It is reported today in the media that a Deputy District Judge in the South Shields County Court has made a finding against MBNA ("the Creditor") in respect of various aspects of the enforceability of a credit card agreement and a payment protection...

...

We will never fully know what Iran and Russia actually think of Assad or each other’s historic role in Syria.

Negotiations between China and its Southeast Asian neighbours for a South China Sea code of conduct have been postponed as the nations involved put their efforts into containing the Covid-19 pandemic, creating uncertainty about whether the two sides can work together amid rising tensions in the contested territory.Southeast Asian nations are increasingly caught in a dilemma whether to maintain relations with Beijing during the pandemic while also fearing that tensions over the disputed waters…

A throwback video of a tarot reader predicting Ranbir Kapoor's relationship with Alia Bhatt back in 2012 is going viral

Voice-enabled technology has rapidly evolved from a novel concept to one that now plays a central role in our day-to-day lives. According to a recent report from Google, 72% of people who own voice-activated speakers say their devices are used as a part...

Purpose: Oral and craniofacial conditions or diseases can impact an individual's health and quality of life. The purpose of this study was to assess the perceived oral health related quality of life (OHRQoL) of children, and evaluate the reported level of agreement between caregivers and their children.Methods: Purposive sampling was used to recruit children ages 8-15, and their caregivers from a dental clinic in a pediatric hospital for this descriptive, cross-sectional study. A modified version of a validated measure, Child Oral Health Impact Profile-Short Form (COHIP-SF), was used for a 22-item questionnaire encompassing three subscales: oral health, functional well-being, and social emotional well-being. Two additional items were included to assess child/caregiver's level of agreement. A dental chart review was also conducted to assess the child's overbite, overjet, and decayed surfaces. Data were analyzed through descriptive statistics and examined for assumptions of normality and linearity.Results: Sixty child/caregiver pairs (n=120) participated in this study. Overbite, overjet and decayed surfaces were not found to be related to any OHRQoL variable, including child/caregiver ratings and overall agreement (p>.05). Average OHRQoL scores for caregivers found to be more positive those of their children (p=.02). Agreement between caregivers and the child's gender was shown to be significant (p=.01). Female child scores differed significantly from males with respect to their caregiver responses (p=.02). Caregivers rated a higher OHRQoL for female children, thus overestimating their female child's reported OHRQoL.Conclusions: The moderate level of agreement found between children and caregivers reinforces the importance of including the child, as well as the caregiver, when assessing OHRQoL.

Antibody-drug conjugates (ADCs) employ overexpressed cell surface antigens to deliver cytotoxic payloads inside cancer cells. However, the relationship between target expression and ADC efficacy remains ambiguous. In this manuscript, we have addressed a part of this ambiguity by quantitatively investigating the effect of antigen expression levels on ADC exposure within cancer cells. Trastuzumab-valine-citrulline-monomethyl auristatin E was used as a model ADC, and four different cell lines with diverse levels of human epidermal growth factor receptor 2 (HER2) expression were used as model cells. The pharmacokinetics (PK) of total trastuzumab, released monomethyl auristatin E (MMAE), and total MMAE were measured inside the cells and in the cell culture media following incubation with two different concentrations of ADC. In addition, target expression levels, target internalization rate, and cathepsin B and MDR1 protein concentrations were determined for each cell line. All the PK data were mathematically characterized using a cell-level systems PK model for ADC. It was found that SKBR-3, MDA-MB-453, MCF-7, and MDA-MB-468 cells had ~800,000, ~250,000, ~50,000, and ~10,000 HER2 receptors per cell, respectively. A strong linear relationship (R² > 0.9) was observed between HER2 receptor count and released MMAE exposure inside the cancer cells. There was an inverse relationship found between HER2 expression level and internalization rate, and cathepsin B and multidrug resistance protein 1 (MDR1) expression level varied slightly among the cell lines. The PK model was able to simultaneously capture all the PK profiles reasonably well while estimating only two parameters. Our results demonstrate a strong quantitative relationship between antigen expression level and intracellular exposure of ADCs in cancer cells.

Upper Lutetian–Bartonian sedimentary mélanges, corresponding to ancient mud-rich submarine mass transport deposits, are widely distributed over an area c. 300 km long and tens of kilometres wide along the exhumed outer part of the External Ligurian accretionary wedge in the Northern Apennines. The occurrence of methane-derived carbonate concretions (septarians) in a specific tectonostratigraphic position below these sedimentary mélanges allows us to document the relationships among a significant period of regional-scale slope failure, climate change (the Early and Mid-Eocene Optimum stages), the dissociation of gas hydrates and accretionary tectonics during the Ligurian Tectonic Phase (early–mid-Lutetian). The distribution of septarians at the core of thrust-related anticlines suggests that the dissociation of gas hydrates was triggered by accretionary tectonics rather than climate change. The different ages of slope failure emplacement and the formation of the septarians support the view that the dissociation of gas hydrates was not the most important trigger for slope failure. The latter occurred during a tectonic quiescence stage associated with a regressive depositional trend, and probably minor residual tectonic pulses, which followed the Ligurian Tectonic Phase, favouring the dynamic re-equilibrium of the External Ligurian accretionary wedge. Our findings provide useful information for a better understanding of the factors controlling giant slope failure events in modern accretionary settings, where they may cause tsunamis.

The Northern Paraguai Belt, at the SE border of the Amazonian Craton, central Brazil, has been interpreted as a Brasiliano–Pan-African (c. 650–600 Ma) belt with a foreland basin, recording collisional polyphase tectonism and greenschist-facies metamorphism extending from the late Precambrian to the Cambrian–Ordovician. New structural investigations indicate that the older metasedimentary rocks of the Cuiabá Group represent a Tonian–Cryogenian basement assemblage deformed in two contemporaneous fault-bounded structural sub-domains of wrench-dominated (rake <10°) and contraction-dominated (rake ~30–40°) sinistral transpression, with tectonic vergence towards the SE. The younger late Cryogenian to early Cambrian sedimentary rocks lying to the NW of the Cuiabá Group are non-metamorphic and display only pervasive brittle transtension characterized by normal-oblique faults, fractures and forced drag folds with no consistent vergence pattern. Our analyses suggest that an unconformity separates the metasedimentary Cuiabá Group basement of the Northern Paraguai Belt from the unmetamorphosed sedimentary cover. It is proposed that the latter units were deposited during a post-glacial marine transgression (after c. 635 Ma) in a post-collisional basin. The Paraguai Belt basement and its post-collisional sedimentary cover share a number of significant geological similarities with sequences in the Bassarides Belt and Taoudéni Basin in the SW portion of the West African Craton.

Pharmacokinetic-based prophylaxis of replacement factor VIII (FVIII) products has been encouraged in recent years, but the relationship between exposure (factor VIII activity) and response (bleeding frequency) remains unclear. The aim of this study was to characterize the relationship between FVIII dose, plasma FVIII activity, and bleeding patterns and individual characteristics in severe hemophilia A patients. Pooled pharmacokinetic and bleeding data during prophylactic treatment with BAY 81-8973 (octocog alfa) were obtained from the three LEOPOLD trials. The population pharmacokinetics of FVIII activity and longitudinal bleeding frequency, as well as bleeding severity, were described using non-linear mixed effects modeling in NONMEM. In total, 183 patients [median age 22 years (range, 1-61); weight 60 kg (11-124)] contributed with 1,535 plasma FVIII activity observations, 633 bleeds and 11 patient/study characteristics [median observation period 12 months (3.1-13.1)]. A parametric repeated time-to-categorical bleed model, guided by plasma FVIII activity from a 2-compartment population pharmacokinetic model, described the time to the occurrence of bleeds and their severity. Bleeding probability decreased with time of study, and a bleed was not found to affect the time of the next bleed. Several covariate effects were identified, including the bleeding history in the 12-month pre-study period increasing the bleeding hazard. However, unexplained inter-patient variability in the phenotypic bleeding pattern remained large (111%CV). Further studies to translate the model into a tool for dose individualization that considers the individual bleeding risk are required. Research was based on a post-hoc analysis of the LEOPOLD studies registered at clinicaltrials.gov identifiers: 01029340, 01233258 and 01311648.

Background:

Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case–control study.

Touch is key to social relationships, and while coronavirus social distancing measures may limit physical interactions, there are still many ways to connect from afar, says evolutionary psychologist Robin Dunbar

Director Josh Trank opens up about the bitterness and resentment he felt towards comic book movies following the critical and commercial failure of his 2015 film Fantastic Four, and praises superhero filmmakers James Gunn and Zack Snyder.

Although 50 doesn't keep in touch with Marquise, he is close to his seven-year-old son Sire, whom he fathered with model Daphne Joy.

Fans think they might be going official

The course of true love never did run smooth, after all

The couple have been on and off since 2015

The actress is in lockdown with Zach Braff in Los Angeles

Ariana Grande has confirmed her relationship with real estate agent Dalton Gomez in a new music video.

Maurizio Sarri has revealed how he shared a "conflicted relationship" with his Chelsea squad but admits he misses the Premier League, describing it as "extraordinary".

A major Chinese mining company warns the Papua New Guinean Government it faces "significant negative impact" on bilateral relations with China if the company doesn't get a lease extension on a gold mine in the country.

The Duke and Duchess of Cambridge's children have been chatting to family members on...

Strictly Come Dancing star Oti Mabuse and her husband Marius Iepure have been happily...

Halifax Hospital Medical Center and Halifax Staffing Inc. (Halifax), a hospital system based in the Daytona Beach, Fla., area, have agreed to pay $85 million to resolve allegations that they violated the False Claims Act by submitting claims to the Medicare program that violated the Physician Self-Referral Law, commonly known as the Stark Law.

I also come to this discussion as my father's son. He was a man born and raised deep in the Jim Crow south. And when the time came for his eldest child and only son to take up driving lessons, dad was my teacher, imparting all the familiar lessons of keeping my eyes on the road and signaling before I turned.

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Mar 24, 2020

While the Middle East Initiative is focused entirely on the MENA region, several other Center programs are also working on issues related to the Middle East, including Future of Diplomacy, Geopolitics of Energy, and the Managing the Atom.

Mar 24, 2020

While the Middle East Initiative is focused entirely on the MENA region, several other Center programs are also working on issues related to the Middle East, including Future of Diplomacy, Geopolitics of Energy, and the Managing the Atom.

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Mar 24, 2020

While the Middle East Initiative is focused entirely on the MENA region, several other Center programs are also working on issues related to the Middle East, including Future of Diplomacy, Geopolitics of Energy, and the Managing the Atom.

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Mar 24, 2020

While the Middle East Initiative is focused entirely on the MENA region, several other Center programs are also working on issues related to the Middle East, including Future of Diplomacy, Geopolitics of Energy, and the Managing the Atom.

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Mar 24, 2020

While the Middle East Initiative is focused entirely on the MENA region, several other Center programs are also working on issues related to the Middle East, including Future of Diplomacy, Geopolitics of Energy, and the Managing the Atom.

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?

Mar 3, 2020

February 7, 2020: With the advent of the digital age and the rise of Russia and China as global powers, the EU must do more to defend itself and its relationship with the United States, according to Janne Kuusela, Director General Janne Kuusela. In an event moderated by  Cathryn Clüver Ashbrook, Executive Director of the Future of Diplomacy Project and the Project on Europe and the Transatlantic Relationship he explained why Finland could be a potential paradigm for the EU’s defense strategy. 

Jan 15, 2020

Joseph Nye writes that some decoupling of interdependence is likely, particularly in areas related to technology that directly affect national security. But will Washington and Beijing go too far?