tor Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06202G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu FangAbstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Fifth storm in a month bears down on the Philippines By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:49:22 +0530 The local government also reported knee-high floods across Santiago, a city of 1,50,000 people along an upper bank of the Cagayan river Full Article Environment
tor New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Leaders of various parties condemn attack on govt. doctor By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:08:06 +0530 Full Article Tamil Nadu
tor Sakhi centre inaugurated at Vizianagaram Collectorate By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:11:36 +0530 Full Article Andhra Pradesh
tor Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
tor Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
tor Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
tor Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:24:15 +0530 The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical Full Article Chennai
tor Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:04:48 +0530 Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care Full Article Health
tor Doctors believe continual upskilling is crucial for diabetes management: survey By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:00:00 +0530 The survey also found that doctors were interested in using AI tools for early detection and personalised treatment plans to manage diabetes Full Article Health
tor Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors By pubs.rsc.org Published On :: RSC Adv., 2024, 14,36352-36369DOI: 10.1039/D4RA07074G, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. CoveyPhotoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
tor Here are the big stories from Karnataka today By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:28:16 +0530 Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar. Full Article Karnataka Today
tor Kalaburagi city police arrests 30 vehicle lifters, recovers 105 motorbikes By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:13 +0530 Full Article Karnataka
tor IL&FS debt resolution: NCLAT sets March 2025 deadline to lift moratorium on IL&FS entities By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:50:28 +0530 Some of the lenders had sought the tribunal’s approval to start proceedings under IBC for recovering dues from the 58 IL&FS entities Full Article Companies
tor Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:20:29 +0530 The attacker, Vignesh, was reportedly frustrated over the treatment given to his mother, who was diagnosed with Hodgkin’s Lymphoma in an advanced stage Full Article Chennai
tor ‘Freelance journalist’ held for extortion in Rein Bazaar By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:21:15 +0530 Full Article Telangana
tor Indian gaming sector urged to embrace diversity beyond performative actions By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:04 +0530 ‘Inclusion of female and LGBTQIA+ characters remains limited, underscoring a lack of representation’ Full Article Hyderabad
tor Yet another incident of doctor being attacked By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:22:03 +0530 Full Article Chennai
tor Exploring urban ecology through stories, verse and flavours By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:27:29 +0530 Full Article Bengaluru
tor Coimbatore round up By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:34:32 +0530 Full Article Coimbatore
tor 80% of non-executive directors believe existing practices, structures are inadequate to oversee AI: Gartner By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:03:00 +0530 Full Article Business
tor Letters to The Editor — November 14, 2024 By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:24:00 +0530 Full Article Letters
tor Private college lecturer arrested for sexual assault on job aspirant in Coimbatore By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:30:13 +0530 Full Article Coimbatore
tor ‘Welcome’ that ‘drink’ with caution, say doctors as hepatitis A cases go up in Kozhikode By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:34:17 +0530 At least five to six cases of the infection being reported every day at the Government Medical College Hospital in recent weeks Full Article Kerala
tor ED initiates restitution of properties of Heera Group of Companies’ investors By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:50:44 +0530 Full Article Telangana
tor Demanding security, Tamil Nadu government doctors begin indefinite strike By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:18:08 +0530 Federation of Government Doctors’ Association will decide on the next course of action at an executive committee meeting to be held on November 17, 2024. Full Article Tamil Nadu
tor Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General By www.thehindu.com Published On :: Thu, 14 Nov 2024 02:50:05 +0530 Donald Trump posted on social media that Matt Gaetz will end Weaponized Government Full Article World
tor Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State By www.thehindu.com Published On :: Thu, 14 Nov 2024 03:23:10 +0530 Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat Full Article World
tor This week's sponsor: FullStory By synd.co Published On :: 2017-01-30T05:01:00+00:00 FullStory, the CX platform that captures every interaction on your site for pixel-perfect playback. Get it free, forever. For real. Full Article
tor Jana Sena Party corporator alleges neglect of crematorium facelift, stages protest By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:10:51 +0530 Full Article Visakhapatnam
tor Prioritising mental wellbeing can help in management of diabetes, say doctors By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:58:26 +0530 Full Article Madurai
tor South Africa declares National Disaster after floods, storms By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 13:56:21 +0530 Disruptive rains, floods, strong winds and hail from Oct. 22 to Oct. 29 affected the Eastern Cape, KwaZulu-Natal, Free State, Limpopo, North-West, Gauteng and Mpumalanga provinces, Elias Sithole, head of the National Disaster Management Centre Full Article World
tor Torrent Power reports 8.5% decline in Q2 net profit By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 18:39:43 +0530 Its revenue from operations rose 3 per cent to ₹7,176 crore in the second quarter Full Article Companies
tor Letters to the Editor dated November 13, 2024 By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 21:11:15 +0530 Full Article Letters
tor Editorial. October retail inflation print raises concerns By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 21:21:35 +0530 Supply chain efficiencies are a must to offset price increase due to rising input costs and the inevitable increases in support prices Full Article Editorial
tor How are Indian investors shaping the real estate boom at Expo City Dubai? By www.thehindubusinessline.com Published On :: Thu, 14 Nov 2024 06:00:00 +0530 Indian investors are among the top three buyers of residential and commercial real estate in Expo City, says Ahmed Al Khatib, Chief Development and Delivery Officer Expo City Dubai. Full Article Podcast
tor Broker’s call: Mrs Bectors Food (Buy) By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 19:47:56 +0530 LKP Securities Full Article Markets
tor SEBI may allow only accredited investors in Angel Funds By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 20:26:29 +0530 The regulator has also mooted several relaxations Full Article Markets
tor Fritz fizzles out, Sinner cruises to victory By www.rediff.com Published On :: Wed, 13 Nov 2024 10:28:34 +0530 Jannik Sinner made it two wins out of two at the ATP Finals as he fought off Taylor Fritz in a high-octane clash inside the Inalpi Arena on Tuesday. Full Article
tor Tata Chess: Uzbek Abdusattorov emerges as early leader By www.rediff.com Published On :: Wed, 13 Nov 2024 21:29:55 +0530 Uzbekistan's young grandmaster Abdusattorov Nodirbek emerged sole leader in the open section of the Tata Steel Chess India Rapid tournament in Kolkata on Wednesday. Full Article
tor Art 370 won't be restored even if Indira returns: Shah By www.rediff.com Published On :: Wed, 13 Nov 2024 22:32:15 +0530 Union Home Minister Amit Shah on Wednesday asserted that Article 370, which granted special status to Jammu and Kashmir, will not be restored even if Congress stalwart and late PM Indira Gandhi comes down from heaven. Full Article
tor SA vs IND: Tilak Varma scripts history with maiden century in 3rd T20I against South Africa By www.dnaindia.com Published On :: Wed, 13 Nov 2024 17:31:00 GMT Despite the early dismissals of Suryakumar Yadav, Hardik Pandya, and Rinku Singh, Tilak continued his onslaught and ensured India posted a formidable total of 219 runs on the board. Full Article Sports Cricket
tor Meet Tulsi Gabbard, Hindu American who is appointed by Donald Trump as US director of national intelligence By www.dnaindia.com Published On :: Thu, 14 Nov 2024 00:59:00 GMT Gabbard, who has served in the Army National Guard for more than two decades, deploying to Iraq and Kuwait, would come to the role as somewhat of an outsider, compared to her predecessor. Full Article World