Gianna Bryant was named an honorary draft pick.

Avery played Uncle Phil and passed away in 2013.

Find out how artists prepare to perform on the main stage!

Rihanna takes the stage to honor Mary J. Blige.

Taraji P. Henson honors media mogul Tyler Perry.

Nipsey Hussle was a revolutionary.

He called the film a "love letter” to New Yorkers.

Rihanna takes the stage to honor Mary J. Blige.

Taraji P. Henson honors media mogul Tyler Perry.

Nipsey Hussle was a revolutionary.

The gymnast turned 23 years old.

Today I said goodbye to the most amazing, resilient, loving cat in the world. After fighting a myriad of diseases like a champ, her body finally tired

Our Beloved Denver (Big Guy), Thank you for teaching us the true meaning of what love was always meant to be. You were a beautiful dog with a beautiful

My dear, beloved friend, whom I loved more than life itself, is gone. My darling Reggie, the Plymouth Rock rooster, was snatched from my arms by a sudden

Turner, Our boy always loving, playful. We will miss you but, we know it's time. We have held you, given you a thousand kisses, and told you how much

I've been reading these stories about beloved pets who died at such young ages, so I feel very blessed to have had you for 14 years. Thank you very much

Our beautiful 23 year old long haired tabby Sophie died peacefully in my husband's arms this week on 19 June 2013 - my birthday. The pain is unbearable

You were the perfect companion. We did not share your life on earth for very long, just 6 short years. I feel privileged to have been part of your life

It's so hard to believe it has now been a year since you went to Rainbow Bridge. I miss you just as much now as I did the day you passed. You will

Yesterday I lost my best friend. Nine years ago you saved my life and brought me happiness every day since. Selfishly I wanted to keep you around forever

Dude you were the best dog ever and I feel sad that we didn't tell you this every day. Yes, you drove us nuts by stealing the cats food and sleeping on

Jason: It's been one month now since you have gone to Rainbow Bridge. Jason your love was unconditional. You have left my life, but you will never leave

Pixie, you came to us beaten, starved, scared and lonely. No one wanted to take on a rescue Staffordshire Bull Terrier, but we did as company for our

Saffron, you were the most perfect being that I could ever envision. You were my sunshine. I miss you beyond words, my little Spoopa Roopa. How can we

Hey Jason! Just checking to see how you are doing at Rainbow Bridge? Hope you are making friends and being a good boy! I missed you so much my baby,

Jess came to me in June 1999 as a birthday gift. She was beautiful white with some brown and black. She was the best birthday present that I ever got or

My Sweet Toby. You were only with us for a short time and was just 15 days shy of 5 months. Why the door had to open when it did, why you ran into the

Khan-li my darling boy you were and always will be the Apple of my Eye, The Love Of My Life My Heart and all that is wonderful. The memories I have of

2 days ago I lost my best friend. Nine years ago you saved my life and stole my heart. You brought me happiness at my lowest point and gave me reason to

My darling, all of Mama's love. You have gone leaving a void in my life. I still hear you sigh, and the patter of your feet up the steps, and the sound

To my beautiful little girl Sassy, I hope wherever you are you are happy and well. I look at your photos that are all around the house and wish you were

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

As climate change accelerates, IBM is galvanizing the global science community with a massive infusion of computing resources, weather data, and cloud services to help researchers examine the effects of climate change, and explore strategies to mitigate its effects. IBM pledges to help direct the equivalent of up to $200 million for up to five climate-related projects judged to offer the greatest potential impact, and will then broadly share the experiments' results.

1. Tributes flow after death of veteran journalist Frank Crook  Sydney Morning Herald
2. Editor, broadcaster, raconteur and writer’s writer Frank Crook dies  Daily Telegraph
3. View Full coverage on Google News

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Alan Gilmour from Glasgow City Community Health Partnership who participated in the PROP2 programme. This research aimed to gain an understanding of how training and information support contributes to positive outcomes for carers. It provided a range of information to answer specific questions such as: • Do carers feel that their needs are identified appropriately at different stages of their journey? • Does training contribute to the carer’s outcomes? • What are the barriers to carers engaging in training?

Great leaders are like mirrors. What they want to see in their team they often exhibit in themselves, even if that means facing things they’d prefer not to. Can a handful of leadership attributes define every great leader? Or could you have a combination of many skills and still be a great leader? Could a [...]Read More...

Girls are great at math. But if they’re even better at reading, they might be more motivated to choose a humanities-focused career.