ge Look: Fox rescued from between walls of home, garage By www.upi.com Published On :: Fri, 08 May 2020 15:12:34 -0400 Animal rescuers in Britain said a fox was rescued from the narrow gap between the external walls of a house and its garage. Full Article
ge Despite Flurry of Actions, Trump Administration Faces Constraints in Achieving Its Immigration Agenda By www.migrationpolicy.org Published On :: Wed, 24 Apr 2019 10:39:18 -0400 Though it has achieved success in some areas, the Trump administration’s many efforts to stiffen immigration enforcement in the U.S. interior and at the Southwest border are being consistently stymied by court injunctions, existing laws and settlements, state and local resistance, congressional pushback, and migration pressures that are beyond the government’s ability to swiftly address, as this article explores. Full Article
ge Crisis in the Courts: Is the Backlogged U.S. Immigration Court System at Its Breaking Point? By www.migrationpolicy.org Published On :: Tue, 01 Oct 2019 12:31:23 -0400 With a backlog of more than 1 million removal cases, the U.S. immigration court system is in crisis. Pressure from external forces, internal challenges, and lagging resources for the courts at a time of massive increases in spending on immigration enforcement have contributed to the backlog. This article explores how the system got to the breaking point, and what opportunities for reform exist. Full Article
ge Drug may curb dangerous urges in pedophiles, study says By www.upi.com Published On :: Sat, 09 May 2020 01:31:06 -0400 A testosterone-lowering drug can reduce male pedophiles' risk of sexually abusing children, according to a new Swedish study. Full Article
ge New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 2) By care.diabetesjournals.org Published On :: 2014-12-01 Hannele Yki-JärvinenDec 1, 2014; 37:3235-3243Emerging Technologies and Therapeutics Full Article
ge Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON By care.diabetesjournals.org Published On :: 2016-05-01 Muh Geot WongMay 1, 2016; 39:694-700Cardiovascular Disease and Diabetes Full Article
ge The Fallacy of Average: How Using HbA1c Alone to Assess Glycemic Control Can Be Misleading By care.diabetesjournals.org Published On :: 2017-08-01 Roy W. BeckAug 1, 2017; 40:994-999Perspectives in Care Full Article
ge National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2014-01-01 Linda HaasJan 1, 2014; 37:S144-S153National Standards Full Article
ge Pathways to Quality Inpatient Management of Hyperglycemia and Diabetes: A Call to Action By care.diabetesjournals.org Published On :: 2013-07-01 Boris DrazninJul 1, 2013; 36:1807-1814Perspectives in Care Full Article
ge Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
ge Personalized Management of Hyperglycemia in Type 2 Diabetes: Reflections from a Diabetes Care Editors' Expert Forum By care.diabetesjournals.org Published On :: 2013-06-01 Itamar RazJun 1, 2013; 36:1779-1788Diabetes Care Expert Forum Full Article
ge Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study By care.diabetesjournals.org Published On :: 2016-01-01 Joseph HensonJan 1, 2016; 39:130-138IDF-ADA Translational Symposium Full Article
ge A Prospective Study of Fruit and Vegetable Intake and the Risk of Type 2 Diabetes in Women By care.diabetesjournals.org Published On :: 2004-12-01 Simin LiuDec 1, 2004; 27:2993-2996Brief Reports Full Article
ge Effects of Gastric Bypass Surgery in Patients With Type 2 Diabetes and Only Mild Obesity By care.diabetesjournals.org Published On :: 2012-07-01 Ricardo V. CohenJul 1, 2012; 35:1420-1428Diabetes Care Symposium Full Article
ge Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial By care.diabetesjournals.org Published On :: 2016-01-01 Saila B. KoivusaloJan 1, 2016; 39:24-30Considerations in the Management of Gestational Diabetes Mellitus Full Article
ge Lipoprotein Physiology in Nondiabetic and Diabetic States: Relationship to Atherogenesis By care.diabetesjournals.org Published On :: 1991-09-01 Henry N GinsbergSep 1, 1991; 14:839-855Diet and Diabetes Full Article
ge Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis By care.diabetesjournals.org Published On :: 2016-07-01 Sunder MudaliarJul 1, 2016; 39:1115-1122Diabetes Care Symposium Full Article
ge Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
ge Globalization of Diabetes: The role of diet, lifestyle, and genes By care.diabetesjournals.org Published On :: 2011-06-01 Frank B. HuJun 1, 2011; 34:1249-1257Kelly West Award Lecture Full Article
ge Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry By care.diabetesjournals.org Published On :: 2015-06-01 Kellee M. MillerJun 1, 2015; 38:971-978Type 1 Diabetes at a Crossroads Full Article
ge Australian Cardinal George Pell knew of child abuse, report says By www.upi.com Published On :: Thu, 07 May 2020 07:21:04 -0400 Pell, a former Vatican treasurer, was aware of child abuse being committed by clergy by 1973, contrary to his long-held assertions that he knew nothing about the accusations. Full Article
ge Report: South Korea tested new ballistic missile with larger warhead By www.upi.com Published On :: Thu, 07 May 2020 09:35:46 -0400 South Korea's military tested a ballistic missile capable of carrying a 2-ton warhead in March, according to local reports on Thursday. Full Article
ge Former intelligence chief Mustafa al-Kadhini named Iraqi prime minister By www.upi.com Published On :: Thu, 07 May 2020 10:36:35 -0400 Former intelligence chief Mustafa al-Kadhini was named prime minister of Iraq on Thursday, after five months of political instability in the Middle Eastern nation. Full Article
ge Northrop Grumman, Raytheon partner for Next Generation Interceptor bid By www.upi.com Published On :: Mon, 04 May 2020 13:19:43 -0400 Northrop Grumman Corp. and Raytheon Missiles and Defense will partner to develop the Defense Department's next missile interceptor, they announced on Monday. Full Article
ge Coast Guard names Rear Adm. Melissa Bert as first female judge advocate general By www.upi.com Published On :: Mon, 04 May 2020 16:56:44 -0400 The U.S. Coast Guard named Rear Adm. Melissa Bert as its first female judge advocate and chief counsel, its top legal position. Full Article
ge Blue Angels to fly over Dallas, Houston, New Orleans on Wednesday By www.upi.com Published On :: Tue, 05 May 2020 13:47:57 -0400 The U.S. Navy Flight Demonstration Squadron, also known as the Blue Angels, will fly over Dallas/Fort Worth, Houston and New Orleans Wednesday to honor frontline workers fighting the COVID-19 pandemic. Full Article
ge Blue Angels to fly over Jacksonville, Miami on Friday By www.upi.com Published On :: Thu, 07 May 2020 15:45:25 -0400 The U.S. Navy Flight Demonstration Squadron, the Blue Angels, will fly over Jacksonville and Miami, Fla., Friday as part of a nationwide tour to show appreciation for healthcare workers and frontline responders. Full Article
ge Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight By care.diabetesjournals.org Published On :: 2018-07-01 Jennifer M. YamamotoJul 1, 2018; 41:1346-1361Reconsidering Pregnancy With Diabetes Full Article
ge Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations By care.diabetesjournals.org Published On :: 2016-06-01 Francesco RubinoJun 1, 2016; 39:861-877Metabolic Surgery and the Changing Landscape for Diabetes Care Full Article
ge Impact of Fat, Protein, and Glycemic Index on Postprandial Glucose Control in Type 1 Diabetes: Implications for Intensive Diabetes Management in the Continuous Glucose Monitoring Era By care.diabetesjournals.org Published On :: 2015-06-01 Kirstine J. BellJun 1, 2015; 38:1008-1015Type 1 Diabetes at a Crossroads Full Article
ge Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers By care.diabetesjournals.org Published On :: 2018-04-01 William J. JeffcoateApr 1, 2018; 41:645-652Perspectives in Care Full Article
ge Management of Inpatient Hyperglycemia and Diabetes in Older Adults By care.diabetesjournals.org Published On :: 2017-04-01 Guillermo E. UmpierrezApr 1, 2017; 40:509-517Emerging Science and Concepts for Management of Diabetes and Aging Full Article
ge Glucose Management Indicator (GMI): A New Term for Estimating A1C From Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2018-11-01 Richard M. BergenstalNov 1, 2018; 41:2275-2280Perspectives in Care Full Article
ge What Should Be the Target Blood Pressure in Elderly Patients With Diabetes? By care.diabetesjournals.org Published On :: 2016-08-01 Anna SoliniAug 1, 2016; 39:S234-S243VI. Cardiovascular Risk and Diabetes Full Article
ge Globalization of Diabetes: The role of diet, lifestyle, and genes By care.diabetesjournals.org Published On :: 2011-06-01 Frank B. HuJun 1, 2011; 34:1249-1257Kelly West Award Lecture Full Article
ge 2017 National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2017-10-01 Joni BeckOct 1, 2017; 40:1409-1419National Standards Full Article
ge Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
ge 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) By care.diabetesjournals.org Published On :: 2020-02-01 John B. BuseFeb 1, 2020; 43:487-493Consensus Report Update Full Article
ge Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE The MHC region harbors the strongest loci for latent autoimmune diabetes in adults (LADA); however, the strength of association is likely attenuated compared with that for childhood-onset type 1 diabetes. In this study, we recapitulate independent effects in the MHC class I region in a population with type 1 diabetes and then determine whether such conditioning in LADA yields potential genetic discriminators between the two subtypes within this region. RESEARCH DESIGN AND METHODS Chromosome 6 was imputed using SNP2HLA, with conditional analysis performed in type 1 diabetes case subjects (n = 1,985) and control subjects (n = 2,219). The same approach was applied to a LADA cohort (n = 1,428) using population-based control subjects (n = 2,850) and in a separate replication cohort (656 type 1 diabetes case, 823 LADA case, and 3,218 control subjects). RESULTS The strongest associations in the MHC class II region (rs3957146, β [SE] = 1.44 [0.05]), as well as the independent effect of MHC class I genes, on type 1 diabetes risk, particularly HLA-B*39 (β [SE] = 1.36 [0.17]), were confirmed. The conditional analysis in LADA versus control subjects showed significant association in the MHC class II region (rs3957146, β [SE] = 1.14 [0.06]); however, we did not observe significant independent effects of MHC class I alleles in LADA. CONCLUSIONS In LADA, the independent effects of MHC class I observed in type 1 diabetes were not observed after conditioning on the leading MHC class II associations, suggesting that the MHC class I association may be a genetic discriminator between LADA and childhood-onset type 1 diabetes. Full Article
ge Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE The long-term influences of sex hormone administration on insulin sensitivity and incretin hormones are controversial. We investigated these effects in 35 transgender men (TM) and 55 transgender women (TW) from the European Network for the Investigation of Gender Incongruence (ENIGI) study. RESEARCH DESIGN AND METHODS Before and after 1 year of gender-affirming hormone therapy, body composition and oral glucose tolerance tests (OGTTs) were evaluated. RESULTS In TM, body weight (2.8 ± 1.0 kg; P < 0.01), fat-free mass (FFM) (3.1 ± 0.9 kg; P < 0.01), and waist-to-hip ratio (–0.03 ± 0.01; P < 0.01) increased. Fasting insulin (–1.4 ± 0.8 mU/L; P = 0.08) and HOMA of insulin resistance (HOMA-IR) (2.2 ± 0.3 vs. 1.8 ± 0.2; P = 0.06) tended to decrease, whereas fasting glucose (–1.6 ± 1.6 mg/dL), glucose-dependent insulinotropic polypeptide (GIP) (–1.8 ± 1.0 pmol/L), and glucagon-like peptide 1 (GLP-1) (–0.2 ± 1.1 pmol/L) were statistically unchanged. Post-OGTT areas under the curve (AUCs) for GIP (2,068 ± 1,134 vs. 2,645 ± 1,248 [pmol/L] x min; P < 0.01) and GLP-1 (2,352 ± 796 vs. 2,712 ± 1,015 [pmol/L] x min; P < 0.01) increased. In TW, body weight tended to increase (1.4 ± 0.8 kg; P = 0.07) with decreasing FFM (–2.3 ± 0.4 kg; P < 0.01) and waist-to-hip ratio (–0.03 ± 0.01; P < 0.01). Insulin (3.4 ± 0.8 mU/L; P < 0.01) and HOMA-IR (1.7 ± 0.1 vs. 2.4 ± 0.2; P < 0.01) rose, fasting GIP (–1.4 ± 0.8 pmol/L; P < 0.01) and AUC GIP dropped (2,524 ± 178 vs. 1,911 ± 162 [pmol/L] x min; P < 0.01), but fasting glucose (–0.3 ± 1.4 mg/dL), GLP-1 (1.3 ± 0.8 pmol/L), and AUC GLP-1 (2,956 ± 180 vs. 2,864 ± 93 [pmol/L] x min) remained unchanged. CONCLUSIONS In this cohort of transgender persons, insulin sensitivity but also post-OGTT incretin responses tend to increase with masculinization and to decrease with feminization. Full Article
ge A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone. RESEARCH DESIGN AND METHODS Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy—both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard stopping rules once 73, 146, and ultimately 220 patients completed the 12-week treatment phase. RESULTS At the first analysis point, the active TWO2 arm was found to be superior to the sham arm, with a closure rate of 41.7% compared with 13.5%. This difference in outcome produced an odds ratio (OR) of 4.57 (97.8% CI 1.19, 17.57), P = 0.010. After adjustment for University of Texas Classification (UTC) ulcer grade, the OR increased to 6.00 (97.8% CI 1.44, 24.93), P = 0.004. Cox proportional hazards modeling, also after adjustment for UTC grade, demonstrated >4.5 times the likelihood to heal DFUs over 12 weeks compared with the sham arm with a hazard ratio of 4.66 (97.8% CI 1.36, 15.98), P = 0.004. At 12 months postenrollment, 56% of active arm ulcers were closed compared with 27% of the sham arm ulcers (P = 0.013). CONCLUSIONS This sham-controlled, double-blind randomized controlled trial demonstrates that, at both 12 weeks and 12 months, adjunctive cyclical pressurized TWO2 therapy was superior in healing chronic DFUs compared with optimal SOC alone. Full Article
ge The Contemporary Prevalence of Diabetic Neuropathy in Type 1 Diabetes: Findings From the T1D Exchange By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the contemporary prevalence of diabetic peripheral neuropathy (DPN) in participants with type 1 diabetes in the T1D Exchange Clinic Registry throughout the U.S. RESEARCH DESIGN AND METHODS DPN was assessed with the Michigan Neuropathy Screening Instrument Questionnaire (MNSIQ) in adults with ≥5 years of type 1 diabetes duration. A score of ≥4 defined DPN. Associations of demographic, clinical, and laboratory factors with DPN were assessed. RESULTS Among 5,936 T1D Exchange participants (mean ± SD age 39 ± 18 years, median type 1 diabetes duration 18 years [interquartile range 11, 31], 55% female, 88% non-Hispanic white, mean glycated hemoglobin [HbA1c] 8.1 ± 1.6% [65.3 ± 17.5 mmol/mol]), DPN prevalence was 11%. Compared with those without DPN, DPN participants were older, had higher HbA1c, had longer duration of diabetes, were more likely to be female, and were less likely to have a college education and private insurance (all P < 0.001). DPN participants also were more likely to have cardiovascular disease (CVD) (P < 0.001), worse CVD risk factors of smoking (P = 0.008), hypertriglyceridemia (P = 0.002), higher BMI (P = 0.009), retinopathy (P = 0.004), reduced estimated glomerular filtration rate (P = 0.02), and Charcot neuroarthropathy (P = 0.002). There were no differences in insulin pump or continuous glucose monitor use, although DPN participants were more likely to have had severe hypoglycemia (P = 0.04) and/or diabetic ketoacidosis (P < 0.001) in the past 3 months. CONCLUSIONS The prevalence of DPN in this national cohort with type 1 diabetes is lower than in prior published reports but is reflective of current clinical care practices. These data also highlight that nonglycemic risk factors, such as CVD risk factors, severe hypoglycemia, diabetic ketoacidosis, and lower socioeconomic status, may also play a role in DPN development. Full Article
ge Refugees and Asylees in the United States By www.migrationpolicy.org Published On :: Tue, 11 Jun 2019 16:21:01 -0400 The United States has historically been the top country for refugee resettlement, but was surpassed in 2018 by Canada amid record cuts to admissions by the Trump administration. Approximately 22,500 refugees were resettled in the United States during fiscal year 2018, as well as 26,500 asylees. This article examines where these newcomers came from and many other characteristics, including religious affiliation, age, and gender. Full Article
ge Amid an Unfolding Humanitarian Crisis in Syria, the European Union Faces the Perils of Devolving Migration Management to Turkey By www.migrationpolicy.org Published On :: Fri, 20 Mar 2020 10:00:26 -0400 The high-stakes gambit taken by Turkish President Recep Tayyip Erdoğan to allow tens of thousands of asylum seekers and migrants free movement to the Greek border demonstrated the fragility of the EU-Turkey deal and the European Union's broader approach to outsource migration management to third countries. This article examines the causes for the tensions, the EU approach to external partnerships, and a hardening European attitude towards unwanted arrivals. Full Article
ge International Experience Suggests Safe Third-Country Agreement Would Not Solve the U.S.-Mexico Border Crisis By www.migrationpolicy.org Published On :: Mon, 24 Jun 2019 10:44:06 -0400 While safe third-country agreements appear to hold the potential of deterring new asylum claims, experience suggests this may be a false promise. As the Trump administration explores the possibility of such agreements with Mexico and Guatemala, this commentary examines the evidence of safe third-country arrangements in Europe, finding them difficult to enforce and playing little role in deterring new claims. Full Article
ge As the United States Resettles Fewer Refugees, Some Countries and Religions Face Bigger Hits than Others By www.migrationpolicy.org Published On :: Mon, 23 Sep 2019 15:09:56 -0400 Even as refugee admissions have dropped sharply during the Trump administration, some countries and religions have been significantly more affected than others, as this commentary explores. In fiscal year 2019, 79 percent of refugees were Christian and 16 percent Muslim—as compared to 44 percent Christian and 46 percent Muslim in fiscal year 2016, which was the last full year of the Obama administration. Full Article
ge The Future of Refugee Resettlement: Made in Europe? By www.migrationpolicy.org Published On :: Sat, 08 Feb 2020 19:39:19 -0500 Europe's refugee resettlement capacity has grown dramatically, with resettlement places more than doubling since 2014, even as European countries have become an emerging center for innovation. As Europe accounts for a rising share of resettlement worldwide, will European policymakers claim a leadership role in shaping the global resettlement agenda or fall into this position by default? Full Article
ge As COVID-19 Slows Human Mobility, Can the Global Compact for Migration Meet the Test for a Changed Era? By www.migrationpolicy.org Published On :: Mon, 27 Apr 2020 16:05:08 -0400 The coronavirus pandemic dramatically reshaped how human mobility is managed just as the Global Compact for Safe, Orderly, and Regular Migration was beginning to move from paper to implementation. As governments face pressing public-health, economic, and other concerns in responding to COVID-19, this MPI Europe commentary explores whether the first comprehensive global agreement on migration can adjust to a changed reality. Full Article
ge A Proxy War on Minorities? India Crafts Citizenship and Refugee Policies through the Lens of Religion By www.migrationpolicy.org Published On :: Wed, 15 Apr 2020 21:34:32 -0400 The Modi government's push for a Citizenship Amendment Act and National Register of Citizens sparked deadly riots and chilled India's 200 million Muslims, who fear being relegated to second-class citizenship—and for some, even statelessness. This article explores actions by Modi's Bharatiya Janata Party, the significance of Bangladeshi illegal immigration as a driver, and what a register of citizens in Assam might mean for India. Full Article
ge Beyond Walls and Tariffs: Responding to Migration Challenges at the U.S.-Mexico Border By www.migrationpolicy.org Published On :: Tue, 18 Jun 2019 10:17:39 -0400 This event organized by the Migration Policy Institute and American Enterprise Institute features a conversation on U.S.-Mexico border conditions, as well as policy responses and regional cooperation on illegal immigration. Full Article