A total of 448kgs of meat smuggled from the Republic were found by local police in Famagusta on Wednesday, the town’s Turkish Cypriot municipality said. The meat, all of it beef, was found in a refrigerator at a butcher’s shop in the town. It was confiscated by the municipality, while legal action was taken against […]

Watch as Stephen Maguire eats a fly off the table during his 13-8 defeat to David Gilbert in the quarter-finals of the Snooker World Championship at the Crucible Theatre, Sheffield.

Explore the Always Dream collection designed in partnership with Kristi Yamaguchi in Heller Jewelers' San Ramon jewelry store.

This innovative film concept is seen as a pioneering packaging solution for solid pharmaceutical products or nutraceuticals. 

Organic anion transporting polypeptides (OATP, gene symbol SLCO) are well-recognized key determinants for the absorption, distribution, and excretion of a wide spectrum of endogenous and exogenous compounds including many antineoplastic agents. It was therefore proposed as a potential drug target for cancer therapy. In our previous study, it was found that low-dose X-ray and carbon ion irradiation both upregulated the expression of OATP family member OATP1A2 and in turn, led to a more dramatic killing effect when cancer cells were cotreated with antitumor drugs such as methotrexate. In the present study, the underlying mechanism of the phenomenon was explored in breast cancer cell line MCF-7. It was found that the nonreceptor tyrosine kinase v-YES-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES-1) was temporally coordinated with the change of OATP1A2 after irradiation. The overexpression of YES-1 significantly increased OATP1A2 both at the mRNA and protein level. The signal transducer and activator of transcription 3 (STAT3) pathway is likely the downstream target of YES-1 because phosphorylation and nuclear accumulation of STAT3 were both enhanced after overexpressing YES-1 in MCF-7 cells. Further investigation revealed that there are two possible binding sites of STAT3 localized at the upstream sequence of SLCO1A2, the encoding gene of OATP1A2. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis suggested that these two sites bound to STAT3 specifically and the overexpression of YES-1 significantly increased the association of the transcription factor with the putative binding sites. Finally, inhibition or knockdown of YES-1 attenuated the induction effect of radiation on the expression of OATP1A2.

IMAGES from the Europa League matches played on Thursday

[Tōkyō] : Square Enix, [1997]

Patience Jonathan: The lockdown arising from coronavirus appears to have slowed down the fight against corrupt practices in the country for close to six weeks.

The post Magu: Lockdown won’t abort cases against Patience Jonathan, 4 ex-govs, others appeared first on Vanguard News.

Maguire's £85million switch - the most money ever spent on a defender - has naturally left fans and pundits closely scrutinizing the 26-year-old's performances in a red shirt.

The couple shared the news to Instagram on Saturday, with the Man United captain, 27, captioning a sweet hospital snap: Welcome to this crazy world baby girl. Piper Rose Maguire'

He made his debut in August 2018 and has gone on to make 52 appearances for the Reds.

During Wednesday's (May 6) watch party, producer Christopher Miller revealed that he wanted cameos for all three actors who have played the web-crawler in the live-action movies.

During Wednesday's (May 6) watch party, producer Christopher Miller revealed that he wanted cameos for all three actors who have played the web-crawler in the live-action movies.

London : Kegan Paul, Trench, Trubner, 1890.

[London?]

“His ultimate passion was for good governance and his advocacy was to help save the environment. He was a highly principled man who sought refuge in his faith.”

The post Dumaguete mourns death of broadcaster 2 days after World Press Freedom Day appeared first on Bulatlat.

Manchester United defender Harry Maguire has offered to supply "food packages of everyday essentials" to the elderly in his hometown of Mosborough in South Yorkshire.

Harry Maguire claims Manchester United have been their own worst enemies this season - but has revealed his determination to lead them back to the top.

The England international defender became a father for the first time in April 2019 but his clan has now expanded after confirming partner Fern Hawkins had given birth again

Ryan Maguire is CTO & VP of emerging capabilities and partnerships at Kin + Carta. Prior to navigating our way through social distancing, Ryan and I connected about his work at Kin + Carta, a business "built for the 2020's" - with a collaborative ecosystem of 1,600 strategists, engineers, and creatives across four continents. When we last checked in, like so many of us, Ryan and his teams are spending their time closely monitoring and manoeuvring the impacts COVID-19 on their business, clients and investors. However, here is the conversation we had in early March.

Keep on reading: Quick Answers to Quick Questions: Ryan Maguire, CTO & VP, KIN + Carta

Stephen Maguire produced what could well be the most astonishing shot in snooker history only to have his celebrations cut short by a cruel twist.

She is currently preparing to fly to Fiji to start filming the third season of Bachelor In Paradise.

Keira Maguire has confirmed she will appear on the next season of Bachelor in Paradise. 

Manchester United defender Harry Maguire, former world champion Andre Ward and New Zealand rugby league star Sonny Bill Williams were among the sport stars to hail Anthony Joshua.

JACK GAUGHAN: Surprise enveloped the offices inside Old Trafford one weekday last month, before the UK was instructed to stay at home, as Harry Maguire strode through the doors.

Harry Maguire is doubtful for Sunday's Manchester derby after missing Manchester United's FA Cup tie at Derby with an ankle injury.

It was another memorable victory for England as they beat Sweden 2-0 to reach the World Cup semi-finals for the first time in 28 years. 

Ann Maguire, 61, was fatally knifed by then 15-year-old Will Cornick on April 28, 2014 after he thrust a 34cm blade into her seven times - one blow slicing her jugular vein.

She's The Bachelor star-turned-influencer who is always evolving her look.

She's become one of Australia's most successful reality stars since shooting to fame on Richie Strahan's season of The Bachelor back in 2016.

The Bachelor's Keira Maguire has sparked a feud with Jessika Power and Ines Basic, after the Married At First Sight 'bad girls' gatecrashed the Logie Awards on Sunday. 

The Logie Awards are TV's night of nights, with stars dressing up the nines to make an impression on the red carpet. 

Maguire played the full 90 minutes as United held Liverpool to a 1-1 draw on Sunday, but ex-Tottenham star Van der Vaart was far from ready to praise the England defender for his part in proceedings.

The Czech Republic are hoping to exploit a perceived weakness in England's defence by targeting centre back Harry Maguire during their Euro 2020 qualifier on Friday.

SPORTS AGENDA BY MIKE KEEGAN: A clue about Harry Maguire's £80million move to Manchester United actually surfaced a week ago.

The Red Devils captain, who joined the club last summer from Leicester for £80million, has seen his side miss multiple chances to break into the top four before the season was suspended.

Rio Ferdinand and Dele Alli have made fun of Manchester United captain Harry Maguire over his 5km run time during the lockdown period.

Hull City are set to pocket a tidy profit once Harry Maguire's £80million move from Leicester to Manchester United is completed.

The photo, taken the day both players signed for the club on 29 July 2014, was hilariously captioned 'When Harry met Andy', and 'Wonder what happened to these two?'

Manchester United will give Harry Maguire, Aaron Wan-Bissaka and Dan James as long as possible to prove their fitness for the Old Trafford derby on Sunday.

Harry Maguire said he joined Manchester United to win trophies and is focused on bringing more silverware to Old Trafford.

Hayden Library - PN1993.5.L3 N49 2018

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