dis How to Disable JavaScript in Almost Any Browser By www.impressivewebs.com Published On :: Mon, 04 Apr 2022 10:00:00 +0000 In 2022 I think it’s still important as a web developer to test your how your websites look and function when users disable JavaScript in their browser. Developing in this way used to be a cornerstone of Progressive Enhancement and can be handy on both desktop or mobile. I still find myself wanting disabling JavaScript on pages I visit. Sometimes it’s to test a page I’m working on, but in other instances it’s simply to visit a web page that’s not functioning correctly and I want to see if JavaScript is the culprit. The post How to Disable JavaScript in Almost Any Browser appeared first on Impressive Webs. Full Article Browsers JavaScript Web Design Articles Web Design Tutorials
dis Caste in jail: On discrimination in prisons By www.thehindu.com Published On :: Sat, 05 Oct 2024 00:10:40 +0530 Time for State governments to end systemic discrimination in prisons Full Article Editorial
dis Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00660G, Review ArticleShutang Li, Jinfei YangAs research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis The role of silicon in drug discovery: a review By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3286-3344DOI: 10.1039/D4MD00169A, Review Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van OtterloThis review aims to highlight the role of silicon in drug discovery.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3477-3484DOI: 10.1039/D4MD00266K, Research ArticleRaitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps JaudzemsThe aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
dis Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:48:04 +0530 Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects Full Article Tiruchirapalli
dis Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival By www.thehindu.com Published On :: Fri, 08 Nov 2024 07:51:25 +0530 Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base Full Article Tiruchirapalli
dis Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
dis Art and literary contests lined up for District Central Library’s National Library Week By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:07:57 +0530 Full Article Tiruchirapalli
dis 568: Display Contents, Passkeys Follow Up, Yellow Fade Technique, and TOTK Talk By shoptalkshow.com Published On :: Mon, 05 Jun 2023 19:53:09 +0000 Macho Man Randy Standards stops by for a quick chat, Passkeys follow up, discussing the safety of Display: contents, the yellow fade technique, how hot CSS is right now (so hot), and a check in on how everyone's doing with Tears of the Kingdom. Full Article All Episodes Astro botw passkeys totk yellow fade
dis In times of distress By www.thehindu.com Published On :: Fri, 27 Mar 2015 19:28:51 +0530 It is only through community action can we tackle water shortage. Full Article Property Plus
dis The art of dispensing water By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:53:00 +0530 Water-ATMs are becoming the rage all over the country. A look at the mechanism. Full Article Property Plus
dis Why we need lane discipline By www.thehindu.com Published On :: Fri, 18 Dec 2015 12:49:08 +0530 Stick to the left lane when making a turn, even in smaller lanes Full Article Property Plus
dis Delhi riots case: HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Tue, 05 Nov 2024 13:00:21 +0530 Mr. Saifi submitted that once the offences under the Arms Act were dropped against him and neither any weapon was recovered nor the alleged gunshot was attributed to him, the charge of attempt to murder could not be framed Full Article Delhi
dis Campaign to discourage open burning from Nov 6, 588 teams to be deployed: Delhi Minister Rai By www.thehindu.com Published On :: Tue, 05 Nov 2024 15:54:55 +0530 Mr. Rai said 588 teams from different civic agencies, including the Municipal Corporation of Delhi (MCD), will be deployed to report open burning incidents across the national capital Full Article Delhi
dis Delhi HC dismisses plea by Khalid Saifi against attempt to murder charge By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:19:07 +0530 Full Article Delhi
dis CBSE disaffiliates 21 schools over ‘dummy admissions’ By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:12:30 +0530 Full Article Delhi
dis Three arrested for raping intellectually disabled research scholar from Odisha By www.thehindu.com Published On :: Fri, 08 Nov 2024 01:09:38 +0530 Full Article Delhi
dis Accessibility for disabled persons is a human and a fundamental right: SC judgment By www.thehindu.com Published On :: Sat, 09 Nov 2024 23:57:55 +0530 The court asked the government to enable the creation of public and private spaces, services and products of an ‘universal design’ which could be accessed by everyone, regardless of their ability, age, or status Full Article India
dis Dribbling past gender stereotypes in rural Odisha By www.thehindu.com Published On :: Sun, 10 Nov 2024 22:10:36 +0530 Odisha takes a lead in inspiring and training young tribal boys and girls to play mixed-gender football matches and drive social change in the State Full Article Odisha
dis 1984 anti-Sikh riots case: Delhi HC says murder trial to continue against Congress leader Jagdish Tytler By www.thehindu.com Published On :: Mon, 11 Nov 2024 18:33:54 +0530 Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court would continue with the hearing on November 29 Full Article India
dis Delhi HC says murder trial to continue against Jagdish Tytler in 1984 riots case By www.thehindu.com Published On :: Tue, 12 Nov 2024 00:54:12 +0530 Justice Manoj Kumar Ohri was hearing a plea filed by Mr. Tytler seeking a stay on the trial proceedings taking place against him in a Delhi court. The court will continue with the hearing on November 29 Full Article Delhi
dis ARRL VEC Services Update During Systems Disruption By www.arrl.org Published On :: Wed, 30 Oct 2024 14:43:00 -0500 Updated 10/30/2024ARRL previously reported that we are responding to a serious incident involving access to our network and headquarters-based systems. Several services have been affected, including those administered by the ARRL Volunteer Examiner Coordinator (ARRL VEC).Exam Registrations and Materials. ARRL Volunteer Examiners (VEs) should continue to submit exam registrations and material re... Full Article
dis Coming to grips with mega disasters By www.thehindubusinessline.com Published On :: Sun, 23 Aug 2020 20:19:40 +0530 Rooted in research, the book reveals the existential threats we face and charts the roadmap ahead Full Article Books
dis Forging a distinctive path By www.thehindubusinessline.com Published On :: Sun, 13 Dec 2020 20:24:17 +0530 Ensuring women-centric workplaces Full Article Books
dis Data and its discontents By www.thehindubusinessline.com Published On :: Sun, 05 Sep 2021 21:11:37 +0530 The quality of the statistics of a country is a measure of its goodness, say the authors Full Article Books
dis Paddy varieties with protein, zinc content get thumbs up in Odisha’s tribal pocket By www.thehindu.com Published On :: Wed, 08 Nov 2023 11:37:33 +0530 Paddy varieties have high protein (10.1%) and moderately high level of zinc (20 ppm) content Full Article Other States
dis Above-normal pre-monsoon rain triggers agriculture activities in Raichur district of Karnataka By www.thehindu.com Published On :: Mon, 20 May 2024 16:18:31 +0530 The district received 26.5 mm of rain in 72 hours against the average of 1.9 mm Full Article Karnataka
dis Taking roots in Tirupati, ‘Konark’ set to reach the kitchens of Odisha and Bengal By www.thehindu.com Published On :: Thu, 22 Aug 2024 11:38:21 +0530 Full Article Agriculture
dis Fertilizers are source of several diseases; switch to organic farming, says Amit Shah By www.thehindu.com Published On :: Fri, 30 Aug 2024 22:03:09 +0530 Shah said that the movement for organic farming has reached an important stage and cooperatives have an important role in making India the world’s largest organic food producing country Full Article India
dis Floriculture blossoms in one of backward regions of Odisha By www.thehindu.com Published On :: Tue, 08 Oct 2024 11:53:18 +0530 Lucknow-based National Botanical Research Institute pitches in with scientific inputs to make the floriculture sustainable in Jujumara region of Sambalpur. Full Article Odisha
dis SL ODIs: Chahar is Most Valuable Player By www.rediff.com Published On :: Mon, 02 Aug 2021 10:13:27 +0530 Srinivas Bhogle and Purnendu Maji list the Most Valuable Players in the Sri Lanka-India ODI series. Full Article IND MVPI ODI Deepak Chahar Dhananjaya D'Silva Hardik Pandya MVP Sri Lanka Bhuvneshwar Kumar Avishka Fernando Prithvi Shaw Dasun Shanaka Charith Asalanka Akila Dananjaya Kuldeep Yadav Wanindu Hasaranga
dis Reliance fails to name arbitrator in KG-D6 dispute By www.thehindu.com Published On :: Mon, 06 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
dis Shoppers’ paradise lost? Singapore’s malls suffer as locals, tourists curb spending By www.thehindu.com Published On :: Tue, 07 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
dis Hyundai Motor India debuts at BSE at a discount of 1.48%, falls nearly 6% post listing By www.thehindu.com Published On :: Tue, 22 Oct 2024 10:15:03 +0530 This is the biggest ever IPO to have ever hit in the Indian capital markets Full Article Business
dis IndusInd Bank shares plunge 17%; Mcap erodes by ₹15,572 crore amid disappointing earnings By www.thehindu.com Published On :: Fri, 25 Oct 2024 11:51:35 +0530 Total income rose to ₹14,871 crore in the quarter under review, from ₹13,530 crore in the same period a year ago, IndusInd Bank said in a regulatory filing Full Article Markets
dis Free salon for persons with disabilities inaugurated in Vellore By www.thehindu.com Published On :: Sat, 09 Nov 2024 23:09:37 +0530 Full Article Tamil Nadu
dis Nilgiris district administration urges people living downstream of Emerald Dam to take adequate safety measures By www.thehindu.com Published On :: Sun, 10 Nov 2024 15:15:31 +0530 The Nilgiris district administration said that owing to work on the new Kundah hydro power house in Kattukuppai, water stored in the Emerald Dam will be released Full Article Coimbatore
dis Dugong trapped in fishing net rescued, safely released into sea, near Thanjavur district By www.thehindu.com Published On :: Sun, 10 Nov 2024 15:37:18 +0530 Forest Department officials said the fishermen who were involved in rescuing the Dugong would be felicitated and rewarded Full Article Tiruchirapalli
dis Police women under the ‘Police Akka’ initiative, to reach out to schoolgirls in Pudukottai district By www.thehindu.com Published On :: Sun, 10 Nov 2024 17:27:18 +0530 Policewomen nominated under this initiative will visit schools and colleges every 15 days to ascertain concerns and grievances of students and render assistance Full Article Tiruchirapalli
dis Panchayat, aided schools in Tiruchi district bag awards for excellence in teaching, better enrolment By www.thehindu.com Published On :: Sun, 10 Nov 2024 20:36:27 +0530 The schools are assessed based on including basic infrastructure, quality of education and teaching practices, technology-enabled teaching, development of the school, and activities done by students Full Article Tiruchirapalli
dis Mediation should be given priority in family dispute cases: Chief Justice By www.thehindu.com Published On :: Sun, 10 Nov 2024 20:44:33 +0530 Full Article Tamil Nadu
dis Agriculture officials conduct surprise checks at fertiliser outlets in Tiruchi district By www.thehindu.com Published On :: Sun, 10 Nov 2024 21:09:17 +0530 63 outlets were checked across various agricultural blocks for illegal hoarding and also to check adherence to maximum retail price; dealers asked to comply with guidelines Full Article Tiruchirapalli