The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.

Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

A method of treating cancer through use of guanosine 3',5'-cyclic monophosphate (cyclic GMP). Cyclic GMP decreases the number of human breast cancer and prostate adenocarcinoma as well as small-cell and squamous lung cells in culture by 30% (1 μM), 84% (1 mM), 31% (1 μM), and 30% (1 μM), respectively. Cyclic GMP decreases DNA synthesis in human pancreatic, breast, and prostate adenocarcinomas as well as small-cell and squamous cell carcinomas of the lung at its 1 μM concentration by 51%, 54%, 56%, 50% and 52%, respectively. Cyclic GMP when infused for one week decreases the tumor volume of human pancreatic adenocarcinomas in athymic mice 95% compared to untreated animals with human pancreatic adenocarcinomas.

Process for the preparation of vinyl aromatic (co) polymers grafted on an elastomer in a controlled manner, comprising: dissolving an elastomer functionalized with bromoalkanes and nitroxy radicals, soluble in non-polar solvents, in a liquid phase consisting of a mixture of vinyl aromatic monomer(s)/polymerization solvent; feeding at least one radical initiator to the mixture, containing the functionalized elastomer in solution, and polymerizing the mixture thus obtained at a temperature higher than or equal to 1200 C; recovering the vinyl aromatic (co) polymer obtained after devolatization; and recycling the solvent/monomer(s) mixture, coming from the devolatization, to step (a).

The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent.

The present invention discloses a log sawing system comprising multiple cutting blades. The multiple cutting blades are positioned to cut laterally or perpendicular to the centerline of the log which is to be cut. The logs are transported into cutting position using some type of log positioner. The multiple cutting blades are rotatably mounted on an arm which is pivotally mounted on a shaft in groups, being driven by an electrical or like motor, all of which are mounted onto a platform positioned adjacent to the log to be cut. Hydraulic lifters are used to partially rotate the saw blades into the cutting position adjacent the log. Means utilizing a computer and lasers are provided to develop a log cutting solution to best utilize the logs.

An emulsion is provided including: an oil component and a water component, the oil component including: fish oil triglycerides in an amount of about 60% to about 90% based on the weight of the oil component; wherein the fish oil triglycerides include omega-3 fatty acids, expressed as triglycerides, in an amount of at least 60%, based on the total weight of the fatty acids of the fish oil triglycerides; wherein the fish oil triglycerides include a total amount of EPA and DHA, expressed as triglycerides, of at least 45%, based on the total weight of the fatty acids of the fish oil triglycerides; and, at least one medium-chain triglyceride, wherein a total amount of the at least one medium-chain triglyceride is from about 10% to about 40% based on the weight of the oil component.

Methods for creating customized children's storybooks with fingerprint art using fingerprint-ready templates stored in association with a software application on a desktop computer, a tablet computer, or a smart phone. The methods include the use of preconfigured templates and prompted discussions that elicit responses from the child to create text for the storybook. The text may be generated by speech recognition software processing digital audio recordings of the child's responses. A digital image of the child's fingerprint is acquired and the fingerprint image and/or the storybook scenes are scaled to fit each other. Fingerprint-ready image templates are used to facilitate the creation of fingerprint art. A completed page image is formed by digitally inserting a fingerprint into the fingerprint-shaped area, and if desired, coloring the image or drawing a scene around the image. When the scenes are completed the software application compiles the book pages and prints the same.

A microelectronic assembly and method of making, which includes a first microelectronic element (including a substrate with first and second opposing surfaces, a semiconductor device, and conductive pads at the first surface which are electrically coupled to the semiconductor device) and a second microelectronic element (including a handler with first and second opposing surfaces, a second semiconductor device, and conductive pads at the handler first surface which are electrically coupled to the second semiconductor device). The first and second microelectronic elements are integrated such that the second surfaces face each other. The first microelectronic element includes conductive elements each extending from one of its conductive pads, through the substrate to the second surface. The second microelectronic element includes conductive elements each extending between the handler first and second surfaces. The conductive elements of the first microelectronics element are electrically coupled to the conductive elements of the second microelectronics element.

Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.

A soybean cultivar designated 131TD735 is disclosed. The invention relates to the seeds of soybean cultivar 131TD735, to the plants of soybean 131TD735, to plant parts of soybean cultivar 131TD735 and to methods for producing a soybean plant produced by crossing soybean cultivar 131TD735 with itself or with another soybean variety. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. This invention also relates to soybean cultivars or breeding cultivars and plant parts derived from soybean cultivar 131TD735, to methods for producing other soybean cultivars, lines or plant parts derived from soybean cultivar 131TD735 and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants and plant parts produced by crossing the cultivar 131TD735 with another soybean cultivar.

A novel soybean variety, designated XB32T13 is provided. Also provided are the seeds of soybean variety XB32T13, cells from soybean variety XB32T13, plants of soybean XB32T13, and plant parts of soybean variety XB32T13. Methods provided include producing a soybean plant by crossing soybean variety XB32T13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB32T13, methods for producing other soybean varieties or plant parts derived from soybean variety XB32T13, and methods of characterizing soybean variety XB32T13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB32T13 are further provided.

A novel soybean variety, designated XB52J13 is provided. Also provided are the seeds of soybean variety XB52J13, cells from soybean variety XB52J13, plants of soybean XB52J13, and plant parts of soybean variety XB52J13. Methods provided include producing a soybean plant by crossing soybean variety XB52J13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB52J13, methods for producing other soybean varieties or plant parts derived from soybean variety XB52J13, and methods of characterizing soybean variety XB52J13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB52J13 are further provided.

A novel soybean variety, designated XB47X13 is provided. Also provided are the seeds of soybean variety XB47X13, cells from soybean variety XB47X13, plants of soybean XB47X13, and plant parts of soybean variety XB47X13. Methods provided include producing a soybean plant by crossing soybean variety XB47X13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB47X13, methods for producing other soybean varieties or plant parts derived from soybean variety XB47X13, and methods of characterizing soybean variety XB47X13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB47X13 are further provided.

The present invention provides an inbred corn line designated FF7354, methods for producing a corn plant by crossing plants of the inbred line FF7354 with plants of another corn plant. The invention further encompasses all parts of inbred corn line FF7354, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line FF7354, and plants produced according to these methods.

A system for radioisotope production uses fast-neutron-caused fission of depleted or naturally occurring uranium targets in an irradiation chamber. Fast fission can be enhanced by having neutrons encountering the target undergo scattering or reflection to increase each neutron's probability of causing fission (n, f) reactions in U-238. The U-238 can be deployed as one or more layers sandwiched between layers of neutron-reflecting material, or as rods surrounded by neutron-reflecting material. The gaseous fission products can be withdrawn from the irradiation chamber on a continuous basis, and the radioactive iodine isotopes (including I-131) extracted.

System, including a code scanner, for using multi-function codes, such as multi-function QR codes, MobiTags, ShotCodes, 2-dimensional bar codes, 3-dimensional bar codes, or images to open multiple ports of a telephone device. One of the ports is a text port, enabling the system to obtain the telephone number of a device that reads a code associated with an item and then generate a lead for follow-up by an agent. The lead is sent to the agent via a text or email message. The system may also pass the lead to other agents if the first agent doesn't respond, and it may also send additional information to the telephone device. The system may include a database of item-associated information and the capability of accessing the item-associated information for inclusion in outgoing messages to the agents and/or the telephone device.

Flip-flops in a monolithic three-dimensional (3D) integrated circuit (IC)(3DIC) and related method are disclosed. In one embodiment, a single clock source is provided for the 3DIC and distributed to elements within the 3DIC. Delay is provided to clock paths by selectively controllable flip-flops to help provide synchronous operation. In certain embodiments, 3D flip-flop are provided that include a master latch disposed in a first tier of a 3DIC. The master latch is configured to receive a flip-flop input and a clock input, the master latch configured to provide a master latch output. The 3D flip-flop also includes at least one slave latch disposed in at least one additional tier of the 3DIC, the at least one slave latch configured to provide a 3DIC flip-flop output. The 3D flip-flop also includes at least one monolithic intertier via (MIV) coupling the master latch output to an input of the slave latch.

The invention relates to an X-ray device comprising an x-ray sensitive camera for creating tomograms, especially panoramic tomograms. Means for creating 3D shots of a partial volume of the mandibular arch are also provided, said 3D shots being created especially by a second image receiver for creating a 2D shot and means for taking a plurality of 2D shots from different directions and creating a 3D shot therefrom, preferably according to conebeam technology with the associated reconstruction algorithms. The x-ray sensitive camera comprises a first x-ray sensitive image receiver for creating a tomogram, and a second x-ray sensitive image receiver for creating plane shots.

The present invention relates to a system, method, and apparatus that include a novel way of automatically assigning materials to 3D CAD models. A predefined material template specifies that a particular part or material name is assigned to a particular material such that all instances of the particular part name are assigned or modified automatically by the material template. By having a consistent naming convention for the parts in the CAD file, this material assignment can be performed automatically when the CAD file is imported or viewed.

In one embodiment, a viewer executing on an electronic device having a touch sensitive display shows a three-dimensional (3D) model of a building created using computer aided design (CAD) software. A plurality of selectable interface nodes are provided at respective locations within the 3D model. Each interface node is linked to at least one corresponding two-dimensional (2D) construction drawing that shows a section view, a plan view, an elevation view or a detail view of the building related to the location of the interface node. In response to receiving input from a user indicating selection of a particular interface node, a menu is displayed with one or more selectable menu options. In response to receiving additional input from the user indicating selection of a particular menu option, a corresponding 2D construction drawing for the particular interface node is displayed in context of the 3D model of the building.

A 360-degree freedom electric cord device system contains and manages automatic extension and retraction of an electric cord/cable supplying power to a push/pull-type electric machine, either self-propelled or not, for intended displacement or steering on a surface by a user. The 360-degree freedom electric cord device system, partly mounted on the electric machine, allows the power cord to clear obstacles on the surface and includes a self-retracting spool to automatically extend and rewind the power cord and continuously keeps physical tension therein, in a straight line and a natural position, during the displacement in any direction of the electric machine. With a ratchet mechanism, the device can also suitably be used independently of the machine as an electric retractable extension cord reel.

Wood particles having fibers aligned in a grain, wherein: the wood particles are characterized by a length dimension (L) aligned substantially parallel to the grain, a width dimension (W) normal to L and aligned cross grain, and a height dimension (H) normal to W and L; the L×H dimensions define two side surfaces characterized by substantially intact longitudinally arrayed fibers; the W×H dimensions define two cross-grain end surfaces characterized individually as aligned either normal to the grain or oblique to the grain; the L×W dimensions define two substantially parallel top and bottom surfaces; and, a majority of the W×H surfaces in the mixture of wood particles have end checking.

A package includes a first die and a second die underlying the first die and in a same first die stack as the first die. The second die includes a first portion overlapped by the first die, and a second portion not overlapped by the first die. A first Thermal Interface Material (TIM) is over and contacting a top surface of the first die. A heat dissipating lid has a first bottom surface contacting the first TIM. A second TIM is over and contacting the second portion of the second die. A heat dissipating ring is over and contacting the second TIM.

A foldable children's tricycle comprises a tricycle front, a link device and a positioning assembly. The tricycle can be folded by using the link device, which can save space and reduce transportation cost. In addition, an inserting rod of the positioning assembly can be engaged in first or second positioning grooves of the link device, so the tricycle can be fixed when expanding or folding, thus improving the structural strength of the tricycle.

A children's tray with a placement indicator includes a tray and a groove/spot formed in the tray to indicate where an eating item (including food, utensils, or dishware) is to be placed. The tray can be mounted, removably or fixedly, to a variety of child support structures, including high chairs, booster seats and bouncers and includes a wall around the periphery intended to prevent items from falling off of the tray. The groove/spot formed in the tray may be formed from of a material having a higher coefficient of friction than the material used to form the tray. The groove/spot formed in the tray may be formed from of a material having a different color than the material used to form the tray.

Polypeptides capable of binding human IL-13 and/or of binding human IL-4 in the presence of IL-4 Rα can be used in medicine, in diagnosis and in screening for agonists/antagonists of IL-13/IL-4. One such polypeptide is shown in FIG. 1.

A manufacture method of a three dimensional (3D) braided composite tube with a throat section includes: providing an assembled mandrel comprising an upper mandrel and a lower mandrel, and braiding an 3D braided inner layer on the upper mandrel; winding fiber yarns to form a fiber yarn layer over the 3D braided inner layer; tightening the 3D braided inner layer to the assembled mandrel by an appropriate tension force when winding; and infiltrating resin and increasing temperature to cure the resin for obtaining a composite tube with a narrower throat section. The present invention takes advantage of winding fiber yarn outer layer to keep the radius of the throat of the 3D braided inner layer to meet design requirement. Additionally, the hoop strength of the throat section is increased so that the metal shell can be made thinner to reduce the weight of the rocket nozzle.

An Engineer's View (EV) wireless video system for powered and unpowered model railroad engines is disclosed. The invention uses commercially available wireless spy cameras, powered by a custom power supply circuit which is compatible with either DC or DCC track systems. The present invention is compatible with all commercial model railroad gauge diesel engines including HO and N Gauge or may be factory installed. The EV system demonstrates a remarkably stable and realistic image of a model railroad layout. Moreover, the present invention may also provide a stable source of power to the engine where stalling could occur at points of track defects.

Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

The method for forming a 3-D metal object by 3-D printing or injection molding comprising providing as a feed material metal particles formed by establishing multiple metal components in a primary billet of a ductile material, working the primary billet through a series of reduction steps to form the components into elongated elements, leaching the ductile material from the elongated elements and reducing the length to short uniform lengths.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

The nurse's travel bag is a travel bag or suitcase for storing a plurality of medical devices and/or supplies that a nurse may need. The nurse's travel bag includes a suitcase with a plurality of compartments integrated inside of and along the exterior of the suitcase. Each storage compartment consists of a clear plastic storage compartment, an identifying label, and a zipper for opening and closing said compartment. The suitcase may include rollers and a telescoping handle, which enable rolling of said suitcase. The suitcase includes a collapsible cooler and sharps container that extend from opposing side surfaces, and enable storage therein.

Disclosed herein is a method of setting valid output sections of a 3-axis acceleration sensor mounted within a tire of a vehicle, including setting an output signal of the 3-axis acceleration sensor in the z-axis direction as a reference signal, setting a specific section of the output signal in the z-axis direction as a valid section where a part of the tire where the 3-axis acceleration sensor is mounted contacts a road surface, and setting sections of output signals of the 3-axis acceleration sensor in the x-axis and y-axis directions corresponding to the valid section in the z-axis direction as valid sections in the x-axis and y-axis directions. The method sets precise valid sections applied to detect information between the tire and a ground surface so as to minimize a component of a noise section by connecting output signals in the x-axis, y-axis and z-axis directions.

Apparatus (2) for exercising a person's calves (4) in two different ways, which apparatus (2) comprises a footrest (8), a kneerest (10), and a length of stretchable material (12) for extending between the footrest (8) and the kneerest (10), and the apparatus (2) being such that: (i) the length of stretchable material (12) is flat sided;(ii) the footrest (8) has roller means (14);(iii) the roller means (14) allows the length of stretchable material (12) to connect to the footrest (8) such that the flat sides of the length of stretchable material (12) slide over the roller means (16);(iv) the kneerest (10) has anchor means (16) for the length of stretchable material (12);(v) the anchor means (16) allows the length of stretchable material (12) to connect to the kneerest (10) such that the flat sides of the length of stretchable material (12) pass over the anchor means (16); and(vi) the footrest (8), the kneerest (10), and the length of flexible material (12) are separable from each other.

A method for processing explosives containing a high loading of CL-20 may advantageously include a binder system having naphthenic oil and/or paraffinic oil. Solid energetic ingredients are added into the binder system and mixed to form a free-flowing suspension in which the solid energetic ingredients are homogeneously mixed and coated with the binder system. The binder system is then cured and cast to form a cross-linked explosive.

The small clothes iron for use with children's clothes is a small iron when compared to a traditional clothes iron. The small clothes iron resembles a toy train wherein a front surface resembles a face of a toy character while a top surface includes a handle, control buttons, and a chimney/smokestack for refilling a water reservoir. The small clothes iron has a smaller iron surface on a bottom surface, which is useful in ironing small clothes for children and infants.

A mechanic's leaning device includes a base, an upper torso support having an adjustable first height above the base, and a combination step and knee support having an adjustable second height above the base which is less than and adjustable relative to the first height. The mechanic's leaning device can be used by mechanics of all sizes for working on a wide variety of vehicles, ranging from very small to very large.

A restraining system is configured to secure and release a rider's footwear to a vehicle footrest in response to inputs to a control interface. The vehicle is typically a motorcycle or bicycle. In the case of a motorcycle, a rider's boot is restrained to a motorcycle foot peg by the action of a restraining device. Exemplary restraining device embodiments include an electromagnet or a mechanical latch. The control interface may be located on the motorcycle handlebar or on the rider's helmet. The rider can provide the inputs directly to the control interface. Alternatively, the inputs may be received from a wireless source.

Methods and apparatus are provided for generating computer 3D models of an object, by registering two or more scans of physical models of an object. The scans may be 3D scans registered by a curve-based registration process. A method is provided for generating a 3D model of a portion of a patient's oral anatomy for use in dental restoration design. Also provided are scanning workflows for scanning physical models of an object to obtain a 3D model.

A battery electrolyte solution contains a lithium salt dissolved in a solvent phase comprising at least 10% by weight of methyl (2,2,3,3-tetrafluoropropyl) carbonate. The solvent phase comprises optionally other solvent materials such as 4-fluoroethylene carbonate and other carbonate solvents. This battery electrolyte is highly stable even when used in batteries in which the cathode material has a high operating potential (such as 4.5V or more) relative to Li/Li+. Batteries containing this electrolyte solution therefore have excellent cycling stability.

A battery electrolyte solution contains a lithium salt dissolved in a solvent phase comprising at least 10% by weight of ethyl (2,2,3,3-tetrafluoropropyl) carbonate. The solvent phase comprises optionally other solvent materials such as 4-fluoroethylene carbonate and either or both of diethyl carbonate and ethyl methyl carbonate. This battery electrolyte is highly stable even when used in batteries in which the cathode material has a high operating potential (such as 4.5V or more) relative to Li/Li+. Batteries containing this electrolyte solution therefore have excellent cycling stability.

Described herein is an arm stabilization member for dampening inadvertent movement of the arm of a user during a surgical procedure, comprising an arm support and a movement mechanism coupled to the arm support. The arm support comprises an outer frame sized to support at least a portion of the user's arm and an inner pad lining an inner surface of the outer frame and configured to conform to the user's arm. The movement mechanism comprises a counterbalance system movably connected by joints and configured to compensate for the gravitational forces exerted by the arm of the user.

A patient support apparatus having a support table, a transfer plate, which is disposed movably in relation to the support table in a direction and on which a patient is supported for a surgical intervention and/or a medical imaging examination, and a surgical head restraint unit, which is disposed on the transfer plate is provided. The patient support apparatus includes a position monitoring apparatus for monitoring and/or checking a position of the surgical head restraint unit.

Hinged assemblies, and children's products including at least one hinged assembly, include a base member and a hinged member operatively and pivotally coupled to the base member to define a hinge. The hinge is configured to release if an obstruction is positioned between the hinged member and the base member while the hinged member is being closed and if a closing torque is greater than or equal to a release torque. The hinge also may be configured to not release when an opening torque is applied when the hinged member is in its open position even when the opening torque is greater than the release torque.