top RE: Online sale of unapproved combinations of Minoxidil as topical solution By connect.raps.org Published On :: Fri, 08 May 2020 08:16:03 -0400 From : Communities>>Regulatory Open ForumThese are all unapproved new drugs. Many people who have very limited knowledge of our OTC drug system, assume that if it is sold OTC, it is a monographed drug and they can change the formulation. They do not know that there are two types of OTC drugs allowed-compliance with a monograph or NDA. Minoxidil is one and chlorhexidine antiseptic wash is another. ------------------------------ David Steinberg,FRAPS President Steinberg & Associates, Inc. Pompton Plains NJ USA 609-902-8860 -------------- [More] Full Article Discussion
top RE: Online sale of unapproved combinations of Minoxidil as topical solution By connect.raps.org Published On :: Fri, 08 May 2020 08:38:05 -0400 From : Communities>>Regulatory Open ForumThe only possible way I can see any of these products being legally marketed in the US without going the OTC NDA route would be if the ingredients other than Minoxidil are considered "inactive" and have some purpose (other than their active ingredient purposes) in the formulation. That said, this might work for the last combination in your listing because all of these can and are often used in OTC products as inactive ingredients with understood and current reasons for existing in a formulation [More] Full Article Discussion
top RE: Online sale of unapproved combinations of Minoxidil as topical solution By connect.raps.org Published On :: Sat, 09 May 2020 10:49:42 -0400 From : Communities>>Regulatory Open ForumThese types of products and combinations you mention are all unapproved drugs and unapproved combinations. Unless the specific combination is approved or listed in an OTC monograph, it is a new drug and requires a NDA to market it. Minoxidil is a Rx to OTC switch product so it requires a NDA or ANDA to market this drug in the US, even as a OTC drug. Thus any combination with minoxidil is a new drug. In the past the FDA has also specifically stated that combining different types of products (drug [More] Full Article Discussion
top Phase 3 trial of Libtayo® (cemiplimab) as monotherapy for first-line advanced non-small cell lung cancer stopped early due to highly significant improvement in overall survival By www.news.sanofi.us Published On :: Mon, 27 Apr 2020 08:40:00 -0400 - Libtayo decreased the risk of death by 32.4% compared to chemotherapy Full Article
top California tops 2,500 coronavirus deaths as fears of second wave temper reopening efforts By www.latimes.com Published On :: Thu, 7 May 2020 14:27:21 -0400 Los Angeles County, which continues to be the hardest hit area in California, announced 51 additional deaths linked to COVID-19 on Thursday. Full Article
top L.A. County coronavirus cases top 30,000 as some businesses reopen By www.latimes.com Published On :: Fri, 8 May 2020 14:27:44 -0400 Amid a plateau in the number of new coronavirus-related deaths in Los Angeles County, officials Friday were easing into an economic recovery plan. Full Article
top Not enough evidence that e-cigarettes help to stop smoking, surgeon general says By www.nbcnews.com Published On :: Thu, 23 Jan 2020 20:04:00 GMT The surgeon general's report is the first in 30 years to focus entirely on quitting tobacco. Full Article
top Meet the Ohio health expert who has a fan club — and Republicans trying to stop her By www.nbcnews.com Published On :: Sat, 09 May 2020 09:04:00 GMT Some Buckeyes are not comfortable being told by a "woman in power" to quarantine, one expert said. Full Article
top Nintendo is at the top of its game with 41% rise in profit By asia.nikkei.com Published On :: Full Article
top Tesla insists Shanghai production stoppage 'normal' By asia.nikkei.com Published On :: Full Article
top Indians must stop spreading anti-Muslim fake news on WhatsApp By asia.nikkei.com Published On :: Full Article
top Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing By feeds.nature.com Published On :: 2020-04-27 Full Article
top 2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy By feeds.nature.com Published On :: Full Article
top Top 5 Current Affairs: 27 March 2020 By www.jagranjosh.com Published On :: 2020-03-27T14:29:00Z The Reserve Bank of India on March 27, 2020 released its 7th Bi-monthly Monetary Policy Statement 2019-20 amidst the COVID-19 outbreak in the country. Full Article
top Top 5 Current Affairs: 7 June 2019 By www.jagranjosh.com Published On :: 2019-06-07T11:50:00Z Get all world cup updates, world cup 2019 points table, team standing, highest run scorer, highest wicket-taker, world cup hundreds, five-wicket hauls, best bowling figures, best batting figures. Full Article
top Implications from autopsy studies of latent prostate cancer By feeds.nature.com Published On :: 2020-04-30 Full Article
top UPSC (IAS) Prelims 2020: Check Important Topics from Economics By www.jagranjosh.com Published On :: 2020-03-27T15:36:00Z Check the most important topics of Economics for the preparation of UPSC (IAS) Prelims Exam 2020. All the important topics have been added after a detailed analysis of the latest UPSC Prelims 2020 Syllabus. Full Article
top HSBC cuts top investment bank jobs despite wider firing freeze By www.dealstreetasia.com Published On :: Tue, 21 Apr 2020 07:16:52 +0000 HSBC's twin homes of Britain and China have been particularly hard hit by the pandemic. The post HSBC cuts top investment bank jobs despite wider firing freeze appeared first on DealStreetAsia. Full Article HSBC
top Alibaba demotes top executive Jiang Fan after probe into behaviour By www.dealstreetasia.com Published On :: Mon, 27 Apr 2020 14:09:27 +0000 Jiang joined Alibaba in 2013 after selling his app analytics company Umeng to the e-commerce giant. The post Alibaba demotes top executive Jiang Fan after probe into behaviour appeared first on DealStreetAsia. Full Article Alibaba
top Igniting autophagy through the regulation of phase separation By feeds.nature.com Published On :: 2020-05-01 Full Article
top Cadmium isotope fractionation reveals genetic variation in Cd uptake and translocation by <i>Theobroma cacao</i> and role of natural resistance-associated macrophage protein 5 and heavy metal ATPase-family transporters By feeds.nature.com Published On :: 2020-05-01 Full Article
top A pentaploid-based linkage map of the ancestral octoploid strawberry <i>Fragaria virginiana</i> reveals instances of sporadic hyper-recombination By feeds.nature.com Published On :: 2020-05-07 Full Article
top Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy By feeds.nature.com Published On :: 2020-04-27 Full Article
top The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias By feeds.nature.com Published On :: 2020-03-02 Full Article
top Adult marrow hematopoiesis: a continuum of change By www.nature.com Published On :: 2014-12-17 Full Article
top Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population By www.nature.com Published On :: 2014-12-17 Full Article
top Deconvoluting MLL1-dependent pathways in hematopoiesis and leukemogenesis By www.nature.com Published On :: 2014-12-17 Full Article
top Autopsy slowdown hinders quest to determine how coronavirus kills By feeds.nature.com Published On :: 2020-05-07 Full Article
top Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide By feeds.nature.com Published On :: 2020-05-05 Full Article
top Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation By feeds.nature.com Published On :: 2020-04-27 Full Article
top Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy By feeds.nature.com Published On :: 2019-10-02 Full Article
top Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome By feeds.nature.com Published On :: 2020-05-06 Full Article
top Oral health in allogeneic hematopoietic stem cells transplantation survivors By feeds.nature.com Published On :: 2020-05-07 Full Article
top Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR By feeds.nature.com Published On :: 2020-05-09 Full Article
top The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors By feeds.nature.com Published On :: 2020-05-07 Full Article
top Dermatophagoides pteronyssinus peptidase 1 (DERP1) By feeds.nature.com Published On :: 2014-12-18 In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma. Full Article
top Topoisomerase II binding protein 1 (TOPBP1) By feeds.nature.com Published On :: 2014-12-18 Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer. Full Article
top Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis By feeds.nature.com Published On :: 2020-05-04 Full Article
top Mendelian neurodegenerative disease genes involved in autophagy By feeds.nature.com Published On :: 2020-05-05 Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH) By feeds.nature.com Published On :: 2020-04-02 Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2 By feeds.nature.com Published On :: 2020-05-06 Full Article
top Mechanisms governing autophagosome biogenesis By feeds.nature.com Published On :: 2020-05-05 Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top Structure of the cytoplasmic ring of the <i>Xenopus laevis</i> nuclear pore complex by cryo-electron microscopy single particle analysis By feeds.nature.com Published On :: 2020-05-06 Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
top How to Topple Dictators and Transform Society By feedproxy.google.com Published On :: Jan 3, 2020 Jan 3, 2020Nonviolent resistance scholar Erica Chenoweth explains the key ingredients of successful social movements. Full Article
