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Los egipcios han luchado valientemente, han echado a Mubarak y le han dado el poder a los militares. Pero resulta que el ejército egipcio está bastante controlado por USA, ya que fueron ellos los que lo financiaron y lo entrenaron [...] En América Latina y otros puntos del mundo, darle más poder un cuerpo militar que se apoya en USA habría significado un tremendo paso atrás. 

Durante ese tiempo, la legación española se sumergió en el peligro. Han pasado más de seis años, pero ahora es cuando el asunto llega a la Justicia ordinaria Leer

Two things:

1. Narrow your focus to your sphere of influence, just for now, because in this moment of helplessness and defeat, when we are feeling powerless, it behooves us to remember we do have immense power. Kamala Harris was never going to bring a casserole to your neighbor when their spouse was in the hospital, that's you. Donald Trump cannot steal the laughter from your friends' lips when you tell them a joke, that laughter is entirely in your power. You have the power to choose connection, fellowship, mutual aid, joy, hard work, love, passion, devotion, faith. To me, remembering that I have power is cause for hope.

2. When you're out there using your power to connect with your fellow human beings, look for the helpers. Take heart in their existence, their perseverance. Do everything you can to become one of them.

My situation is not exactly the same as yours but it is a story of how to get along with friends and family who are on the total opposite side of the aisle, so perhaps you can find something to help you in my strategies.

My parents are extremely right wing - in India. It is mortifying and horrifying enough that they are this way but to make things worse my mother is also deep into conspiracy theories on a similar scale and off-the-charts-insane like QAnon in the US. At the same time I am also still engaged in a decade-long effort to build a decent relationship with my parents. So even though this is a self-imposed form of hell, the fact remains I am trying to actively love (as in verb-love) these people whose political opinions horrify me and who ruined their relationship with me in the past by throwing me out of their home as a teenager, abusing me as a child, etc.

Step 0 in accomplishing this task is to actually be clear, honest, and fully committed with yourself that you do want to keep and build these relationships.

For many years I was on the fence about it and I made no effort at all to build a relationship with my parents. That was fine! If you are here, you are not doing anything wrong! And neither will you be doing anything wrong if you do choose to walk away properly from people who trigger you too much. Many years after not working and fence-sitting, I intellectually realized I wanted to fix things but emotionally I remained uncommitted, angry, resentful, and blisteringly mad about how unfair it was that *I* was the one doing this fixing and building. This was also a valid stage to go through, and I suspect you're somewhere around here, feeling angry and hurt and torn within yourself that these are your fucking choices: to learn how to get along with assholes or else to lose all your family and friends. The unfairness REALLY RANKLES. This is extremely valid and extremely real, and there is no way out of this stage but through it. But sadly, no forward movement will happen FOR YOU EMOTIONALLY in this phase, as far as making your peace with your situation goes. (Also no forward movement will happen in fixing the relationship but that is not necessarily a bad thing, if you're in this stage.)

Accomplishing Step 0 - becoming fully and truly committed to building and maintaining these relationships - is a hue, huge task in itself. I would strongly encourage you to work with a psychodynamic therapist or some other modality that pays attention to childhood issues, in order to get to Step 0. You will know you have reached Step 0 when you can "radically accept" that your friends and family voted against your life, your rights, and your wellbeing. That is who they are, this is what you are dealing with, and you no longer have any wish to wrestle with this reality (try to convince them, try to lead by example, try to explain yourself, try to talk to them, try to get them to acknowledge your pain or at least be forced to see it, etc) because you. just. fully. accept their political position is their political position - you accept their total separateness from you and you accept their right to be separate from you - and even though you may be angry, even though you may be hurt, even though you still hate their politics, you want to just get on with building the relationship. If you're there, then you can move on to

Stratagem 1: find things you enjoy about this person, and trying to do things you mutually enjoy with them. Even the smallest movement towards identifying and then amplifying the good (by having small good interactions) will help. Repeated good interactions are what finally defeated my insecurity about "giving my parents an inch" - it felt so threatening to me to have anything nice with these people against whom I was nursing so much anger, and I TREASURED my anger, I didn't want to lose it! Having repeated nice experiences made me feel like, okay, I still haven't lost my right to anger or my anger even though I am having fun with them. Both my anger and my love can coexist. This has been a HUGE relief.

Stratagem 2: stop talking politics with them entirely. These are not your politics buddies. FIND OTHER POLITICS BUDDIES YOU CAN RELIABLY GET SUPPORT FROM for the political side of you. This type of compartmentalization is a healthy practice because nobody can be everything to us. Nobody in our personal life can check all the boxes and be everything we need from the world. People's failings are sometimes located near the very things we consider "basic shit". They are human, and this is okay, and we can find others to fill this basic need for us.

Stratagem 3: This may seem like the opposite of Stratagem 2 but it is not - don't stay silent when your friends and family say horrible political things to you or around you. You don't bring up politics but you don't stay quiet when unacceptable things are spoken in your vicinity. You MUST say something, you MUST speak your mind. Make it short but make it honest. Otherwise you build up an incredible amount of resentment and anger that will poison the relationship and run counter to your Step 0 goals.

Stratagem 4: After you say it, move on without belaboring your point or trying to get them to agree with you. Say it, and then completely let it go. Saying it is the point. The goal is NOT to change them, move them, make them think like you, make them acknowledge you, make them apologize, etc. The goal is unburdening yourself by speaking your truth, protecting the relationship by not allowing thoughts to fester in secret. If what they have said is horrible, say, "Wow, that's pretty horrible," and then move on immediately - warmly, affectionately, taking the sting out of it with your manner, without holding a grudge. You get your satisfaction by speaking up, not by making them bend. This strikes a great balance between being authentic and yet sidestepping useless conflict.

Stratagem 5: If they want to argue with you, you have to learn how to bow out smoothly without engaging in that. Say things like, "Oh, dad, that's fine, we can let it go. Tell me about Auntie's health..." Again it is important to remain non-retaliatory, don't punish them for wanting to hash this out by being angry. Be calm and warm and affectionate, but do not be moved into engaging in the political discussion. Walk out and take a short break if you need to. But come back on your own as soon as possible, and be loving. These are your people. You have boundaries with them, not walls.

Der US-Außenminister behauptet, China habe das Corona-Virus aus einem Forschungslabor in Wuhan entweichen lassen. Dafür gebe es „enorme Beweise“. Doch die könnten auf einer ebenso plumpen Fälschung beruhen wie die „Beweise“, die 2003 den Irak-Krieg gerechtfertigt haben.

ABD Savunma Bakanı Robert Gates, sürpriz Irak ziyareti sırasında ABD birliklerinin muharip görevi geçen ay Irak güçlerine bırakması sonrası ülkede güvenlik koşullarındaki düzelmeyi övdü.

Key Points

Key Points

Kaposi sarcoma-associated herpesvirus (KSHV) is necessary but not sufficient for primary effusion lymphoma (PEL) development. Alterations in cellular signaling pathways are also a characteristic of PEL. Other B cell lymphomas have acquired an oncogenic mutation in the myeloid differentiation primary response 88 (MYD88) gene. The MYD88 L265P mutant results in the activation of interleukin-1 receptor associated kinase (IRAK). To probe IRAK/MYD88 signaling in PEL, we employed CRISPR/Cas9 technology to generate stable deletion clones in BCBL-1Cas9 and BC-1Cas9 cells. To look for off-target effects, we determined the complete exome of the BCBL-1Cas9 and BC-1Cas9 cells. Deletion of either MYD88, IRAK4, or IRAK1 abolished interleukin-1 beta (IL-1β) signaling; however, we were able to grow stable subclones from each population. Transcriptome sequencing (RNA-seq) analysis of IRAK4 knockout cell lines (IRAK4 KOs) showed that the IRAK pathway induced cellular signals constitutively, independent of IL-1β stimulation, which was abrogated by deletion of IRAK4. Transient complementation with IRAK1 increased NF-B activity in MYD88 KO, IRAK1 KO, and IRAK4 KO cells even in the absence of IL-1β. IL-10, a hallmark of PEL, was dependent on the IRAK pathway, as IRAK4 KOs showed reduced IL-10 levels. We surmise that, unlike B cell receptor (BCR) signaling, MYD88/IRAK signaling is constitutively active in PEL, but that under cell culture conditions, PEL rapidly became independent of this pathway.

IMPORTANCE One hundred percent of primary effusion lymphoma (PEL) cases are associated with Kaposi sarcoma-associated herpesvirus (KSHV). PEL cell lines, such as BCBL-1, are the workhorse for understanding this human oncovirus and the host pathways that KSHV dysregulates. Understanding their function is important for developing new therapies as well as identifying high-risk patient groups. The myeloid differentiation primary response 88 (MYD88)/interleukin-1 receptor associated kinase (IRAK) pathway, which has progrowth functions in other B cell lymphomas, has not been fully explored in PEL. By performing CRISPR/Cas9 knockout (KO) studies targeting the IRAK pathway in PEL, we were able to determine that established PEL cell lines can circumvent the loss of IRAK1, IRAK4, and MYD88; however, the deletion clones are deficient in interleukin-10 (IL-10) production. Since IL-10 suppresses T cell function, this suggests that the IRAK pathway may serve a function in vivo and during early-stage development of PEL.

Zill, Dennis G., 1940- author

Hayden Library - TA418.9.N35 S54 2011

Dewey Library - PS3545.R815 Z798 2018

Online Resource

Online Resource

Online Resource

With farmers indulging in stubble burning post wheat harvesting season, pollution is back to haunt the residents of Zirakpur, who had been enjoying clean air following restrictions on plying of vehicles during the ongoing lockdown.