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Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06202G, Edge Article
Open Access
Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu Fang
Abstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fifth storm in a month bears down on the Philippines

The local government also reported knee-high floods across Santiago, a city of 1,50,000 people along an upper bank of the Cagayan river




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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells

RSC Med. Chem., 2024, 15,3795-3799
DOI: 10.1039/D4MD00458B, Research Article
Kazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki Tamaoki
A photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cistrans photoisomerization with blue-green light and fast thermal relaxation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Leaders of various parties condemn attack on govt. doctor




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Sakhi centre inaugurated at Vizianagaram Collectorate




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested

The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical




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Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening

Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care




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Doctors believe continual upskilling is crucial for diabetes management: survey

The survey also found that doctors were interested in using AI tools for early detection and personalised treatment plans to manage diabetes




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Here are the big stories from Karnataka today

Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar.




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Kalaburagi city police arrests 30 vehicle lifters, recovers 105 motorbikes




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IL&FS debt resolution: NCLAT sets March 2025 deadline to lift moratorium on IL&FS entities

Some of the lenders had sought the tribunal’s approval to start proceedings under IBC for recovering dues from the 58 IL&FS entities




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Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock

The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage




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‘Freelance journalist’ held for extortion in Rein Bazaar




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Indian gaming sector urged to embrace diversity beyond performative actions

‘Inclusion of female and LGBTQIA+ characters remains limited, underscoring a lack of representation’




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Yet another incident of doctor being attacked 




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Exploring urban ecology through stories, verse and flavours




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Coimbatore round up




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80% of non-executive directors believe existing practices, structures are inadequate to oversee AI: Gartner




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Letters to The Editor — November 14, 2024




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Private college lecturer arrested for sexual assault on job aspirant in Coimbatore




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‘Welcome’ that ‘drink’ with caution, say doctors as hepatitis A cases go up in Kozhikode

At least five to six cases of the infection being reported every day at the Government Medical College Hospital in recent weeks




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ED initiates restitution of properties of Heera Group of Companies’ investors




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Demanding security, Tamil Nadu government doctors begin indefinite strike

Federation of Government Doctors’ Association will decide on the next course of action at an executive committee meeting to be held on November 17, 2024.




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Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General

Donald Trump posted on social media that Matt Gaetz will end Weaponized Government




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Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State

Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat




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This week's sponsor: FullStory

FullStory, the CX platform that captures every interaction on your site for pixel-perfect playback. Get it free, forever. For real.




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Jana Sena Party corporator alleges neglect of crematorium facelift, stages protest




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Prioritising mental wellbeing can help in management of diabetes, say doctors




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South Africa declares National Disaster after floods, storms

Disruptive rains, floods, strong winds and hail from Oct. 22 to Oct. 29 affected the Eastern Cape, KwaZulu-Natal, Free State, Limpopo, North-West, Gauteng and Mpumalanga provinces, Elias Sithole, head of the National Disaster Management Centre




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Torrent Power reports 8.5% decline in Q2 net profit

Its revenue from operations rose 3 per cent to ₹7,176 crore in the second quarter




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Letters to the Editor dated November 13, 2024




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Editorial. October retail inflation print raises concerns

Supply chain efficiencies are a must to offset price increase due to rising input costs and the inevitable increases in support prices




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How are Indian investors shaping the real estate boom at Expo City Dubai?

Indian investors are among the top three buyers of residential and commercial real estate in Expo City, says Ahmed Al Khatib, Chief Development and Delivery Officer Expo City Dubai.




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Broker’s call: Mrs Bectors Food (Buy)

LKP Securities




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SEBI may allow only accredited investors in Angel Funds

The regulator has also mooted several relaxations




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Fritz fizzles out, Sinner cruises to victory

Jannik Sinner made it two wins out of two at the ATP Finals as he fought off Taylor Fritz in a high-octane clash inside the Inalpi Arena on Tuesday.




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Tata Chess: Uzbek Abdusattorov emerges as early leader

Uzbekistan's young grandmaster Abdusattorov Nodirbek emerged sole leader in the open section of the Tata Steel Chess India Rapid tournament in Kolkata on Wednesday.




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Art 370 won't be restored even if Indira returns: Shah

Union Home Minister Amit Shah on Wednesday asserted that Article 370, which granted special status to Jammu and Kashmir, will not be restored even if Congress stalwart and late PM Indira Gandhi comes down from heaven.




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SA vs IND: Tilak Varma scripts history with maiden century in 3rd T20I against South Africa

Despite the early dismissals of Suryakumar Yadav, Hardik Pandya, and Rinku Singh, Tilak continued his onslaught and ensured India posted a formidable total of 219 runs on the board.




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Meet Tulsi Gabbard, Hindu American who is appointed by Donald Trump as US director of national intelligence

Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider, compared to her predecessor.