Member of the European Central Bank (ECB) Governing Council and Bank of France Governor Francois Villeroy de Galhau indicated on Wednesday that more interest rate cuts could be on the horizon, noting ...

The threat actors behind the AndroxGh0st malware are now exploiting a broader set of security flaws impacting various internet-facing applications, while also deploying the Mozi botnet malware. "This botnet utilizes remote code execution and credential-stealing methods to maintain persistent access, leveraging unpatched vulnerabilities to infiltrate critical infrastructures," CloudSEK said in a

Princeton's first alumni affinity conference since 2019 welcomed more than 600 alumni and guests to campus Sept. 19-21, for “Every Voice: Honoring and Celebrating Princeton’s LGBTQ+ Alumni.” 

The festival’s opening-night gala will feature the West Coast Premiere of Tom Nesher’s Come Closer at the Saban Theatre in Beverly Hills.

Paleontologist Dave Hone rates the realism of the dinosaur attacks in the "Jurassic Park" and "Jurassic World" movies.

Tuesday 12 November 2024 – Best Wallet ($BEST) sold out its first presale stage in just six hours, raising $162,000… Continue reading Best Wallet’s Presale Generates $162K in 6 Hours, Sells Out on Launch Day

The post Best Wallet’s Presale Generates $162K in 6 Hours, Sells Out on Launch Day appeared first on ReadWrite.

Instant Reaction: Mortgage Rates, August 15, 2024

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K Schoonjans
May 1, 1996; 37:907-925
Reviews

Litong Nie
Dec 1, 2020; 19:2015-2029
Research

When you publish a model to SAS Metadata Repository by using SAS Model Manager, the publishing process fails and the following error is generated: "The model model-name has a function of ';Transformation';, which is not supported for

The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has implicated ceramides with different LCBs and N-acyl chains in distinct biological processes; moreover, they may play different roles in disease states and possibly even act as prognostic markers. We now demonstrate that the half-life, or turnover rate, of ceramides containing diverse N-acyl chains is different. By means of a pulse-labeling protocol using stable-isotope, deuterated free fatty acids, and following their incorporation into ceramide and downstream SLs, we show that very-long-chain (VLC) ceramides containing C24:0 or C24:1 fatty acids turn over much more rapidly than long-chain (LC) ceramides containing C16:0 or C18:0 fatty acids due to the more rapid metabolism of the former into VLC sphingomyelin and VLC hexosylceramide. In contrast, d16:1 and d18:1 ceramides show similar rates of turnover, indicating that the length of the sphingoid LCB does not influence the flux of ceramides through the biosynthetic pathway. Together, these data demonstrate that the N-acyl chain length of SLs may not only affect membrane biophysical properties but also influence the rate of metabolism of SLs so as to regulate their levels and perhaps their biological functions.

Using a simple, environment friendly proteome extraction (TOP), we were able to optimize the analysis of clinical samples. Using our TOP method we analyzed a clinical cohort of microsatellite stable (MSS) and unstable (MSI-H) colorectal carcinoma (CRC). We identified a tumor cell specific, STAT1-centered, immune signature expressed by the MSI-H tumor cells. We then showed that long, but not short, exposure to Interferon- induces a similar signature in vitro. We identified 10 different temporal protein expression patterns, classifying the Interferon- protein temporal regulation in CRC. Our data sheds light on the changes that tumor cells undergo under long-term immunological pressure in vivo, the importance of STAT proteins in specific biological scenarios. The data generated could help find novel clinical biomarkers and therapeutic approaches.

Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/Wnt and YAP/Hippo pathways by targeting the degradation of several tumor suppressors. Tankyrases 1 and 2 (TNKS1/2) are the only known poly-ADP-ribosyltransferases that require RNF146 to degrade their substrates. However, systematic identification of RNF146 substrates have not yet been performed. To uncover substrates of RNF146 that are targeted for degradation, we generated RNF146 knockout cells and TNKS1/2-double knockout cells and performed proteome profiling with label-free quantification as well as transcriptome analysis. We identified 160 potential substrates of RNF146, which included many known substrates of RNF146 and TNKS1/2 and 122 potential TNKS-independent substrates of RNF146. In addition, we validated OTU domain-containing protein 5 and Protein mono-ADP-ribosyltransferase PARP10 as TNKS1/2-independent substrates of RNF146 and SARDH as a novel substrate of TNKS1/2 and RNF146. Our study is the first proteome-wide analysis of potential RNF146 substrates. Together, these findings not only demonstrate that proteome profiling can be a useful general approach for the systemic identification of substrates of E3 ligases but also reveal new substrates of RNF146, which provides a resource for further functional studies.

PITTSBURGH, Sept. 24, 2024 — Ansys and TSMC today announced a successful pilot with Microsoft that significantly speeds-up the simulation and analysis of silicon photonic components. Together, the companies achieved […]

The post TSMC Collaborates with Ansys and Microsoft to Accelerate Photonic Simulations appeared first on HPCwire.

Oct. 29, 2024 — NVIDIA has announced that xAI’s Colossus supercomputer cluster comprising 100,000 NVIDIA Hopper GPUs in Memphis, Tennessee, achieved this massive scale by using the NVIDIA Spectrum-X Ethernet […]

The post NVIDIA Ethernet Networking Accelerates xAI’s Colossus AI Supercomputer appeared first on HPCwire.

Nov. 11—Class 3A preseason No. 1 Greensburg opened the season Friday with an 81-23 victory over Jac-Cen-Del. The Lady Pirates opened the scoring with a steal and layup by Mylie Wilkison. After buckets by Clarie Larrison, Mary Harmon, Wilkison and Leah West, the Lady Pirates led 10-0. JCD got on the board with a 3-pointer by Brooklyn Simon. It was all Greensburg from there in the first quarter. ...

Robbert Havekes
Dec 12, 2012; 32:18137-18149
BehavioralSystemsCognitive

Salzburg – Austria, marked a significant milestone as it celebrated the formal recognition of Traditional Hay Milk Farming in the Austrian Alpine Arc as a FAO Globally Important Agricultural [...]

Aerial America: Wilderness premieres Sunday, Sept. 7 at 9PM ET/PT

Sending a man to the moon required an overhaul of the entire space program, involving more powerful rockets and new spacecraft (Video: Lauren Hogan, Beth Py-Lieberman, Brian Wolly)

African cuisine has always been well represented in the United States, particularly in dishes characterized as “Southern” in origin, like gumbo or hoppin’ john. But even before chef Serigne Mbaye’s New Orleans eatery Dakar NOLA was named (https://www.eater.com/24175309/james-beard-awards-2024-winners-restaurant-and-chef-awards) the Best New Restaurant of 2024 at the James Beard Awards this week, the contributions of the African diaspora to the American diet had at last begun to enjoy a long-overdue reappraisal via reality television, Netflix docuseries and, most important, a number of widely praised dining establishments: If you want to book a table at Tatiana (https://www.tatiananyc.com/story/) in Manhattan, Dept of Culture (https://www.deptofculturebk.com/) in Brooklyn or Kann (https://kannrestaurant.com/) in Portland, you’d better plan ahead, because their tables are often booked up well in advance. In this episode, Smithsonian contributor Rosalind Cummings-Yeates explains how the ascendancy of pan-African cuisine from “auntie” restaurants into the rarefied fine dining sphere is part of a larger and more meaningful campaign of cultural reclamation. And Mbaye tells us why it was so important to him to make Dakar NOLA (https://www.dakarnola.com/) a showcase of the distinctive flavors of Senegal, where he spent his formative years. Read Rosalind's Smithsonian story about the rise of West African fine dining in the U.S. here (https://www.smithsonianmag.com/arts-culture/these-chefs-are-elevating-african-and-caribbean-cuisines-from-carryouts-to-fine-dining-180984466/) . See the full list of 2024's James Beard Award winners here (https://www.jamesbeard.org/blog/the-2024-james-beard-award-winners) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz / photography by Katherine Kimball, Joshua Brasted, and Jeremy Tauriac Music by APM Music.

The Kyoto museum will feature interactive exhibits, gaming artifacts, workshop spaces and oversized controllers inspired by iconic video games