high BPMC's VOYAGER Fails, CLSD's NDA Resubmission Faces Delay, SNDX Hits New High By www.rttnews.com Published On :: Wed, 29 Apr 2020 04:59:15 GMT Today's Daily Dose brings you news about Blueprint Medicines' disappointing results from gastrointestinal stromal tumor trial; revised timeline of Clearside Biomedical's resubmission of XIPERE NDA; encouraging trial results of INOVIO's MERS coronavirus vaccine and initial data from Syndax Pharma's acute leukemia trial. Full Article
high New Study Highlights OptiMSM's Influence on Key Metabolic Reactions By feedproxy.google.com Published On :: Thu, 08 Feb 2018 22:09:00 GMT Bergstrom Nutrition, manufacturer of OptiMSM®, a branded form of methylsulfonylmethane (MSM), recently published an article detailing how the small intestine absorbs MSM, particularly in relation to sulfur. Full Article
high Phase 3 trial of Libtayo® (cemiplimab) as monotherapy for first-line advanced non-small cell lung cancer stopped early due to highly significant improvement in overall survival By www.news.sanofi.us Published On :: Mon, 27 Apr 2020 08:40:00 -0400 - Libtayo decreased the risk of death by 32.4% compared to chemotherapy Full Article
high The Hill today highlights the recent recommendation by Europe's chief drug regulator to suspend 700 generic drugs By searchingforsafety.net Published On :: Mon, 16 Mar 2015 03:06:17 GMT Posted by Roger Bate My op-ed with Dinesh Thakur in The Hill today highlights the recent recommendation by Europe's chief drug regulator to suspend 700 generic drugs whose approvals were based on flawed – or forged – clinical studies conducted by GVK Bio, an Indian contract research organization. We urge U.S. Federal regulators to follow Europe’s lead and move to rescind market approval for these drugs while conducting their own investigation. You can read the op-ed here [...] Full Article Uncategorized
high BENEO president: ‘We have seen higher and more volatile demand during the pandemic’ By www.foodnavigator-usa.com Published On :: Tue, 05 May 2020 02:05:00 +0100 From fewer containers and reduced shift work at harbors to delays in planned maintenance in factories, the coronavirus pandemic is impacting global supply chains in myriad ways. FoodNavigator-USA (FNU) caught up with Jon Peters (JP), president at Beneo, a leading supplier of chicory root fiber, rice ingredients, and the specialty low-GI carbs Isomalt and Palatinose, to find out more. Full Article Suppliers
high Personalized Nutrition: New research highlights value society places on genetic testing By www.nutraingredients-usa.com Published On :: Thu, 07 May 2020 15:58:00 +0100 The results provide priceless information on ancestry and predispositions to various illnesses. Full Article Research
high COVID-19 cases higher among San Diego's Latinos; advocates call for more testing By www.latimes.com Published On :: Thu, 7 May 2020 14:16:36 -0400 In several states and in parts of California, black and Latino people are dying of COVID-19 at higher rates than their white and Asian counterparts. Full Article
high UCLA softball is on 'really big high' with return of Rachel Garcia and Bubba Nickles By www.latimes.com Published On :: Fri, 8 May 2020 22:36:51 -0400 UCLA, the NCAA champion in 2019 and the No. 1 team in 2020 when the COVID-19 pandemic hit, got a boost with the return of Rachel Garcia and Bubba Nickles. Full Article
high India's unemployment at record high amid tough COVID-19 lockdown By asia.nikkei.com Published On :: Full Article
high Japanese high schools start to return from virus hiatus By asia.nikkei.com Published On :: Full Article
high Foreign workers left high and dry in Japan's coronavirus economy By asia.nikkei.com Published On :: Full Article
high High climate sensitivity in CMIP6 model not supported by paleoclimate By feeds.nature.com Published On :: 2020-04-30 Full Article
high High climate sensitivity in CMIP6 model not supported by paleoclimate By feeds.nature.com Published On :: 2020-04-30 Full Article
high PSMA PET–CT outperforms conventional imaging in high-risk prostate cancer By feeds.nature.com Published On :: 2020-05-05 Full Article
high A high-quality reference genome of wild <i>Cannabis sativa</i> By feeds.nature.com Published On :: 2020-05-02 Full Article
high Engineering high-energy-density sodium battery anodes for improved cycling with superconcentrated ionic-liquid electrolytes By feeds.nature.com Published On :: 2020-05-04 Full Article
high A high-resolution <i>HLA</i> imputation system for the Taiwanese population: a study of the Taiwan Biobank By feeds.nature.com Published On :: 2020-02-11 Full Article
high Blood pressure load per body surface area is higher in women than in men By feeds.nature.com Published On :: 2020-05-04 Full Article
high Structural basis for selectivity in a highly reducing type II polyketide synthase By feeds.nature.com Published On :: 2020-05-04 Full Article
high Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble By feeds.nature.com Published On :: 2020-05-06 Full Article
high Global Warming Linked to Higher Suicide Rates across North America By feeds.nature.com Published On :: 2018-10-11 A 1 degree Celsius rise corresponded to a 1.4 percent increase in suicides Full Article
high High-level Postdoctoral research fellow recruitment - The international Joint Center for Biomedical Innovation (JCBI), Henan University : Kaifeng, China By feeds.nature.com Published On :: Tue, 15 Oct 2019 09:23:52 +0000 The international Joint Center for Biomedical Innovation (JCBI) is comprised of two partner research nodes using nanoparticle technologies to develop solutions for cancer and neurodegenerative diseases diagnostics. Henan University has established a new research laboratory in nano-bio system innovation and theranostics, with start-up funding and new academic positions. Macquarie’s node is built upon its established excellence in neuroscience and cancer research programs. The collaborative succes… Full Article
high Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma By feeds.nature.com Published On :: 2020-05-07 Full Article
high The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer By feeds.nature.com Published On :: 2020-04-20 Full Article
high High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission By feeds.nature.com Published On :: 2020-05-06 Full Article
high Nanomolar-scale, high throughput chemical synthesis of drug-like molecules By feeds.nature.com Published On :: 2014-12-18 A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds. Full Article
high High-purity orbital angular momentum states from a visible metasurface laser By feeds.nature.com Published On :: 2020-04-27 Full Article
high An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9 By feeds.nature.com Published On :: 2020-04-27 Full Article
high High-risk additional chromosomal abnormalities at low blast counts herald death by CML By feeds.nature.com Published On :: 2020-05-07 Full Article
high Paired TCR discovery in high throughput By feeds.nature.com Published On :: 2020-05-05 Full Article
high Impact of the COVID-19 lockdown on basic science research in ophthalmology: the experience of a highly specialized research facility in France By feeds.nature.com Published On :: 2020-05-07 Full Article
high ART with high viscosity GIC and composite restorations in class II cavities: can they thrive in the post-amalgam era? By feeds.nature.com Published On :: 2020-03-27 Full Article
high Idea Exchange with Pakistan High Commissioner to India Salman Bashir: Send us your questions By archive.indianexpress.com Published On :: Mon, 06 Aug 2012 05:32:25 GMT Salman Bashir, Pakistan High Commissioner to India, will be our guest at Idea Exchange. Send us your questions. Full Article
high How High Is Risk of Nuclear War Between Russia and US? By www.belfercenter.org Published On :: Aug 6, 2019 Aug 6, 2019Former U.S. Energy Secretary Ernie Moniz and former U.S. Sen. Sam Nunn argue in a new Foreign Affairs article that the threat of nuclear war between Russia and the U.S. is higher now than at any point since the Cuban Missile Crisis. Full Article
high Supply crunch sends BRBF premiums to 11-month highs By www.argusmedia.com Published On :: 08 May 2020 10:25 (+01:00 GMT) Full Article Metals Ferrous Steelmaking raw materials Iron ore Asia-Pacific Latin America and Caribbean Northeast Asia Brazil China Fundamentals Supply
high Helping Americans work more and gain skills for higher-paying jobs is vital for boosting mobility By webfeeds.brookings.edu Published On :: Thu, 03 Dec 2015 00:01:00 -0500 Improving the labor market and encouraging work are central to our goals of achieving greater responsibility and opportunity in America. The private economy is the arena where most Americans work hard to realize their dreams. But employment today is failing to achieve the promise it did a few decades ago. Wages of unskilled workers have been fairly stagnant in real terms (especially among men) and have fallen relative to those of more-educated workers; and some groups of Americans (like less-educated men generally and black men, specifically) are working considerably less than they once did. Stagnant wages and low work participation among some groups of workers are blocking progress. Both must be addressed. In Chapter 4 of a new report from the AEI-Brookings Working Group on Poverty and Opportunity, the Working Group recommends policies that: Expand opportunities for the disadvantaged by improving their skills; Make work pay better than it does now for the less educated; Expand both work requirements and opportunities for the hard-to-employ while maintaining an effective work-based safety net for the most vulnerable members of our society, especially children; and Make more jobs available. Downloads Download Chapter 4: WorkExplore the full report Authors AEI-Brookings Working Group on Poverty and Opportunity Full Article
high Honda running 'very conservative' due to higher temps By en.espnf1.com Published On :: Sat, 14 Mar 2015 11:31:40 GMT Honda is running its engines on "very conservative" settings at the first race of the season in Australia for fear of damaging one of its four power units per car Full Article
high Highlights: New transportation technologies bring rewards and risks By webfeeds.brookings.edu Published On :: Fri, 13 Sep 2019 18:09:47 +0000 New technologies are transforming the transportation sector. These include autonomous vehicles, ride-sharing services, remote sensors, and unmanned aerial systems, among other developments. As is true with many technologies, however, the products have advanced faster than the policies and regulations surrounding them. On September 10, The Center for Technology Innovation hosted a panel discussion featuring Brookings… Full Article
high How instability and high turnover on the Trump staff hindered the response to COVID-19 By webfeeds.brookings.edu Published On :: Thu, 07 May 2020 18:04:06 +0000 On Jan. 14, 2017, the Obama White House hosted 30 incoming staff members of the Trump team for a role-playing scenario. A readout of the event said, “The exercise provided a high-level perspective on a series of challenges that the next administration may face and introduced the key authorities, policies, capabilities, and structures that are… Full Article
high How instability and high turnover on the Trump staff hindered the response to COVID-19 By webfeeds.brookings.edu Published On :: Thu, 07 May 2020 18:04:06 +0000 On Jan. 14, 2017, the Obama White House hosted 30 incoming staff members of the Trump team for a role-playing scenario. A readout of the event said, “The exercise provided a high-level perspective on a series of challenges that the next administration may face and introduced the key authorities, policies, capabilities, and structures that are… Full Article
high Report Launch & Panel Discussion | Reviving Higher Education in India By webfeeds.brookings.edu Published On :: Tue, 19 Nov 2019 05:44:48 +0000 Brookings India is launching a report on “Reviving Higher Education in India”, followed by a panel discussion. The report provides a unique and comprehensive analysis of the challenges facing the higher education sector in India and makes policy recommendations to reform the space. Abstract: In the last two decades, India has seen a rapid expansion in… Full Article
high Physician payment in Medicare is changing: Three highlights in the MACRA proposed rule that providers need to know By webfeeds.brookings.edu Published On :: Wed, 04 May 2016 08:54:00 -0400 Editor’s Note: This analysis is part of The Leonard D. Schaeffer Initiative for Innovation in Health Policy, which is a partnership between the Center for Health Policy at Brookings and the USC Schaeffer Center for Health Policy and Economics. The Initiative aims to inform the national health care debate with rigorous, evidence-based analysis leading to practical recommendations using the collaborative strengths of USC and Brookings. The passage of the Medicare Access and CHIP Reauthorization Act (MACRA) just over a year ago signaled a strong and unique bipartisan agreement to move towards value-based care, but until recently, many of the details surrounding how it would be implemented remained unknown. But last week, the Centers for Medicare and Medicaid Studies (CMS) released roughly 1,000 pages that shed more light on how physician payment will hopefully dramatically change for the better. Some Historical Context Prior to MACRA, how doctors were paid for providing care to Medicare patients was subject to a reimbursement formula known as the Sustainable Growth Rate (SGR). Established in 1997 to control the rate of increase in spending on physician services, the SGR pegged total spending among all Medicare-participating physicians to an overall budget target. Yet in this “tragedy of the commons,” no one physician benefitted from her good stewardship of health care resources. Total physician spending often exceeded the overall budget target, triggering reimbursement rate cuts. However, lawmakers chose to push them off into the future through what were called “doc fixes,” deferring the rate cuts temporarily. The pending cut rose to over 21 percent before MACRA’s passage as a result of compounding doc fixes. Moving Forward with MACRA When it was signed into law on April 16, 2015, MACRA ended the SGR, its cuts, and many previous payment incentive programs. In their place, MACRA established two overarching payment incentive schemes for providers to choose from: the Merit-Based Incentive Payment System (MIPS) program, which supplants three previous payment incentives and makes positive or negative adjustments to a physician’s payment based on her performance; or the Alternative Payment Model (APM) program, which awards a 5 percent bonus through 2024—with higher annual payment updates thereafter—for having a minimum percentage of Medicare and/or all-payer revenue through eligible APMs. Base physician fee rates for all Medicare providers would be updated 0.5 percent for each of the first four years, followed by no increases until 2026, when base fees would increase at different rates depending on the payment incentive program in which a physician participates. MIPS addresses providers’ longstanding complaints that reporting that reporting under the existing programs—the Physician Quality Reporting System, the Value-Based Modifier, and Meaningful Use — is duplicative and cumbersome. Under the new MIPS program, physicians report to the government payer directly (CMS) and receive a bonus or penalty based on performance on measures of quality, resource use, meaningful use of electronic health records, and clinical practice improvement activities. The bonus or penalty physicians may see starts at 4 percent of the fee schedule in 2019 (based on their performance two years prior—in this case 2017) and increases successively to 5 percent in 2020, 7 percent in 2021, and 9 percent from 2022 onward. From 2026 onward, MIPS providers would receive an annual increase of 0.25 percent on their base fee schedules rates. In contrast, the APM incentive program awards qualifying physicians a fixed, annual bonus of 5 percent of their reimbursement from 2019- – 2024, and provides that their fee schedule rates grow 0.5 percentage points faster than those of MIPS in 2026 and beyond, in recognition of the risk they assume in these contracts. Yet, according to MACRA, not all APMs are created equal. APMs eligible for this track must use quality measures similar to those of MIPS, ensure electronic health records are used, and either be an approved patient-centered medical home (PCMH) or require that the participating entity “bears more than nominal financial risk” for excessive costs. Then, in order to receive the APM track bonus, physicians must have a minimum of 25 percent of their revenue from Medicare come through eligible APMs in 2019, with the minimum increasing through 2023 up to 75 percent. In 2021, a new all-payer Advanced APM option becomes available, allowing providers in APM contracts with other payers to participate in the Advanced APM incentive. To do so, they must meet the same minimum thresholds—50 percent in 2021, 75 percent in 2023—but through all provider contracts, not solely Medicare revenue, while still meeting a significantly lower Medicare-specific threshold. By creating an all-payer option, CMS hopes to enable greater provider participation by allowing all payer revenue to count toward the same minimum threshold. Under the all-payer model in 2021, for example, providers must have no less than 25 percent of Medicare revenue through Advanced APMs and 50 percent of all revenue through Advanced APMs. MACRA Implementation Details Revealed The newly released proposed rule provides answers to significant questions that had been left unanswered in the law surrounding the specifics of implementation of MIPS and the APM incentives. At long last, providers are gleaning insight into how CMS intends to implement MIPS and the APM track. Given the fast-approaching MIPS performance period in January 2017, here are three key highlights providers need to know: Qualifying for the APM incentive track—and getting out of MIPS—will be difficult. In order to qualify for the bonus-awarding Advanced APM designation, APMs must meet the “nominal financial risk” criteria, which will be measured in three ways: an APM’s marginal rate sharing for losses, minimum loss ratio (the threshold above which providers would begin sharing in losses), and total potential risk as a percent of expected costs. Clinicians must further have a minimum share of revenue that comes in through the designated APMs. Providers will have fewer opportunities to see and improve their performance on MIPS. Despite calls from provider groups for more frequent reporting and feedback periods, MIPS reporting periods will be annual, not quarterly. This is true for performance feedback from CMS, as well, though they may explore more frequent feedback cycles in the future. Quarterly reporting and feedback periods could have made the incentive programs more “actionable” for providers, alerting them to their performance closer to the time the services were rendered and providing more opportunities to improve performance. MIPS allows greater flexibility than previous programs. Put simply, MIPS is the performance incentive program clinicians will participate in if not on the Advanced APM track. While compelling participation, the proposed MIPS implementation also responds to stakeholder concerns that earlier performance incentive programs were onerous and sometimes irrelevant—MIPS reduces the number of measures required in some categories and allows physicians to select from a set of measures to report on based on relevancy to their practice. With last week’s release of the proposed rule, the Leonard D. Schaeffer Initiative for Innovation in Health Policy is kicking off a series of work products that will focus dually on further MACRA implementation issues and on translating complex policy into providers’ experience. In the blogs and publications to follow, we will dive into greater detail and discussion of the pieces of MACRA implementation highlighted here, as well as many other emerging physician payment reform issues, as the law’s implementation unfolds. Authors Kavita PatelMargaret DarlingCaitlin BrandtPaul Ginsburg Image Source: © Jim Bourg / Reuters Full Article
high How high are infrastructure costs? Analyzing Interstate construction spending By webfeeds.brookings.edu Published On :: Mon, 19 Aug 2019 11:49:25 +0000 Although the United States spends over $400 billion per year on infrastructure, there is a consensus that infrastructure investment has been on the decline and with it the quality of U.S. infrastructure. Politicians across the ideological spectrum have responded with calls for increased spending on infrastructure to repair this infrastructure deficit. The issue of infrastructure… Full Article
high India at the global high table By webfeeds.brookings.edu Published On :: Wed, 20 Apr 2016 15:30:00 -0400 Event Information April 20, 20163:30 PM - 5:00 PM EDTFalk AuditoriumBrookings Institution1775 Massachusetts Avenue NWWashington, DC 20036 Register for the EventIn recent decades, India has taken on a growing global presence, one that has been seen as increasing even more since Prime Minister Narendra Modi took office nearly two years ago. In a new book, “India at the Global High Table: The Quest for Regional Primacy and Strategic Autonomy” (Brookings Institution Press, 2016), former U.S. ambassadors Teresita Schaffer and Howard Schaffer explore how India is managing its evolving international role, assessing the country’s strategic vision and foreign policy, and the negotiating behavior that links the two. On April 20, The India Project at Brookings hosted a panel discussion to discuss the book and, particularly, four elements highlighted in it: India’s exceptionalism; its nonalignment and drive for “strategic autonomy;” its determination to maintain regional primacy; and, more recently, its surging economy. Join the conversation on Twitter using #IndiaHighTable Audio India at the global high table Transcript Uncorrected Transcript (.pdf) Event Materials 20160420_india_transcript Full Article
high At the Corner of Future and Main: The Benefits of High Density, Center City Development By webfeeds.brookings.edu Published On :: Mon, 20 Sep 2004 00:00:00 -0400 This keynote presentation by Bruce Katz at City Hall in Seattle describes how a vibrant center city stimulates a region's economy. The presentation also assesses how Seattle is faring on this front and what steps the city should take as it looks to the future.The metro program hosts and participates in a variety of public forums. To view a complete list of these events, please visit the metro program's Speeches and Events page which provides copies of major speeches, powerpoint presentations, event transcripts, and event summaries. Downloads Download Authors Bruce Katz Publication: Center City Seattle Open House Full Article
high A New Goal for America’s High Schools: College Preparation for All By webfeeds.brookings.edu Published On :: Thu, 14 May 2009 12:00:00 -0400 INTRODUCTION Economic inequality has been on the rise in America for more than three decades. The nation’s traditional engine for promoting equality and opportunity—its public education system—has been unable to halt that upward trend despite increased public spending at the preschool, K–12, and postsecondary levels. Meanwhile, accumulating research evidence reveals that postsecondary education has, for the past few decades, proved an increasingly powerful tool in boosting the income and economic mobility of disadvantaged students. Here we outline steps that high schools can take to increase the college readiness of poor and minority students, making it more likely that they will be accepted into and graduate from college. The annual income difference between Americans with a college degree and those with a high school degree was more than $33,000 in 2007, up from $12,500 in 1965. More to the point, long-term intergenerational data from the Panel Study of Income Dynamics show that a college degree helps disadvantaged children move up the income distribution past peers in their own generation. Adult children with parents in the bottom fifth of income, for example, nearly quadruple (from 5 percent to 19 percent) their chance of moving all the way to the top fifth by earning a college degree.But too few poor kids get a college degree. About one-third of all youngsters from the bottom fifth of family income enter college and only 11 percent get a degree. By contrast, 80 percent of those from the top fifth enter college and well over half earn a degree.Perhaps the primary reason that poor and minority students do not enter and graduate from college is that they are poorly prepared to do well there. The problem is especially evident in the huge gap between the academic achievement of white, Asian, and middle- and upper-income students as compared with black, Hispanic, and low-income students. And decades of educational reform aimed at reducing this gap have had, at best, modest success. Striking evidence of how few college freshmen meet even the most basic college preparation standards is provided by Jay Greene and Greg Forster of the Manhattan Institute. Defining minimum college readiness as receiving a high school diploma, taking courses required by colleges for basic academic preparedness, and demonstrating basic literacy skills, Greene and Forster report that only around 40 percent of white and Asian students were college ready by these criteria. But that figure was twice the 20 percent rate for black students and more than twice the 16 percent rate for Hispanic students.The latest issue of The Future of Children, devoted to exploring how to improve America’s high schools, contains several articles that touch on student preparation for postsecondary education and the world of work. An especially compelling article, written by Melissa Roderick, Jenny Nagaoka, and Vanessa Coca, of the Consortium on Chicago School Research at the University of Chicago, contains a careful analysis of how to measure whether students are ready for college and a host of proposals for actions high schools can take to increase their students’ readiness for postsecondary education. As the Roderick article and related research and analysis make clear, recent years have seen an upsurge of support for the goal of helping all students, but especially poor, urban, and minority students, prepare for college, enter college, and earn a terminal degree. Attaining that goal, we believe, would boost economic mobility in the United States and help the nation live up to its ideals of equality of educational and economic opportunity. Downloads Download Authors Ron HaskinsJames Kemple Publication: The Future of Children Full Article
high The unreal dichotomy in COVID-19 mortality between high-income and developing countries By webfeeds.brookings.edu Published On :: Tue, 05 May 2020 16:23:05 +0000 Here’s a striking statistic: Low-income and lower-middle income countries (LICs and LMICs) account for almost half of the global population but they make up only 2 percent of the global death toll attributed to COVID-19. We think this difference is unreal. Views about the severity of the pandemic have evolved a lot since its outbreak… Full Article
high High-priced drugs in Medicare Part D: Diagnosis and prescription By webfeeds.brookings.edu Published On :: Thu, 04 Jan 2018 22:06:09 +0000 Drug pricing in the U.S. is a persistently vexing policy problem. High drug prices stress consumers, payers, employers and “budgeteers”. At the same time the public demands new and better treatments, and the scientific advances that make such treatments possible. The pharmaceutical industry insists, with merit, that delivering new improved treatments, and in some cases… Full Article
high How high are infrastructure costs? Analyzing Interstate construction spending By webfeeds.brookings.edu Published On :: Mon, 19 Aug 2019 11:49:25 +0000 Although the United States spends over $400 billion per year on infrastructure, there is a consensus that infrastructure investment has been on the decline and with it the quality of U.S. infrastructure. Politicians across the ideological spectrum have responded with calls for increased spending on infrastructure to repair this infrastructure deficit. The issue of infrastructure… Full Article
high Higher power to deliver: The overlooked nexus between religion and development By webfeeds.brookings.edu Published On :: Tue, 25 Feb 2020 22:12:32 +0000 Why did some world-leading economists recently meet the Pope? It wasn’t, contrary to what one might think, to confess the sins of bad economic policy. Still, when such a meeting took place in early February, the conversation was serious. Invited by Pope Francis, thought leaders and decisionmakers in economics and global finance gathered for a… Full Article