The new HALO Cloud App was designed to provide customers with a modern tool that places crucial alerts at their fingertips, wherever they might be in a building.

Ramzan M. Zakir, MD, RPVI, FACC, FSCAI, shared his professional achievements and industry expertise in GQ magazine

The latest report from the hot desk of Sir Howard Elston

Revolutionary production process allows a simple transfer of a common OPV preliminary product to real customised OPV products

After the most recent successfully completed project for OPV optimization with regard to weak light behavior, OPVIUS has now developed an IoT platform based on this. The platform allows the integration of an OPV-based power supply into IoT sensors.

Up to 20 homes and structures are destroyed in the village of Rappville, as watch and act warnings are issued for several bushfires burning within 100km of each other in northern NSW.

An RFS crew drives through the northern NSW village of Rappville, one of the areas worst affected by a series of bushfires in northern NSW on October 8, 2019.

Rappville residents share stories of survival after a bushfire swept through their small community in northern NSW, with one 82-year-old pensioner hiding in his shed in a bid to escape the inferno.

After watching their home burn on the news, Tina Hag, Robert Collier and their four children return to Rappville, wondering about the future of their northern New South Wales town, which lost 15 homes and 20,000 hectares of grazing land to a bushfire.

The community of Rappville in northern NSW is banding together to make sure everyone gets back on their feet, but Allan Robertson is dreading having to tell his partner that their home is now just ashes.

As ferocious blazes tore through Rappville last week, many of the community's young people displayed extraordinary bravery, rescuing their neighbours and animals while fighting tooth and nail to save homes.

If you’re feeling awful, you know who to blame.

Visions 2020: Nydia Han and 6abc celebrates Asian Pacific American Heritage Month - 6abc  WPVI-TV

SIPVicious tools address the need for traditional security tools to be ported to SIP. This package consists of a SIP scanner, a SIP wardialer, and a SIP PBX cracker. Written in Python.

Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2. Here, the role of dynamin 2 was investigated in platelet hemostatic function using both pharmacological and genetic approaches. Dnm2^fl/fl Pf4-Cre (Dnm2^Plt–/–) mice specifically lacking dynamin 2 within the platelet lineage developed severe thrombocytopenia and bleeding diathesis and Dnm2^Plt–/– platelets adhered poorly to collagen under arterial shear rates. Signaling via the collagen receptor GPVI was impaired in platelets treated with the dynamin GTPase inhibitor dynasore, as evidenced by poor protein tyrosine phosphorylation, including that of the proximal tyrosine kinase Lyn on its activating tyrosine 396 residue. Platelet stimulation via GPVI resulted in a slight decrease in GPVI, which was maintained by dynasore treatment. Dynasore-treated platelets had attenuated function when stimulated via GPVI, as evidenced by reduced GPIbα downregulation, α-granule release, integrin αIIbβ3 activation, and spreading onto immobilized fibrinogen. By contrast, responses to the G-protein coupled receptor agonist thrombin were minimally affected by dynasore treatment. GPVI expression was severely reduced in Dnm2^Plt–/– platelets, which were dysfunctional in response to stimulation via GPVI, and to a lesser extent to thrombin. Dnm2^Plt–/– platelets lacked fibrinogen in their α-granules, but retained von Willebrand factor. Taken together, the data show that dynamin 2 plays a proximal role in signaling via the collagen receptor GPVI and is required for fibrinogen uptake and normal platelet hemostatic function.