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How to Disable JavaScript in Almost Any Browser

In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile.

I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit.

The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs.




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Caste in jail: On discrimination in prisons

Time for State governments to end systemic discrimination in prisons




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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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The role of silicon in drug discovery: a review

RSC Med. Chem., 2024, 15,3286-3344
DOI: 10.1039/D4MD00169A, Review Article
Open Access
Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van Otterlo
This review aims to highlight the role of silicon in drug discovery.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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Art and literary contests lined up for District Central Library’s National Library Week




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568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk

Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom.




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In times of distress

It is only through community action can we tackle water shortage.




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The art of dispensing water

Water-ATMs are becoming the rage all over the country. A look at the mechanism.




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Why we need lane discipline

Stick to the left lane when making a turn, even in smaller lanes




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Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge

Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed




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Campaign to discourage open burning from Nov 6, 588 teams to be deployed: Delhi Minister Rai

Mr. Rai said 588 teams from different civic agencies, including the Municipal Corporation of Delhi (MCD), will be deployed to report open burning incidents across the national capital




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Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge




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CBSE disaffiliates 21 schools over ‘dummy admissions’




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Three arrested for raping intellectually disabled research scholar from Odisha




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Accessibility for disabled persons is a human and a fundamental right: SC judgment

The court asked the government to enable the creation of public and private spaces, services and products of an ‘universal design’ which could be accessed by everyone, regardless of their ability, age, or status




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Dribbling past gender stereotypes in rural Odisha

Odisha takes a lead in inspiring and training young tribal boys and girls to play mixed-gender football matches and drive social change in the State




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1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29




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Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case

Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29




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ARRL VEC Services Update During Systems Disruption

Updated 10/30/2024

ARRL previously reported that we are responding to a serious incident involving access to our network and headquarters-based systems. Several services have been affected, including those administered by the ARRL Volunteer Examiner Coordinator (ARRL VEC).

Exam Registrations and Materials. ARRL Volunteer Examiners (VEs) should continue to submit exam registrations and material re...




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Coming to grips with mega disasters

Rooted in research, the book reveals the existential threats we face and charts the roadmap ahead




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Forging a distinctive path

Ensuring women-centric workplaces




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Data and its discontents

The quality of the statistics of a country is a measure of its goodness, say the authors




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Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket

Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content




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Above-normal pre-monsoon rain triggers agriculture activities in Raichur district of Karnataka

The district received 26.5 mm of rain in 72 hours against the average of 1.9 mm




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Taking roots in Tirupati, ‘Konark’ set to reach the kitchens of Odisha and Bengal




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Fertilizers are source of several diseases; switch to organic farming, says Amit Shah 

Shah said that the movement for organic farming has reached an important stage and cooperatives have an important role in making India the world’s largest organic food producing country




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Floriculture blossoms in one of backward regions of Odisha 

Lucknow-based National Botanical Research Institute pitches in with scientific inputs to make the floriculture sustainable in Jujumara region of Sambalpur.





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Reliance fails to name arbitrator in KG-D6 dispute




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Shoppers’ paradise lost? Singapore’s malls suffer as locals, tourists curb spending




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Hyundai Motor India debuts at BSE at a discount of 1.48%, falls nearly 6% post listing

This is the biggest ever IPO to have ever hit in the Indian capital markets




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IndusInd Bank shares plunge 17%; Mcap erodes by ₹15,572 crore amid disappointing earnings

Total income rose to ₹14,871 crore in the quarter under review, from ₹13,530 crore in the same period a year ago, IndusInd Bank said in a regulatory filing




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Free salon for persons with disabilities inaugurated in Vellore




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Nilgiris district administration urges people living downstream of Emerald Dam to take adequate safety measures

The Nilgiris district administration said that owing to work on the new Kundah hydro power house in Kattukuppai, water stored in the Emerald Dam will be released




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Dugong trapped in fishing net rescued, safely released into sea, near Thanjavur district

Forest Department officials said the fishermen who were involved in rescuing the Dugong would be felicitated and rewarded




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Police women under the ‘Police Akka’ initiative, to reach out to schoolgirls in Pudukottai district

Policewomen nominated under this initiative will visit schools and colleges every 15 days to ascertain concerns and grievances of students and render assistance




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Panchayat, aided schools in Tiruchi district bag awards for excellence in teaching, better enrolment

The schools are assessed based on including basic infrastructure, quality of education and teaching practices, technology-enabled teaching, development of the school, and activities done by students




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Mediation should be given priority in family dispute cases: Chief Justice




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Agriculture officials conduct surprise checks at fertiliser outlets in Tiruchi district

63 outlets were checked across various agricultural blocks for illegal hoarding and also to check adherence to maximum retail price; dealers asked to comply with guidelines