Princeton University has offered admission to 1,890 students, or 6.1 percent of the record 31,056 applicants for the Class of 2021, in what is the University's most selective admission process to date. Last year, the University's admission rate was 6.46 percent. The class size is expected to be 1,308 students for the Class of 2021.

NEW YORK - In conjunction with Air Quality Awareness Week, the U.S. Environmental Protection Agency (EPA) Region 2 recently approved several updates to New York and New Jersey’s clean air plans.

Valparaiso Vikings were set up for a tournament run before defection of star guard, who has offers from IU and Purdue.

The Boilermakers open the 2018 ESPN Charleston Classic against Appalachian State, with the winner facing Davidson or Wichita State.

Now you can read all of IndyStar's sports content in one place with our free INSports app.

Emacs "predates Linux, and was once far more popular," writes LWN.net, while adding that the text editor "has fallen into relative obscurity over the years." Then it reports on a "mega-thread" on the emacs-devel mailing list about how to make Emacs more appealing and attractive to users: The discussion started with a post from "ndame" asking why Emacs is "so square"; the appearance of things like buttons could be improved with rounded corners, they said. Richard Stallman, one of the original authors of Emacs, seemed somewhat dismissive in his reply: "Perhaps we should implement a mode that puts cosmetics on Emacs so it will appeal to those who judge by the surface of things." But Stefan Kangas thought there was more to it than that: I think it's unfortunate if we assume that this is all bells and whistles. Graphical design elements can also improve usability. I also don't know that it's helpful to assume that the rest of the world will take the enlightened stance.... He wondered if there was "any reason not to improve the default look". Stallman said that there are some technical barriers in finding someone interested in and capable of doing the work needed, but there is an overarching problem that needs to be addressed first: The code to interface Emacs to X-based GUIs needs rewriting by an expert, and has needed it for decades. Until it gets that rewrite, changes in it are likely to break something. Stallman did agree that the graphical design could improve usability, "but I have a feeling that the changes that would help are deeper issues than the shape of corners". It was a long and interesting discussion, touching on the popularity of both Vim and Visual Studio Code, while another post questioned whether Emacs should even be prioritizing its menu bar and tool bar. One post suggested "starter kits" to make the text editor more friendly to newcomers, another suggested making Cntrl-C cut-and-paste the default key binding, and one asked whether it was Emacs' terminology and keyboard shortcuts that might be confusing to users coming from Microsoft Word. "You are basically making a commitment to being or becoming a power user..." argued another post. "If you just want to do 'casual' text editing emacs is a very weird choice in 2020."

Read more of this story at Slashdot.

Apple India Website Puts Siri in Silent Mode

Filed under: North America, United States, Airlines, Airports, News

The new application process allows U.S. citizens to directly enroll in TSA Pre✓[TM], an expedited screening program that allows travelers to leave on their shoes, light outerwear and belt, keep their laptop in its case and their 3-1-1 compliant liquids/gels bag in a carry-on, in select screening lanes. To date, passengers have only been eligible through existing programs such as U.S. Custom and Border Protection's Global Entry program and frequent flier programs with certain airlines, but this announcement will allow travelers to apply directly for the expedited screening program.

Continue reading TSA Lets Travelers Apply for PreCheck

TSA Lets Travelers Apply for PreCheck originally appeared on Gadling on Wed, 04 Dec 2013 16:58:00 EST. Please see our terms for use of feeds.

Some kids took advantage of the opportunity to show their appreciation for their moms on Saturday afternoon at the Love You Mama event.

Soon after CTV News Edmonton aired a story about a local wood carver who had one of his carvings stolen, he got a knock on his door.

SuperSport United winger Aubrey Modiba says a conversation with club CEO Stanley Matthews convinced him to stay despite interest from Mamelodi Sundowns.

Canadians working aboard two cruise ships who weren't allowed to come to shore because of concerns about COVID-19 are finally able to return home.

gali_nette posted a photo:

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlled to avoid chronic inflammation. Members of the NF-κB family of transcription factors are key drivers of inflammation that activate sets of genes in response to inflammatory signals. Such responses are typically short-lived and can be suppressed by proteins that act post-translationally, such as the SOCS (suppressor of cytokine signaling) family. Less is known about direct transcriptional regulation of these responses, however. Here, using a combination of in vitro approaches and in vivo animal models, we show that endotoxin treatment induced expression of the well-characterized transcriptional repressor Krüppel-like factor 3 (KLF3), which, in turn, directly repressed the expression of the NF-κB family member RELA/p65. We also observed that KLF3-deficient mice were hypersensitive to endotoxin and exhibited elevated levels of circulating Ly6C+ monocytes and macrophage-derived inflammatory cytokines. These findings reveal that KLF3 is a fundamental suppressor that operates as a feedback inhibitor of RELA/p65 and may be important in facilitating the resolution of inflammation.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

Declaring it has been “pained” by the Jodian Fearon situation, the embattled Andrews Memorial Hospital (AMH) is speaking out, saying it has never been approached for or rejected efforts at registration or certification since it began operating 76...

Letter submitted by Marc R. Rosenblum, Deputy Director, U.S. Immigration Program, at the request of the Minority Staff of the House Oversight and Government Reform Committee for the February 25, 2015 joint subcommittee hearing reviewing apprehension, detention, and release policies regarding unauthorized immigrants.

As interest in the application of plasma medicine -- the use of low-temperature plasma created by an electrical discharge to address medical problems -- continues to grow, so does the need for research advancements proving its capabilities and potential impacts on the health care industry.

(May 6, 2020) On April 16, 2020, the Norwegian government launched a smartphone app to track the spread of the coronavirus in Norway. By downloading the app, users voluntarily allow the app to track their physical location and notify them if they have been in close proximity to a person who later becomes infected with […]

The singer-composer, who has collaborated with quite a few international names in music, has his plans firmly in place.

Personal Agenda with Ricky Kej: “Best thing about lockdown? My dog is really happy!”  Hindustan Times

1. Happy Mother's Day: Karisma to Sushmita, a look at Bollywood's single mum's who have paved their own way  PINKVILLA
2. Mother’s Day 2020: From Aishwarya Rai to Kareena Kapoor, check out pics of these Bollywood moms and...  Hindustan Times
3. Happy Mother's Day 2020: Kareena Kapoor, Shilpa Shetty lead B-Town stars celebrate motherhood, wish mothers on this precious day | In Pics  Jagran English
4. When Aishwarya Rai Bachchan was asked to pick between Kareena Kapoor Khan & Rani Mukerji; Here’s what she said  PINKVILLA
5. Mother’s Day 2020: Single Mothers of Bollywood  News18
6. View Full coverage on Google News

1. The person who loves us tirelessly and unconditionally: Ravi Shastri, Virat Kohli wish Happy Mother's Day  India Today
2. Maa Jaisa Koi Nahi: Virat Kohli and Virender Sehwag Lead Mother's Day Wishes  News18
3. Mother’s Day: Sports stars thank their moms for unconditional love, sacrifices and prayers  The Indian Express
4. Virat Kohli, Yuvraj Singh Lead Wishes As Sports Fraternity Celebrate Mother's Day 2020  NDTVSports.com
5. Mothers Day: Laxman, Mayank, Rahane lead as cricketers extend wishes to super moms - Republic World  Republic World
6. View Full coverage on Google News

On 23 January 2015, OM South Africa celebrated Pranesh Anandlal’s leadership as director since 2008 and welcomed his successor, Andrè van der Bergh.

OM Philippines meets some of the young girls caught in the rising tide of underage sex tourism.

A story how an Asian sister found her way to a local church service in Greece.

Michel Di Feliciantonio and three other Italian Christians spent a week in Šid, Serbia, helping refugees on their way into Europe.

Mahmood, a refugee from Sudan, travelled the 'West Balkan' migrant route. Months later, settled in The Netherlands, he recalls worship in OM's tent in Serbia.

Jude, project coordinator of OM's Refugee Relief Serbia describes her busy role, and how OM’s service can be a powerful practical witness of the love of Jesus to hundreds of refugees.

OM Norway Field Leader Willy Andre Meberg expresses condolences and prayer for the people of Norway.

In January 2013, OM Norway and Norwegian Naval Training Agency agreed on internship programme for deckhands and motormen on board MV Logos Hope.

Venturing out for a week of teambuilding and spiritual growth, OM Lifehope training participants leave the base by faith, not knowing what’s in store.

Two workers share their motivation to keep going when they encounter disappointments in ministry.

Source: www.justjared.com - Saturday, May 09, 2020
Kristen Wiig is the host of the season finale of Saturday Night Live ! The 46-year-old Wonder Woman 1984 actress hosted the Mother’s Day episode remotely from her home. During her monologue, Kristen took the opportunity to wish her mom a Happy Mother’s Day. “This is the Mother’s Day show and at SNL it’s a very special time to celebrate moms,” Kristen said. “Unfortunately, like a lot of you, I can’t be with my mom this Mother’s Day so I hope it’s okay I tell her I love her.” “You know I’ve been thinking lately, I don’t know if I truly appreciated my mom the first 45 years of my life, but this year I’m feeling especially grateful for all the things she taught me, preparing me to be a mom myself,” Kristen said before showing a plate of raw chicken breast. “Things like breastfeeding, babies love that chicken, she would always say that.” Kristen ended her monologue by thanking all the parents supporting their families during the pandemic. “So I do want to thank my mom and all the moms out there helping us get through this and have been there,” Kristen said. “We thank you so much, happy Mother’s Day. Thank you moms and thank you dads.” Find out when Wonder Woman 1984 will be out in theaters .

Jude, project coordinator of OM's Refugee Relief Serbia describes her busy role, and how OM’s service can be a powerful practical witness of the love of Jesus to hundreds of refugees.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

“As I watched the ending scene (that lasted about three minutes) I thought about the “happy ending” notion,” says Ava. “Is it real or is it a fairy tale? A utopia created by Hollywood to give their viewers a false sense of hope in the reality of a broken world? And so, I said to myself: I believe in happy endings.”

Jude, project coordinator of OM's Refugee Relief Serbia describes her busy role, and how OM’s service can be a powerful practical witness of the love of Jesus to hundreds of refugees.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

“As I watched the ending scene (that lasted about three minutes) I thought about the “happy ending” notion,” says Ava. “Is it real or is it a fairy tale? A utopia created by Hollywood to give their viewers a false sense of hope in the reality of a broken world? And so, I said to myself: I believe in happy endings.”

Jude, project coordinator of OM's Refugee Relief Serbia describes her busy role, and how OM’s service can be a powerful practical witness of the love of Jesus to hundreds of refugees.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.

“As I watched the ending scene (that lasted about three minutes) I thought about the “happy ending” notion,” says Ava. “Is it real or is it a fairy tale? A utopia created by Hollywood to give their viewers a false sense of hope in the reality of a broken world? And so, I said to myself: I believe in happy endings.”

Officials in Italy say an Italian aid worker who was kidnapped in Kenya in late 2018 has been freed in Somalia

Jude, project coordinator of OM's Refugee Relief Serbia describes her busy role, and how OM’s service can be a powerful practical witness of the love of Jesus to hundreds of refugees.

Bahia Blanca, Argentina :: A missionary couple teaches church members about serving God as a family.