In which Nicole checks in with Orthodox-Twitter’s Favorite Protestant™ Traci Rhoades on the topic of “anniversary reaction.” Connect with Nicole on Instagram or Twitter (@NicoleRoccas). Mentioned in this episode: ● TIME ETERNAL BOOK CLUB - August 12, 2021 - Register on Eventbrite: https://bit.ly/2UMvP5r ● Find Traci Rhoades online: ○ Twitter: @tracesoffaith ○ Instagram: @tracesoffaithblog ○ Facebook: @tracesoffaithblog ● Traci’s article on anniversary reaction: The Intersection of Peter’s Passion with the Passion of The Christ” (Medishare, 2021, https://www.medishare.com/blog/the-intersection-of-peters-passion-with-the-passion-of-the-christ) ● Ellen Hendriksen, “5 Ways to Deal With Anniversary Reactions,” (Psychology Today, 2016, https://www.psychologytoday.com/us/blog/how-be-yourself/201609/5-ways-deal-anniversary-reactions) ● Nicole Roccas, “The Love of God and the Calendar of Shame” (Time Eternal Blog, 2016, https://blogs.ancientfaith.com/timeeternal/love-god-calendar-shame/) ● "Every Moment Holy: New Liturgies for Daily Life," www.everymomentholy.com, including A Liturgy for the Anniversary of a Loss, https://static1.squarespace.com/static/59764bcb725e2575438613ad/t/603d4da4b9906c6d9e7501b6/1614630309096/Anniversary+of+a+Loss.pdf The intro and outro of this podcast are the songs "Idea" and "Remedy for Melancholy" by Kai Engel, available under a CC BY-NC 4.0 license. News Theme 2 by Audionautix is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Artist: http://audionautix.com/

The reunion episode also sees Kandi Burruss and Porsha opening up about where their friendship stands today as they're now following each other on social media after years of ups and downs.

Albany : State University of New York Press, [1991]

Archives, Room Use Only - TK5262.R46 1924

In related news, Eva allegedly 'felt disrespected' during a heated fight at 'The Real Housewives of Atlanta' season 12 reunion, which will air on Sunday, May 10.

Prior to this, it was said that the Bravo honchos decided to fire Cynthia and fellow 'The Real Housewives of Atlanta' star Eva Marcille because their 'storylines were the weakest.'

In a new video from part 1 of the reunion, the Housewives are talking about Kenya's subdued persona named Ken, the nickname given by Kenya's estranged husband Marc Daly.

In a new video from part 1 of the reunion, the Housewives are talking about Kenya's subdued persona named Ken, the nickname given by Kenya's estranged husband Marc Daly.

Social distancing hasn’t stopped the shade.

Find out what caused the dysfunction.

Have we reached peak pandemic entertainment?

The ladies spilled plenty of tea.

Andy Cohen had to put both of the reality tv stars on mute.

Monica L. Salgado-Lucio, Danelia Ramirez-Ramirez, Coral Y. Jorge-Cruz, Ana L. Roa-Espitia, and Enrique O. Hernandez-Gonzalez

Actin polymerization is a crucial process during sperm capacitation. We have recently described the participation of FAK during actin polymerization in guinea pig spermatozoa. However, the mechanism by which FAK mediates these processes is unknown. Our previous data have shown that MAPK1 (hereafter referred to as ERK2) is activated during the first minutes of capacitation, and inhibition of ERK2 blocked actin polymerization and the acrosome reaction. In this current study, we found that FAK is involved in ERK2 activation – as FAK was phosphorylated at tyrosine residue 925 and bound to Grb2 – and that inhibition of FAK results in a significant decrease of ERK2 activation. We also confirmed the presence of Rho guanine nucleotide exchange factor 2 (ARHGEF2, hereafter referred to as GEF-H1), which is able to associate with RhoA during capacitation. RhoA activation and its participation in actin polymerization were also analyzed. Inhibition of FAK or ERK1/2 impeded GEF-H1 phosphorylation, RhoA activation, and the association between GEF-H1 and RhoA. Finally, we observed the presence of fibronectin on the sperm surface, its role in sperm–sperm interaction as well as participation of β-integrin in the activation of ERK2. Our results show that the signaling pathway downstream of fibronectin, via integrin, FAK, Grb2, MEK1/2, ERK2, GEF-H1 and RhoA regulates the actin polymerization associated with spermatozoa capacitation.

Proteinase-activated receptors (PARs) are a four-member family of G-protein–coupled receptors that are activated via proteolysis. PAR4 is a member of this family that is cleaved and activated by serine proteinases such as thrombin, trypsin, and cathepsin-G. PAR4 is expressed in a variety of tissues and cell types, including platelets, vascular smooth muscle cells, and neuronal cells. In studying PAR4 signaling and trafficking, we observed dynamic changes in the cell membrane, with spherical membrane protrusions that resemble plasma membrane blebbing. Since nonapoptotic membrane blebbing is now recognized as an important regulator of cell migration, cancer cell invasion, and vesicular content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that leads to such events. Using a combination of pharmacological inhibition and CRISPR/CRISPR-associated protein 9 (Cas9)–mediated gene editing approaches, we establish that PAR4-dependent membrane blebbing occurs independently of the Gα_q/11- and Gα_i-signaling pathways and is dependent on signaling via the β-arrestin-1/2 and Ras homolog family member A (RhoA) signaling pathways. Together these studies provide further mechanistic insight into PAR4 regulation of cellular function.

Have we reached peak pandemic entertainment?

The ladies spilled plenty of tea.

Andy Cohen had to put both of the reality tv stars on mute.