Scientists have made a breakthrough in the field of bioelectronics by successfully injecting gel polymers inside leeches and zebrafish, which organized themselves into functional electrodes.  The study was published in Science journal. It was revealed that when the gel molecules came in contact with enzymes inside an animal's body, they became electrically conductive.  This innovation could lead to better treatments for people with neurological conditions such as Parkinson's and epilepsy by allowing scientists to stimulate areas of the body with an external voltage. Professor Magnus Berggren at the Laboratory for Organic Electronics, LOE, at Linköping University, Sweden, noted that for decades, they have tried to create electronics that mimic biology, but now they let biology create the electronics for them.

The Covid-19 pandemic restricted millions of people to their homes, limited daily exercise in patients with parkinson's disease.

Michael A. Hyland, DPT, is lauded for treating Parkinson's patients at Hyland Physical Therapy and Wellness LLC

A new study suggests that molecular mechanisms triggered by low-dose carbon monoxide (CO) could slow the progression of Parkinson's disease (PD).

A new study suggests that molecular mechanisms triggered by low-dose carbon monoxide (CO) could slow the progression of Parkinson's disease (PD).

A class of drugs used to treat diabetes has been linked to a 20% lower risk of dementia and Parkinson's disease.

A class of drugs used to treat diabetes has been linked to a 20% lower risk of dementia and Parkinson's disease.

Brett Favre, 54, says he has Parkinson's disease while testifying before a House committee about welfare fraud in which he was allegedly involved in Mississippi.

Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to quantify pRab10 levels for drug target engagement or patient stratification. To meet this challenge, we developed an high accuracy and sensitivity targeted mass spectrometry (MS)-based assay for determining Rab10-Thr73 phosphorylation stoichiometry in human samples. It uses synthetic stable isotope-labeled (SIL) analogues for both phosphorylated and nonphosphorylated tryptic peptides surrounding Rab10-Thr73 to directly derive the percentage of Rab10 phosphorylation from attomole amounts of the endogenous phosphopeptide. The SIL and the endogenous phosphopeptides are separately admitted into an Orbitrap analyzer with the appropriate injection times. We test the reproducibility of our assay by determining Rab10-Thr73 phosphorylation stoichiometry in neutrophils of LRRK2 mutation carriers before and after LRRK2 inhibition. Compared with healthy controls, the PD predisposing mutation carriers LRRK2 G2019S and VPS35 D620N display 1.9-fold and 3.7-fold increased pRab10 levels, respectively. Our generic MS-based assay further establishes the relevance of pRab10 as a prognostic PD marker and is a powerful tool for determining LRRK2 inhibitor efficacy and for stratifying PD patients for LRRK2 inhibitor treatment.

Title: Parkinson's: Treatment for Symptoms
Category: Health News
Created: 8/31/2006 12:00:00 AM
Last Editorial Review: 8/31/2006 12:00:00 AM

Title: Brain 'Pacemaker' Treats Parkinson's
Category: Health News
Created: 8/31/2006 12:00:00 AM
Last Editorial Review: 8/31/2006 12:00:00 AM

Title: Sleep Boosts Memory for Parkinson's Patients, Study Suggests
Category: Health News
Created: 8/24/2012 6:05:00 PM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Discovery May Improve Diagnosis of Alzheimer's, Parkinson's
Category: Health News
Created: 8/29/2012 6:05:00 PM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: Spinal Fluid Test May Aid Early Detection of Parkinson's Disease
Category: Health News
Created: 8/27/2013 9:35:00 AM
Last Editorial Review: 8/27/2013 12:00:00 AM

Title: Deep Brain Stimulation Safe for Older Parkinson's Patients: Study
Category: Health News
Created: 8/26/2014 12:35:00 PM
Last Editorial Review: 8/27/2014 12:00:00 AM

Title: New Hope From Old Drugs in Fight Against Parkinson's
Category: Health News
Created: 8/31/2017 12:00:00 AM
Last Editorial Review: 9/1/2017 12:00:00 AM

Title: Is It Parkinson's? These 10 Signs Could Tell
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM

α-Synuclein (AS) is a small presynaptic protein that is genetically, biochemically, and neuropathologically linked to Parkinson's disease (PD) and related synucleinopathies. We present here a review of the topic of this relationship, focusing on more recent knowledge. In particular, we review the genetic evidence linking AS to familial and sporadic PD, including a number of recently identified point mutations in the SNCA gene. We briefly go over the relevant neuropathological findings, stressing the evidence indicating a correlation between aberrant AS deposition and nervous system dysfunction. We analyze the structural characteristics of the protein, in relation to both its physiologic and pathological conformations, with particular emphasis on posttranslational modifications, aggregation properties, and secreted forms. We review the interrelationship of AS with various cellular compartments and functions, with particular focus on the synapse and protein degradation systems. We finally go over the recent exciting data indicating that AS can provide the basis for novel robust biomarkers in the field of synucleinopathies, while at the same time results from the first clinical trials specifically targeting AS are being reported.

A groundbreaking study has revealed hundreds of genetic variations that influence the development of critical brain structures. Researchers examined DNA

A video-processing technique developed, utilizing medlinkartificial intelligence/medlink, will assist neurologists in more accurately tracking the

Scientists have developed a low-cost, portable smartphone-based sensor system designed to assist in managing symptoms of medlinkParkinson's disease/medlink

A California-based company has received approval for trying out the world's first stem therapy on patients affected with mild to severe Parkinson's disease.

A test that can detect Parkinson's disease in the early stages of the illness has moved a step closer.

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Research out of Venice finds Irish dancing more helpful than physiotherapy for the symptoms of Parkinson's disease.

A great hero and champion has left a legacy and many are stepping in to honor all that he stood for. Human Earth Foundation, a Non-Profit Organization, has started a campaign to help raise money to tribute to the Muhammad Ali Parkinson's Center.

Currently, no effective drug is available to halt the progression of Parkinson's disease. Scientists have shown that low-dose aspirin may help Parkinson patients.

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

A producer on 'The Nine Lives of Ozzy Osbourne', Jack Osbourne spills why the former Black Sabbath frontman and his wife Sharon were reluctant to share his health battle with the world.

Port Macquarie resident Kim Dahler was diagnosed with Parkinson's disease in her 40s and wants others to know life can still be fulfilling.

(MedPage Today) -- Male British physicians who smoked tobacco in 1951 had a 30% lower risk of death from Parkinson's disease, an analysis of data from the British Doctors Study showed. Moreover, doctors who continued to smoke over the years had...

Greenwood Mayor Mark Myers announced Friday that he has been diagnosed with Parkinson's disease, a nervous system disorder.

Researcher: Christopher Butson, Scientific Computing and Imaging Institute, University of Utah. Christopher Butson talks about work he's done to help treat Parkinson's disease.

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distributions. We exemplify this use case by using single-sensor accelerometer data from healthy subjects performing activities of daily living - ADLs (source dataset), to extract features relevant to multi-sensor accelerometer gait data (target dataset) for Parkinson's disease classification. We train the pre-trained model using the source dataset and use it as a feature extractor. We show that the features extracted for the target dataset can be used to train an effective classification model. Our pre-trained source model consists of a convolutional autoencoder, and the target classification model is a simple multi-layer perceptron model. We explore two different pre-trained source models, trained using different activity groups, and analyze the influence the choice of pre-trained model has over the task of Parkinson's disease classification.

The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-prone Fischer-344 (F344) male rats. In a second cohort, rats received the Nurr1 agonist amodiaquine (AQ) together with l-DOPA or ropinirole. All rats received a chronic DA agonist and were evaluated for LID severity. Finally, we performed single-unit recordings and dendritic spine analyses on striatal medium spiny neurons (MSNs) in drug-naïve rAAV-injected male parkinsonian rats. rAAV-GFP injected LID-resistant hemi-parkinsonian Lewis rats displayed mild LID and no induction of striatal Nurr1 despite receiving a high dose of l-DOPA. However, Lewis rats overexpressing Nurr1 developed severe LID. Nurr1 agonism with AQ exacerbated LID in F344 rats. We additionally determined that in l-DOPA-naïve rats striatal rAAV-Nurr1 overexpression (1) increased cortically-evoked firing in a subpopulation of identified striatonigral MSNs, and (2) altered spine density and thin-spine morphology on striatal MSNs; both phenomena mimicking changes seen in dyskinetic rats. Finally, we provide postmortem evidence of Nurr1 expression in striatal neurons of l-DOPA-treated PD patients. Our data demonstrate that ectopic induction of striatal Nurr1 is capable of inducing LID behavior and associated neuropathology, even in resistant subjects. These data support a direct role of Nurr1 in aberrant neuronal plasticity and LID induction, providing a potential novel target for therapeutic development.

SIGNIFICANCE STATEMENT The transcription factor Nurr1 is ectopically induced in striatal neurons of rats exhibiting levodopa-induced dyskinesia [LID; a side-effect to dopamine replacement strategies in Parkinson's disease (PD)]. Here we asked whether Nurr1 is causing LID. Indeed, rAAV-mediated expression of Nurr1 in striatal neurons was sufficient to overcome LID-resistance, and Nurr1 agonism exacerbated LID severity in dyskinetic rats. Moreover, we found that expression of Nurr1 in l-DOPA naïve hemi-parkinsonian rats resulted in the formation of morphologic and electrophysiological signatures of maladaptive neuronal plasticity; a phenomenon associated with LID. Finally, we determined that ectopic Nurr1 expression can be found in the putamen of l-DOPA-treated PD patients. These data suggest that striatal Nurr1 is an important mediator of the formation of LID.

A former miner who was forced to breathe in a fine aluminum dust before each shift says he’s not surprised a new report links that dust and a higher risk of Parkinson’s disease.

Title: Depression Before Parkinson's Disease?
Category: Health News
Created: 4/30/2007 12:00:00 AM
Last Editorial Review: 4/30/2007 12:00:00 AM

Title: Adding Surgery to Meds May Improve Life With Parkinson's
Category: Health News
Created: 4/29/2010 8:10:00 AM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Group Doctor Visits May Help Parkinson's Patients
Category: Health News
Created: 4/28/2011 11:01:00 AM
Last Editorial Review: 4/28/2011 12:00:00 AM

Title: Muhammad Ali's Daughter Champions Fight Against Parkinson's Disease
Category: Health News
Created: 5/3/2013 10:35:00 AM
Last Editorial Review: 5/3/2013 12:00:00 AM

Title: Ex-Baseball Star Kirk Gibson Has Parkinson's Disease
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: Therapy by Phone Helps Parkinson's Patients Manage Depression
Category: Health News
Created: 4/10/2020 12:00:00 AM
Last Editorial Review: 4/13/2020 12:00:00 AM

Highlights: Cognitive behavioral therapy helps Parkinson's patients overcome negative thoughts About 50% of P

In people with Parkinson's disease, cognitive-behavioral therapy by telephone was found to be effective for treating depression, revealed study published

New study adds to evidence that Parkinson's disease is partly an autoimmune disease. Signs of autoimmunity can develop in Parkinson's disease patients years before their official diagnosis.

New small molecule or drug like compound could slow down or stop the progression of Parkinson's disease, according to scientists at Rutgers University and Scripps.

Fatigue symptoms in Parkinson's disease are related to an insignificant but constant slump in diastolic blood pressure. Scientists in the iJournal