The bike does win when it comes to its look and sound, but, is that enough?

अनिल कपूर और माधुरी दीक्षित की जोड़ी बॉलीवुड की पॉपुलर जोड़ियों में से एक है, जिन्होंने हिफाजत, बेटा, खेल, राम लखन, परिंदा और तेजाब जैसी फिल्मों में काम किया.

Shah Rukh Khan, well-known for his elegant yet approachable style, makes a statement with each presentation by fusing traditional elegance with contemporary elements. The Bollywood king's penchant for timeless appeal with a contemporary twist characterizes his ageless sense of style. He

Tezaab, released in November 1988, was a major commercial success at the box office, becoming the highest-grossing Indian film of the year. Running in theatres for over 50 weeks, it achieved Golden Jubilee status.

Shah Rukh Khan was mobbed by a throng of enthusiastic fans at Mumbai airport early Thursday morning as he departed for Abu Dhabi to host the IIFA Awards.

'I think because India is a bigger country and Bollywood is such a well-oiled machine, the star thing has become so much bigger than the actor thing.'

'I get scared. I feel insecure. I lose confidence many times in the day. But that is why I keep going because the weaker you are, the stronger you get'

Will Akki, who remade Vijay's Thuppakki in Hindi as Holiday: A Soldier Is Never Off Duty, thwart SRK?

Atlee gives temporary relief from reality, by blinding us into a make-believe world where the perfect family hero and messiah makes the world a safer and equal place for all, explains Divya Nair.

The lawyer told the police that he lost his phone a week before and had filed a police complaint, the official said.

Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage mAb that prevents extracellular proteolytic activation of pro- and latent myostatin. Here we used integrated structural and biochemical approaches to elucidate the molecular mechanism of antibody-mediated neutralization of pro-myostatin activation. The crystal structure of pro-myostatin in complex with 29H4-16 Fab, a high-affinity variant of SRK-015, at 2.79 Å resolution revealed that the antibody binds to a conformational epitope in the arm region of the prodomain distant from the proteolytic cleavage sites. This epitope is highly sequence-divergent, having only limited similarity to other closely related members of the transforming growth factor β superfamily. Hydrogen/deuterium exchange MS experiments indicated that antibody binding induces conformational changes in pro- and latent myostatin that span the arm region, the loops contiguous to the protease cleavage sites, and the latency-associated structural elements. Moreover, negative-stain EM with full-length antibodies disclosed a stable, ring-like antigen–antibody structure in which the two Fab arms of a single antibody occupy the two arm regions of the prodomain in the pro- and latent myostatin homodimers, suggesting a 1:1 (antibody:myostatin homodimer) binding stoichiometry. These results suggest that SRK-015 binding stabilizes the latent conformation and limits the accessibility of protease cleavage sites within the prodomain. These findings shed light on approaches that specifically block the extracellular activation of growth factors by targeting their precursor forms.

Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage mAb that prevents extracellular proteolytic activation of pro- and latent myostatin. Here we used integrated structural and biochemical approaches to elucidate the molecular mechanism of antibody-mediated neutralization of pro-myostatin activation. The crystal structure of pro-myostatin in complex with 29H4-16 Fab, a high-affinity variant of SRK-015, at 2.79 Å resolution revealed that the antibody binds to a conformational epitope in the arm region of the prodomain distant from the proteolytic cleavage sites. This epitope is highly sequence-divergent, having only limited similarity to other closely related members of the transforming growth factor β superfamily. Hydrogen/deuterium exchange MS experiments indicated that antibody binding induces conformational changes in pro- and latent myostatin that span the arm region, the loops contiguous to the protease cleavage sites, and the latency-associated structural elements. Moreover, negative-stain EM with full-length antibodies disclosed a stable, ring-like antigen–antibody structure in which the two Fab arms of a single antibody occupy the two arm regions of the prodomain in the pro- and latent myostatin homodimers, suggesting a 1:1 (antibody:myostatin homodimer) binding stoichiometry. These results suggest that SRK-015 binding stabilizes the latent conformation and limits the accessibility of protease cleavage sites within the prodomain. These findings shed light on approaches that specifically block the extracellular activation of growth factors by targeting their precursor forms.

Myostatin (or growth/differentiation factor 8 (GDF8)) is a member of the transforming growth factor β superfamily of growth factors and negatively regulates skeletal muscle growth. Its dysregulation is implicated in muscle wasting diseases. SRK-015 is a clinical-stage mAb that prevents extracellular proteolytic activation of pro- and latent myostatin. Here we used integrated structural and biochemical approaches to elucidate the molecular mechanism of antibody-mediated neutralization of pro-myostatin activation. The crystal structure of pro-myostatin in complex with 29H4-16 Fab, a high-affinity variant of SRK-015, at 2.79 Å resolution revealed that the antibody binds to a conformational epitope in the arm region of the prodomain distant from the proteolytic cleavage sites. This epitope is highly sequence-divergent, having only limited similarity to other closely related members of the transforming growth factor β superfamily. Hydrogen/deuterium exchange MS experiments indicated that antibody binding induces conformational changes in pro- and latent myostatin that span the arm region, the loops contiguous to the protease cleavage sites, and the latency-associated structural elements. Moreover, negative-stain EM with full-length antibodies disclosed a stable, ring-like antigen–antibody structure in which the two Fab arms of a single antibody occupy the two arm regions of the prodomain in the pro- and latent myostatin homodimers, suggesting a 1:1 (antibody:myostatin homodimer) binding stoichiometry. These results suggest that SRK-015 binding stabilizes the latent conformation and limits the accessibility of protease cleavage sites within the prodomain. These findings shed light on approaches that specifically block the extracellular activation of growth factors by targeting their precursor forms.

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Fresh trouble for SRK brought by the Shiv Sena men http://bit.ly/i8tocu #IMCRadio.net</span></span>

<strong>New Delhi:</strong> Gauri Khan took a stroll down her memory lane and shared a throwback family picture from their vacation featuring husband and megastar Shah Rukh Khan and their two kids. However, it is the doting father and a husband's response over the adorable picture which will just melt

Our Editor, Arpit Mahendra recently got a chance to speak to King Khan on the sidelines of the Hyundai Creta unveil at the Auto Expo 2020. Shah Rukh Khan talked to us about his favourite car apart from a Hyundai, of course. He also spoke about his likes and dislikes in modern cars and what […]

Zero

U/A: Comedy, Drama, Romance
Director: Anand L Rai
Cast: Shah Rukh Khan, Katrina Kaif, Anushka Sharma
Rating: 

For a couple of decades now, relentlessly citing exceptions like Swades (2004) and Chak De India (2007), viewers (and fans) of actor Shah Rukh Khan have often complained about how he plays SRK on screen, regardless of the script, which pretty much is designed around him playing himself, in some form or the other, anyway.

Alert to this obvious feedback, and with audiences, in general, upping its expectations, even from wholly star-driven pics—demanding a certain level of authenticity in stories regardless—you find SRK trying hard to up his own game. Which is great, of course. Raees (2017) and Fan (2016) are relatively good examples on that front. With Zero, as actor-producer, he appears to be trying a bit too hard, I suspect.

For one, this SRK film doesn't star SRK at all! He plays a Meeruthiya, uneducated 'bauna' (dwarf) Bauua Singh, obsessed with two women, almost simultaneously. Both ladies seem out of his reach. One's a fully celestial Bollywood heroine. That's Katrina Kaif. Tells you a lot about this film that she comes across as by far the most credible character around—a heart-broken drunk, dumped by a certain superstar with the surname Kapoor, who "pretends to be a misunderstood, shy type, but is actually a full-on ch*****."

Check out the trailer here:

The other woman (Anushka Sharma), strangely modeled on Stephen Hawking, in a high-tech wheelchair, her mouth contorted, wrist twisted and shaking, is a space scientist. She meets the vertically challenged dude through an odd, offline version of a matrimonial site. What she likes about him is that he can overlook her disabilities and see her as the person she is, rather than somebody one must simply sympathise with.

There is much banter between the two. This is tricky stuff. I understand that all humour is at the expense of some person/group or the other, and we mustn't get all too sensitive about such matters. But I just felt slightly discomfited throughout—mostly in anticipation of a poor joke, punching downwards, rather than one that actually occurs (expect tonnes of think pieces on the web soon though!).

As a viewer, you are rarely made to look beyond the fact that she suffers from cerebral palsy. More so, that he's about a foot shorter than usual, a man-child at the centre of this film— in his late 30s, wholly jobless bloke, blowing up his father's money. You can't tell if he's a duffer or just a dwarf. As if the two were even vaguely related. He is supposed to be a die-hard romantic. Your heart must melt for this simpleton still.

It's hard, if not impossible, to feel anything for such a parody of a person, as Zero jerkily jostles between heartland, rustic realism (Aanand L Rai's Tanu Weds Manu), and a far-out romantic fantasy, vaguely along the lines of SRK's wonderfully sorted Om Shanti Om (2007), also partly set in show-biz. You're in fact bored rather than bothered by all the travels on screen.

The only take-away is how tough it must've been to pull this off. Which is true for films of this massive scale—regardless of the emotional payoff. The VFX work, cutting down SRK's size, is by itself a work of art. And that's just a fraction of the craft and cost involved in a picture perennially on a flight of imagination—whether the penny drops, or not.

Guess it'd be impossible for filmmakers to attempt a leap of faith so high, without quite convincing themselves that they're on to a masterpiece. One hopes (for them), others feel so too. Clearly, I didn't.

Also Read: Zero Movie Interview: Shah Rukh Khan, Katrina Kaif And Anushka Sharma Reveal All

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Shah Rukh Khan just made his fans' day by telling them how to be on a video call with him. But, there's a challenge.

एमसीए के बयान और कथित तौर पर शाहरुख के शराब पीकर उत्पात मचाने की खबरों के बीच सभी यह जानना चाहते हैं कि आखिर कल रात की हकीकत क्या थी?

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Why you don't admire SRK in Raees

The TKR has involved their local icons Kieron Pollard, Dwayne Bravo, Darren Bravo, Lendl Simmons and Sunil Narine, who along with the team's support staff will be personally distributing the hampers to various areas of the island nation.