Highlights: AI-powered liquid biopsy detects ovarian cancer early Combines DNA fragment analysis and biomarkers

A breakthrough AI-powered liquid biopsy combining cell-free DNA and protein biomarkers improves early detection of ovarian cancer, aiding in accurate screening.

Five of the nation's most innovative early-career cancer researchers receive Hopper-Belmont Inspiration Award

Montreal — Women employed in hairdressing, construction and accounting may face a higher risk of developing ovarian cancer, a recent study out of Canada suggests.

Ovarian cancer should not be categorized as a single disease, but rather as a constellation of different cancers involving the ovary, yet questions remain on how and where various ovarian cancers arise, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

Proteomic landscape of epithelial ovarian cancer  Nature.com

Title: Inner Workings of Gene Tied to Breast, Ovarian Cancer Revealed
Category: Health News
Created: 8/22/2010 2:10:00 PM
Last Editorial Review: 8/23/2010 12:00:00 AM

Title: New Hope for Early Detection of Ovarian Cancer
Category: Health News
Created: 8/26/2013 9:35:00 AM
Last Editorial Review: 8/26/2013 12:00:00 AM

Title: Blood Pressure Drugs Linked to Longer Ovarian Cancer Survival
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

UK's current standard of care test for bmedlinkovarian cancer/medlink shall be replaced with an ultrasound test that can detect 96% of ovarian tumors

A team of scientists has uncovered a mechanism by which ovarian cancer tumors evade immunotherapy. They've also pinpointed a potential drug target to counter this resistance (!--ref1--).

Ovarian cancer should not be categorized as a single disease, but rather as a constellation of different cancers involving the ovary, yet questions remain on how and where various ovarian cancers arise, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

The latest, largest study finds talcum powder likely causes little risk for ovarian cancer.

Metformin, an inexpensive and common diabetes drug, may fight ovarian cancer, according to a new study.

A group of textile artists in Newcastle has thrown down a challenge to artists around Australia to create hand-made flowers to raise funds for ovarian cancer research.

What would you do if you were told you had 16 months to live? That was the harsh reality for Jill Emberson when she was diagnosed with ovarian cancer. With the survival rate of the disease half that of the breast cancer survival rate, she's using her last moments to make a change.

Title: Study Makes Strides in Understanding Ovarian Cancer
Category: Health News
Created: 4/26/2010 6:10:00 PM
Last Editorial Review: 4/27/2010 12:00:00 AM

Background:

Total antioxidant capacity (TAC) reflects an individual's overall antioxidant intake. We sought to clarify whether higher TAC is associated with lower risks of pancreatic cancer incidence and mortality in the U.S. general population.

Ovarian cancer imposes a substantial health and economic burden. We systematically reviewed current health-economic evidence for ovarian cancer early detection or prevention strategies. Accordingly, we searched relevant databases for cost-effectiveness studies evaluating ovarian cancer early detection or prevention strategies. Study characteristics and results including quality-adjusted life years (QALY), and incremental cost-effectiveness ratios (ICER) were summarized in standardized evidence tables. Economic results were transformed into 2017 Euros. The included studies (N = 33) evaluated ovarian cancer screening, risk-reducing interventions in women with heterogeneous cancer risks and genetic testing followed by risk-reducing interventions for mutation carriers. Multimodal screening with a risk-adjusted algorithm in postmenopausal women achieved ICERs of 9,800–81,400 Euros/QALY, depending on assumptions on mortality data extrapolation, costs, test performance, and screening frequency. Cost-effectiveness of risk-reducing surgery in mutation carriers ranged from cost-saving to 59,000 Euros/QALY. Genetic testing plus risk-reducing interventions for mutation carriers ranged from cost-saving to 54,000 Euros/QALY in women at increased mutation risk. Our findings suggest that preventive surgery and genetic testing plus preventive surgery in women at high risk for ovarian cancer can be considered effective and cost-effective. In postmenopausal women from the general population, multimodal screening using a risk-adjusted algorithm may be cost-effective.

Sutro Biopharma Inc.'s (STRO) interim phase I updated clinical data for a dose-escalation study of antibody drug-conjugate STRO-002 in ovarian cancer has been encouraging.

Ovarian cancer cells become detached from their point of origin and shift using fats as an energy source, according to Benjamin Bitler, PhD, and CU Cancer

New study published online today by Nature Communications revealed which patients with ovarian cancer won't benefit from immune-PARP combo. The study

Since ovarian cancer has very silent symptoms, women can take care of themselves by staying vigilant and going for regular health checkups. It is a

New type of immunotherapy that targets macrophages has undergone preliminary testing on mice and shows promise for the future treatment of ovarian cancer.

This study uses mendelian randomization to estimate the associations between genetic variants related to reduced HMG-CoA reductase activity and epithelial ovarian cancer in the general population and in BRCA1/2 mutation carriers.

Interview with Mollie E. Barnard, ScD, and Shelley Tworoger, PhD, authors of Association of Analgesic Use With Risk of Ovarian Cancer in the Nurses’ Health Studies, and Andrew T. Chan, MD, MPH, author of Association Between Aspirin Use and Risk of Hepatocellular Carcinoma

Interview with Michael J. Barry, MD, Task Force member and co-author of Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement