advanced Discontinuation of RAAS Inhibition in Children with Advanced CKD By cjasn.asnjournals.org Published On :: 2020-05-07T10:00:25-07:00 Background and objectives Although renin-angiotensin-aldosterone system inhibition (RAASi) is a cornerstone in the treatment of children with CKD, it is sometimes discontinued when kidney function declines. We studied the reasons of RAASi discontinuation and associations between RAASi discontinuation and important risk markers of CKD progression and on eGFR decline in the Cardiovascular Comorbidity in Children with CKD study. Design, setting, participants, & measurements In this study, 69 children with CKD (67% male, mean age 13.7 years, mean eGFR 27 ml/min per 1.73 m2) who discontinued RAASi during prospective follow-up were included. Initial change in BP, albuminuria, and potassium after discontinuation were assessed (median time 6 months). Rate of eGFR decline (eGFR slope) during a median of 1.9 years before and 1.2 years after discontinuation were estimated using linear mixed effects modeling. Results Physician-reported reasons for RAASi discontinuation were increase in serum creatinine, hyperkalemia, and symptomatic hypotension. After discontinuation of RAASi, BP and albuminuria increased, whereas potassium decreased. eGFR declined more rapidly after discontinuation of RAASi (–3.9 ml/min per 1.73 m2 per year; 95% confidence interval, –5.1 to –2.6) compared with the slope during RAASi treatment (–1.5 ml/min per 1.73 m2 per year; 95% confidence interval, –2.4 to –0.6; P=0.005). In contrast, no change in eGFR slope was observed in a matched control cohort of patients in whom RAASi was continued. Conclusions Discontinuation of RAASi in children with CKD is associated with an acceleration of kidney function decline, even in advanced CKD. Full Article
advanced Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled Trial By cjasn.asnjournals.org Published On :: 2020-05-07T10:00:25-07:00 Background and objectives Large, randomized, controlled trials targeting higher hemoglobin level with erythropoiesis-stimulating agents for Western patients with CKD showed harm. However, the effect of anemia correction using erythropoiesis-stimulating agents may differ between CKD subpopulations. The Prevention of ESKD by Darbepoetin Alfa in CKD Patients with Non-diabetic Kidney Disease study, a multicenter, randomized, open-label, parallel-group study, aimed to examine the effect of targeting hemoglobin levels of 11–13 g/dl using darbepoetin alfa with reference to a low-hemoglobin target of 9–11 g/dl on kidney outcome in patients with advanced CKD without diabetes in Japan. Design, setting, participants, & measurements We enrolled 491 patients with CKD without diabetes, and an eGFR of 8–20 ml/min per 1.73 m2. Of these 491 patients, 239 and 240 were ultimately assigned to the high- and low-hemoglobin groups, respectively (12 patients were excluded). The primary outcome was a kidney composite end point (starting maintenance dialysis, kidney transplantation, eGFR≤6 ml/min per 1.73 m2, and 50% reduction in eGFR). Results Mean hemoglobin levels were 11.2±1.1 and 10.0±0.9 g/dl in the high- and low-hemoglobin groups, respectively, during the mean study period of 73.5±29.7 weeks. The kidney composite end point occurred in 105 (44%) and 116 (48%) patients in the high- and low-hemoglobin groups, respectively (log-rank test; P=0.32). The adjusted Cox proportional hazards model showed that the hazard ratio for the high- versus low-hemoglobin group was 0.78 (95% confidence interval, 0.60 to 1.03; P=0.08). Cardiovascular events occurred in 19 (8%) and 16 (7%) patients in each group, respectively, with no significant between-group difference (log-rank test; P=0.66). Conclusions Targeting a higher hemoglobin level (11–13 g/dl) with darbepoetin alfa did not improve kidney outcome compared with targeting a lower hemoglobin level (9–11 g/dl) in patients with advanced CKD without diabetes. Clinical Trial registry name and registration number Prevention of ESKD by Darbepoetin Alfa in CKD Patients with Non-diabetic Kidney Disease (PREDICT), NCT01581073. Full Article
advanced Benefits of Continuing RAAS Inhibitors in Advanced CKD By cjasn.asnjournals.org Published On :: 2020-05-07T10:00:25-07:00 Full Article
advanced Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Neuroendocrine Tumors: Results From the Phase II KEYNOTE-158 Study By clincancerres.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Purpose: KEYNOTE-158 (ClinicalTrials.gov identifier: NCT02628067) investigated the efficacy and safety of pembrolizumab across multiple cancers. We present results from patients with previously treated advanced well-differentiated neuroendocrine tumors (NET). Patients and Methods: Pembrolizumab 200 mg was administered every 3 weeks for 2 years or until progression, intolerable toxicity, or physician/patient decision. Tumor imaging was performed every 9 weeks for the first year and then every 12 weeks. Endpoints included objective response rate (ORR) per RECIST v1.1 by independent central radiologic review (primary) and duration of response (DOR), progression-free survival (PFS), overall survival (OS), and safety (secondary). Results: A total of 107 patients with NETs of the lung, appendix, small intestine, colon, rectum, or pancreas were treated. Median age was 59.0 years (range, 29–80), 44.9% had ECOG performance status 1, 40.2% had received ≥3 prior therapies for advanced disease, and 15.9% had PD-L1–positive tumors (combined positive score ≥1). Median follow-up was 24.2 months (range, 0.6–33.4). ORR was 3.7% (95% CI, 1.0–9.3), with zero complete responses and four partial responses (three pancreatic and one rectal) all in patients with PD-L1–negative tumors. Median DOR was not reached, with one of four responses ongoing after ≥21 months follow-up. Median PFS was 4.1 months (95% CI, 3.5–5.4); the 6-month PFS rate was 39.3%. Median OS was 24.2 months (95% CI, 15.8–32.5). Treatment-related adverse events (AE) occurred in 75.7% of patients, 21.5% of whom had grade 3–5 AEs. Conclusions: Pembrolizumab monotherapy showed limited antitumor activity and manageable safety in patients with previously treated advanced well-differentiated NETs. Full Article
advanced Targeting HER2 with Trastuzumab Deruxtecan: A Dose-Expansion, Phase I Study in Multiple Advanced Solid Tumors [Research Articles] By cancerdiscovery.aacrjournals.org Published On :: 2020-05-01T00:05:26-07:00 HER2-targeted therapies are approved only for HER2-positive breast and gastric cancers. We assessed the safety/tolerability and activity of the novel HER2-targeted antibody–drug conjugate trastuzumab deruxtecan (T-DXd) in 60 patients with pretreated, HER2-expressing (IHC ≥ 1+), non-breast/non-gastric or HER2-mutant solid tumors from a phase I trial (NCT02564900). Most common (>50%) treatment-emergent adverse events (TEAE) were nausea, decreased appetite, and vomiting. Two drug-related TEAEs were associated with fatal outcomes. The confirmed objective response rate (ORR) was 28.3% (17/60). Median progression-free survival (PFS) was 7.2 [95% confidence interval (CI), 4.8–11.1] months. In HER2-mutant non–small cell lung cancer (NSCLC), ORR was 72.7% (8/11), and median PFS was 11.3 (95% CI, 8.1–14.3) months. Confirmed responses were observed in six tumor types, including HER2-expressing NSCLC, colorectal cancer, salivary gland cancer, biliary tract cancer, endometrial cancer, and HER2-mutant NSCLC and breast cancer. Results suggest T-DXd holds promise for HER2-expressing/mutant solid tumors. Significance: T-DXd demonstrated promising activity in a heterogeneous patient population with heavily pretreated HER2-expressing or HER2-mutant solid tumors, especially HER2-mutant NSCLC. The safety profile was generally acceptable. Interstitial lung disease can be severe and requires prompt monitoring and intervention. Further research of T-DXd is warranted to address these unmet medical needs. See related commentary by Rolfo and Russo, p. 643. This article is highlighted in the In This Issue feature, p. 627 Full Article
advanced Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium [FUNCTIONAL] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma. MATERIALS AND METHODS: A clinical trial using the poly (adenosine diphosphate ribose) polymerase (PARP) inhibitor veliparib concurrently with radiation therapy, followed by maintenance therapy with veliparib + temozolomide, in children with diffuse intrinsic pontine glioma was conducted by the Pediatric Brain Tumor Consortium. Standard MR imaging, DWI, dynamic contrast-enhanced perfusion, and DSC perfusion were performed at baseline and approximately every 2 months throughout treatment. ADC histogram metrics of T2-weighted FLAIR and enhancing tumor volume, dynamic contrast-enhanced permeability metrics for enhancing tumors, and tumor relative CBV from DSC perfusion MR imaging were calculated. Baseline values, post-radiation therapy changes, and longitudinal trends for all metrics were evaluated for associations with survival and pseudoprogression. RESULTS: Fifty children were evaluable for survival analyses. Higher baseline relative CBV was associated with shorter progression-free survival (P = .02, Q = 0.089) and overall survival (P = .006, Q = 0.055). Associations of higher baseline mean transfer constant from the blood plasma into the extravascular extracellular space with shorter progression-free survival (P = .03, Q = 0.105) and overall survival (P = .03, Q = 0.102) trended toward significance. An increase in relative CBV with time was associated with shorter progression-free survival (P < .001, Q < 0.001) and overall survival (P = .004, Q = 0.043). Associations of longitudinal mean extravascular extracellular volume fraction with progression-free survival (P = .03, Q = 0.104) and overall survival (P = .03, Q = 0.105) and maximum transfer constant from the blood plasma into the extravascular extracellular space with progression-free survival (P = .03, Q = 0.102) trended toward significance. Greater increases with time were associated with worse outcomes. True radiologic progression showed greater post-radiation therapy decreases in mode_ADC_FLAIR compared with pseudoprogression (means, –268.15 versus –26.11, P = .01.) CONCLUSIONS: ADC histogram, perfusion, and permeability MR imaging metrics in diffuse intrinsic pontine glioma are useful in predicting survival and pseudoprogression. Full Article
advanced Early Devonian Fossil Provides Earliest Evidence for Advanced Reproductive Biology in Land Plants By feedproxy.google.com Published On :: Wed, 06 May 2020 18:26:20 +0000 A species of plant that grew about 400 million years ago (Early Devonian period) produced a spectrum of spore sizes, which is an essential innovation necessary for all advanced plant reproductive strategies, including seeds and flowers. The Devonian period is one of the most important time periods for the evolution of land plants. It witnessed [...] Full Article Paleontology Barinophyte Campbellton Formation Canada Chaleuria Devonian Heterospory Plant Reproductive behavior Sporangia Spore
advanced Olanzapine may help control nausea, vomiting in patients with advanced cancer By www.sciencedaily.com Published On :: Thu, 07 May 2020 16:40:05 EDT Olanzapine, a generic drug used to treat nervous, emotional and mental conditions, also may help patients with advanced cancer successfully manage nausea and vomiting unrelated to chemotherapy. Full Article
advanced Google Play has been spreading advanced Android malware for years By arstechnica.com Published On :: Wed, 29 Apr 2020 22:15:56 +0000 Advanced hacker group seeded market with at least 8 apps likely since 2016. Full Article Biz & IT
advanced QPR in advanced talks over purchasing new site for training ground after scrapping Warren Farm plans By www.standard.co.uk Published On :: 2020-05-06T10:35:00Z QPR have now scrapped plans to build a new training ground on the Warren Farm site first identified in 2012, the club and Ealing Council have confirmed. Full Article
advanced Olanzapine may help control nausea, vomiting in patients with advanced cancer By www.eurekalert.org Published On :: Thu, 07 May 2020 00:00:00 EDT Olanzapine, a generic drug used to treat nervous, emotional and mental conditions, also may help patients with advanced cancer successfully manage nausea and vomiting unrelated to chemotherapy. These are the findings of a study published Thursday, May 7, 2020 in JAMA Oncology. Full Article
advanced ICR welcomes new advanced prostate cancer treatment guideline By www.pharmatimes.com Published On :: Wed, 06 May 2020 12:11:18 +0100 NHS England has expanded access to targeted hormone therapies for advanced prostate cancer Full Article
advanced Phase 3 Libtayo monotherapy trial halted early due to strong benefit in advanced non-small cell lung cancer By www.pharmafile.com Published On :: Wed, 29 Apr 2020 11:49:31 +0000 A Phase 3 study of Sanofi and Regeneron’s Libtayo (cemiplimab) as a monotherapy for advanced or metastatic non-small cell lung cancer (NSCLC) has been stopped early after showing strong overall survival benefit, it has emerged. Full Article cancer Libtayo lung cancer Regeneron Research and Development Sanofi
advanced Justice Department Files Lawsuit Against MasTec Advanced Technologies to Enforce the Employment Rights of Army Reserve Member By www.justice.gov Published On :: Mon, 30 Nov 2009 17:41:24 EST The department filed a lawsuit in federal court in West Virginia alleging that MasTec Advanced Technologies willfully violated the Uniformed Services Employment and Reemployment Rights Act of 1994 by discriminating against a U.S. Army Reserve member on the basis of his military service and by failing to offer Burress an appropriate reemployment position when he returned from military service. Full Article OPA Press Releases
advanced Justice Department Settles Lawsuit Against MasTec Advanced Technologies to Enforce the Employment Rights of Army Reserve Member By www.justice.gov Published On :: Thu, 4 Feb 2010 16:19:17 EST The Department has reached a settlement in its lawsuit against MasTec Advanced Technologies on behalf of Eugene C. Burress, a U.S. Army Reserve member, alleging that MasTec willfully violated the Uniformed Services Employment and Reemployment Rights Act of 1994 (USERRA). Full Article OPA Press Releases
advanced General Electric Hitachi Nuclear Energy Americas Agrees to Pay $2.7 Million for Alleged False Claims Related to Design of Advanced Nuclear Reactor By www.justice.gov Published On :: Thu, 23 Jan 2014 10:31:54 EST The Justice Department announced today that General Electric Hitachi Nuclear Energy Americas LLC (GE Hitachi) has agreed to pay $2.7 million to resolve allegations under the False Claims Act that it made false statements and claims to the Department of Energy and the Nuclear Regulatory Commission (NRC) concerning an advanced nuclear reactor design. Full Article OPA Press Releases
advanced Phase 3 trial of Libtayo® (cemiplimab) as monotherapy for first-line advanced non-small cell lung cancer stopped early due to highly significant improvement in overall survival By www.news.sanofi.us Published On :: Mon, 27 Apr 2020 08:40:00 -0400 - Libtayo decreased the risk of death by 32.4% compared to chemotherapy Full Article
advanced Libtayo® (cemiplimab) shows clinically meaningful and durable responses in second-line advanced basal cell carcinoma By www.news.sanofi.us Published On :: Tue, 05 May 2020 08:25:00 -0400 Objective responses seen in 29% of patients with locally advanced basal cell carcinoma (BCC) Full Article
advanced Kirigami/origami: unfolding the new regime of advanced 3D microfabrication/nanofabrication with “folding” By feeds.nature.com Published On :: 2020-04-30 Full Article
advanced No benefit of initial invasive strategy for managing CAD in advanced CKD By feeds.nature.com Published On :: 2020-04-15 Full Article
advanced Early assessment of <i>KRAS</i> mutation in cfDNA correlates with risk of progression and death in advanced non-small-cell lung cancer By feeds.nature.com Published On :: 2020-05-07 Full Article
advanced Youth and Civil Society Action on Sustainable Development Goals: New Multi-Stakeholder Framework Advanced at UN Asia-Pacific Hosted Forum By webfeeds.brookings.edu Published On :: Wed, 05 Nov 2014 16:27:00 -0500 In late October at the United Nations Economic and Social Commission for Asia and the Pacific (UN ESCAP) headquarters in Bangkok, a multi-stakeholder coalition was launched to promote the role of youth and civil society in advancing post-2015 United Nations Sustainable Development Goals (SDGs). The youth initiatives, fostering regional integration and youth service impact in the Association of Southeast Asian Nations (ASEAN) and counterpart regions of Northeast and South Asia, will be furthered through a new Asia-Pacific Peace Service Alliance. The alliance is comprised of youth leaders, foundations, civil society entities, multilateral partners and U.N. agencies. Together, their initiatives illustrate the potential of youth and multi-stakeholder coalitions to scale impacts to meet SDG development targets through youth service and social media campaigns, and partnerships with multilateral agencies, nongovernmental organizations, corporations and research institutes. The “Asia-Pacific Forum on Youth Volunteerism to Promote Participation in Development and Peace” at UN ESCAP featured a new joint partnership of the U.S. Peace Corps and the Korea International Cooperation Agency (KOICA) as well as USAID support for the ASEAN Youth Volunteering Program. With key leadership from ASEAN youth entitles, sponsor FK Norway, Youth Corps Singapore and Peace Corps’ innovative program in Thailand, the forum also furthered President Obama’s goal of Americans serving “side by side” with other nations’ volunteers. The multi-stakeholder Asia-Pacific alliance will be powered by creative youth action and a broad array of private and public partners from Thailand, Malaysia, Myanmar, Indonesia, Singapore, the Philippines, Australia, Korea, China, Mongolia, Japan, India, Nepal, Pakistan, the U.S. and other nations. During the event, Dr. Shamshad Akhtar, ESCAP executive secretary, pointed out that “tapping youth potential is critical to shape our shared destiny, as they are a source of new ideas, talent and inspiration. For ESCAP and the United Nations, a dynamic youth agenda is vital to ensure the success of post-2015 sustainable development.” Dr. Surin Pitsuwan, former ASEAN secretary-general, called for a new Asia-wide multilateralism engaging youth and civil society. In his remarks, he drew from his experience in mobilizing Asian relief and recovery efforts after Cyclone Nargis devastated the delta region of Myanmar in May 2008. Surin, honorary Alliance chairman and this year’s recipient of the Harris Wofford Global Citizenship Award, also noted the necessity of a “spiritual evolution” to a common sense of well-being to redress the “present course of possible extinction” caused by global conflicts and climate challenges. He summoned Asia-Pacific youth, representing 60 percent of the world’s young population, to “be the change you want to see” and to “commit our youth to a useful cause for humanity.” The potential for similar upscaled service efforts in Africa, weaving regional integration and youth volunteering impact, has been assessed in Brookings research and policy recommendations being implemented in the Common Market of Eastern and Southern Africa (COMESA). Recommendations, many of which COMESA and ASEAN are undertaking, include enabling youth entrepreneurship and service contributions to livelihoods in regional economic integration schemes, and commissioning third-party support for impact evidence research. A good example of successful voluntary service contributions from which regional economic communities like ASEAN can learn a lot is the current Omnimed pilot research intervention in Uganda. In eastern Ugandan villages, 1,200 village health workers supported by volunteer medical doctors, Uganda’s Health Ministry, Peace Corps volunteers and Global Peace Women are addressing lifesaving maternal and child health outcomes furthering UNICEF’s campaign on “integrated health” addressing malaria, diarrheal disease and indoor cooking pollution. The effort has included construction of 15 secure water sources and 1,200 clean cook stoves along with randomized controlled trials. Last week, the young leaders from more than 40 nations produced a “Bangkok Statement” outlining their policy guidance and practical steps to guide volunteering work plans for the new Asia-Pacific alliance. Youth service initiatives undertaken in “collective impact” clusters will focus on the environment (including clean water and solar villages), health service, entrepreneurship, youth roles in disaster preparedness and positive peace. The forum was co-convened by ESCAP, UNESCO, the Global Peace Foundation and the Global Young Leaders Academy. Authors David L. Caprara Full Article
advanced Canada’s advanced industries: A path to prosperity By webfeeds.brookings.edu Published On :: Fri, 08 Jun 2018 18:03:30 +0000 Canada is having a moment. In a world where talent is mobile and technology central, Canada stands out with its vibrant democracy, growing tech clusters, and unparalleled openness to the world’s migrants. Yet there is a problem: Despite the nation’s many strengths, Canada’s economy faces serious structural challenges, including an aging population and slowing output… Full Article
advanced How the Small Businesses Investment Company Program can better support America’s advanced industries By webfeeds.brookings.edu Published On :: Wed, 26 Jun 2019 19:20:56 +0000 On June 26, Brookings Metro Senior Fellow and Policy Director Mark Muro testified to the Senate Committee on Small Business and Entrepreneurship about the need for the reauthorization of the Small Business Administration (SBA), and particularly on the Small Business Investment Company (SBIC) program, to be better positioned to further support America’s advanced industry sector.… Full Article
advanced Global China’s advanced technology ambitions By webfeeds.brookings.edu Published On :: Tue, 28 Apr 2020 09:00:08 +0000 In this special edition of the Brookings Cafeteria Podcast, Lindsey Ford, a David M. Rubenstein Fellow in Foreign Policy, interviews two authors of the most recent release of papers in the Global China series focused on China's aspiration to be a global technology leader. Saif Khan and Remco Zwetsloot are both research fellows at the… Full Article
advanced Youth and Civil Society Action on Sustainable Development Goals: New Multi-Stakeholder Framework Advanced at UN Asia-Pacific Hosted Forum By webfeeds.brookings.edu Published On :: Wed, 05 Nov 2014 16:27:00 -0500 In late October at the United Nations Economic and Social Commission for Asia and the Pacific (UN ESCAP) headquarters in Bangkok, a multi-stakeholder coalition was launched to promote the role of youth and civil society in advancing post-2015 United Nations Sustainable Development Goals (SDGs). The youth initiatives, fostering regional integration and youth service impact in the Association of Southeast Asian Nations (ASEAN) and counterpart regions of Northeast and South Asia, will be furthered through a new Asia-Pacific Peace Service Alliance. The alliance is comprised of youth leaders, foundations, civil society entities, multilateral partners and U.N. agencies. Together, their initiatives illustrate the potential of youth and multi-stakeholder coalitions to scale impacts to meet SDG development targets through youth service and social media campaigns, and partnerships with multilateral agencies, nongovernmental organizations, corporations and research institutes. The “Asia-Pacific Forum on Youth Volunteerism to Promote Participation in Development and Peace” at UN ESCAP featured a new joint partnership of the U.S. Peace Corps and the Korea International Cooperation Agency (KOICA) as well as USAID support for the ASEAN Youth Volunteering Program. With key leadership from ASEAN youth entitles, sponsor FK Norway, Youth Corps Singapore and Peace Corps’ innovative program in Thailand, the forum also furthered President Obama’s goal of Americans serving “side by side” with other nations’ volunteers. The multi-stakeholder Asia-Pacific alliance will be powered by creative youth action and a broad array of private and public partners from Thailand, Malaysia, Myanmar, Indonesia, Singapore, the Philippines, Australia, Korea, China, Mongolia, Japan, India, Nepal, Pakistan, the U.S. and other nations. During the event, Dr. Shamshad Akhtar, ESCAP executive secretary, pointed out that “tapping youth potential is critical to shape our shared destiny, as they are a source of new ideas, talent and inspiration. For ESCAP and the United Nations, a dynamic youth agenda is vital to ensure the success of post-2015 sustainable development.” Dr. Surin Pitsuwan, former ASEAN secretary-general, called for a new Asia-wide multilateralism engaging youth and civil society. In his remarks, he drew from his experience in mobilizing Asian relief and recovery efforts after Cyclone Nargis devastated the delta region of Myanmar in May 2008. Surin, honorary Alliance chairman and this year’s recipient of the Harris Wofford Global Citizenship Award, also noted the necessity of a “spiritual evolution” to a common sense of well-being to redress the “present course of possible extinction” caused by global conflicts and climate challenges. He summoned Asia-Pacific youth, representing 60 percent of the world’s young population, to “be the change you want to see” and to “commit our youth to a useful cause for humanity.” The potential for similar upscaled service efforts in Africa, weaving regional integration and youth volunteering impact, has been assessed in Brookings research and policy recommendations being implemented in the Common Market of Eastern and Southern Africa (COMESA). Recommendations, many of which COMESA and ASEAN are undertaking, include enabling youth entrepreneurship and service contributions to livelihoods in regional economic integration schemes, and commissioning third-party support for impact evidence research. A good example of successful voluntary service contributions from which regional economic communities like ASEAN can learn a lot is the current Omnimed pilot research intervention in Uganda. In eastern Ugandan villages, 1,200 village health workers supported by volunteer medical doctors, Uganda’s Health Ministry, Peace Corps volunteers and Global Peace Women are addressing lifesaving maternal and child health outcomes furthering UNICEF’s campaign on “integrated health” addressing malaria, diarrheal disease and indoor cooking pollution. The effort has included construction of 15 secure water sources and 1,200 clean cook stoves along with randomized controlled trials. Last week, the young leaders from more than 40 nations produced a “Bangkok Statement” outlining their policy guidance and practical steps to guide volunteering work plans for the new Asia-Pacific alliance. Youth service initiatives undertaken in “collective impact” clusters will focus on the environment (including clean water and solar villages), health service, entrepreneurship, youth roles in disaster preparedness and positive peace. The forum was co-convened by ESCAP, UNESCO, the Global Peace Foundation and the Global Young Leaders Academy. Authors David L. Caprara Full Article
advanced Tracking and Advanced Placement By webfeeds.brookings.edu Published On :: Thu, 24 Mar 2016 00:00:00 -0400 Full Article
advanced NASA's Advanced Space Tech Gets Turned Into Self-Aware Eco Building By www.treehugger.com Published On :: Mon, 10 Aug 2009 17:35:26 -0400 NASA is using decades of space exploration technology to build a new eco-aware base here in California. Full Article Design
advanced Are you an 'advanced sleeper'? By www.treehugger.com Published On :: Wed, 07 Aug 2019 17:35:08 -0400 One in 300 people are extreme early birds, and it may be genetic. Full Article Living
advanced Invuity® Launches Hidden Scar Program For Breast Cancer Surgery At American College Of Surgeons (ACS) Annual Clinical Congress 2015 - Top Breast Cancer Surgeons Discuss Advanced Surgical Options By feedproxy.google.com Published On :: 01 Oct 2015 17:06:00 EDT Top Breast Cancer Surgeons Discuss Advanced Surgical Options Full Article Computer Electronics Healthcare Hospitals Medical Pharmaceuticals Medical Equipment New Products Services Trade show news Broadcast Feed Announcements MultiVu Video
advanced New Drug may Reverse Treatment Resistance in Advanced Multiple Myeloma By www.medindia.net Published On :: New drug, called FL118, was found to be more effective against advanced multiple myeloma cancer cells than the newly diagnosed cases, reports a new study. Full Article
advanced Advanced economies growing again but some emerging economies slowing, says OECD By www.oecd.org Published On :: Tue, 03 Sep 2013 12:08:00 GMT A moderate recovery is underway in the major advanced economies, according to the OECD’s latest Interim Economic Assessment. Growth is proceeding at encouraging rates in North America, Japan and the UK. The euro area as a whole is out of recession, although output remains weak in a number of countries. Full Article
advanced Advanced economies growing again but some emerging economies slowing, says OECD By www.oecd.org Published On :: Tue, 03 Sep 2013 12:08:00 GMT A moderate recovery is underway in the major advanced economies, according to the OECD’s latest Interim Economic Assessment. Growth is proceeding at encouraging rates in North America, Japan and the UK. The euro area as a whole is out of recession, although output remains weak in a number of countries. Full Article
advanced Tax administration: OECD publishes new comparative information on OECD and other advanced and emerging economies By www.oecd.org Published On :: Fri, 17 May 2013 10:00:00 GMT This fifth edition describes institutional setups, organisational arrangements and reforms, aspects of strategic management and human resource management, resources for tax administration, important areas of operational performance, the use of technology, and elements of the legislative and administrative framework for tax administration across the 52 economies covered by the series. Full Article
advanced Healthcare costs unsustainable in advanced economies without reform By www.oecd.org Published On :: Thu, 24 Sep 2015 11:00:00 GMT Healthcare costs are rising so fast in advanced economies that they will become unaffordable by mid-century without reforms, according to a new OECD report. Full Article
advanced Global Value Chains offer major opportunity for growth and progress in advanced and developing economies, according to OECD-WTO-UNCTAD report to G20 By www.oecd.org Published On :: Fri, 06 Sep 2013 22:53:00 GMT Global value chains (GVCs) have become a dominant feature of world trade and investment, offering new prospects for growth, development and jobs, according to a new joint report by the Organization for Economic Cooperation and Development (OECD), the World Trade Organization (WTO) and the United Nations Conference on Trade and Development (UNCTAD). Full Article
advanced Healthcare costs unsustainable in advanced economies without reform By www.oecd.org Published On :: Thu, 24 Sep 2015 11:00:00 GMT Healthcare costs are rising so fast in advanced economies that they will become unaffordable by mid-century without reforms, according to a new OECD report. Full Article
advanced Advanced economies growing again but some emerging economies slowing, says OECD By www.oecd.org Published On :: Tue, 03 Sep 2013 12:08:00 GMT A moderate recovery is underway in the major advanced economies, according to the OECD’s latest Interim Economic Assessment. Growth is proceeding at encouraging rates in North America, Japan and the UK. The euro area as a whole is out of recession, although output remains weak in a number of countries. Full Article
advanced Advanced economies growing again but some emerging economies slowing, says OECD By www.oecd.org Published On :: Tue, 03 Sep 2013 12:08:00 GMT A moderate recovery is underway in the major advanced economies, according to the OECD’s latest Interim Economic Assessment. Growth is proceeding at encouraging rates in North America, Japan and the UK. The euro area as a whole is out of recession, although output remains weak in a number of countries. Full Article
advanced Czech Republic needs new reforms to boost productivity and accelerate convergence with the most advanced countries By www.oecd.org Published On :: Mon, 06 Jun 2016 15:20:00 GMT The Czech Republic needs new reforms to boost productivity, improve economic growth and accelerate convergence toward the levels of income and well-being seen in the most advanced European countries, according to a new OECD report. Full Article
advanced Enhancing advanced skills to better meet labour market demand in the Slovak Republic By www.oecd-ilibrary.org Published On :: Thu, 28 Sep 2017 09:30:00 GMT Changing labour market demand and moving up the global value chain requires high-skilled workers. Full Article
advanced A new perspective on inequality: The income distribution across advanced countries By oecdecoscope.wordpress.com Published On :: Wed, 04 Apr 2018 10:38:00 GMT What is the relevant perspective for evaluating people’s living standards in advanced countries? According to standard assessments of inequality it is fellow citizens within the country. Full Article
advanced Poorer regions struggling to catch up in advanced economies, says OECD By www.oecd.org Published On :: Mon, 06 Oct 2014 15:00:00 GMT Living standards continue to diverge within many economically advanced countries as poorer regions struggle to catch up with richer ones. Half of the 34 OECD countries have seen the income gap between their best-off and worst-off regions widen since the 2008 crisis, according to new OECD research. Full Article
advanced Healthcare costs unsustainable in advanced economies without reform By www.oecd.org Published On :: Thu, 24 Sep 2015 11:00:00 GMT Healthcare costs are rising so fast in advanced economies that they will become unaffordable by mid-century without reforms, according to a new OECD report. Full Article
advanced Investment Treaties and Shareholder Claims for Reflective Loss: Insights from Advanced Systems of Corporate Law, International Investment Working Paper 2014/2 By dx.doi.org Published On :: Wed, 23 Jul 2014 13:41:00 GMT This paper examines shareholder claims for reflective loss under investment treaties in light of comparative analysis of advanced systems of corporate law; considers the impact of allowing shareholder claims for reflective loss on key characteristics of the business corporation; and explores possible responses by different categories of investors to the availability of shareholder claims for reflective loss under investment treaties. Full Article
advanced Napoli in advanced talks to extend Fabian Ruiz's contract as they reject £40m bid from Real Madrid By www.dailymail.co.uk Published On :: Sat, 07 Sep 2019 14:56:44 GMT The 23-year-old Spanish midfielder has built a strong reputation for himself following his £27m transfer from La Liga outfit Real Betis just last summer. Full Article
advanced Iran's President Rouhani warns his nuclear experts are testing new advanced centrifuges By www.dailymail.co.uk Published On :: Thu, 19 Dec 2019 17:30:26 GMT President Hassan Rouhani used his platform at the Islamic conference in the city to rebuke the 'heaviest sanctions' by the US, claiming Iran's economy is on the mend and moving away from reliance on oil. Full Article
advanced Man City 'in advanced talks over signing Nelson Semedo... with Joao Cancelo moving to Barcelona' By www.dailymail.co.uk Published On :: Thu, 30 Apr 2020 09:48:29 GMT Pep Guardiola is keen to bring Semedo to the Etihad and is willing to part with money and offer his former club Cancelo, who only signed from Juventus for £60m last summer, in order to reach a deal. Full Article
advanced Newcastle United and Amanda Staveley in advanced talks over £350m takeover By Published On :: Tue, 14 Apr 2020 12:25:28 +0100 Documents lodged last week and made public on Tuesday appear to be laying the legal framework for a deal to proceed. Sources close to the club say it is proof of talks being advanced. Full Article
advanced Man City 'in advanced talks over signing Nelson Semedo... with Joao Cancelo moving to Barcelona' By Published On :: Thu, 30 Apr 2020 08:09:23 +0100 Pep Guardiola is keen to bring Semedo to the Etihad and is willing to part with money and offer his former club Cancelo, who only signed from Juventus for £60m last summer, in order to reach a deal. Full Article
