In the early 1990s, the unprecedented wave of aliyah followed the fall of the USSR. A million olim came to Israel and ensured that the country would keep growing.

PROLIM, a global leader in PLM, IT, Mendix, and Cloud Services, proudly announces its achievement of AWS Advanced Tier Services Partner Status.

With Three-Year Revenue Growth of 242%, PROLIM Ranks No. 153 Among America's Fastest-Growing Private Companies

Manufacturing

Cuatro directores de medios de comunicación analizaron el primer encuentro de precandidatos. Resaltaron complejidades para entender el centro como espectro político en la carrera presidencial.

La Luciérnaga se enciende para analizar los resultados de la encuesta polimétrica de este mes. Se encontró que, por primera vez, la desfavorabilidad del presidente es superior a su favorabilidad asimismo la de Francia Marquez. Además, se presentó una fuerte explosión en Medellín la cual se presentó en una edificación. Hubo personas heridas y varios vehículos como edificios sufrieron daños producto del estallido. También, según la (ONU) se conoció que Colombia es el mayor productor de coca en el mundo, con un aumento de 43% frente al año inmediatamente anterior. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Franz Bedoya, gerente de la Fábrica de Licores del Tolima, habló en Caracol Radio sobre el nuevo producto lanzado por la empresa y lo llamativo de su color dentro del mercado colombiano

En la previa del juego en Ibagué, El Alargue analiza lo que será una final que define al nuevo campeón de Colombia, como siempre, con los mejores invitados.

En un nuevo episodio de El Alargue, analizamos los partidos de ida de Deportes Tolima y Deportivo Cal en los torneos Conmebol, así como también lo que se viene para ambos equipos en los juegos de vuelta. Leonardo Pico, nuevo defensa de Once Caldas, habló de sus imporesiones tras llegar al equipo de Manizales.

En este episodio de El Alargue hablamos sobre los bochornosos hechos en Ibagué contra Daniel Cataño y entrevistamos con el padre de Alejandro Montenegro, quien agedió por la espalda al volante de Millonarios.

Yhormar Hurtado ve al Tolima en la gran final: “Vamos a jugar con el desespero de Junior”

Nueva encuesta de Cifras y Conceptos reveló datos importantes frente a la gestión y favorabilidad del Gobierno nacional

En 6AM Hoy por Hoy estuvo Dalia Marleny Bernal, directora de Olímpica Estéreo, explicando detalles sobre la vida del artista

En 6AM, estuvo Adriana Matiz, gobernadora del Tolima, e hizo hincapié en cuántos incendios forestales están activos y cuáles son los municipios afectados 

Dr Aluvihare

Developed by a fitness instructor coping with chronic pain & fatigue herself, Cocolime Fitness is bringing real relief to people around the world suffering with debilitating health issues.

Active maintenance of β-cell identity through fine-tuned regulation of key transcription factors ensures β-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying molecular mechanisms are unclear. Here we show that tacrolimus induces loss of human β-cell maturity and β-cell failure through activation of the BMP/SMAD signaling pathway when administered under mild metabolic stress conditions. Tacrolimus-induced phosphorylated SMAD1/5 acts in synergy with metabolic stress–activated FOXO1 through formation of a complex. This interaction is associated with reduced expression of the key β-cell transcription factor MAFA and abolished insulin secretion, both in vitro in primary human islets and in vivo in human islets transplanted into high-fat diet–fed mice. Pharmacological inhibition of BMP signaling protects human β-cells from tacrolimus-induced β-cell dysfunction in vitro. Furthermore, we confirm that BMP/SMAD signaling is activated in protocol pancreas allograft biopsies from recipients on tacrolimus. To conclude, we propose a novel mechanism underlying the diabetogenicity of tacrolimus in primary human β-cells. This insight could lead to new treatment strategies for new-onset diabetes and may have implications for other forms of diabetes.

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination both in vitro and ex vivo models. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. These in vivo findings corroborate initial in vitro studies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.

SIGNIFICANCE STATEMENT This study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.

Topical corticosteroids are often used to treat atopic dermatitis (AD) in infants, although compliance is poor due to concerns over side effects. Pimecrolimus was shown to be a safe and effective noncorticosteroid treatment of AD in infants in short-term studies.

The Petite Study shows that long-term management of mild-to-moderate AD in infants with pimecrolimus or topical corticosteroids was safe without any effect on the developing immune system. Pimecrolimus had similar efficacy to topical corticosteroids and a marked steroid-sparing effect. (Read the full article)

In December 2019, a novel coronavirus causing an infectious respiratory disease (COVID-19) was identified, which since then has developed into a pandemic with higher rates of mortality in older individuals and those with underlying medical conditions.¹ Multiple sclerosis (MS) is an immune-mediated neurologic disease which requires long-term treatment with immunotherapies that have been shown to increase the risk of infections.² As a result, there is significant anxiety among patients and neurologists during the pandemic regarding the infection outcome in this patient population. We present a patient with MS treated with fingolimod who was diagnosed with COVID-19 and had a favorable outcome.

Dr Aluvihare

It has been officially confirmed by the Six Nations that Italy's home match against England next Saturday has been postponed due to the coronavirus crisis.

It has been officially confirmed by the Six Nations that Italy's home match against England next Saturday has been postponed due to the coronavirus crisis.

The manager of the Czech Republic national team Karel Jarolim has left his position by mutual consent, the country's Football Association said on Twitter on Tuesday.

Chartrand, Gary, author

The "gol olimpico" or "Olympic goal" – an unassisted corner kick bent into goal – is one of the rarest in soccer. WIRED's Robbie Gonzalez straps on his shin-guards to explore the shot's perfect mix of soccer science and skill.

Hayden Library - P118.R44 2019

D'Olimpio, Laura, author

Dewey Library - TN876.A1 S55 2019

Interview with Stephan Windecker, MD, author of Effect of Biolimus-Eluting Stents With Biodegradable Polymer vs Bare-Metal Stents on Cardiovascular Events Among Patients With Acute Myocardial Infarction: The COMFORTABLE AMI Randomized Trial

Interview with Deepak L. Bhatt, MD, MPH, author of Three vs Twelve Months of Dual Antiplatelet Therapy After Zotarolimus-Eluting Stents