Trippy beats with rhodes piano, mandolin and various instruments. One for late nights.

He was born in Corinth of pious Christian parents. At the age of eighteen he went to Palestine, where, after studying under several holy fathers, he entered monastic life and became the disciple of St Gerasim of the Jordan. After St Gerasim's death he lived in strict solitude, asceticism and silence for many years, finally entering the monastery of St Chariton, where he reposed in peace at the age of 109. Despite his very severe asceticism, he was large and strong, remaining so until the end of his life. According to the rule of St Chariton, he and his fellow-monks ate only once a day, after sunset. In the desert, he lived for years on nothing but the raw plants that he gathered there. He said of himself that, while he was a monk, the sun never saw him eat or be angry with any man.

He was born in Corinth of pious Christian parents. At the age of eighteen he went to Palestine, where, after studying under several holy fathers, he entered monastic life and became the disciple of St Gerasim of the Jordan. After St Gerasim's death he lived in strict solitude, asceticism and silence for many years, finally entering the monastery of St Chariton, where he reposed in peace at the age of 109. Despite his very severe asceticism, he was large and strong, remaining so until the end of his life. According to the rule of St Chariton, he and his fellow-monks ate only once a day, after sunset. In the desert, he lived for years on nothing but the raw plants that he gathered there. He said of himself that, while he was a monk, the sun never saw him eat or be angry with any man.

Solitary Hunter by Kitty Cantrell is a(n) Limited Edition. The Edition is Limited to Limited Edition of 350 pcs

Solitary Hunter AP by Kitty Cantrell is a(n) Limited Edition. The Edition is Limited to Artist Proof of 35 pcs

Solitary White Iris by Brian Davis is a(n) Limited Edition. The Edition is Limited to 95 pcs

For those who want to get away from it all, there’s always the Maldives

Top Indians Arjun Erigaisi and Vidit Gujrathi drew with Iranians Parham Maghsoodloo and Amin Tabatabaei

Rooting through the garbage for a late-night snack or stealing food from the cat’s bowl, the suburban raccoon is a nocturnal, intelligent animal. Yet life […]

The post Suburban raccoons more social yet dominance behavior remains that of a solitary animal appeared first on Smithsonian Insider.

Quilty the rescue cat will not be contained at the shelter.

In this work we consider the initial-value problem associated with a coupled system of generalized Korteweg-de Vries equations. We present a relationship between the best constant for a Gagliardo-Nirenberg type inequality and a criterion for the existence of global solutions in the energy space. We prove that such a constant is directly related to the existence problem of solitary-wave solutions with minimal mass, the so called ground state solutions. To guarantee the existence of ground states we use a variational method.

Svetlana Mastitskaya
Apr 8, 2020; 40:3052-3062
Systems/Circuits

Maintenance of cardiorespiratory homeostasis depends on autonomic reflexes controlled by neuronal circuits of the brainstem. The neurophysiology and neuroanatomy of these reflex pathways are well understood, however, the mechanisms and functional significance of autonomic circuit modulation by glial cells remain largely unknown. In the experiments conducted in male laboratory rats we show that astrocytes of the nucleus of the solitary tract (NTS), the brain area that receives and integrates sensory information from the heart and blood vessels, respond to incoming afferent inputs with [Ca²⁺]_i elevations. Astroglial [Ca²⁺]_i responses are triggered by transmitters released by vagal afferents, glutamate acting at AMPA receptors and 5-HT acting at 5-HT_2A receptors. In conscious freely behaving animals blockade of Ca²⁺-dependent vesicular release mechanisms in NTS astrocytes by virally driven expression of a dominant-negative SNARE protein (dnSNARE) increased baroreflex sensitivity by 70% (p < 0.001). This effect of compromised astroglial function was specific to the NTS as expression of dnSNARE in astrocytes of the ventrolateral brainstem had no effect. ATP is considered the principle gliotransmitter and is released by vesicular mechanisms blocked by dnSNARE expression. Consistent with this hypothesis, in anesthetized rats, pharmacological activation of P2Y₁ purinoceptors in the NTS decreased baroreflex gain by 40% (p = 0.031), whereas blockade of P2Y₁ receptors increased baroreflex gain by 57% (p = 0.018). These results suggest that glutamate and 5-HT, released by NTS afferent terminals, trigger Ca²⁺-dependent astroglial release of ATP to modulate baroreflex sensitivity via P2Y₁ receptors. These data add to the growing body of evidence supporting an active role of astrocytes in brain information processing.

SIGNIFICANCE STATEMENT Cardiorespiratory reflexes maintain autonomic balance and ensure cardiovascular health. Impaired baroreflex may contribute to the development of cardiovascular disease and serves as a robust predictor of cardiovascular and all-cause mortality. The data obtained in this study suggest that astrocytes are integral components of the brainstem mechanisms that process afferent information and modulate baroreflex sensitivity via the release of ATP. Any condition associated with higher levels of "ambient" ATP in the NTS would be expected to decrease baroreflex gain by the mechanism described here. As ATP is the primary signaling molecule of glial cells (astrocytes, microglia), responding to metabolic stress and inflammatory stimuli, our study suggests a plausible mechanism of how the central component of the baroreflex is affected in pathological conditions.

A reduced nephron number is associated with glomerular hyperfiltration, resulting in renal injury such as hypertension, proteinuria, and chronic kidney disease. Patients with a solitary functioning kidney have an increased risk of dialysis in early adulthood.

This study demonstrates that a subset of children with a solitary functioning kidney progress toward renal injury during childhood. Risk factors for renal injury are ipsilateral anomalies of the kidney and urinary tract and small renal length. (Read the full article)

The discovery of a species of octopus that lives in groups and mates face-to-face is changing our thinking about what cephalopods are capable of

BACKGROUND AND PURPOSE:

Accurate differentiation between glioblastoma and solitary brain metastasis is of vital importance clinically. This study aimed to investigate the potential value of the inflow-based vascular-space-occupancy MR imaging technique, which has no need for an exogenous contrast agent, in differentiating glioblastoma and solitary brain metastasis and to compare it with DSC MR imaging.

The Justice Department issued a findings letter detailing the results of its investigation into the use of solitary confinement on prisoners with serious mental illness at the Pennsylvania State Correctional Institution at Cresson in Cambria County, Pa

Speaking in a video message posted on the Justice Department’s website, Attorney General Eric Holder on Wednesday called for an end to the excessive use of solitary confinement for youth that suffer from mental illness. Attorney General Holder said the practices can have lasting, substantial effects on young people that could result in self-harm or, in some cases, even suicide.

TWH's Mexico columnist, Jaime Gironés, reflects on what it means to be isolated on Beltane.

Continue reading Column: A Solitary Celebration at The Wild Hunt.

The disgraced athlete was led down to holding cells as he was handed a five-year prison term after the judge ruled that a non-custodial sentence would send the 'wrong message to the community'.

Online Resource

Dewey Library - QC174.45.B7357 2019