Interview with Frank-Erik de Leeuw, MD, PhD and Loes C. A. Rutten-Jacobs, MSc, authors of Long-term Mortality After Stroke Among Adults Aged 18 to 50 Years

Interview with Hope Weiler, RD, PhD, author of Effect of Different Dosages of Oral Vitamin D Supplementation on Vitamin D Status in Healthy, Breastfed Infants: A Randomized Trial

Interview with Emily Y. Chew, MD, author of Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial

Interview with Sayeed Ikramuddin, MD, author of Roux-en-Y Gastric Bypass vs Intensive Medical Management for the Control of Type 2 Diabetes, Hypertension, and Hyperlipidemia: The Diabetes Surgery Study Randomized Clinical Trial

Interview with Anurag N. Malani, MD, author of Magnetic Resonance Imaging Screening to Identify Spinal and Paraspinal Infections Associated With Injections of Contaminated Methylprednisolone Acetate

Interview with Karen L. Margolis, MD, MPH, author of Effect of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Control: A Cluster Randomized Clinical Trial

Interview with Daniel D. Matlock, MD, MPH, author of Geographic Variation in Cardiovascular Procedure Use Among Medicare Fee-for-Service vs Medicare Advantage Beneficiaries

Interview with Jared P. Reis, PhD, author of Association Between Duration of Overall and Abdominal Obesity Beginning in Young Adulthood and Coronary Artery Calcification in Middle Age

Interview with Stephen MacMahon, DSc, FMedSci, author of Industry-Sponsored Clinical Trials in Emerging Markets: Time to Review the Terms of Engagement

Interview with Richard Saitz, MD, MPH, author of Chronic Care Management for Dependence on Alcohol and Other Drugs

Interview with Christian Torp-Pedersen, MD, DSc, author of Association of National Initiatives to Improve Cardiac Arrest Management With Rates of Bystander Intervention and Patient Survival After Out-of-Hospital Cardiac Arrest

Interview with Prashanthan Sanders, MBBS, PhD, author of Effect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation: A Randomized Clinical Trial

Interview with Paul A. James, MD, author of 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)

Interview with Joseph S. Ross, MD, MHS, author of Clinical Trial Evidence Supporting FDA Approval of Novel Therapeutic Agents, 2005-2012

Interview with Norrina B. Allen, PhD, MPH, author of Blood Pressure Trajectories in Early Adulthood and Subclinical Atherosclerosis in Middle Age

Interview with Constantine G. Lyketsos, MD, MHS, author of Effect of Citalopram on Agitation in Alzheimer Disease

Interview with Matthew D. Barber, MD, MHS, author of Comparison of 2 Transvaginal Surgical Approaches and Perioperative Behavioral Therapy for Apical Vaginal Prolapse

Interview with Derek C. Angus, MD, MPH, author of Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation

Interview with Nynne Nyboe Andersen, MD, author of Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Interview with Kurt Kroenke, MD, author of Telecare Collaborative Management of Chronic Pain in Primary Care

Interview with George R. Buchanan, MD, author of Management of Sickle Cell Disease

Interview with Andrea S. Gershon, MD, MSc, author of Combination Long-Acting β-Agonists and Inhaled Corticosteroids Compared With Long-Acting β-Agonists Alone in Older Adults With Chronic Obstructive Pulmonary Disease

Interview with Steven A. Narod, MD, FRCPC, author of Differences in Breast Cancer Stage at Diagnosis and Cancer-Specific Survival by Race and Ethnicity in the United States

Interview with Joann G. Elmore, MD, MPH, author of Diagnostic Concordance Among Pathologists Interpreting Breast Biopsy Specimens

Interview with Jeffrey G. Jarvik, MD, MPH, author of Association of Early Imaging for Back Pain With Clinical Outcomes in Older Adults

Interview with Francis Couturaud, MD, PhD, author of Six Months vs Extended Oral Anticoagulation After a First Episode of Pulmonary Embolism: The PADIS-PE Randomized Clinical Trial

Edward H. Livingston, MD discusses atrial fibrillation with Eric N. Prystowsky, MD, author of Treatment of Atrial Fibrillation. This review article reports that therapy for atrial fibrillation should include rate control for all patients, but maintenance of sinus rhythm with drugs or catheter ablation should be considered on an individual patient basis. Also on the program is a conversation about new technologies to facilitate screening for atrial fibrillation with Leslie Saxon, MD.

Interview with Bridget A. Fernandez, MD, author of Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder

Interview with Jeffrey L. Cummings, MD, ScD, author of Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial

Interview with Kevin C. Oeffinger, MD, author of Breast Cancer Screening for Women at Average Risk: 2015 Guideline Update From the American Cancer Society

Constipation is one of the most frequent problems clinicians are asked to deal with. Despite how common it is, constipation is frequently not treated adequately. In this podcast, Arnold Wald, MD, explains a stepwise approach to the management of constipation ranging from very simple measures to the most novel and complicated new medical therapies.

Mononucleosis is a common disease of young adults manifested by lethargy, fever, pharyngitis, lymphadenopathy and splenomegaly. In this podcast, we review the clinical features of the disease and how good each of them is at establishing a diagnosis of mononucleosis. We also review how Epstein Barr virus was discovered as the cause of mononucleosis and talk to Mark H. Ebell, MD, MS, author of Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review.

Articles discussed in this episode:

• Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review (2016)
• Acute Lymphatic Leukemia and Infectious Mononucleosis (1931)
• Infectious Mononucleosis: Part I. Clinical Aspects (1935) 
• Infectious Mononucleosis: Clinical Manifestations in Relation to EB Virus Antibodies (1968)

Drs Stuart Spechler and Peter Kahrilis discuss GERD and esophagitis--how they occur and how they are treated. Dr Spechler also discusses a new hypothesis regarding how reflux esophagitis is caused that differs from the traditional teaching that acid and pepsin reflux into the esophagus and burn the mucosa layers.

Related articles:
Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes
Turning the Pathogenesis of Acute Peptic Esophagitis Inside Out

Interview with Jeff D. Williamson, MD, MHS, author of Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial

Persistent diarrhea is a poorly recognized syndrome in all populations that requires proper assessment and diagnosis to ensure that affected individuals receive the treatment needed to experience improvement of clinical symptoms. Listen to Drs Herbert DuPont and Annie Feagins discuss how to diagnose and treat diarrhea. Related article: Persistent Diarrhea

Patrick Soon-Shiong, MD, physician-scientist and entrepreneur, talks about the National MoonShot Initiative, his MoonShot 2020 Program, as well as promising approaches in cancer immunotherapy. This podcast was originally recorded on June 3, 2016

Workplace violence–related injuries occur disproportionately in health care settings. In this podcast, we discuss how individual clinicians should manage violent patients who might attack them. Article discussed in this episode: Ensuring Staff Safety When Treating Potentially Violent Patients

In 2017 the Society for Critical Care Medicine updated its guidelines for sepsis management. These new guidelines differ significantly from ones in the past in that they no longer recommend protocolized resuscitation and emphasize early and aggressive fluid resuscitation when patients present with septic shock. This is the first podcast in the Surviving Sepsis guideline series. The next episode discusses why the new sepsis guideline changed.

Article discussed in this episode: Management of Sepsis and Septic Shock

Speakers:

Laura Evans, MD, MSc, of Bellevue Hospital and NYU Medical Center

Andrew Rhodes, MBBS, MD, of St George’s University Hospitals NHS Trust and co-chair of the Surviving Sepsis guideline panel

Mitchell M. Levy, MD, of the Alpert Medical School of Brown University and Rhode Island Hospital

Interview with Andrew A. Nierenberg, MD, author of Evolving Issues in the Treatment of Depression

Interview with Robert M. Wachter, MD, author of Reimagining Specialty Consultation in the Digital Age: The Potential Role of Targeted Automatic Electronic Consultations

Interview with Julia A. Segre, Ph.D., author of Manipulating the Human Microbiome to Manage Disease

Interview with Ezekiel J. Emanuel, M.D., Ph.D., author of The Inevitable Reimagining of Medical Education

Noninvasive ventilation (NIV), working with dying patients’ families, use of experimental therapies, and more. JAMA Associate Editor Derek Angus, MD, MPH, Distinguished Professor and Chair of Critical Care Medicine at the University of Pittsburgh, provides a COVID-19 ICU management update.

Watch the recording of this livestream

Interview with Chien-Wen W Tseng, MD, MPH, USPSTF member and coauthor of Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery: US Preventive Services Task Force Recommendation Statement

Dyer, Andy, author

Carolan, Michael S