The first minister was speaking after SNP MPs put their names forward to stand at the 2026 Holyrood election.

SNP SE, a leading provider of software for digital transformation, automated data migration and data management in the SAP environment, has published a meta study examining the current state of SAP S/4HANA migrations.

Ministers could face a huge bill if they lose a legal fight over beleaguered bottle return plans.

Hello everyone, 
I have a testbench for generating s2p files from a SP simulation that was working until few months ago. Today I have reopened (w/o making changes that I am aware of) and I get the error as shown below:

first I show the testbench settings:

notice how the s2p generation is disabled: the field "file" is left blank

in the corner I defined some parameters, "filename" is the word that is suppose to generate the name for the s2p. 

where the two variables are defined as follows

And now the output log:

spectre.out file gives the following error:


When clicking on the error message at "9", the input.scs file opens up and the line 9 gets highlighted in green



now, so far I understood that the problem seem to be related tom the "pathcds" variable, but I really don't understand what the error message here means, since I don't see any error in the input.scs file

by the way - if for instance I define the variable "filename" as shown below, then I get no errors:

thanks
Tommaso

Human rights campaigners are calling on SNP ministers to do all they can to “mitigate” Prevent, the UK Government's controversial anti-terror strategy.

"I look forward to any contest, where of course it will be for branch members to select those they wish to represent them in Holyrood in the 2026 Scottish Parliament elections.”

"Kate Forbes still has her own leadership ambitions, setting them aside this Spring in the interest of party unity to accept Mr Swinney's offer to become Deputy First Minister."

Stephen Flynn has been criticised by SNP colleagues after saying he would stay on at Westminster, even if elected to Holyrood.

The SNP's Westminster leader has announced he is to contest a seat at Holyrood – and will ‘double-job’ as an MP and MSP if he wins.

Former MP Joanna Cherry has said that the SNP rules which prevented her from standing for a seat at Holyrood would not block Stephen Flynn from doing the same.  

The MP is aiming to hold seats at both the UK and Scottish parliaments, sparking criticism from colleagues.

THE Treasury has bombarded us all week with facts, figures and forecasts making the case for the UK to remain in the European Union. Its big report, on Monday, warned Brexit would tip the country into a year-long recession, resulting in up to 820,000 job losses within two years.

MSPS were really quite excited last week to be taking part in a largely symbolic vote with an entirely predictable outcome.

Something unintentionally funny keeps happening on the politically feverish fringes of Scottish social media.

Plasma lipoprotein (a) [Lp(a)] levels are largely determined by variation in the LPA gene, which codes for apo(a). Genome-wide association studies (GWASs) have identified nonsynonymous variants in LPA that associate with low Lp(a) levels, although their effect on apo(a) function is unknown. We investigated two such variants, R990Q and R1771C, which were present in four null Lp(a) individuals, for structural and functional effects. Sequence alignments showed the R990 and R1771 residues to be highly conserved and homologous to each other and to residues associated with plasminogen deficiency. Structural modeling showed both residues to make several polar contacts with neighboring residues that would be ablated on substitution. Recombinant expression of the WT and R1771C apo(a) in liver and kidney cells showed an abundance of an immature form for both apo(a) proteins. A mature form of apo(a) was only seen with the WT protein. Imaging of the recombinant apo(a) proteins in conjunction with markers of the secretory pathway indicated a poor transit of R1771C into the Golgi. Furthermore, the R1771C mutant displayed a glycosylation pattern consistent with ER, but not Golgi, glycosylation. We conclude that R1771 and the equivalent R990 residue facilitate correct folding of the apo(a) kringle structure and mutations at these positions prevent the proper folding required for full maturation and secretion. To our knowledge, this is the first example of nonsynonymous variants in LPA being causative of a null Lp(a) phenotype.

Zhonghua Liu, Ian Barnett, Xihong Lin.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 433--451.

Abstract:
Principal component analysis (PCA) is a popular method for dimension reduction in unsupervised multivariate analysis. However, existing ad hoc uses of PCA in both multivariate regression (multiple outcomes) and multiple regression (multiple predictors) lack theoretical justification. The differences in the statistical properties of PCAs in these two regression settings are not well understood. In this paper we provide theoretical results on the power of PCA in genetic association testings in both multiple phenotype and SNP-set settings. The multiple phenotype setting refers to the case when one is interested in studying the association between a single SNP and multiple phenotypes as outcomes. The SNP-set setting refers to the case when one is interested in studying the association between multiple SNPs in a SNP set and a single phenotype as the outcome. We demonstrate analytically that the properties of the PC-based analysis in these two regression settings are substantially different. We show that the lower order PCs, that is, PCs with large eigenvalues, are generally preferred and lead to a higher power in the SNP-set setting, while the higher-order PCs, that is, PCs with small eigenvalues, are generally preferred in the multiple phenotype setting. We also investigate the power of three other popular statistical methods, the Wald test, the variance component test and the minimum $p$-value test, in both multiple phenotype and SNP-set settings. We use theoretical power, simulation studies, and two real data analyses to validate our findings.

Armin Schwartzman, Andrew J. Schork, Rong Zablocki, Wesley K. Thompson.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2509--2538.

Abstract:
Analysis of genome-wide association studies (GWAS) is characterized by a large number of univariate regressions where a quantitative trait is regressed on hundreds of thousands to millions of single-nucleotide polymorphism (SNP) allele counts, one at a time. This article proposes an estimator of the SNP heritability of the trait, defined here as the fraction of the variance of the trait explained by the SNPs in the study. The proposed GWAS heritability (GWASH) estimator is easy to compute, highly interpretable and is consistent as the number of SNPs and the sample size increase. More importantly, it can be computed from summary statistics typically reported in GWAS, not requiring access to the original data. The estimator takes full account of the linkage disequilibrium (LD) or correlation between the SNPs in the study through moments of the LD matrix, estimable from auxiliary datasets. Unlike other proposed estimators in the literature, we establish the theoretical properties of the GWASH estimator and obtain analytical estimates of the precision, allowing for power and sample size calculations for SNP heritability estimates and forming a firm foundation for future methodological development.

WELL that didn’t take long. Scotland’s latest experiment in direct democracy was all but killed off this week, barely two months after Nicola Sturgeon announced it.

In “Painting Nationalism Red?”, an engaging new pamphlet published by Democratic Left Scotland, the journalist Neal Ascherson pays tribute to Tom Nairn as Scotland’s “pre-eminent political intellectual”.

Shortly before the second general election of 1974, the late John P Mackintosh attempted to explain the rise of the Scottish National Party to a predominantly left-wing (and English) audience in an essay for the New Statesman.

“Scotland”, declared a young Alex Salmond in May 1975, “knows from bitter experience what treatment is in store for a powerless region of a common market.”

SNP MP Steven Bonnar has apologised after a heated altercation with a neighbour.

THE SNP is so rotten it may have to be replaced by a new independence party, its former deputy leader has said.

The Scottish political world is holding its breath this weekend.

AN SNP MP has been accused of capitalising on the virus crisis to undermine Nicola Sturgeon and boost their own profile following a series of remarks made in an online party meeting.

Although genome-wide association studies (GWAS) have identified more than 100 colorectal cancer risk loci, most of the biological mechanisms associated with these loci remain unclear. Here we first performed a comprehensive expression quantitative trait loci analysis in colorectal cancer tissues adjusted for multiple confounders to test the determinants of germline variants in established GWAS susceptibility loci on mRNA and long noncoding RNA (lncRNA) expression. Combining integrative functional genomic/epigenomic analyses and a large-scale population study consisting of 6,024 cases and 10,022 controls, we then prioritized rs174575 with a C>G change as a potential causal candidate for colorectal cancer at 11q12.2, as its G allele was associated with an increased risk of colorectal cancer (OR = 1.26; 95% confidence interval = 1.17–1.36; P = 2.57 × 10–9). rs174575 acted as an allele-specific enhancer to distally facilitate expression of both FADS2 and lncRNA AP002754.2 via long-range enhancer–promoter interaction loops, which were mediated by E2F1. AP002754.2 further activated a transcriptional activator that upregulated FADS2 expression. FADS2, in turn, was overexpressed in colorectal cancer tumor tissues and functioned as a potential oncogene that facilitated colorectal cancer cell proliferation and xenograft growth in vitro and in vivo by increasing the metabolism of PGE2, an oncogenic molecule involved in colorectal cancer tumorigenesis. Our findings represent a novel mechanism by which a noncoding variant can facilitate long-range genome interactions to modulate the expression of multiple genes including not only mRNA, but also lncRNA, which provides new insights into the understanding of colorectal cancer etiology.Significance:This study provides an oncogenic regulatory circuit among several oncogenes including E2F1, FADS2, and AP002754.2 underlying the association of rs174575 with colorectal cancer risk, which is driven by long-range enhancer–promoter interaction loops.Graphical Abstract:http://cancerres.aacrjournals.org/content/canres/80/9/1804/F1.large.jpg.

THE leader of the Scottish Conservative Party has outlined his plan to stop Nicola Sturgeon and the SNP becoming Scotland's biggest party at the 2021 Scottish election.

The SNP have been ramping up calls for independence. But with their ex-leader (pictured with Nicola Sturgeon) on trial for attempted rape, their record in power is shameful, the Mail reports.

SNP Westminster leader Ian Blackford delivered the extraordinary tirade at PMQs, hammering Mr Johnson for describing muslim women in veils as 'letterboxes'.

Labour looked set to stop Boris Johnson's plans for an early election last night following talks with the SNP. The parties are thought to have agreed an election can only come after a Brexit extension.

Jeremy Corbyn met Ian Blackford, the Scottish nationalists' Westminster leader, yesterday to agree an election should only be held after Britain has secured another Brexit delay from the EU.

Piers Morgan challenged Nicola  Sturgeon to 'suck it up' comparing her defeat in the 2014 Scottish independence referendum to Scotland's rugby loss to Japan yesterday.

Nicola Sturgeon today issued a fresh rallying cry for Scottish independence as she claimed the SNP is 'winning the case' for a split from the rest of the UK, but Downing Street was quick to rebuff her.

The SNP Westminster leader backs Mr Corbyn's (pictured) claim to be the best person to form a government if a no confidence vote against Boris Johnson succeeds.

Prime Minister Boris Johnson could get a Christmas general election. MPs from across the UK are set to vote on Mr Johnson's call for election.

The first minister of Scotland said that her party's message would be 'clear, simple and unambiguous - vote SNP to demand independence and secure Scotland's right to choose'.

Jeremy Corbyn is ready to 'throw the UK under a bus' by forming a coalition with the SNP that would break up Britain, Michael Gove has warned. He said that Labour and the SNP were now 'in bed together'.

Ian Blackford said today the SNP will draw up a 'wish list' of demands ahead of potential post-election cooperation talks with Labour as he hinted scrapping Trident could be one of the party's red lines.

Nicola Sturgeon today confirmed she would demand the UK's Trident nuclear deterrent be scrapped as the price of SNP support for a minority Labour government led by Jeremy Corbyn.

Labour's leader in Scotland, Richard Leonard, today suggested that if would only require 'the election of parties into a majority' to provide a mandate.

Lord Kerslake said the Labour party would 'need to have conversations' with the Liberal Democrats and SNP if the election produces a hung parliament. Labour played down the comments.

John Nicholson, the candidate for the marginal seat of Ochil and South Perthshire, tried to rally supporters with a tub-thumping speech ahead of the tightly-fought ballot on December 12.

In a dramatic intervention, Dominic Cummings said the General Election was 'much tighter' than the polls suggested and warned of a 'very real possibility of a hung parliament'.

The Liberal Democrats lost the East Dunbartonshire seat to the SNP's Amy Callaghan by just 149 votes. Nicola Sturgeon was filmed shaking her fists with joy at the news of her party's gain.

The SNP won 35 seats in 2017 but managed to secure 12 more at the general election last week - a surge which has bolstered Ms Sturgeon's calls for a second breakaway ballot.

Steven Bonnar, the newly elected MP for Coatbridge, Chryston and Bellshill, crossed his index finger and his middle finger as he made a 'solemn affirmation' to the monarch.

The Labour leadership challenger made the comment at a hustings event last week and provoked fury from the party as she labelled its members 'Tories wrapped up in nationalist clothing'.

Nicola Sturgeon is alleged to have issued the edict after concerns were raised at staff meetings about Derek Mackay's behaviour.