de

Abnormal enterohepatic circulation of bile acids caused by fructooligosaccharide supplementation along with a high-fat diet

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03353A, Paper
Fang Zeng, Shi He, Ying Sun, Xue Li, Kaiyang Chen, Hongbin Wang, Shuli Man, Fuping Lu
Fructooligosaccharide (FOS) is a widely used prebiotic and health food ingredient, but few reports have focused on its risk to specific populations.
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de

Shatianyu (Citrus grandis L. Osbeck) whole fruit alleviated loperamide-induced constipation via enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis

Food Funct., 2024, 15,10614-10627
DOI: 10.1039/D4FO02765E, Paper
Mei Deng, Jiamin Ye, Ruifen Zhang, Shuai Zhang, Lihong Dong, Dongxiao Su, Mingwei Zhang, Fei Huang
The effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms were explored.
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de

Rice bran supplement ameliorates chronic restraint stress-induced depression-like behaviors in mice

Food Funct., 2024, 15,10600-10613
DOI: 10.1039/D4FO00718B, Paper
Minji Kim, Minseok Yoon, Suengmok Cho, Min Jung Kim, Min Young Um
RBS alleviates chronic stress-induced depressive-like behaviors by modulating the HPA axis, increasing neurotransmitter levels, downregulating GR, and enhancing ERK-CREB-BDNF signaling. γ-Oryzanol, a major component, acts as a GR antagonist, contributing to RBS's antidepressant effects.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Multi-omics analysis reveals that agaro-oligosaccharides with different degrees of polymerization alleviate colitis in mice by regulating intestinal flora and arginine synthesis

Food Funct., 2024, 15,10628-10643
DOI: 10.1039/D4FO03650F, Paper
Long Yuan, Chunhui Liu, Bolun Li, Sai Wang, Jianan Sun, Xiangzhao Mao
Inflammatory bowel disease (IBD) is a common chronic disease with a complex etiology, characterized by body weight loss, intestinal barrier damage, and an imbalance of intestinal flora, posing a significant threat to people's health.
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de

Impact of complementary feeding on infant gut microbiome, metabolites and early development

Food Funct., 2024, 15,10663-10678
DOI: 10.1039/D4FO03948C, Paper
Open Access
Yudong Shi, Ran Yin, Jinzhu Pang, Yun Chen, Zhouyong Li, Shengpeng Su, Yongping Wen
Introducing complementary foods is critical for promoting infant health and development.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Immune-enhancing effect of Weizmannia coagulans BCG44 and its supernatant on cyclophosphamide-induced immunosuppressed mice and RAW264.7 cells via the modulation of the gut microbiota

Food Funct., 2024, 15,10679-10697
DOI: 10.1039/D4FO02452D, Paper
Open Access
Yafang Xu, Yi Wang, Tao Song, Xiaxia Li, Haolin Zhou, Oumarou Zafir Chaibou, Bing Wang, Huajun Li
W. coagulans BCG44 and its supernatant possess potential immunomodulatory activity and modulate gut microbiota dysbiosis in CTX-induced immunosuppression.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Specific vegetable types are associated with lower long-term risk for late-life dementia: the Perth Longitudinal Study of Aging Women

Food Funct., 2024, 15,10885-10895
DOI: 10.1039/D4FO03239J, Paper
Negar Ghasemifard, Simone Radavelli-Bagatini, Simon M. Laws, Helen Macpherson, Emma Stevenson, Jonathan M. Hodgson, Richard L. Prince, Joshua R. Lewis, Marc Sim
This study found an association between total vegetable intake as well as specific types of vegetables including yellow/orange/red, green leafy, and allium vegetables with lower long-term risk for late-life dementia in older women.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Oral delivery of electrohydrodynamically encapsulated Lactiplantibacillus plantarum CRD7 modulates gut health, antioxidant activity, and cytokines-related inflammation and immunity in mice

Food Funct., 2024, 15,10761-10781
DOI: 10.1039/D4FO02732A, Paper
Vinay Venkatesh Varada, Sachin Kumar, Sravani Balaga, Antony Johnson Thanippilly, Heartwin A. Pushpadass, Rashmi H. M., Babu Lal Jangir, Nitin Tyagi, Ashish Kumar Samanta
The current study aimed to evaluate the effects of L. plantarum CRD7 on performance and gut health biomarkers in a Swiss albino mouse model.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism

Food Funct., 2024, 15,10698-10716
DOI: 10.1039/D4FO02598A, Paper
Huijuan Wang, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli Yue
Inflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis

Food Funct., 2024, 15,10811-10822
DOI: 10.1039/D4FO03904A, Paper
Yanjie Chen, Wenjuan Chen, Yu Dai, Xiangyun Yan, Chengyao Jiang, Fan Zhang, Min Zhang, Xiaoshan Hu, Juyi Zhao, Tingyue Wu, Shushu Li, Shuping Han, Xiaohui Chen
Human breast milk-derived dioleoyl phosphatidylethanolamine (DOPE) mitigates intestinal dysfunction in Necrotizing Enterocolitis (NEC) through the suppression of ferroptosis.
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de

Correction: A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice

Food Funct., 2024, 15,10913-10914
DOI: 10.1039/D4FO90102A, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tian Liu, Xue Wang, Yan-Ming Wang, Feng-Rong Sui, Xue-Ying Zhang, Hai-Di Liu, Dong-Yue Ma, Xiao-Xiao Liu, Shou-Dong Guo
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Lacticaseibacillus paracasei 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial

Food Funct., 2024, 15,10732-10745
DOI: 10.1039/D4FO01684J, Paper
Open Access
Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue Cheng
Probiotics have been reported to exert beneficial effects on sleep through the gut–brain axis.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

Food Funct., 2024, 15,10746-10760
DOI: 10.1039/D4FO03023K, Paper
Open Access
Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała, Agnieszka Zabłocka
The nutraceutical potential of yolkin health benefits from hen egg yolk.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage

Food Funct., 2024, 15,10795-10810
DOI: 10.1039/D4FO03217A, Paper
Sara Gonçalves, Francisco Peixoto, Tayse F. F. da Silveria, Lillian Barros, Isabel Gaivão
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey

Food Funct., 2024, 15,10823-10837
DOI: 10.1039/D4FO03859B, Paper
Zhen Zhou, Jin Xu, Yang Zhao, Yuanjie Niu
Prior investigations identified correlations between dietary habits and the risk of prostate cancer (PCa); however, the causative dynamics are unclear.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Integrated transcriptomics and untargeted metabolomics reveal bone development and metabolism of newly weaned mice in response to dietary calcium and boron levels

Food Funct., 2024, 15,10853-10869
DOI: 10.1039/D4FO03657C, Paper
Shuo Li, Xuehai Cao, Tiande Zou, Zirui Wang, Xingping Chen, Jun Chen, Jinming You
Boron supplementation in diets with varying calcium levels modulates bone development and bone parameters in mice by regulating calcium signaling, lipid metabolism, and neural signaling and inflammatory signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04194A, Paper
Zhiguo Li, Mengyu Li, Xuexun Fang, Dahai Yu, Xin Hu
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The imbalance of gut microbiota is associated with IBD progression. Various...
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03484H, Paper
Yidan Cai, Siyu Liu, Xing Ge, Lu Cheng, Xin Zhang
Tea flower polysaccharides (TFPS) can improve the disorder of gut microbiota, alleviate oxidative damage to glial cells, alleviate neuroinflammation, and play a role in delaying aging.
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de

Enzymatic treatment to decrease the allergenicity of Pru p 3 from peach

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03052D, Paper
Open Access
Ana Pilar Tobajas, Ana Agulló-García, Jose Luis Cubero, Carlos Colás Sanz, Alba Civera, Clara Esteban, L. Sanchez, M. D. Perez
Pru p 3, a member of the Lipid Transfer Protein family, is considered a major allergen from peach and it often induces serious allergic reactions in peach allergic individuals. The...
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Preparation and characterization of white shrimp hydrolysate-xylooligosaccharides Maillard products and their in vivo promotive effects of zinc absorption in mice

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03709J, Paper
Shijie Dou, Xuening Yu, Yuewen Xu, Xiaoyang Liu, Fawen Yin, Deyang Li, Da-Yong Zhou
The Maillard reaction products, as a kind of glycosylation-based reaction, possess the metal-chelating ability. In this study, the white shrimp hydrolysate (WH) and xylooligosaccharides (XOS) were used to prepare the...
The content of this RSS Feed (c) The Royal Society of Chemistry




de

Brassica rapa L. crude polysaccharide meditated synbiotic fermented whey beverage ameliorates hypobaric and hypoxia induced intestinal damage

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04667F, Paper
Yuanlin Niu, Tingting Zhao, Zhenjiang Liu, Diantong Li, Dongxu Wen, Bin Li, Xiaodan Huang
Hypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa...
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de

A probiotic multi-strain mixture combined with hydroxyectoine improves intestinal barrier function by alleviating inflammation in lipopolysaccharide stimulated differentiated Caco-2 cells

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03130J, Paper
Azza Dabous, Antonietta Stellavato, Donatella Cimini, Valentina Vassallo, Maria D'Agostino, Chiara Schiraldi
Freeze-dried formula containing three probiotic strains and hydroxyectoine reduces LPS-induced inflammation in Caco-2 cells, assessed via RT-PCR, western blot, ELISA, and immunofluorescence for tight junction integrity.
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de

Goat milk derived small extracellular vesicles ameliorate LPS-induced intestinal epithelial barrier dysfunction, oxidative stress, and apoptosis by inhibiting the MAPK signaling pathway

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04067H, Paper
Feng Gao, Xin Zhang, Zhiming Xu, Kang Zhang, Fusheng Quan
Intestinal injury is often accompanied by epithelial barrier dysfunction, oxidative stress, and apoptosis.
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de

Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper
Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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de

Galacto-oligosaccharides regulates intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper
Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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de

Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper
Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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de

Immunomodulatory properties of hempseed oligopeptides in an LRRK2-associated Parkinson's disease animal model

Food Funct., 2024, 15,11115-11128
DOI: 10.1039/D4FO03167A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Torrecillas-Lopez, Fernando Rivero-Pino, Paula Trigo, Rocio Toscano-Sanchez, Teresa Gonzalez-de la Rosa, Alvaro Villanueva, M. Carmen Millan-Linares, Sergio Montserrat-de la Paz, Carmen M. Claro-Cala
Hemp protein hydrolysate is capable of alleviating neuroinflammation by reducing the expression of pro-inflammatory cytokines, which could have promising effects in Parkinson's disease.
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de

Metagenomic and transcriptomic profiling of the hypoglycemic and hypotriglyceridemic actions of Tremella fuciformis-derived polysaccharides in high-fat-diet- and streptozotocin-treated mice

Food Funct., 2024, 15,11096-11114
DOI: 10.1039/D4FO01870B, Paper
Xiaofei Xu, Xiaofei Liu, Liyan Liu, Jin Chen, Jingjing Guan, Donghui Luo
Tremella fuciformis polysaccharides exhibit hypoglycemic and hypotriglyceridemic activities through altering the taxonomic and functional attributes of the gut microbiota and modulating gene expression in the liver.
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de

Solid-state fermentation of green lentils by Lactiplantibacillus plantarum leads to formation of distinct peptides that are absorbable and enhances DPP-IV inhibitory activity in an intestinal Caco-2 cell model

Food Funct., 2024, 15,11220-11235
DOI: 10.1039/D4FO03326D, Paper
Elisa Di Stefano, Nico Hüttmann, Pieter Dekker, Monic M. M. Tomassen, Teresa Oliviero, Vincenzo Fogliano, Chibuike C. Udenigwe
In vitro gastrointestinal digestion, brush border enzyme activity, and microbial fermentation with Lactiplantibacillus plantarum influenced the peptidome of green lentils and peptide transport across the intestinal Caco-2 cell monolayer.
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de

Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides

Food Funct., 2024, 15,10956-10980
DOI: 10.1039/D4FO03549F, Review Article
Joy I. Obeme-Nmom, Raliat O. Abioye, Samanta S. Reyes Flores, Chibuike C. Udenigwe
Several nutraceutical compounds, such as polyphenols and peptides, modulate the enzymatic antioxidant defence system, providing an avenue for the development of multifunctional functional foods.
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de

CoQ10 bioaccessibility and Caco-2 cell uptake improved with novel medium chain triglyceride encapsulation

Food Funct., 2024, 15,10981-10986
DOI: 10.1039/D4FO02844A, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ziqi Li, Rachel E. Kopec
Coenzyme Q10 (CoQ10), a key component of the electron transport chain, is better micellarized and absorbed by intestinal cells following novel encapsulation with MCTs + phospholipid.
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de

Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions

Food Funct., 2024, 15,11252-11265
DOI: 10.1039/D4FO03851G, Paper
Xinzhang Chen, Shengjun Yang, Zhengtao Guo, Bailiang Li, Zhongjiang Wang, Lianzhou Jiang
Human milk oligosaccharides (HMOs) and the milk fat globule membrane (MFGM) represent novel treatments for cow's milk allergy (CMA).
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de

Techno-functional, antioxidant, and amino acid characterization of hydrolyzed bioactive peptides from coconut (Cocos nucifera L.) meal protein

Food Funct., 2024, 15,11266-11279
DOI: 10.1039/D4FO02741H, Paper
Roshanak Zolqadri, Zahra Akbarbaglu, Khashayar Sarabandi, Seyed Hadi Peighambardoust, Seid Mahdi Jafari, Amin Mousavi Khaneghah
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated.
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de

Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder

Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper
Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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de

Advances in plant-derived extracellular vesicles: isolation, composition, and biological functions

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04321A, Review Article
Yao-Bo Zeng, Xun Deng, Li-Sha Shen, Yong Yang, Xing Zhou, Lianbao Ye, Sibao Chen, Da-Jian Yang, Guo-Qing Chen
Plant-derived extracellular vesicles (PDEVs) are nanoscale vesicles released from plant cells into the extracellular space.
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de

Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
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de

A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02493A, Paper
Rui Liang, Fangliang Song, Ying Liang, Yanpeng Fang, Jianqiang Wang, Yajuan Chen, Zhongxu Chen, Xiaorong Tan, Jie Dong
The diagram of the strategy to explore peptide targets based on model predictions and experiments.
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de

Correction: Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO90094D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xianli Wang, Yuxin Jing, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhengyang Wu, Ruihong Ge, Wei Cheng, Yuanyuan Yan, Shilong Jiang, Jianguo Sun, Jingquan Li, Qinggang Xie, Xiaoguang Li, Hui Wang
To cite this article before page numbers are assigned, use the DOI form of citation above.
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de

Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03468F, Paper
Open Access
Zeyu Cui, Te Liu, Yichao Wen, Weihao Li, Jianghong Xu, Yingjuan Chen, Danping Chen, Ying Zhu
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
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de

Big gender shift in our workforce

Latest PLFS data show a heartening increase in female employment. What needs to be addressed now is the quality of jobs




de

Chennai’s floods are man-made

The root causes are encroachments into water bodies, choking of waterways, reckless construction, and lack of a hydrological plan




de

Diwali, amidst a choking Delhi

Green crackers are a step in the right solution. But they are not a complete solution




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Librarians’ vital role in the world of academics

Their part in fostering knowledge is invaluable




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Another star makes a political debut

Vijay’s entry adds an interesting twist to the 2026 TN elections



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Editorial. Eye on debt

Centre, States should augment revenue to bring down debt




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Understanding the election process: How is the US President elected?

While citizens cast their votes, the actual selection of the president is determined by the Electoral College




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GST circulars should be clear and easy to understand

This will smoothen the assessment process and reduce the piling up of appeals at the Tribunals




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The rise and rise of online food delivery market

The online food delivery market in India is expected to outpace the growth of the food services market itself between 2023 and 2028




de

What Indian trade can expect from Trump 2.0

India could well face higher tariffs on exports like textiles, chemicals, pharma and auto/engineering products




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Corporate ‘assurance’ on sustainability needed

Sustainability-assured statements ensure risks not captured by financial statements are properly disclosed and evaluated