Israeli archeologists use models based on their find to spin flax into yarn, indicating these pebbles were used as a version of a spinning wheel.

Stories from a Dominican barbershop, a tattoo parlor, a lawyer’s office, a coffee counter, and a collaborative arts hub, all neighbors in the melting pot that is Eastern Avenue in Baltimore’s Highlandtown neighborhood. 

With 7g of complete protein per serving, Fit Butters x PEBBLES™ is made with premium whey protein and coconut oil to provide healthy fats and a decadent, low-sugar nut butter. 

Available in Fruity and Cocoa flavors, Pebbles Waffles are a fun, easy way for consumers to enjoy cereal in waffle form.

I stumbled upon my Pebble smartwatch collection while decluttering, and it sent me down memory lane! We've come a long way since the 'OG' smartwatch craze to today's Apple Watch Ultra 2. Who else remembers the early days of smart tech on our wrists? #TechThrowback #SmartwatchEvolution #PebbleToAppleWatch #TechNostalgia

The newly sworn-in governor of Edo State, Monday Okpebholo,  is set to probe the administration of his predecessor, Godwin Obaseki. Okpebholo announced he will set up a panel of inquiry to investigate the past administration’s refusal to inaugurate 14 elected lawmakers of the State House of Assembly in 2019. The 14 lawmakers elected on the […]

The post Edo: Okpebholo to probe Obaseki’s govt first appeared on Business Hallmark.

The mining project, one of the largest ever conceived, could hold $500 billion in gold and copper.

The Utah company designs and sells men's clothing for tall, slim builds

53rd Pacific Marine Expo, the West Coast's largest commercial marine and fishing trade show, set for the CenturyLink Field Event Center Nov. 21 through Nov. 23. Last year's Expo attracted more than 6,000 visitors from 40 states and 24 countries.

"Pebble Mine: The Changing Minds" Keynote Panel set to provide an in-depth discussion of the recent Army Corp of Engineers' Draft Environmental Impact Statement on Pebble Mine Development in Bristol Bay at 2019 Pacific Marine Expo.

Bronze grapevine sculptures to inspire during luxe event April 4-7.

Taylor is seeking his second PGA Tour victory. Phil Mickelson, who is in second place, has won five Pebble Beach tournaments.

Taylor, 31, led after each round in his second PGA Tour victory.

This week host Matt Egan is joined by producer Chris to talk about the recent batch of new Pebble devices and the smartwatch market. Staff writer at PC Advisor Lewis Painter joins in to talk about the death of the hoverboard (13:00). Finally, regular podder David Price comes on to talk about Appl...oh Twitter, specifically changes to the character limit and the sad loss of the @ (24:00).  

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This week Henry Burrell is in the presenter chair and he has brought puns, sing-songs and tenuous Field of Dreams references. First up is producer Chris to discuss the Fitbit acquisition of fellow wearable maker Pebble and why owners are sad. Then online editor at Techworld Tamlin Magee is discussing the Met Police's decision to upload their body camera footage to the cloud and why this could be problematic (12:00). Finally, fellow online editor Scott Carey runs us through the Amazon Go news and how the retail giant is trying to pull off the technology behind its 'just walk out' shopping experience (24:00).  

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Some early ichthyosaurs used rounded, pebble-like teeth to crush the shells of snails and clam-like bivalves, according to new research.

Stress alters brain function by modifying the structure and function of neurons and astrocytes. The fine processes of astrocytes are critical for the clearance of neurotransmitters during synaptic transmission. Thus, experience-dependent remodeling of glial processes is anticipated to alter the output of neural circuits. However, the molecular mechanisms that underlie glial structural plasticity are not known. Here we show that a single exposure of male and female mice to an acute stress produced a long-lasting retraction of the lateral processes of cerebellar Bergmann glial cells. These cells express the GluA1 subunit of AMPA-type glutamate receptors, and GluA1 knockdown is known to shorten the length of glial processes. We found that stress reduced the level of GluA1 protein and AMPA receptor-mediated currents in Bergmann glial cells, and these effects were absent in mice devoid of CPEB3, a protein that binds to GluA1 mRNA and regulates GluA1 protein synthesis. Administration of a β-adrenergic receptor blocker attenuated the reduction in GluA1, and deletion of adenylate cyclase 5 prevented GluA1 suppression. Therefore, stress suppresses GluA1 protein synthesis via an adrenergic/adenylyl cyclase/CPEB3 pathway, and reduces the length of astrocyte lateral processes. Our results identify a novel mechanism for GluA1 subunit plasticity in non-neuronal cells and suggest a previously unappreciated role for AMPA receptors in stress-induced astrocytic remodeling.

SIGNIFICANCE STATEMENT Astrocytes play important roles in synaptic transmission by extending fine processes around synapses. In this study, we showed that a single exposure to an acute stress triggered a retraction of lateral/fine processes in mouse cerebellar astrocytes. These astrocytes express GluA1, a glutamate receptor subunit known to lengthen astrocyte processes. We showed that astrocytic structural changes are associated with a reduction of GluA1 protein levels. This requires activation of β-adrenergic receptors and is triggered by noradrenaline released during stress. We identified adenylyl cyclase 5, an enzyme that elevates cAMP levels, as a downstream effector and found that lowering GluA1 levels depends on CPEB3 proteins that bind to GluA1 mRNA. Therefore, stress regulates GluA1 protein synthesis via an adrenergic/adenylyl cyclase/CPEB3 pathway in astrocytes and remodels their fine processes.

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Experts believe they are more closely related to crocodiles and dinosaurs and birds than they are to lizards and snakes

Ichthyosaurs were marine reptiles during the time of the dinosaurs, and scientists don't know much about their ancestry. But by CT-scanning the fossil of one of the first ichthyosaurs, scientists discovered pebble-shaped teeth hidden in its short snout. These strange teeth, probably used for crushing the shells of snails and clam-like bivalves, help illuminate the ways that early ichthyosaurs filled different roles in Triassic marine ecosystems.

Based on the belief that we carry black or white pebbles with us, depending on the choices we make in our lives (black pebbles represent self-focused, irresponsible decisions; white pebbles represent a life of sound,

CNBC's Morgan Brennan and Tom's Guide Editor-in-Chief Mark Spoonauer talk about Pebble's place in the smart watch market.

DEREK LAWRENSON - WORLD OF GOLF SPECIAL: America's leading golfers have the chance to complete a clean sweep of all four majors at the Open at Royal Portrush in July.

DEREK LAWRENSON AT PEBBLE BEACH: With eight top five finishes in the majors but no victories, it's hardly surprising that Rickie Fowler is considered the best player under the age of 40.

McIlroy's second victory of the season followed his only missed cut of 2019 in the Memorial Tournament and gave the former world No 1 a timely confidence boost.

DEREK LAWRENSON - WORLD OF GOLF: Rory McIlroy has been made the joint favourite to win this week's US Open. Here are six reasons for McIlroy backers to be cheerful.

Under-fire organisers of the US Open have admitted it is 'critical' they get it right at Pebble Beach this week after four years of controversy.

MARTIN SAMUEL - CHIEF SPORTS WRITER AT PEBBLE BEACH: After years of woe in the US Open first round, Rory McIlroy delivered arguably his strongest opening day since 2014.

US Open 2019 gets underway this week. Sportmail provides you with all the US Open tee times for the first and second round at Pebble Beach, California.

The third round of the US Open takes place at Pebble Beach in California on Saturday. Here are all the tee times and pairings as the main contenders look to make their move.

The US Open reaches it climax at Pebble Beach in California on Sunday. England's Justin Rose sits just one shot off the lead held by American Gary Woodland heading into the final day.

Phil Mickelson came up short on Sunday in his bid to win one of the oldest events on the PGA Tour, the Pebble Beach pro-am, for a record sixth time.

The 119th US Open continues at Pebble Beach Golf Links on Friday, with Justin Rose leading after a stunning six-under-par first round of 65. You can keep up with all the latest scores right here.

The third round of the US Open takes place at Pebble Beach in California on Saturday. Here are all the tee times and pairings as the main contenders look to make their move.

The US Open reaches it climax at Pebble Beach in California on Sunday. England's Justin Rose sits just one shot off the lead held by American Gary Woodland heading into the final day.

The 119th US Open continues at Pebble Beach Golf Links on Sunday, with Justin Rose one shot behind leader Gary Woodland in the final round. Get latest score and updates here.

DEREK LAWRENSON - WORLD OF GOLF SPECIAL: America's leading golfers have the chance to complete a clean sweep of all four majors at the Open at Royal Portrush in July.

Phil Mickelson came up short on Sunday in his bid to win one of the oldest events on the PGA Tour, the Pebble Beach pro-am, for a record sixth time.

BETTING GUIDE: The US Open at glorious Pebble Beach is nearly upon us. CHRIS CUTMORE runs through the betting market and offers some tips on where the smart money might lie.

The 119th US Open starts today at one of its most iconic venues, the glorious Pebble Beach Golf Links in California. You can keep up with all the latest scores right here.

The 119th US Open continues at Pebble Beach Golf Links on Friday, with Justin Rose leading after a stunning six-under-par first round of 65. You can keep up with all the latest scores right here.

The 119th US Open continues at Pebble Beach Golf Links on Sunday, with Justin Rose one shot behind leader Gary Woodland in the final round. Get latest score and updates here.

Mobile accessory brand Pebble has launched new wireless headphones for music enthusiasts in India. Priced at Rs. 2,750, ELITE headphones are over-ear Bluetooth headphones, and will be available online on company's official website Pebblecart.com and e-commerce platforms Flipkart & Amazon.in. The

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