On Oct. 17, American Industrial Partners announced its definitive agreement to acquire PPG’s U.S. and Canadian architectural coatings business, which generated $2 billion in 2023 revenue.

Tom Maziarz, current VP, will move to traffic solutions business effective December 1. PPG (NYSE:PPG) today announced Rodolfo Ramirez, currently PPG vice president, packaging coatings, will become PPG vice president, automotive refinish, Americas, effective January 1. Ramirez will report to Chancey Hagerty, PPG senior vice president, automotive refinish. Tom Maziarz, currently PPG vice president, automotive […]

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PPG has signed a strategic agreement with flooring leader Shaw Industries Group, Inc. to offer the PPG Flooring line of resinous flooring products. The products will be available to Shaw’s customers in the commercial property market via its Patcraft brand. 

Recent research compared the carrying capacity of PPG’s precipitated silica to maltodextrin. Results showed that PPG Flo-Gard silicas provided more than 40 times the carrying capacity of maltodextrin.

Leading national distributor of commercial supplies, equipment, and chemicals expands its resinous coatings and epoxy flooring selection with PPG.

Meet Amy Mercante, General Manager of Specialty Products at PPG.

You have been sent a MALICIOUS file!

A fake Facebook message, taking you to some online pharmacy site.

You have been sent a MALICIOUS file!

A fake Facebook message, taking you to some online pharmacy site.

ABSTRACT

The initiation of Escherichia coli chromosomal DNA replication starts with the oligomerization of the DnaA protein at repeat sequences within the origin (ori) region. The amount of ori DNA per cell directly correlates with the growth rate. During fast growth, the cell generation time is shorter than the time required for complete DNA replication; therefore, overlapping rounds of chromosome replication are required. Under these circumstances, the ori region DNA abundance exceeds the DNA abundance in the termination (ter) region. Here, high ori/ter ratios are found to persist in (p)ppGpp-deficient [(p)ppGpp⁰] cells over a wide range of balanced exponential growth rates determined by medium composition. Evidently, (p)ppGpp is necessary to maintain the usual correlation of slow DNA replication initiation with a low growth rate. Conversely, ori/ter ratios are lowered when cell growth is slowed by incrementally increasing even low constitutive basal levels of (p)ppGpp without stress, as if (p)ppGpp alone is sufficient for this response. There are several previous reports of (p)ppGpp inhibition of chromosomal DNA synthesis initiation that occurs with very high levels of (p)ppGpp that stop growth, as during the stringent starvation response or during serine hydroxamate treatment. This work suggests that low physiological levels of (p)ppGpp have significant functions in growing cells without stress through a mechanism involving negative supercoiling, which is likely mediated by (p)ppGpp regulation of DNA gyrase.

IMPORTANCE Bacterial cells regulate their own chromosomal DNA synthesis and cell division depending on the growth conditions, producing more DNA when growing in nutritionally rich media than in poor media (i.e., human gut versus water reservoir). The accumulation of the nucleotide analog (p)ppGpp is usually viewed as serving to warn cells of impending peril due to otherwise lethal sources of stress, which stops growth and inhibits DNA, RNA, and protein synthesis. This work importantly finds that small physiological changes in (p)ppGpp basal levels associated with slow balanced exponential growth incrementally inhibit the intricate process of initiation of chromosomal DNA synthesis. Without (p)ppGpp, initiations mimic the high rates present during fast growth. Here, we report that the effect of (p)ppGpp may be due to the regulation of the expression of gyrase, an important enzyme for the replication of DNA that is a current target of several antibiotics.

Fuel Euality Ppgradation Projects