I like the philosophy behind shooting with primes; that a photographer shouldn’t stand still but instead, continuously move closer, further, lower, or higher relative to his/her subject as a means of establishing a deeper connection. ????????
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A research team led by a Northwestern University scientist has discovered that male animals, through their invisible chemical "essence," prime female animals for reproduction but with the unfortunate side effect of also hastening females' aging process.

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Featuring the AMD Ryzen 7 PRO 5750G, this case=heatsink PC costs from $2,179.

BASF a primit aprobarea de finanțare din partea Ministerului Federal German pentru Afaceri Economice și Acțiune Climatică pentru construcția celei mai puternice pompe de căldură industriale din lume. Astfel, în următoarele luni, compania va putea începe lucrările de construcție pregătitoare pentru acest proiect la platforma sa din Ludwigshafen. Proiectul își propune să aducă o contribuție ...

The post BASF primește aprobarea de finanțare pentru construcția celei mai mari pompe de căldură industriale din lume appeared first on Forbes Romania.

Boston : Birkhäuser, [2007]

Cambridge, United Kingdom ; New York, NY : Cambridge University Press, 2021.

I like the philosophy behind shooting with primes; that a photographer shouldn’t stand still but instead, continuously move closer, further, lower, or higher relative to his/her subject as a means of establishing a deeper connection. ????????
—
Save 50% on my custom Lightroom presets with HOLIDAY50. Link in profile. (at Toronto, Ontario)

Jonathan P. Sorenson and Jonathan Webster
Math. Comp. 89 (2020), 1953-1968.
Abstract, references and article information

Branched esters of palmitic acid and hydroxystearic acid (PAHSA) are anti-inflammatory and antidiabetic lipokines that connect glucose and lipid metabolism. We aimed to characterize involvement of the 5-PAHSA regioisomer in the adaptive metabolic response of white adipose tissue (WAT) to cold exposure (CE) in mice, exploring the cross talk between glucose utilization and lipid metabolism. CE promoted local production of 5- and 9-PAHSAs in WAT. Metabolic labeling of de novo lipogenesis (DNL) using ²H₂O revealed that 5-PAHSA potentiated the effects of CE and stimulated triacylglycerol (TAG)/fatty acid (FA) cycling in WAT through impacting lipogenesis and lipolysis. Adipocyte lipolytic products were altered by 5-PAHSA through selective FA re-esterification. The impaired lipolysis in global adipose triglyceride lipase (ATGL) knockout mice reduced free PAHSA levels and uncovered a metabolite reservoir of TAG-bound PAHSAs (TAG estolides) in WAT. Utilization of ¹³C isotope tracers and dynamic metabolomics documented that 5-PAHSA primes adipocytes for glucose metabolism in a different way from insulin, promoting DNL and impeding TAG synthesis. In summary, our data reveal new cellular and physiological mechanisms underlying the beneficial effects of 5-PAHSA and its relation to insulin action in adipocytes and independently confirm a PAHSA metabolite reservoir linked to ATGL-mediated lipolysis.

The requisites for protein translation in T cells are poorly understood and how translation shapes the antitumor efficacy of T cells is unknown. Here we demonstrated that IL15-conditioned T cells were primed by the metabolic energy sensor AMP-activated protein kinase to undergo diminished translation relative to effector T cells. However, we showed that IL15-conditioned T cells exhibited a remarkable capacity to enhance their protein translation in tumors, which effector T cells were unable to duplicate. Studying the modulation of translation for applications in cancer immunotherapy revealed that direct ex vivo pharmacologic inhibition of translation elongation primed robust T-cell antitumor immunity. Our work elucidates that altering protein translation in CD8⁺ T cells can shape their antitumor capability.