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NeuroMix with MRA: A Fast MR Protocol to Reduce Head and Neck CTA for Patients with Acute Neurologic Presentations [RESEARCH]

BACKGROUND AND PURPOSE:

Overuse of CT-based cerebrovascular imaging in the emergency department and inpatient settings, notably CTA of the head and neck for minor and nonfocal neurologic presentations, stresses imaging services and exposes patients to radiation and contrast. Furthermore, such CT-based imaging is often insufficient for definitive diagnosis, necessitating additional MR imaging. Recent advances in fast MRI may allow timely assessment and a reduced need for head and neck CTA in select populations.

MATERIALS AND METHODS:

We identified inpatients or patients in the emergency department who underwent CTAHN (including noncontrast and postcontrast head CT, with or without CTP imaging) followed within 24 hours by a 3T MRI study that included a 2.5-minute unenhanced multicontrast sequence (NeuroMix) and a 5-minute intracranial time of flight MRA) during a 9-month period (April to December 2022). Cases were classified by 4 radiologists in consensus as to whether NeuroMix and NeuroMix + MRA detected equivalent findings, detected unique findings, or missed findings relative to CTAHN.

RESULTS:

One hundred seventy-four cases (mean age, 67 [SD, 16] years; 56% female) met the inclusion criteria. NeuroMix alone and NeuroMix + MRA protocols were determined to be equivalent or better compared with CTAHN in 71% and 95% of patients, respectively. NeuroMix always provided equivalent or better assessment of the brain parenchyma, with unique findings on NeuroMix and NeuroMix + MRA in 35% and 36% of cases, respectively, most commonly acute infarction or multiple microhemorrhages. In 8/174 cases (5%), CTAHN identified vascular abnormalities not seen on the NeuroMix + MRA protocol due to the wider coverage of the cervical arteries by CTAHN.

CONCLUSIONS:

A fast MR imaging protocol consisting of NeuroMix + MRA provided equivalent or better information compared with CTAHN in 95% of cases in our population of patients with an acute neurologic presentation. The findings provide a deeper understanding of the benefits and challenges of a fast unenhanced MR-first approach with NeuroMix + MRA, which could be used to design prospective trials in select patient groups, with the potential to reduce radiation dose, mitigate adverse contrast-related patient and environmental effects, and lessen the burden on radiologists and health care systems.




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Lack of Knowledge of Antibiotic Risks Contributes to Primary Care Patients Expectations of Antibiotics for Common Symptoms [Research Briefs]

Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications.




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Challenges in Receiving Care for Long COVID: A Qualitative Interview Study Among Primary Care Patients About Expectations and Experiences [Original Research]

BACKGROUND

For many patients with post–COVID-19 condition (long COVID), primary care is the first point of interaction with the health care system. In principle, primary care is well situated to manage long COVID. Beyond expressions of disempowerment, however, the patient’s perspective regarding the quality of long COVID care is lacking. Therefore, this study aimed to analyze the expectations and experiences of primary care patients seeking treatment for long COVID.

METHODS

A phenomenological approach guided this analysis. Using purposive sampling, we conducted semistructured interviews with English-speaking, adult primary care patients describing symptoms of long COVID. We deidentified and transcribed the recorded interviews. Transcripts were analyzed using inductive qualitative content analysis.

RESULTS

This article reports results from 19 interviews (53% female, mean age = 54 years). Patients expected their primary care practitioners (PCPs) to be knowledgeable about long COVID, attentive to their individual condition, and to engage in collaborative processes for treatment. Patients described 2 areas of experiences. First, interactions with clinicians were perceived as positive when clinicians were honest and validating, and negative when patients felt dismissed or discouraged. Second, patients described challenges navigating the fragmented US health care system when coordinating care, treatment and testing, and payment.

CONCLUSION

Primary care patients’ experiences seeking care for long COVID are incongruent with their expectations. Patients must overcome barriers at each level of the health care system and are frustrated by the constant challenges. PCPs and other health care professionals might increase congruence with expectations and experiences through listening, validating, and advocating for patients with long COVID.

Annals Early Access article




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Stellar views of some of the most spectacular sights in the universe

These dazzling images taken by NASA's Hubble Space Telescope are from the upcoming book Cosmos: Explore the wonders of the universe, which has a foreword by astrophysicist Becky Smethurst




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Google tool makes AI-generated writing easily detectable

Google DeepMind has been using its AI watermarking method on Gemini chatbot responses for months – and now it’s making the tool available to any AI developer




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Slowing growth in life expectancy means few people will live to 100

While the 20th century saw rapid rises in average life expectancy at birth, more recent years have seen a slowdown, suggesting we may be reaching the limit of human lifespan




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‘Game Changer’ teaser: Ram Charan is ‘unpredictable’ in Shankar’s political actioner

‘Game Changer’ also stars Kiara Advani, Anjali, Samuthirakani, SJ Suryah, Srikanth and Sunil




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'A lot of eyeballs': Canada's Watpool and Bahdi aim to capitalize on Friday's Paul vs. Tyson spectacle

Together, Melinda Watpool and Lucas Bahdi add a heavy dose of Canadian content to the undercard of next Friday's megawatt showdown between Mike Tyson and Jake Paul, which could become the most-viewed boxing event in history.




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[EN IMAGES] Vol spectaculaire: un guichet automatique extirpé d’une caisse Desjardins en Mauricie

Des voleurs ont réussi à dérober un guichet automatique en le tirant à travers la devanture vitrée de l’immeuble à l’aide d’un camion.




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Spectacles de Noël: «l’offre est beaucoup plus grande»

Les spectateurs québécois auront encore l’embarras du choix durant le temps des Fêtes.




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Des Swifties québécois témoignent: «En spectacle, le monde arrête de tourner»

Des Swifties québécoises racontent leur expérience durant un concert de la tournée «Eras».




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Humour: un premier spectacle solo pour Patrice L’Ecuyer

Un premier spectacle d’humour en solo, intitulé «Après seulement 32 ans d’absence sur scène».




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FOPE spots potential opportunities for Indian cos in Australia & ECTA seen to propel easy market access

The Federation of Pharmaceutical Entrepreneurs (FOPE) has identified potential opportunities for Indian pharmaceutical companies to expand in Australia. Further, the India─Australia Economic Cooperation and Trade




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Al Maryah Island lights up Abu Dhabi with Spectacular New Year�s Eve Celebrations - Al Maryah Island lights up Abu Dhabi with Spectacular New Year�s Eve Celebrations

Al Maryah Island lights up Abu Dhabi with Spectacular New Year�s Eve Celebrations




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Ondori Asian Kitchen, A Delectable Duality of Chinese and Japanese Cuisines, Now Open at The Orleans - Ondori Asian Kitchen

Special guests helped celebrate the opening of Ondori Asian Kitchen, a distinctive new dining concept at The Orleans Hotel and Casino, on March 2, 2016.





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Google tool makes AI-generated writing easily detectable

Google DeepMind has been using its AI watermarking method on Gemini chatbot responses for months – and now it’s making the tool available to any AI developer




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Return of unpredictable president puts UK defence spending top of agenda

Politicians say we're living in dangerous times, and Trump is a lot less willing than Biden to pay for Europe's defence.




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Mexico drug tsar's spectacular fall from grace culminates in NY court

Genaro García Luna is the highest-ranking Mexican official ever to be convicted in the US.




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The Reluctant Doctor: An Interview With Dr. Balesh Jindal

Highlights: Dr. Jindal's journey reflects resilience, transitioning from international glamour to the profound fulf




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Government Reluctant to Formalize Online Drug Sales

In a significant setback for the ePharmacy sector, government officials have displayed reluctance in formalizing the online sale of drugs and medications.





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Circadian Disruption and Gut Microbiome Fuel Colorectal Cancer

Disruptions to the body's internal clock can speed up the development of colorectal cancer. By influencing the gut microbiome and intestinal barrier,




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Chronic Stress: A Hidden Risk Factor for Colorectal Cancer

While stress is known to significantly contribute to the onset of various health issues, a new study on Sunday showed how stress can worsen colorectal cancer (CRC) (!--ref1--).




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New Screening Tests for Colorectal Cancer

Colorectal cancer (CRC) is the third most common cancer in U.S. adults. Early detection can prevent more than half of CRC-related deaths. However, 40% of people in the U.




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Zebrafish Helps Assess Cryoprotectant Agents for Organ Preservation

medlinkZebrafish/medlink exhibits a crucial role in the fields of solid organ preservation and transplantation, especially with respect to experimental transplantation efforts.




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Liver Transplants Superior for Metastatic Colorectal Cancer

medlinkColorectal cancer/medlink frequently metastasizes to the liver, and for some patients, surgical removal of liver tumors is not feasible. A




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Glucagon Injectable Solution Prevents Low Blood Sugar (Hypoglycemia)

Injectable solution was found to prevent low blood sugar or hypoglycemia by stabilizing glucose levels. The finding provides a hope for diabetics.




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Trends in Oral and Injectable HIV Pre-exposure Prophylaxis Prescription

Pre-exposure prophylaxis (PrEP) with antiretroviral medications is effective in preventing HIV infections. PrEP use has increased between 2013 and 2023.




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Waters Corporation and NIBRT Partner to Bring Greater Control and Predictability to Biopharmaceutical Processing

Waters Corporation and NIBRT Partner to Bring Greater Control and Predictability to Biopharmaceutical Processing




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New Protection Device Exceeds Expectations in Carotid Stenting

New Protection Device Exceeds Expectations in Carotid Stenting




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Virtual Comfort for Expectant Mothers

medlinkVirtual Reality/medlink (VR) relaxation programs synchronized with contractions may alleviate the pain experienced during medlinklabor/medlink and childbirth.




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Boosting Newborn Health: India's Initiative on Lactation Management

The Indian government has taken a significant step towards improving the health of medlinknewborn babies/medlink by establishing Comprehensive Lactation




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Hospital Disinfectant Fails Against Global Health Threat Posed by Antibiotic Resistance

Chlorine disinfectant used in hospitals proves ineffective against the leading cause of medlinkantibiotic/medlink-associated sickness globally as




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Biosimilar Bevacizumab for Metastatic Colorectal Cancer Launched in India

One of the generic Indian pharmaceutical companies, Hetero Drugs has launched a biosimilar for the treatment of metastatic colorectal cancer (mCRC) in India.




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These Spectacular Places in the World Actually Looks Unreal

Our planet is extremely a magical place filled with surprises.




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Ion concentration polarization causes a nearly pore-length-independent conductance of nanopores

Faraday Discuss., 2024, Advance Article
DOI: 10.1039/D4FD00148F, Paper
DaVante Cain, Ethan Cao, Ivan Vlassiouk, Tilman E. Schäffer, Zuzanna S. Siwy
The conductance and selectivity of low-aspect-ratio nanopores are almost independent of the length due to polarization effects controlled by the geometric and electrochemical properties of the whole (pore + reservoir) system.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Nanoscale visualization of the anti-tumor effect of a plasma-activated Ringer's lactate solution

Faraday Discuss., 2024, Advance Article
DOI: 10.1039/D4FD00116H, Paper
Open Access
Junichi Usuda, Kenshin Yagyu, Hiromasa Tanaka, Masaru Hori, Kenji Ishikawa, Yasufumi Takahashi
To characterize the anti-tumor effect of plasma-activated Ringer's lactate solutions, we used scanning ion conductance microscopy, using glass nanopipettes as probes, to visualize the structural changes of the cell surface.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Need for a nuanced approach and realistic expectations from BRICS+

PM Modi met with Chinese President Xi Jinping on the sidelines of the BRICS+ Summit. This was the first meeting between Modi and Xi after the military standoff between both countries in Galwan in 2020 (the previous one being in Mahabalipuram in 2019).




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Queer for fear : horror film and the queer spectator [Electronic book] / Heather O. Petrocelli.

Cardiff : University of Wales Press, 2023.




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Octavia's brood : science fiction stories from social justice movements [Electronic book] / edited by Walidah Imarisha and adrienne maree brown ; foreword by Sheree Renée Thomas.

Oakland, CA : AK Press ; [Albany, NY] : Institute for Anarchist Studies, [2015]




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Making and unmaking in early modern English drama : Spectators, aesthetics and incompletion [Electronic book] / Chloe Porter.

Manchester : Manchester University Press, [2014]




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Houses built on sand : Violence, sectarianism and revolution in the Middle East [Electronic book] / Simon Mabon.

Manchester : Manchester University Press, [2020]




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Chalcogen bond provided supramolecular association of beta-octamolybdate and chalconium cations

Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02258K, Research Article
Anna A Mukhacheva, Vadim V. Yanshole, Mikhail V. Il’in, Alexander S. Novikov, Dmitrii Bolotin, Maksim Nailyevich Sokolov, Pavel A Abramov
The interactions of triple σ-(QIV)-hole donating chalconium cations ([Q(bPh)R]+, when Q = S, Se, Te) with nucleophilic beta-octamolybdate ([β-Mo8O26]4–) results in supramolecular association. The main focus of such assembling is...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants

Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper
Open Access
Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
The content of this RSS Feed (c) The Royal Society of Chemistry




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“25 years of The Netherlands' Catalysis and Chemistry Conference (NCCC)” themed collection – A personal invitation Aromatization of n-alkanes: a mini review on catalysts and reactants

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00384E, Minireview
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hongqi Wang, Raveendran N. Shiju
The catalytic aromatization of n-alkanes is an important process in the chemical industry, especially for the production of valued-added aromatics from the abundant and unreactive small alkanes. This mini review...
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The fractal geometry of polymeric materials surfaces: surface area and fractal length scales

Soft Matter, 2024, 20,3082-3096
DOI: 10.1039/D3SM01497E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
H. Eduardo Roman, Federico Cesura, Rabia Maryam, Igor Levchenko, Katia Alexander, Claudia Riccardi
Non-treated (NT) and plasma-treated (PT) polymeric surfaces display self-affine fractal scaling. The plasma increases both the surface area and the fractal length scales, helping the design of PT interfaces with larger surface areas at the nm scale.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Surfactant-induced alterations in optoelectronic properties of perylene diimide dyes: modulating sensing responses in the aqueous environment

Soft Matter, 2024, 20,3044-3052
DOI: 10.1039/D3SM01694C, Paper
Animesh Pal, Nilanjan Dey
The compartmentalization effect of microheterogeneous systems, like surfactant aggregates, showcases altered optoelectronic properties of a perylene diimide-based chromogenic dye (PDI-Ala) compared to bulk water.
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The effect of structural changes on the self-assembly of novel green pyridinium-carboxylate gemini surfactants in Langmuir and Langmuir–Blodgett films

Soft Matter, 2024, Advance Article
DOI: 10.1039/D3SM01671D, Paper
Ala’a F. Eftaiha, Abdussalam K. Qaroush, Dina M. Foudeh, Ahmad S. Abo-shunnar, Suhad B. Hammad, Khaleel I. Assaf, Matthew F. Paige
The synthesis and interfacial characterization of a series of gemini surfactants based on pyridine-n-carboxylic acids, including picolinic, nicotinic, and isonicotinic acids, in Langmuir and Langmuir–Blodgett films have been reported.
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Effects of shear-induced crystallization on the complex viscosity of lamellar-structured concentrated surfactant solutions

Soft Matter, 2024, 20,3299-3312
DOI: 10.1039/D3SM01198D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Parth U. Kelkar, Matthew Kaboolian, Ria D. Corder, Marco Caggioni, Seth Lindberg, Kendra A. Erk
Material relationships at low temperatures were determined for concentrated surfactant solutions using a combination of rheological experiments, cross-polarized microscopy, calorimetry, and small angle X-ray scattering.
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