A multi-contact type position detection apparatus for a target board includes a first membrane board having a plurality of first signal lines formed in a first direction, a second membrane board having a plurality of second signal lines formed in a second direction, and a plurality of dots which are formed on the first membrane board or the second membrane board such that the first membrane plate and the second membrane plate are spaced at a predetermined distance from each other, wherein the plurality of dots can be arranged at a distance of “k/2±A (A is 1%˜2% of k)” when a magnetic body diameter of a pin attached on the target board is “kmm”.

Embodiments of the present invention relate to detecting irregularities in audio, such as music. An input signal corresponding to an audio stream is received. The input signal is transformed from a time domain into a frequency domain to generate a plurality of frames that each comprises frequency information for a portion of the input signal. An irregular event in a portion of the input signal corresponding to a set of frames in the plurality of frames is identified based on a comparison of frequency information of the set of frames to the frequency information of other sets of frames of the plurality of frames. This allows an indication of the irregular event to be provided, or for the input signal to be automatically synchronized to a multimedia event.

In embodiments of the present invention improved capabilities are described for an antenna-based detection method and system for sensing an environmental change condition. The method and system is adapted such that the states comprising the environmental change condition are capable of being determined at the location of the detection point utilizing only the magnitude component of the antenna impedance as altered by the discrete change in the environmental condition.

A single molecule sensing or detecting device includes a first electrode and a second electrode separated from the first electrode by a gap. The first electrode and the second electrode have an opening formed therethrough. At least one of the first electrode and the second electrode is functionalized with a recognition molecule. The recognition molecule has an effective length L1 and is configured to selectively bind to a target molecule having an effective length L2. The size of the gap is configured to be greater than L2, but less than or equal to the sum of L1 and L2.

A sputtering system that includes a sputtering chamber having a target material serving as a cathode, and an anode and a work piece. A direct current (DC) power supply supplies electrical power to the anode and the cathode sufficient to generate a plasma within the sputtering chamber. A detection module detects the occurrence of an arc in the sputtering chamber by monitoring an electrical characteristic of the plasma. In one embodiment the electrical characteristic monitored is the impedance of the plasma. In another embodiment the electrical characteristic is the conductance of the plasma.

The present invention provides a system including: a protein having a domain that binds a membranal component; an inlet for sample flow, an Isotachophoresis (ITP) system and a flow generating means connected or coupled to the aqueous parts of the ITP. The invention also provides a method for detecting and or sorting cells with this system.

A movement detection unit includes a movable body, a first sensor, a second sensor, and a signal processor. The movable body performs a movement in a first direction. The first sensor detects a first magnetic field change which is caused by the movement of the movable body and outputs a first signal. The second sensor is provided in the first direction at a location different from a location of the first sensor. The second sensor detects a second magnetic fled change which is caused by the movement of the movable body and outputting a second signal. The signal processor includes a signal generating circuit that generates a third signal and a fourth signal on a basis of the first signal. The third signal and the fourth signal have waveforms different from each other.

Embodiments include apparatuses, systems, and methods including a switching converter having an output stage including a power switch or first switching device to convert an input switching signal to an output switching signal and a sensor stage including a second switching device and a third switching device. In embodiments, the sensor stage may be coupled to receive the output switching signal from the first switching device and to substantially replicate a condition of the first switching device to generate a continuous signal rather than a switched signal. In embodiments, the continuous signal may allow detection of a current level. In some embodiments, the current level may indicate an overcurrent event. A digital post-processing circuit may be coupled to the switching device to count a number of overcurrent events according to various embodiments. Other embodiments may also be described and claimed.

A voltage of a first capacitor is compared with a threshold voltage and a signal corresponding to the comparison result is generated at each of a first timing during a period after the transfer of a positive charge has ended and before the transfer of a negative charge starts and a second timing during a period after the transfer of the negative charge has ended and before the transfer of the positive charge starts. In each of the case where a positive charge is transferred and the case where a negative charge is transferred, operations (digitization of an integrated value and a feedback operation) of a delta sigma modulator are performed.

Methods and systems for monitoring an integrity of electrical connectivity between a repair patch and a parent structure include providing the repair patch with an embedded sensor configured to detect electrical conductivity. The repair patch includes a ply of conductive material that overlaps a portion of a conductive layer of the parent structure. A baseline set of sensor data is acquired from the sensor indicative of an electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure. One or more additional sets of data may be obtained from the sensor and compared to the baseline set of data to determine an integrity of the electrical connectivity between the ply of conductive material of the repair patch and the conductive layer of the parent structure.

Disclosed are a circuit fault detection system and method for a circuit fault detection. A circuit fault detection system includes: a detection circuit including a diode, a first resistor, and a second resistor, which are positioned between an applied voltage source and a top of a detection target circuit in series, and a third resistor and a fourth resistor, which are positioned between the detection target circuit and a ground in series, an input unit including a first input terminal configured to receive a voltage measured between the first resistor and the second resistor as an input, and a second input terminal configured to receive a voltage measured between the third resistor and the fourth resistor as an input, a controller configured to detect a failure in the detection target circuit and in an operation of the detection target circuit based on values of the voltages detected by the input unit; and a display unit configured to provide a warning to a user when the failure is detected.

A magnetic field sensing apparatus and detection method thereof are provided. The magnetic field sensing apparatus includes an anisotropic magneto-resistive (AMR) magnetic field detector, a reference magnetic field detector, and a controller. The AMR magnetic field detector generates a first output voltage according to a detected magnetic field. The reference magnetic field detector generates a second output voltage according to the detected magnetic field. The controller identifies whether an absolute value of a field density of the detected magnetic field is larger or smaller than a predetermined value or not, and selects the first output voltage or a saturation voltage to be a magnetic field detection result accordingly.

An abnormality detecting apparatus (10) for a rotating machine includes: a calculating part (15) which calculates a phase difference between signals respectively output from two sensors of one or more sets, the one or more sets being predetermined combinations of two sensors among the plurality of sensors, the plurality of sensors each of which detects an elastic wave generating in the rotating machine (1) having a rotor during rotation of the rotor, the sensors being arranged at predetermined different locations of the rotating machine (1); a storing part (16) which stores in advance information concerning a relationship between a phase difference and a contact position when a contact occurs during the rotation of the rotor, regarding the one or more sets; and a specifying part (17) which specifies a contact position by using a phase difference calculated by the calculating part (15) and the information stored in the storing part (16).

A system comprising: a parent structure made of composite material and having a repair site; a repair patch made of composite material, the repair patch being bonded to the parent structure at the repair site; and a sensor embedded in the repair patch. The system may further comprise non-volatile memory and an interface unit embedded in the repair patch and electrically connected to the sensor. In one embodiment, the sensor is a loop-shaped sensor comprising an electrically conductive structure having an electrical conductivity that varies as a function of a pressure exerted on the repair patch. In another embodiment, the sensor comprises a sensor chip having nonvolatile memory. In a further embodiment, the sensor comprises an optical fiber that is sensitive to changes in pressure on or strain in the repair patch.

A detecting element unit of a physical quantity detection apparatus includes a detection part and a supporting part. The detection part has a base part, a movable part coupled to the base part via a joint part, and a vibrator provided over the base part and the movable part, and the supporting part includes a fixing portion to be fixed to a base for supporting the base part. A processing unit of the physical quantity detection apparatus extracts vibration response signals at a resonance frequency of the detecting element unit from output of the vibrator.

A substrate for a sensor includes: a base section; a movable section connected to the base section; an arm portion as a support portion extending along the movable section from the base section; a first gap portion having a protrusion portion in which one of the movable section and the arm portion protrudes toward the other of the movable section and the arm portion, and having a predetermined gap between the protrusion portion on one side and the other of the movable section and the support portion; and a second gap portion which is located further toward the base section side than the first gap portion has a gap wider than the predetermined gap, in which in the first gap portion, one of the movable section and the arm portion has a ridge portion on the side facing the first gap portion.

System, including methods and apparatus, for optical detection. The system may comprise a light source to generate a beam of light, an optical element, and a detector. The optical element may include a light guide having a shaft and a tip, with the tip forming a beveled end of the light guide. The optical element may extend into the beam, such that the tip and at least a portion of the shaft are located inside the beam, and a window of the optical element is located outside the beam. Light of the beam incident on the tip may be transmitted longitudinally through the light guide and out the window, while light of the beam incident on the shaft may be transmitted transversely through the shaft and remains in the beam downstream. The detector may be configured to detect light received from the window.

The present invention discloses a mail detection device and method. The device comprises a broad-band terahertz generator, a collimator, a beam splitter, a fixed reflector, a movable reflector, a wave buncher, a matrix detector, an acquisition card and an information processing module; wherein the information processing module is used for generating a terahertz image of a mail to be detected according to the electric signals sent by the acquisition card when the movable reflector is motionless; and when finding suspicious articles according to the terahertz image of a mail to be detected, the information processing module controls the movable reflector to move, and generates spectral information of the suspicious articles according to an electric signal sequence sent by the acquisition card during the movement of the movable reflector.

The present technology provides methods for increasing sensitivity of detection and/or quantification of a negatively charged analyte, e.g., an oligonucleotide, using an analytical system that comprises liquid chromatography and mass spectrometry. The methods comprise passing an acidic solution through the analytical system, i.e., through a fluidic path from the mobile phase reservoir to the detector to remove or displace, at least in part, metal ions adsorbed to charged sites in the fluidic path.

A semiconductor detector includes a plate-shaped semiconductor part, a signal output electrode for outputting a signal provided at one surface of the semiconductor part, a plurality of curved electrodes provided at the one surface of the semiconductor part and which have distances from the signal output electrode that are different from each other, and an arc-shaped collection electrode for collecting an electric charge generated at the semiconductor part. The plurality of curved electrodes are applied with voltage to generate in the semiconductor part a potential gradient in which a potential varies toward the signal output electrode. The collection electrode is located at a part of the semiconductor part between an adjacent pair of curved electrodes. The collection electrode is connected to a curved electrode located a distance from the signal output electrode shorter than a distance between the collection electrode and the signal output electrode among the curved electrodes.

A semiconductor detector for detecting radiation comprises a first semiconductor part in which an electron and a hole are generated by incident radiation; a signal output electrode outputting a signal base on the electron or the hole; and a gettering part gettering impurities in the first semiconductor part. In addition, the semiconductor detector further comprises a second semiconductor part doped with a type of dopant impurities and having dopant impurity concentration higher than that of the first semiconductor part. The second semiconductor part is in contact with the first semiconductor part. The gettering part is in contact with the second semiconductor part and not in contact with the first semiconductor part.

Blood separation systems and methods are provided for detecting lipids in plasma that has been separated from a plasma-containing fluid, such as blood. The system includes a fluid processing region in which a plasma-containing fluid is separated into plasma and other fluid components. A plasma flow path is associated with the fluid processing region for the flow of at least a portion of the separated plasma into or out of the region. A lipid detector shines blue and/or ultraviolet light through the separated plasma in the plasma line to optically detect the presence of lipids therein. The lipid detector may be used alone or in combination with a hemoglobin detector to reduce the number of false hemoglobin alarms or an interface detector for improved detection and correction of the location of an interface between separated fluid components in the fluid processing region.

A semiconductor device used for fluorescent-based molecule detection and a method for manufacturing the same are provided. The semiconductor device has a fluid channel layer defining a fluid channel through which a sample stream flows. A target cell coupled with a fluorescent source is contained by the sample stream. The semiconductor device also has an excitation light source for generating excitation light that reaches the target cell coupled with the fluorescent source to generate fluorescent light. The semiconductor device also has a light filter layer for permitting the fluorescent light to pass through and to block the excitation light and a light detection layer for detecting the fluorescent light. The functional components of the device are highly integrated. Leakage of the excitation light and background noise into the light detection component can be minimized to improve the quality of detection.

The present invention relates to a novel method for detecting a detection object in a sample, and a detection device using the same. The detecting method of the present invention uses a “bridge composite” in which gold nanoparticles and an antibody specific to a detection object are coupled in order to induce a sufficient coupling reaction between the antibody and the detection object, thereby improving reactivity. Accordingly, since excellent resolution is provided, the method of the present invention has advantages of enabling accurate concentration measurement of a detection object in a sample, and amplifying a measurement signal. In addition, the method of the present invention can effectively detect small molecules such as hormones, vitamins, etc. having a small molecular weight.

Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

The present invention provides assays for detecting and measuring the presence or level of anti-TNFα drug therapeutics and autoantibodies in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFα drug therapeutics to detect the presence or level of autoantibodies (e.g., HACA and/or HAHA) against the drug.

An antigenic characterization method using polyclonal antibody-based proximity ligation assays (polyPLA). Methods, kits, and other tools disclosed herein are useful in detecting microbial antigenic variants in samples, including clinical samples. The methods and kits have great utility in detecting antigenic variants for pathogenic microbes, including viruses, bacteria, and parasites.

Provided are a detection agent for detecting hydroxy vitamin D, preparation method thereof, and use thereof in 25-hydroxy vitamin D immunological detection. The detection agent comprises a conjugate formed by a 25-hydroxy vitamin D antigen derivative and protein carrier, and magnetic spheres coated by the conjugate. Also provided is a 25-hydroxy vitamin D detection kit comprising the detection agent.

When thinking about the concept of a “micro aggression”, what we’re really doing is subscribing to signal detection theory. What is the theory and how does it come into play when we’re dissecting the behaviors of others? In the first episode of this two-part conversation on Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke discuss...

We’ve covered what signal detection theory is, so how does it come up when we assign labels to behaviors that could be considered “micro aggressions”? Are there significant benefits to these labels? In the second episode of this two-part conversation on Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke continue their discussion on signal detection....

Draft Redpaper, last updated: Wed, 29 Apr 2020

Having appropriate storage for hosting business-critical data and advanced Security Information and Event Management software for deep inspection, detection, and prioritization of threats has become a necessity of any business.

Learn how Guardium database monitoring is extended with enhanced security intelligenceknown as outlier detectionto detect potential threats based on relative changes in behavior. Use cases, configuration guidance, and operational considerations are covered.

Using cameras and wind disturbance, a Tasmanian wind farm will be the first in Australia to deter wedge-tailed eagles from flying into the turbine blades.

Volunteer detection dogs have been trained to find the endangered alpine stonefly at Falls Creek, an insect measuring just 50 millimetres in length.

Fire ants are spreading into new areas across south-east Queensland according to a Biosecurity Queensland insider who says the war to eradicate the potential killers is all but lost, a claim vehemently denied by the man tasked with stopping the spread.

(United States Seventh Circuit) - District court's granting of summary judgment and bench verdict for Defendant affirmed. Sherman Act claim fails where the only current feasible way to comply with Chicagoland area city commercial fire safety ordinances was to use an exclusive provider. Under Fisher v. City of Berkeley, government restraints on trade imposed unilaterally do not form the basis of a Section 1 or Section 2 claim.

(United States Seventh Circuit) - Affirmed, reversed, and remanded in part. Largely affirming the dismissal of claims alleging a conspiracy between a city and alarm companies, but reversing the dismissal of a contracts clause claim against the city.

(United States Seventh Circuit) - District court's granting of summary judgment and bench verdict for Defendant affirmed. Sherman Act claim fails where the only current feasible way to comply with Chicagoland area city commercial fire safety ordinances was to use an exclusive provider. Under Fisher v. City of Berkeley, government restraints on trade imposed unilaterally do not form the basis of a Section 1 or Section 2 claim.

Most nuclear data measurements are performed at accelerators large enough to occupy a geologic formation a kilometer wide. But a portable device that can reveal the composition of materials quickly on-site would greatly benefit cases such as in archaeology and nuclear arms treaty verification. Research published this week in AIP Advances used computational simulations to show that with the right geometric adjustments, it is possible to perform accurate neutron resonance transmission analysis in a device just 5 meters long.

The IBM Research findings achieve the highest recorded accuracy of 86 percent by using deep learning and pathology insights to identify the severity of diabetic retinopathy.

‘Sentiment mining’ – i.e. trying to gauge the Public’s attitude towards an institution, product, firm (etc. etc.) though automatic analysis of Social Media posts (etc. etc.) is now considered an essential tool for market researchers and ‘reputation managers’. But there are problems. One of which is sarcasm. Given its prevalence, serious errors can be introduced […]

The Department of Nuclear Engineering at the University of California, Berkeley welcomes applications for a postdoctoral scholar to support a project on radiation detection for nuclear security applications. The goal of this work, in collaboration with Lawrence Berkeley and Sandia National Laborator

Donna Tomky
Jan 1, 2005; 18:39-44
Articles

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

Purpose: To explore the value of ⁶⁸Ga-PSMA-PET/CT for detection of phosphatase and tensin homolog (PTEN) - loss prostate cancer (PCa). Methods: We retrospectively enrolled 75 patients who underwent multiparametric MRI (mpMRI) and ⁶⁸Ga-PSMA PET/CT before radical prostatectomy. Lesions were outlined on pathological images and regions of interest were drawn on matched mpMRI and PET/CT images. Imaging parameters including average apparent diffusion coefficient (ADCmean) and maximum standardized uptake value (SUV_max) were derived. Immunohistochemical staining was carried out to evaluate the PTEN status. The diagnostic performance of imaging parameters was analyzed by receiver operating characteristics (ROC) analysis. A univariate logistic regression analyses were used to evaluate the association between clinical and imaging variables and PTEN status. Results: Totally, 103 lesions from 54 patients were analyzed. Of these lesions, 34 of 103 (33.0%) showed PTEN-loss status. Our study showed a strong association between SUV_max and PTEN-loss tumors both in the per-patient analysis (P < 0.01) and per-lesion analysis (P < 0.01), yielding the sensitivity and specificity of 0.80 and 0.77 in the per-patient analysis and 0.83 and 0.74 in the per-lesion analysis. Meanwhile, higher pathological PSMA expression was found in the PTEN-deficiency tumors. However, there was no significant difference between PTEN-loss tumors and PTEN-intact tumors using parameters including ADCmean (P > 0.05) and PI-RADS score (P > 0.05). Surprisingly, SUV_max was a significant predictor for detection of PTEN-loss tumors (odds ratio: 7.56, 95% confidence interval: 2.18-26.24, per-patient analysis; odds ratio: 13.66, 95% confidence interval: 4.32-43.24, per-lesion analysis). Conclusion: ⁶⁸Ga-PSMA-PET/CT could effectively detect aggressive PTEN-loss tumors.