The all-pervasive Internet has created serious problems, such as Internet overuse, which has triggered considerable debate over its relationship with addiction. To further explore its genetic susceptibilities and alternative explanations for Internet overuse, we proposed and evaluated four hypotheses, each based on existing knowledge of the biological bases of addiction, inattention, novelty-seeking, and harm-avoidance. Four genetic loci including DRD4 VNTR, DRD2 Taq1A, COMT Val158Met and 5-HTTLPR length polymorphisms were screened from seventy-three individuals. Our results showed that the DRD4 4R/4R individuals scored significantly higher than the 2R or 7R carriers in Internet Addiction Test (IAT). The 5-HTTLPR short/short males scored significantly higher in IAT than the long variant carriers. Bayesian analysis showed the most compatible hypothesis with the observed genetic results was based on attention (69.8%), whereas hypotheses based harm-avoidance (21.6%), novelty-seeking (7.8%) and addiction (0.9%) received little support. Our study suggests that carriers of alleles (DRD4 2R and 7R, 5-HTTLPR long) associated with inattentiveness are more likely to experience disrupted patterns and reduced durations of Internet use, protecting them from Internet overuse. Furthermore, our study suggests that Internet overuse should be categorized differently from addiction due to the lack of shared genetic contributions.

When it comes to formulating sweet and salty snacks, a huge challenge is that of matching the vibrancy, versatility, and stability of synthetic food colorants. “The sensitivity of natural compounds to various stressors within the system causes them to be difficult to depend on and use effectively,” explains Ryan Erwin, food chemist and Innovation Manager for Fresca Foods, Inc.

Len Solomon has been making instruments out of random objects for over 30 years. He's performed as a one-man-band all over the world, and The Majestic Bellowphone is perhaps his DIY novelty masterpiece. Check out Len Solomon's YouTube channel at https://www.youtube.com/user/bellowphone.

In a freewheeling conversation, Vidushi Ashwini Bhide Deshpande tells Manjari Sinha what makes her performance an emotional experience.

A novelty apparel includes multiple attached conformable, selectable and viewable occupational role playing indicia. A baseball cap includes a dome shaped crown of compound curves and a forward facing sun visor brim portion, a display region in a central front face portion of the dome shaped crown, where the display region displays a first permanent occupational status identifier and a mounting region for a secondary occupational status identifier selectable from a number of different indicia carried on a display surface conformable to said dome shaped crown. The selected indicium is displayed centered above the brim. The display surface conforms to the curved exterior of the dome shaped crown, wherein the baseball cap does not deviate substantially from the look of a typical baseball cap with a single permanent indicium.

A quick-thinking Helsinki bakery has saved itself from financial ruin due to the new coronavirus pandemic by creating a cake that looks like a toilet roll.

Innovation policy involves trading off monopoly output and pricing in the short run in exchange for incentives for firms to develop new products in the future. While existing research demonstrates that expected profits fuel R&D investments, little is known about the novelty of the projects funded by these investments. Relying on data that describe the scientific approaches used by a large sample of experimental drug projects, we expand on this literature by examining the scientific novelty of pharmaceutical R&D investments following the creation of the Medicare Part D program. We find little evidence that the positive demand shock implied by this program prompted firms to undertake scientifically novel R&D activity, as measured by whether the specific scientific approach had been used before. However, we find some evidence that firms invested in products involving novel combinations of scientific approaches. These estimates can inform economists and policymakers assessing the tradeoffs associated with marginal changes in commercial returns from newly developed pharmaceutical products.

The three previous outdoor games the Kings have participated in ahead of Saturday's showdown with the Avalanche continue to be a big part of the team's history.

Lewis Hamilton appears to be the first victim of the FIA's controversial helmet ban after being blocked from wearing a novelty lid in Malaysia

A quick-thinking Helsinki bakery has saved itself from financial ruin due to the new coronavirus pandemic by creating a cake that looks like a toilet roll.

A quick-thinking Helsinki bakery has saved itself from financial ruin due to the new coronavirus pandemic by creating a cake that looks like a toilet roll.

New York, NY : Oxford University Press, 2019.

Dewey Library - B105.N4 M46 2020