Oh, the memories.

New to the all-star cast!

"As one sage ends, another begins..."

Look back at Mary Jane's romantic milestones.

Beau surprises Mary Jane with a life-changing request.

Mary J. Blige inspires the crowd through song.

Warwick Academy were crowned the Bermuda School Sports Federation’s Primary School Division One Netball champions at the Bernard Park Netball courts. Warwick Academy edged past Northlands Primary 5 – 4 in a very close encounter. Quin Burgess scored four goals to lead Warwick with Francesca Cressall-Haycock scoring the other. Sofia Odouri led Northlands with three […]

Bermudian sailors are competing at the Annual Internationals Comet Sailing Regatta at the Corsica River Yacht Club in Maryland this weekend. Six local sailors and their crew are taking part in the competition, which started yesterday [Oct 11] and finishes tomorrow [Oct 13]. The sailors in action are Rudy Bailey and his crew George Bailey, […]

Somerset Primary School students recently hosted an International Dinner for students and parents, where the students highlighted the culture and cuisine of countries, including Japan, Mexico, India, and Bermuda. The event offered a variety of dishes for attendees to sample, celebrating the diversity within the school community. In honor of Diwali, the PTA also organized […]

Somerset Primary School is set to host its International Day Dinner today [November 5], offering students and their families a rich experience of global cuisine and culture. The event will take place in the school’s Assembly Hall from 4 pm to 6 pm. Each class will represent a different country such as Bermuda, Mexico, Japan, […]

The Mary Prince Legacy Bus Tour will be held on select Sundays in July and August. A spokesperson said, “In recognition of Emancipation & Mary Prince Day, Titan Express & The African Ancestories in Bermuda are offering in July & August, “The Mary Prince Legacy Bus Tour”. The tour highlights Mary Prince’s experiences and visits […]

The Bermuda Post Office [BPO] announced the latest commemorative stamp issue ~ “Mary Prince”. A Government spokesperson said, “In keeping with this month’s Emancipation observations, the Bermuda Post Office [BPO] is pleased to advise of the latest commemorative stamp issue ~ ‘Mary Prince’. This newest stamp series features imagery and renditions of Bermuda’s National Hero Mary […]

Mapping Black London — which is led by Northeastern University and aims to “visualise the multi-racial foundations and histories of London and the UK” — has created an interactive map chronicling the life of Bermudian Mary Prince. The organization said, “This exhibit traces the life of Mary Prince through the locations she described in her […]

The Better Breaks funding programme is focused on improving the range and availability of short break opportunities for disabled children and young people, particularly those with multiple support needs, including short break opportunities that families can enjoy together, or which allow parents and siblings to have time away from their caring responsibilities. This is the summary report.

The Short Breaks Fund helping to make breaks better and brighter for unpaid carers and cared-for people in Scotland. Launched in 2010 for one year, the fund has now been running for five years and has proved to be a lifeline for many carers. During the past five years the Scottish Government, through Shared Cared Scotland has distributed 12,547,409 to 697 projects to deliver innovative, tailor made breaks to groups and individuals.

Professor Wendy Laura Belcher and a primarily Ethiopian team of researchers and translators have brought new insight and access to Marian miracle stories — all now available on a website.

Remembering Rosemary Hollis (1952-2020) News Release sysadmin 12 June 2020

Professor Rosemary Hollis, a highly respected authority on the Middle East, died suddenly last week. Rosy is remembered with great respect and affection, as a colleague and a friend.

Alison M. Kurimchak
Dec 1, 2020; 19:2068-2089
Research

Endometrial carcinoma (EC) is the most common gynecologic malignancy in the United States, with limited effective targeted therapies. Endometrial tumors exhibit frequent alterations in protein kinases, yet only a small fraction of the kinome has been therapeutically explored. To identify kinase therapeutic avenues for EC, we profiled the kinome of endometrial tumors and normal endometrial tissues using Multiplexed Inhibitor Beads and Mass Spectrometry (MIB-MS). Our proteomics analysis identified a network of kinases overexpressed in tumors, including Serine/Arginine-Rich Splicing Factor Kinase 1 (SRPK1). Immunohistochemical (IHC) analysis of endometrial tumors confirmed MIB-MS findings and showed SRPK1 protein levels were highly expressed in endometrioid and uterine serous cancer (USC) histological subtypes. Moreover, querying large-scale genomics studies of EC tumors revealed high expression of SRPK1 correlated with poor survival. Loss-of-function studies targeting SRPK1 in an established USC cell line demonstrated SRPK1 was integral for RNA splicing, as well as cell cycle progression and survival under nutrient deficient conditions. Profiling of USC cells identified a compensatory response to SRPK1 inhibition that involved EGFR and the up-regulation of IGF1R and downstream AKT signaling. Co-targeting SRPK1 and EGFR or IGF1R synergistically enhanced growth inhibition in serous and endometrioid cell lines, representing a promising combination therapy for EC.

At a recent clinical meeting, I heard that GPs local to me are about to lose the ability to request magnetic resonance imaging (MRI) scans for patients presenting with musculoskeletal symptoms. We’re instead advised to refer our patients to a musculoskeletal clinical assessment and triage service (CATS)—staffed largely by musculoskeletal advanced practitioners, who will assess our patients and determine whether imaging is warranted.The hope is that fewer patients will have unnecessary imaging and that this will reduce the potential harms of overdiagnosis. Radiologists rarely report musculoskeletal MRI scans as entirely normal, and it can be hard to know what to do with abnormal findings on an MRI. More often than not, patients with abnormal scans are referred to orthopaedic teams, even though there may not necessarily be a surgical target.At a population level, this is problematic on two fronts. Firstly, MRI scans are expensive and need to be used judiciously....

C-X-C motif chemokine receptor 4 (CXCR4)–directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [^99mTc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [^99mTc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52–1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [^99mTc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [⁶⁸Ga]Ga-pentixafor PET.

Cancer of unknown primary (CUP) represents a heterogeneous group of metastatic tumors for which standardized diagnostic work-up fails to identify the primary site. We aimed to describe the Peter MacCallum Cancer Centre experience with ¹⁸F-FDG PET/CT in extracervical CUP with respect to detection of a primary site and its impact on management. A secondary aim was to compare overall survival (OS) in patients with and without a detected primary site. Methods: CUP patients treated between 2014 and 2020 were identified from medical oncology clinics and ¹⁸F-FDG PET/CT records. Information collated from electronic medical records included the suspected primary site and treatment details before and after ¹⁸F-FDG PET/CT. Clinicopathologic details and genomic analysis were used to determine the clinically suspected primary site and compared against 2 independent masked reads of ¹⁸F-FDG PET/CT images by nuclear medicine specialists to determine sensitivity, specificity, accuracy, and the rate of detection of the primary site. Results: We identified 147 patients, 65% of whom had undergone molecular profiling. The median age at diagnosis was 61 y (range, 20–84 y), and the median follow-up time was 74 mo (range, 26–83 mo). Eighty-two percent were classified as having an unfavorable CUP subtype as per international guidelines.¹⁸F-FDG PET/CT demonstrated a primary site detection rate of 41%, resulted in a change in management in 22%, and identified previously occult disease sites in 37%. Median OS was 16.8 mo for all patients and 104.7 and 12.1 mo for favorable and unfavorable CUP subtypes, respectively (P < 0.0001). Median OS in CUP patients when using ¹⁸F-FDG PET/CT, clinicopathologic, and genomic information was 19.8 and 8.5 mo when a primary site was detected and not detected, respectively (P = 0.016). Multivariable analysis of survival adjusted for age and sex remained significant for identification of a potential primary site (P < 0.001), a favorable CUP (P < 0.001), and an Eastern Cooperative Oncology Group status of 1 or less (P < 0.001). Conclusion: ¹⁸F-FDG PET/CT plays a complementary role in CUP diagnostic work-up and was able to determine the likely primary site in 41% of cases. OS is improved with primary site identification, demonstrating the value of access to diagnostic ¹⁸F-FDG PET/CT for CUP patients.

A Maryland Lottery player said following a friend's advice led to her winning a $30,000 prize from a Fast Play game.

A Maryland man found some loose cash in his back pocket and ended up using it to buy a lottery ticket worth more than $45,000.

Marc Tucker discusses the work of the Maryland Commission on Excellence and Innovation in Education, with support from NCEE, to update the state's school funding formula and to develop policies and practices to match the performance of the world's top-performing education systems.

Maryland's state school board will allow noneducators to be appointed as superintendents of school systems.

A vote by a professional-standards board means Maryland will not permit noneducators to be appointed as schools superintendents, after all.

The Maryland State Department of Education "inappropriately stored" personal information of 1.4 million students and more than 230,000 teachers, leaving them vulnerable to potential bad actors, according to an audit published earlier this month.

Thousands of teachers marched in Annapolis on Monday evening, pushing for higher pay and more resources for their students.

The state, which earned a B, saw its educational strength buoyed by strong performance in areas that measure socioeconomic factors that can affect the educational environment.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

Maryland's legislature has proposed a unique way to fund schools and also wants to hold school districts more accountable for how they spend their money as part of a new funding formula.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.

Charter schools are playing a notable role in remarks about education from candidates like Joe Biden and Bernie Sanders. Yet it's not clear what if any role they'll have in important states like Iowa and New Hampshire.

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.

The southern widow's Maryland house was a crucial stop on the escape route for assassin John Wilkes Booth the night he shot the president. Read more about Abraham Lincoln at http://www.smithsonianmag.com/history-archaeology/life-of-lincoln.html

How do you encapsulate everything that goes into a full week of teaching, worship music, workshops, meals and so much more? Enjoy a brief overview of TeenStreet 2019.

Relies on SolidWorks Simulation Software to Ensure Flight Worthiness, Safety