The present invention provides a system including: a protein having a domain that binds a membranal component; an inlet for sample flow, an Isotachophoresis (ITP) system and a flow generating means connected or coupled to the aqueous parts of the ITP. The invention also provides a method for detecting and or sorting cells with this system.

An insert for a catheter system can include an insert housing which defines a portion of a fluid pathway of the catheter system, a cartridge positioned within the insert housing in a manner to allow fluid flow along the fluid pathway such that fluid contacts the insert during the fluid flow, and an active agent associated with the cartridge. The active agent and the cartridge can be adapted to release active agent from the cartridge during the fluid flow.

The invention relates to an arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device, comprising an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. Furthermore, the invention relates to a method for determining a position (x) of a stopper relative to a container in a drug delivery device, the method comprising the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.

A closed loop catheter useable for heat exchange is manufactured by forming a plurality of generally transverse bore holes though a flexible, multilumen catheter body, lacing a tube trough the bore holes so that loops of the tube protrude from the catheter body, connecting one end of the tube to an inflow lumen of the catheter and connecting the other end of the tube to an outflow lumen of the catheter. A heated or cooled heat exchange medium may then be circulated through the tube while the catheter is inserted in the vasculature of a subject, thereby resulting in heat exchange between the subject's flowing blood and the heat exchange medium being circulated through the tube.

Disclosed herein are methods for treating solid mass tumors with direct delivery of an anti-tumor immunotherapeutic agent to the tumor site. In one aspect, this invention encompasses methods of treating solid mass tumors by direct microinjection via a microcatheter of an anti-tumor immunotherapeutic agent into the microvasculature leading into tumor thereby providing high levels of contact with the tumor while minimizing the degree of systemic buildup of the immunotherapeutic agent.

A sheath introducer for a catheter includes a sheath having a lumen, a hub positioned on a proximal end of the sheath, and a housing positioned on the hub. The hub can include a splittable penetration member having a port in fluid communication with the sheath lumen. The housing can include a valve having a closed upper surface and a channel surrounding the splittable penetration member. Movement of the housing with respect to the hub can expose the port of the splittable penetration member for insertion of the catheter.

A catheter includes a catheter body having a proximal end, a beveled distal end, and a lumen therethrough. The beveled distal end defines an elliptical port for releasing contrast or other media through the lumen and from the elliptical port. The catheter may also be used delivering devices or for aspirating or extracting materials from the vasculature or other body lumens. A fixed guidewire extends distally from the distal end of the catheter body, typically from the distal-most edge of the elliptical port. The fixed wire is typically malleable so that it can be manually formed into a desired shape. The elliptical port may be flat or concave.

A medical balloon of a balloon catheter assembly includes a balloon wall formed of at least two layers. The first layer is made of an impervious polymeric material. The second layer, which is integral with the first layer is made of a radiopaque and/or echogenic material and a polymeric material. In the preferred embodiment, there is provided 60 to 80% by weight of radiopaque material in the second layer. It has been found that these concentrations of radiopaque material provide good visibility of the balloon under ultrasonic imaging.

The present disclosure is directed to a medical port drainage assembly that includes a port component and a replaceable catheter. The port component includes a tube having a proximal end, a distal end, and tube walls defining a catheter access lumen. A head component is located on a proximal end of the tube and an assembly retention element is located on a distal end of the tube. The head component is deployed outside the patient's body and defines an opening to the catheter access lumen. The assembly retention element is deployed within a lumen of the patient's body. The port component includes a valve assembly which may be a single valve (e.g., a duckbill valve) or a system of valves. The port component also includes a connector for coupling and decoupling the replaceable catheter to the port component.

A movement detection unit includes a movable body, a first sensor, a second sensor, and a signal processor. The movable body performs a movement in a first direction. The first sensor detects a first magnetic field change which is caused by the movement of the movable body and outputs a first signal. The second sensor is provided in the first direction at a location different from a location of the first sensor. The second sensor detects a second magnetic fled change which is caused by the movement of the movable body and outputting a second signal. The signal processor includes a signal generating circuit that generates a third signal and a fourth signal on a basis of the first signal. The third signal and the fourth signal have waveforms different from each other.

Embodiments include apparatuses, systems, and methods including a switching converter having an output stage including a power switch or first switching device to convert an input switching signal to an output switching signal and a sensor stage including a second switching device and a third switching device. In embodiments, the sensor stage may be coupled to receive the output switching signal from the first switching device and to substantially replicate a condition of the first switching device to generate a continuous signal rather than a switched signal. In embodiments, the continuous signal may allow detection of a current level. In some embodiments, the current level may indicate an overcurrent event. A digital post-processing circuit may be coupled to the switching device to count a number of overcurrent events according to various embodiments. Other embodiments may also be described and claimed.

A system for configuration of power meters.

A voltage of a first capacitor is compared with a threshold voltage and a signal corresponding to the comparison result is generated at each of a first timing during a period after the transfer of a positive charge has ended and before the transfer of a negative charge starts and a second timing during a period after the transfer of the negative charge has ended and before the transfer of the positive charge starts. In each of the case where a positive charge is transferred and the case where a negative charge is transferred, operations (digitization of an integrated value and a feedback operation) of a delta sigma modulator are performed.

Methods and systems for monitoring an integrity of electrical connectivity between a repair patch and a parent structure include providing the repair patch with an embedded sensor configured to detect electrical conductivity. The repair patch includes a ply of conductive material that overlaps a portion of a conductive layer of the parent structure. A baseline set of sensor data is acquired from the sensor indicative of an electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure. One or more additional sets of data may be obtained from the sensor and compared to the baseline set of data to determine an integrity of the electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure.

Disclosed are a circuit fault detection system and method for a circuit fault detection. A circuit fault detection system includes: a detection circuit including a diode, a first resistor, and a second resistor, which are positioned between an applied voltage source and a top of a detection target circuit in series, and a third resistor and a fourth resistor, which are positioned between the detection target circuit and a ground in series, an input unit including a first input terminal configured to receive a voltage measured between the first resistor and the second resistor as an input, and a second input terminal configured to receive a voltage measured between the third resistor and the fourth resistor as an input, a controller configured to detect a failure in the detection target circuit and in an operation of the detection target circuit based on values of the voltages detected by the input unit; and a display unit configured to provide a warning to a user when the failure is detected.

A method of detecting an electric arc in an electrical system from a signal originating from at least one sensor detecting acoustic waves in the system, including: a) calculating by means of a processing device, over a sliding window of signal samples, at least one statistical parameter selected from the skewness and the kurtosis of the signal; b) detecting a possible occurrence of an event by taking into account said at least one statistical parameter; and c) performing a frequency analysis of the signal enabling to identify an electric arc when an event is detected at step b).

A magnetic field sensing apparatus and detection method thereof are provided. The magnetic field sensing apparatus includes an anisotropic magneto-resistive (AMR) magnetic field detector, a reference magnetic field detector, and a controller. The AMR magnetic field detector generates a first output voltage according to a detected magnetic field. The reference magnetic field detector generates a second output voltage according to the detected magnetic field. The controller identifies whether an absolute value of a field density of the detected magnetic field is larger or smaller than a predetermined value or not, and selects the first output voltage or a saturation voltage to be a magnetic field detection result accordingly.

A method for determining a position of an RF coil in a magnetic resonance imaging (MRI) system is disclosed. As an example, a center of a field of view (FOV) to be scanned may be adjusted to a magnetic field center of an MRI system, and coordinate values in a coordinate system for shape-characteristic points of the FOV may be determined, where an origin of the coordinate system is located at the magnetic field center of the MRI system. A preset gradient magnetic field may be applied to the FOV, and coil units respectively covering the shape-characteristic points may be determined. An effective region may be obtained by connecting the determined coil units according to the shape of the FOV, and a coil unit located in the effective region may be determined as an effective coil unit for imaging the FOV by the MRI system.

A system for calibration of power meters.

Disclosed is a device for detecting wall abrasion of a solid-filling feeding well and a detection method thereof. The device comprises a well wall abrasion detector, a horizontal displacement meter, a vertical displacement monitor, and a limit guide rod. One end of the limit guide rod is connected to the well wall abrasion detector. The signal output terminal of the well wall abrasion detector is connected to the signal input terminal of the horizontal displacement meter, and the other end of the limit guide rod passes through the vertical displacement monitor for slidable setting. This disclosure mainly utilizes a resistance strain displacement sensor to detect the abrasion and deformation degree of the well wall, determines the position of damages with the vertical displacement monitor, and draws wall abrasion curves by using the obtained data. The device provided is easy to use, has low cost, has high reliability, and can effectively detect the wall abrasion condition of a solid-filling feeding well, thereby providing a basis for ensuring the working efficiency of the feeding well.

The present invention provides a cushion pad with improved durability without feeling of a foreign object. The present invention thus provides a system for detecting a deformation of a cushion pad, comprising; the cushion pad comprising a matrix layer, in which electroconductive or magnetic filler is dispersed, and a soft polyurethane foam including the matrix layer incorporated therein, anda detecting portion that detects an electric or magnetic change caused by a deformation of the cushion pad,wherein the matrix layer has a hardness lower than the soft polyurethane, and it production method.

The invention relates to a method for determining a liquid level in a tank (1) comprised in a vehicle, wherein said method uses an ultrasonic sensor (4) for emitting and receiving ultrasonic waves (11). Basically the liquid level is determined based upon measuring the transition time of an ultrasonic wave (11) emitted by the ultrasonic sensor, wherein said emitted wave is deflected two times before being reflected by the surface (2) of the liquid contained in the tank.

A first detection electrode that outputs a first flow rate signal and a second detection electrode that outputs a second flow rate signal, a differential circuit that outputs a differential flow rate signal obtained by obtaining a difference between the first flow rate signal and the second flow rate signal, an AC signal generation circuit that causes a first AC current to flow between the first detection electrode and the ground electrode and causes a second AC current with a reverse phase at the same frequency as that of the first AC current to flow between the second detection electrode and the ground electrode, and a diagnosis unit that diagnoses an abnormality of at least either of the first detection electrode or the second detection electrode based on a differential flow rate signal.

An abnormality detecting apparatus (10) for a rotating machine includes: a calculating part (15) which calculates a phase difference between signals respectively output from two sensors of one or more sets, the one or more sets being predetermined combinations of two sensors among the plurality of sensors, the plurality of sensors each of which detects an elastic wave generating in the rotating machine (1) having a rotor during rotation of the rotor, the sensors being arranged at predetermined different locations of the rotating machine (1); a storing part (16) which stores in advance information concerning a relationship between a phase difference and a contact position when a contact occurs during the rotation of the rotor, regarding the one or more sets; and a specifying part (17) which specifies a contact position by using a phase difference calculated by the calculating part (15) and the information stored in the storing part (16).

A force detector includes a first substrate, a second substrate, a circuit board provided between the first substrate and the second substrate, and an element mounted on the circuit board and outputting a signal in response to an external force, wherein a hole is formed in the circuit board at a location where the element is placed, and a first convex part inserted into the hole and protruding toward the element is provided on the first substrate. Further, the element is placed within a periphery of the first convex part as seen from a direction perpendicular to the first substrate.

A planet gear train based torque detector is provided with idler gears between an input shaft and an output shaft wherein a rotation of the input shaft rotates the idler gears which rotate the output shaft, and a force is applied to a tangent line between each idler gear and the input shaft; peripheral resilient members, each having a fixed first end and a second end for receiving force applied thereon by the revolution of idler gears; and at least one strain gauge, each attached on one resilient member for measuring a deformation at the resilient member due to the revolution of the idler gears. A torque between the input shaft and the output shaft is obtained by calculating the deformation. The resilient members parallel the input shaft.

A sensor for detecting a pressure of a fluid medium is provided. The sensor includes a sensor element for detecting the pressure of the fluid medium, a supply duct for supplying the fluid medium to the sensor element and a control and/or evaluation circuit for processing signals of the sensor element. The control and/or evaluation circuit is situated on the sensor element.

A system comprising: a parent structure made of composite material and having a repair site; a repair patch made of composite material, the repair patch being bonded to the parent structure at the repair site; and a sensor embedded in the repair patch. The system may further comprise non-volatile memory and an interface unit embedded in the repair patch and electrically connected to the sensor. In one embodiment, the sensor is a loop-shaped sensor comprising an electrically conductive structure having an electrical conductivity that varies as a function of a pressure exerted on the repair patch. In another embodiment, the sensor comprises a sensor chip having nonvolatile memory. In a further embodiment, the sensor comprises an optical fiber that is sensitive to changes in pressure on or strain in the repair patch.

A detecting element unit of a physical quantity detection apparatus includes a detection part and a supporting part. The detection part has a base part, a movable part coupled to the base part via a joint part, and a vibrator provided over the base part and the movable part, and the supporting part includes a fixing portion to be fixed to a base for supporting the base part. A processing unit of the physical quantity detection apparatus extracts vibration response signals at a resonance frequency of the detecting element unit from output of the vibrator.

A rheometer includes a drive shaft, a drag cup motor for rotating the drive shaft, a first measuring object supported by the drive shaft, a second measuring object, a linear position sensor, and processing and control electronics. The linear position sensor includes a target (e.g., an aluminum target) mounted to the drive shaft, and a pair of coils. The linear position sensor is configured to measure thermal expansion of the drive shaft based on a change in impedance of the coils resulting from a displacement of the target relative to the coils. The processing and control electronics are in communication with the coils and are configured to adjust a position of one of the measuring objects relative to the other based on a change in impedance of the coils resulting from a displacement of the target relative to the coils, thereby to maintain a substantially constant measurement gap therebetween.

Described is a system which includes: a cable including: a first fiber optic interconnect to provide an input light; and a second fiber optic interconnect to provide an output light; and a first housing coupled to the cable, the first housing including: a first deflection circuit to deflect the input light received from the first fiber optic interconnect in response to a vibration or movement of the first housing; and a second housing coupled to the cable, the second housing including: a light source to generate the input light for transmission to the first deflection circuit via the first fiber optic interconnect; and a photo detector to receive the output light from the first deflection circuit via the second fiber optic interconnect.

A substrate for a sensor includes: a base section; a movable section connected to the base section; an arm portion as a support portion extending along the movable section from the base section; a first gap portion having a protrusion portion in which one of the movable section and the arm portion protrudes toward the other of the movable section and the arm portion, and having a predetermined gap between the protrusion portion on one side and the other of the movable section and the support portion; and a second gap portion which is located further toward the base section side than the first gap portion has a gap wider than the predetermined gap, in which in the first gap portion, one of the movable section and the arm portion has a ridge portion on the side facing the first gap portion.

A process for fabricating an organic photodetector is presented. The process includes providing an array of thin film transistor assemblies, each thin film transistor assembly including a first electrode disposed on a thin film transistor; disposing an organic semiconductor layer on the array; disposing a second electrode layer including a first inorganic material on the organic semiconductor layer through a shadow mask to form a first etch stop layer; and removing portions of the organic semiconductor layer unprotected by the first etch stop layer using a dry etching process to form a multilayered structure. An organic photodetector, for example an organic x-ray detector fabricated by the process is further presented. An x-ray system including the organic x-ray detector is also presented.

The present invention generally relates to fluorescent marking compositions and their use to determine whether a surface has been cleaned. More particularly, the marking compositions comprise fluorescent polymers.

System, including methods and apparatus, for optical detection. The system may comprise a light source to generate a beam of light, an optical element, and a detector. The optical element may include a light guide having a shaft and a tip, with the tip forming a beveled end of the light guide. The optical element may extend into the beam, such that the tip and at least a portion of the shaft are located inside the beam, and a window of the optical element is located outside the beam. Light of the beam incident on the tip may be transmitted longitudinally through the light guide and out the window, while light of the beam incident on the shaft may be transmitted transversely through the shaft and remains in the beam downstream. The detector may be configured to detect light received from the window.

A spectrometer module comprising a plurality of separate electronic circuit modules is disclosed. Each separate electronic module comprises an integrated sensor circuit including a light sensitive area occupying part of an area of the integrated sensor circuit, the integrated sensor circuit being arranged to detect incident light. In one aspect, the plurality of separate electronic circuit modules includes a group of adjacent electronic circuit modules. The light sensitive areas of the electronic circuit modules in the group are so arranged on the respective integrated sensor circuits that the group of adjacent electronic circuit modules is mounted so that the light sensitive areas thereof are arranged in vicinity to each other. The spectrometer module includes an optical module, which is common to said plurality of separate electronic circuit modules and arranged to direct incident light towards the light sensitive areas of each of said electronic circuit modules.

The present invention discloses a mail detection device and method. The device comprises a broad-band terahertz generator, a collimator, a beam splitter, a fixed reflector, a movable reflector, a wave buncher, a matrix detector, an acquisition card and an information processing module; wherein the information processing module is used for generating a terahertz image of a mail to be detected according to the electric signals sent by the acquisition card when the movable reflector is motionless; and when finding suspicious articles according to the terahertz image of a mail to be detected, the information processing module controls the movable reflector to move, and generates spectral information of the suspicious articles according to an electric signal sequence sent by the acquisition card during the movement of the movable reflector.

A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. In a mode of operation ions from the second ion trap or ion guide are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator.

The present technology provides methods for increasing sensitivity of detection and/or quantification of a negatively charged analyte, e.g., an oligonucleotide, using an analytical system that comprises liquid chromatography and mass spectrometry. The methods comprise passing an acidic solution through the analytical system, i.e., through a fluidic path from the mobile phase reservoir to the detector to remove or displace, at least in part, metal ions adsorbed to charged sites in the fluidic path.

Detectors, a system and a method for detecting ionizing radiation are provided. In some aspects, a detector includes a first layer comprising a first conducting material, and a second layer comprising a second conducting material, wherein at least one of the first layer and second layer is configured to produce secondary particles upon irradiation by an ionizing radiation. The detector also includes a separating layer positioned between the first and second layer configured to transport therebetween at least one of charges associated with the secondary particles and charges produced by the secondary particles, wherein an electric current generated by the charges, and collected between the first and second layer, is indicative of properties the ionizing radiation.

A semiconductor detector includes a plate-shaped semiconductor part, a signal output electrode for outputting a signal provided at one surface of the semiconductor part, a plurality of curved electrodes provided at the one surface of the semiconductor part and which have distances from the signal output electrode that are different from each other, and an arc-shaped collection electrode for collecting an electric charge generated at the semiconductor part. The plurality of curved electrodes are applied with voltage to generate in the semiconductor part a potential gradient in which a potential varies toward the signal output electrode. The collection electrode is located at a part of the semiconductor part between an adjacent pair of curved electrodes. The collection electrode is connected to a curved electrode located a distance from the signal output electrode shorter than a distance between the collection electrode and the signal output electrode among the curved electrodes.

A semiconductor detector for detecting radiation comprises a first semiconductor part in which an electron and a hole are generated by incident radiation; a signal output electrode outputting a signal base on the electron or the hole; and a gettering part gettering impurities in the first semiconductor part. In addition, the semiconductor detector further comprises a second semiconductor part doped with a type of dopant impurities and having dopant impurity concentration higher than that of the first semiconductor part. The second semiconductor part is in contact with the first semiconductor part. The gettering part is in contact with the second semiconductor part and not in contact with the first semiconductor part.

The present application, pertaining to the field of slow neutron detection, relates to a slow neutron converter and a slow neutron detector. The slow neutron converter includes a substrate, the substrate including a plurality of holes extending along a first direction and insulating walls between the plurality of holes, wherein the plurality of holes are through holes. The slow neutron converter further includes a boron layer at least covering an exposed surface of the plurality of holes. The slow neutron converter and the slow neutron detector having the slow neutron converter according to the present disclosure are capable of maintaining a high slow neutron detection efficiency. In addition, the manufacturing complexity and manufacturing cost of the detector are reduced, and thus the effective, convenient and low-cost slow neutron detection is achieved.

An apparatus comprises a neutron detector. The neutron detector comprises a conversion layer comprising a mixture of a neutron absorbing material and a scintillation material; and a photodetector optically coupled to the conversion layer and arranged to detect photons generated as a result of neutron absorption events in the conversion layer; wherein the apparatus is adapted to be carried by a user and the conversion layer is positioned within the neutron detector such that when the apparatus is being carried by a user in normal use neutrons are absorbed in the conversion layer after passing through the user such that the user's body provides a neutron moderating effect. In some cases the apparatus may be carried in association with a backpack or clothing worn by a user, for example, the neutron detector may be sized to fit in a pocket. In other cases the apparatus may be a hand-held device with the conversion layer arranged within a handle of the device to be gripped by a user when being carried.

Methods and related systems are described for gamma-ray detection. A gamma-ray detector is made depending on its properties and how those properties are affected by the data analysis. Desirable properties for a downhole detector include; high temperature operation, reliable/robust packaging, good resolution, high countrate capability, high density, high Z, low radioactive background, low neutron cross-section, high light output, single decay time, efficiency, linearity, size availability, etc. Since no single detector has the optimum of all these properties, a downhole tool design preferably picks the best combination of these in existing detectors, which will optimize the performance of the measurement in the required environment and live with the remaining non-optimum properties. A preferable detector choice is one where the required measurement precision (logging speed) is obtained for all of the required inelastic elements and/or minimization of unwanted background signals that complicate the data analysis.

A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time T further comprises determining a time when the mass spectral data being acquired during the single experimental run or acquisition is equal to or below a threshold. The mass spectrometer is then calibrated by introducing calibrant or lockmass ions at the first time T.

Superconducting nanowire avalanche photodetectors (SNAPs) have using meandering nanowires to detect incident photons. When a superconducting nanowire absorbs a photon, it switches from a superconducting state to a resistive state, producing a change in voltage that can be measured across the nanowire. A SNAP may include multiple nanowires in order to increase the fill factor of the SNAP's active area and the SNAP's detection efficiency. But using multiple meandering nanowires to achieve high fill-factor in SNAPs can lead to current crowding at bends in the nanowires. This current crowding degrades SNAP performance by decreasing the switching current, which the current at which the nanowire transitions from a superconducting state to a resistive state. Fortunately, staggering the bends in the nanowires reduces current crowding, increasing the nanowire switching current, which in turn increases the SNAP dynamic range.

Blood separation systems and methods are provided for detecting lipids in plasma that has been separated from a plasma-containing fluid, such as blood. The system includes a fluid processing region in which a plasma-containing fluid is separated into plasma and other fluid components. A plasma flow path is associated with the fluid processing region for the flow of at least a portion of the separated plasma into or out of the region. A lipid detector shines blue and/or ultraviolet light through the separated plasma in the plasma line to optically detect the presence of lipids therein. The lipid detector may be used alone or in combination with a hemoglobin detector to reduce the number of false hemoglobin alarms or an interface detector for improved detection and correction of the location of an interface between separated fluid components in the fluid processing region.

'Don’t build technology for Mordor.' On Saturday at Peter Thiel’s San Francisco home overlooking the Bay, protesters demonstrated against a collaboration between Immigration and Customs Enforcement and Palantir Technologies, a data-mining firm that Thiel co-founded. As reported in The Intercept, ICE will be using a new Palantir product called Investigative Case Management to to aid in its expanded deportation mission.…

A method of detecting a cancer progression observation index gene group, comprising: a) preparing a plurality of AKR/J mice in which an oncogene is inserted into a thymocyte; b) dividing the AKR/J mice into three groups, raising the first group of the AKR/J mice after high-dose ionizing radiation of 0.8 Gy/min, raising the second group of the AKR/J mice after low-dose ionizing radiation of 0.7 mGy/hr, and raising the third group of the AKR/J mice in a general environment; c) obtaining a thymus of a dead mouse of the first or second group of the AKR/J mice throughout the b) operation and diagnosing cancer when a weight of the thymus is increased to twice or more than before radiation; d) extracting thymuses by sacrificing the first to third groups of the AKR/J mice at the time at which the third group of the AKR/J mice initially die; and e) selecting only a thymus having no change in weight compared to the organs of the same-aged non-irradiated AKR/J mice from the organs extracted in d) and detecting a gene of the organ whose weight is increased or decreased by a factor of two or more through gene analysis.