHA), secured $200,000 in American Rescue Plan Act funding this month for an innovative pilot program that will help low-income renters in Delaware build credit.

The Delaware State Housing Authority (DSHA) announced four new programs designed to increase access to homeownership in the First State. Now, whether a homebuyer is purchasing their first or next home, DSHA offers mortgage products that can make the dream of homeownership a reality.

First New Money Tax-Exempt Deal Since 2013 Will Provide $75 Million To Fund Down Payment Assistance Programs and Offer Competitive Mortgage Loan Interest Rates    The Delaware State Housing Authority (DSHA) announced Tuesday new competitive mortgage programs and the relaunch of down payment and closing cost assistance programs that can make the dream of homeownership a […]

A group of 80 gather in São José dos Campos, Brazil, to celebrate Christmas in a fundraising dinner for the oppressed in the world.

A new recording studio aims to bring Central Asian musicians together for collaboration and worship.

OM workers in Central Asia minister to homeless people. Some people reject their help, but others find new life.

All eyes will be on the Congress and INDIA bloc as 31 constituencies vote in Assembly bypolls across 10 states, apart from Lok Sabha bypolls in Kerala's Wayanad

Fast-rising methane emissions could undermine efforts to limit global warming by mid-century, prompting scientists and policymakers to urge aggressive action to curb output of the potent greenhouse gas.

Ahead of the voting in the first phase of Assembly elections in Jharkhand on Wednesday, the Returning Officer for Ranchi Assembly constituency, Utkarsh Kumar said that the mock poll will begin at 5.30 am after which polling will commence.

In a twist worthy of a Bollywood movie, the 24-year-old lyricist of a song in an upcoming Salman Khan film has been arrested for issuing a death threat - purportedly from the Lawrence Bishnoi gang - to the actor and himself.

The final entry of Queen Elizabeth's private diary has been made public. During her record-breaking 70-year reign, the monarch, who died in 2022 at age 96, kept a private diary to take note of the events of the day and record her activities.

All eyes will be on the Congress and INDIA bloc as 31 constituencies vote in Assembly bypolls across 10 states, apart from Lok Sabha bypolls in Kerala's Wayanad

Singer-actor Selena Gomez has showered her boyfriend Benny Blanco with love after he received an honourable mention in People magazine's 'Sexiest Man Alive' 2024 issue.

A high-tech marijuana operation, using imported seeds and full-spectrum grow lights, has been busted in Greater Noida and an English graduate from Meerut has been arrested.

Realme GT 7 Pro will launch in India on November 26 at 12pm IST. The phone was unveiled in China earlier this month. The Indian variant is expected to be similar to its Chinese counterpart. Now Realme has revealed several camera specifications and features of the Realme GT 7 Pro.

Google is said to be working on an artificial intelligence (AI) feature that will let users get real-time responses and ask follow-up queries. As per a leak, the new feature is called conversational search, and it is being added to the Google app for Android. With this, when users ask a voice query, the app is said to show real-time responses as well as allow them to ask follow-up questions.

Apple recently released the iOS 18.2 Developer beta 2 update which reportedly included a new feature that enabled users to share the location of lost or misplaced items with third parties such as airlines. The Cupertino-based tech giant has now confirmed the arrival of this feature which is dubbed Share Item Location. It is said to have been rolled out in most regions worldwide with the iOS 18.2 Public beta update and will be available to all users with the public release of iOS 18.2.

Indiana Jones and the Great Circle received a gameplay deep dive Monday that detailed more of the game’s combat, exploration and puzzles. Publisher Bethesda also shed more light on the premise of the story that sees Indy join the chase for a priceless stolen relic.

Signal has been updated with Call Links, a feature that enables users to initiate a group call with multiple participants without the need to form a separate group chat. Additional updates include a "raise hand" button, emoji reactions, and a dedicated calls tab on Signal.

Honor Magic 7 RSR Porsche Design will join the Honor Magic 7 series soon. As we await the formal launch of the handset, its key specifications have surfaced online. The Honor Magic 7 RSR Porsche Design is tipped to feature a 6.8-inch display with 1.5K resolution and a triple rear camera unit comprising a 200-megapixel periscope telephoto sensor.

Scientists from IISc, University of Pennsylvania, and MIT reveal a breakthrough with indium selenide that transforms crystalline structures to glass using significantly less energy. By passing a continuous electric current, the crystalline material experiences a “shock” that converts it to glass. The low energy requirement could help lower power needs for data storage devices, potentially advancing phase-change memory in computers and mobile devices. This research opens a pathway for integrating this memory tech on CMOS platforms.

ENS Labs will be launching its own layer-2 blockchain network, called Namechain by the end of 2025. The network is being built atop the Ethereum blockchain and will use scaling technology called zero-knowledge rollups to make transactions more cost and time efficient.

Instagram might be working on a new artificial intelligence (AI) feature that will allow users to upload AI-generated images. A new leak claims that the Meta-owned social media platform is testing a feature that will allow users to use AI models to generate profile pictures using AI. While not a lot is known about the feature at this point, similar features are reportedly being developed for Facebook and WhatsApp as well.

Xiaomi announced the the latest operating system (OS) for its devices dubbed HyperOS 2.0 last month. A company official has now previewed another new feature which improves compatibility of Xiaomi smartphones with Apple devices such as the iPhone, enabling the user to share files easily across ecosystems.

Sudha Murty and Narayana Murthy appeared on the latest episode of The Great Indian Kapil Show  

The nominations for Now And Then mark the first time since the late 1990s that The Beatles have received Grammy nominations 

The Great Indian Kapil Show episode featuring Navjot Singh Sidhu will premiere on Netflix on Saturday, November 16 

"The script is ready, and I will start shooting from February-March. I was traveling from Dubai to Delhi, and I realized I had left the Masoom 2 script on the plane seat," said Shekhar Kapur

Amit said, "In that moment, I let parts of my past carry forward"

Medvedev, who lifted the title in 2020, did not face a single break point and broke De Minaur's serve three times.

Nifty hit a fresh record high on Friday, as faster-than-expected economic growth in the September-quarter added to optimism over the global interest rate outlook.

Masaba Gupta shared an Instagram story describing her delicious birthday cake crafted by chef and baker, Pooja Dhingra.

A woman was left shocked when she was offered food at a BBQ only after there were some leftovers.

Acidity? We got some expert tips to tackle acid reflux with a good diet and eating habits. Dietitian shared some dos and don'ts to follow in your diet.

Calling all croissant fans! Check out these incredibly delicious and indulgent recipes you can make at home using croissants.

Eating at irregular times is said to be related to weight gain and diabetes, largely because it is not in sync with one's body clock.

Anshula shared a heartwarming video from the intimate gathering on Instagram, where Boney Kapoor can be seen feeding cake to everyone.

Pecans are not just a treat for your taste buds - they're also packed with health benefits.

A video showing a digital creator making three different types of hot chocolate has got 30 million views on Instagram.