Former British Columbia premier John Horgan loomed large over the swearing-in ceremony Wednesday for 47 New Democrat members of the legislature, a day after his death. 

Achieving business goals starts with having the best metrics in place to understand and respond to customers.

The traditional 11 November two-minute period of remembrance took place at 11:00 across the country.

Chloe Morrison was struck by part of a lorry's extended stabiliser leg as she walked on a pavement.

BBC Radio WM listeners share their memories and thoughts following the stars death.

This paper systematically discusses the security and privacy concerns for e-learning systems. A five-layer architecture of e-learning system is proposed. The security and privacy concerns are addressed respectively for five layers. This paper further examines the relationship among the security and privacy policy, the available security and privacy technology, and the degree of e-learning privacy and security. The digital identity attributes are introduced to e-learning portable devices to enhance the security and privacy of e-learning systems. This will provide significant contributions to the knowledge of e-learning security and privacy research communities and will generate more research interests.

The quality attributes of a software system are, to a large extent, determined by the decisions taken early in the development process. Best practices in software engineering recommend the identification of important quality attributes during the requirements elicitation process, and the specification of software architectures to satisfy these requirements. Over the years the software engineering community has studied the relationship between quality attributes and the use of particular architectural styles and patterns. In this paper we study the relationship between quality attributes and Aspect-Oriented Software Architectures - which apply the principles of Aspect-Oriented Software Development (AOSD) at the architectural level. AOSD focuses on identifying, modeling and composing crosscutting concerns - i.e. concerns that are tangled and/or scattered with other concerns of the application. In this paper we propose to use AO-ADL, an aspect-oriented architectural description language, to specify quality attributes by means of parameterizable, and thus reusable, architectural patterns. We particularly focus on quality attributes that: (1) have major implications on software functionality, requiring the incorporation of explicit functionality at the architectural level; (2) are complex enough as to be modeled by a set of related concerns and the compositions among them, and (3) crosscut domain specific functionality and are related to more than one component in the architecture. We illustrate our approach for usability, a critical quality attribute that satisfies the previous constraints and that requires special attention at the requirements and the architecture design stages.

Numerous scandals due to unethical decisions occur despite the growing use of decision support systems (DSS). Several scholars recommend incorporating ethical attributes along with business requirements in DSS design. However, little guidance exists to indicate which ethical attributes to include and the importance ethical attributes should be given in comparison to business requirements. This study addresses this deficiency by identifying ethical requirements to integrate in DSS design drawn from the business ethics literature. This study conducted a large-scale empirical survey with information technology decision-makers to examine the relative importance of DSS fit with ethical and business requirements as well as the appropriate balance of those requirements on perceived DSS performance. The results show that decision makers perceive better DSS performance when the ethical and business requirements align with its organisation's beliefs than from ethical or business requirements alone.

Based on the diffusion of innovation (DOI) theory (Rogers, 2003), the uses and gratifications (U&G) theory, and trust theory, this study investigated the factors that influence the use of Twitter among the Kuwaiti community. The study surveyed Twitter users in Kuwait. A structured online questionnaire was used to collect data, and 463 respondents who provided complete answers participated. Multiple regression analysis was used to examine the effect of three theoretical perspectives on Twitter usage. The result of the analysis showed that Twitter usage is better explained by DOI constructs than by U&G constructs. The findings indicated that the perceived relative advantage from DOI, and the need for information, need to pass time, and need for interpersonal utility from the U&G approach, have a direct positive significant effect on the use of Twitter. None of the trust theory constructs was found to be significant in predicting the general use of Twitter. The study results help Twitter providers and users in individual or organizational contexts to understand what factors generally affect the usage of the Twitter service.

Ian Theodoreson, who was diagnosed with muscular dystrophy in 2019, wrote that he ‘had lived a good life’ in a blog post posthumously published on 27 October

A coating uniquely embodies all the key traits in a finished food product—texture, appearance, flavor, and even, in most cases, aroma. With the increased demand for clean-label nutritious foods, developers are leveraging food coatings as a way to take those attributes and build healthfulness into texture in products designed to meet such requirements.

Smokers who are exposed to radon appear to be at even greater risk for lung cancer, because the effects of smoking and radon are more powerful when the two factors are combined, says a new report by a committee of the National Research Council.

Bacteria that resist antibiotics can be passed from food animals to humans, but not enough is known to determine the public health risks posed by such transmission, says a new report by a committee of the National Research Council.

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine was an active contributor at the first in-person Gulf of Mexico Conference (GoMCon) held in Baton Rouge, Louisiana, from April 25-28. The four-day conference gathered more than 800 researchers, resource managers, and interested stakeholders, and highlighted the intersection of scientific research and the management of human and natural systems in the Gulf of Mexico region.

No longer relegated to taco night, tortillas are playing a major role in Americans' meal plans, both at home and when dining out.

How is power distributed in an organization and how does it affect safety?

With no shortage of contributing factors for Americans’ rising stress levels, ingredient suppliers are turning to holistic ingredients that promote relaxation and stress relief to help beverage-makers meet consumers’ growing need states.

Future Electronics is contributing to reforestation efforts in Quebec by matching all employee donations to One Tree Planted.

We are into the 13th episode of Dan and Art's series on team building! This week, they're talking about structure and synergy in your company, and within your team.

We all know that air pollution is bad for the environment and our health. A new study out of the University of Michigan now shows that it is contributing to a loss of independence among older adults. The study also shows that the economic impact of that loss comes in at an estimate of over $11 billion. WEMU's David Fair spoke with the lead author of the study, Dr. Sara Adar, about the findings.

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Alan Gilmour from Glasgow City Community Health Partnership who participated in the PROP2 programme. This research aimed to gain an understanding of how training and information support contributes to positive outcomes for carers. It provided a range of information to answer specific questions such as: • Do carers feel that their needs are identified appropriately at different stages of their journey? • Does training contribute to the carer’s outcomes? • What are the barriers to carers engaging in training?

The amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)–linked RNA-binding protein called FUS (fused in sarcoma) has been implicated in several aspects of RNA regulation, including mRNA translation. The mechanism by which FUS affects the translation of polyribosomes has not been established. Here we show that FUS can associate with stalled polyribosomes and that this association is sensitive to mTOR (mammalian target of rapamycin) kinase activity. Specifically, we show that FUS association with polyribosomes is increased by Torin1 treatment or when cells are cultured in nutrient-deficient media, but not when cells are treated with rapamycin, the allosteric inhibitor of mTORC1. Moreover, we report that FUS is necessary for efficient stalling of translation because deficient cells are refractory to the inhibition of mTOR-dependent signaling by Torin1. We also show that ALS-linked FUS mutants R521G and P525L associate abundantly with polyribosomes and decrease global protein synthesis. Importantly, the inhibitory effect on translation by FUS is impaired by mutations that reduce its RNA-binding affinity. These findings demonstrate that FUS is an important RNA-binding protein that mediates translational repression through mTOR-dependent signaling and that ALS-linked FUS mutants can cause a toxic gain of function in the cytoplasm by repressing the translation of mRNA at polyribosomes.

Ryunosuke Ohkawa
Dec 1, 2020; 61:1577-1588
Research Articles

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflammatory cytokines that alter allopregnanolone (AlloP) levels, an important neurosteroid in the brain. We assessed the levels and regulation of AlloP and the effects of AlloP supplementation on cognitive function in 4-month-old and 24-month-old male C57BL/6 mice. With age, the expression of enzymes involved in the AlloP synthetic pathway was decreased and corticosterone (CORT) synthesis increased. Supplementation of AlloP improved cognitive function. Interestingly, interleukin 6 (IL-6) infusion in young animals significantly reduced the production of AlloP compared with controls. It is notable that inhibition of IL-6 with its natural inhibitor, soluble membrane glycoprotein 130, significantly improved spatial memory in aged mice. These findings were supported by in vitro experiments in primary murine astrocyte cultures, indicating that IL-6 decreases production of AlloP and increases CORT levels. Our results indicate that age-related increases in IL-6 levels reduce progesterone substrate availability, resulting in a decline in AlloP levels and an increase in CORT. Furthermore, our results indicate that AlloP is a critical link between inflammatory cytokines and the age-related decline in cognitive function.

Lipoproteins play a key role in transport of cholesterol to and from tissues. Recent studies have also demonstrated that red blood cells (RBCs), which carry large quantities of free cholesterol in their membrane, play an important role in reverse cholesterol transport. However, the exact role of RBCs in systemic cholesterol metabolism is poorly understood. RBCs were incubated with autologous plasma or isolated lipoproteins resulting in a significant net amount of cholesterol moved from RBCs to HDL, while cholesterol from LDL moved in the opposite direction. Furthermore, the bi-directional cholesterol transport between RBCs and plasma lipoproteins was saturable and temperature-, energy-, and time-dependent, consistent with an active process. We did not find LDLR, ABCG1, or scavenger receptor class B type 1 in RBCs but found a substantial amount of ABCA1 mRNA and protein. However, specific cholesterol efflux from RBCs to isolated apoA-I was negligible, and ABCA1 silencing with siRNA or inhibition with vanadate and Probucol did not inhibit the efflux to apoA-I, HDL, or plasma. Cholesterol efflux from and cholesterol uptake by RBCs from Abca1^+/+ and Abca1^–/– mice were similar, arguing against the role of ABCA1 in cholesterol flux between RBCs and lipoproteins. Bioinformatics analysis identified ABCA7, ABCG5, lipoprotein lipase, and mitochondrial translocator protein as possible candidates that may mediate the cholesterol flux. Together, these results suggest that RBCs actively participate in cholesterol transport in the blood, but the role of cholesterol transporters in RBCs remains uncertain.

Although common ‘disorders’ (e.g., eating disorders, anxiety, and depression) look different on the surface, there are some common underlying mechanisms. One of these is checking. I’m going to go explain the role of checking in a selection of common mental health problems. Checking in Health Anxiety Examples: – Person goes to the Dr for blood […]

The post CBT: How Checking Contributes to Mental Health Problems (Eating Disorders, Depression, Anxiety) appeared first on Dr Alice Boyes.

DOVER, DE (Jan. 3, 2023) – Through the Centers for Disease Control and Prevention’s State Unintentional Drug Overdose Reporting System (SUDORS), Delaware was recently among 47 states to contribute data to the CDC’s Dec. 16, 2022, Morbidity and Mortality Weekly Report, titled “Drug Overdose Deaths Among Persons Aged 10-19 Years – United States, July 2019-December 2021.” The Division of Public Health (DPH) utilizes SUDORS to track available trends and characteristics of […]

Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications.

A mum-of-four was tragically found dead at her home following a fire.

Music director and singer Adnan Sami said he was saddened by the demise of “one of the greatest Sarangi Maestros that the entire Indian subcontinent has ever witnessed”.

Dec 19, 2017

Celebrating the life and achievements of Professor Calestous Juma.

Feb 14, 2024

The Harvard Project participates in a major Harvard initiative aimed at reducing emissions of methane, a powerful greenhouse gas. Participating researchers represent a range of academic disciplines and Harvard schools.

In youth and adolescents, medlinkunhealthy lifestyle habits/medlink, including obesity, lack of sleep, and the consumption of junk and processed food,

One of the HTML elements that frequently comes into collision with CSS is the img element. As we learned in Request Metrics’ Fixing Cumulative Layout Shift Problems on DavidWalshBlog article, providing image dimensions within the image tag will help to improve your website’s score. But in a world where responsive design is king, we need […]

The post How to Override width and height HTML attributes with CSS appeared first on David Walsh Blog.

Kishor Pate writes on factors that determine the value of your property

The Members of Raja Raghbir Singh Club (RRSC) Dharamshala handed over a cheque of Rs. 50,000/- to Sh. Sandeep Kumar – DC Kangra (President of the RRSC Club Dharamshala) in favour of Smt. Savitri Devi wife of Martyr Tilak Raj. The Himachali CRPF jawan, Martyr Tilak Raj hailed from village Jandro in Jawali area of Kangra […]

Prime Minister Narendra Modi and President Droupadi Murmu were among those who paid tribute to the PM’s Economic Advisory Council chairman

Government reached the doorsteps of those who had never received any benefits: Modi

Skipper all praise for Cutting, SRH’s incisive bowling attack

The words humble and affectionate were among the many adjectives that reverberated during the virtual thanksgiving service for 62-year-old Roger Chang, as family friends paid tribute to the late businessman.  Chang, who went missing on...