ps1

Trojan.PS1.POWLOAD.JKP

Threat type: Trojan

Aliases: N/A

Platforms: Windows

Overall Risk Rating: Low

Damage Potential: Medium

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Low

Overview:

This POWLOAD variant is seen distributed via spam. The spam campaign is in Italian and lures users to click by using COVID-19 in its subject.

This Trojan arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.




ps1

Trojan.PS1.BOXTER.A

Threat type: Trojan

Aliases:

Platforms: Windows

Overall Risk Rating: Low

Damage Potential: Medium

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Medium

Overview:

This Trojan arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.




ps1

Ransom.PS1.LOCKBIT.AA

Threat type: Ransomware

Aliases: Trojan:Win32/Leonem (MICROSOFT); Win32/Filecoder.Lockbit.M trojan (NOD32)

Platforms: Windows

Overall Risk Rating: Low

Damage Potential: Medium

Distribution Potential: Low

Reported Infection: Low

Information Exposure: Low

Overview:

This Ransomware arrives on a system as a file dropped by other malware or as a file downloaded unknowingly by users when visiting malicious sites.

It drops files as ransom note. It avoids encrypting files with the following file extensions.




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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Illiquid Assets - New FCA rules (PS19/24) and “Dear Chair” Letter

Introduction The FCA published its Policy Statement (PS19/24) in relation to illiquid assets and open-ended funds on 30 September 2019. The statement responds to feedback provided in response to Consultation Paper (CP18/27) and settles on a final sl...




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Phenotypic variability in chorea-acanthocytosis associated with novel VPS13A mutations

Objective

To perform a comprehensive characterization of a cohort of patients with chorea-acanthocytosis (ChAc) in Sweden.

Methods

Clinical assessments, targeted genetic studies, neuroimaging with MRI, [18F]-fluorodeoxyglucose (FDG) PET, and dopamine transporter with 123I FP-CIT (DaTscan) SPECT. One patient underwent magnetic resonance spectroscopy (MRS).

Results

Four patients living in Sweden but with different ethnical backgrounds were included. Their clinical features were variable. Biallelic VPS13A mutations were confirmed in all patients, including 3 novel mutations. All tested patients had either low or absent chorein levels. One patient had progressive caudate atrophy. Investigation using FDG-PET revealed severe bilateral striatal hypometabolism, and DaTscan SPECT displayed presynaptic dopaminergic deficiency in 3 patients. MRS demonstrated reduced N-acetylaspartate/creatine (Cr) ratio and mild elevation of both choline/Cr and combined glutamate and glutamine/Cr in the striatum in 1 case. One patient died during sleep, and another was treated with deep brain stimulation, which transiently attenuated feeding dystonia but not his gait disorder or chorea.

Conclusions

Larger longitudinal neuroimaging studies with different modalities, particularly MRS, are needed to determine their potential role as biomarkers for ChAc.




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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035




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The influence of amyloid-beta, a major pathological marker in Alzheimer's disease, on molecular cognitive processes of APP+PS1 transgenic mice