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Tras una investigación de la Oficina del jefe estatal de bomberos (State Fire Marshal’s Office, SFMO, por su nombre y siglas en inglés), un gran jurado del condado Jasper acusó a un instalador de equipos de seguridad contra incendios de dos cargos de manipulación de un documento gubernamental.

Ourian Plastic Surgery is proud to announce new content for liposuction procedures at its Beverly Hills cosmetic surgery center. Modern liposuction can even be done while fully awake in the office.

Ouerian Plastic Surgery is proud to announce that liposuction treatments in Beverly Hills are taking "center stage." The clinic highlights the benefits of body sculpting for a slimmer figure.

Deborah Lee Kazel Sipos is noted for her success as a music therapist and founder of Music Matterz Inc.

Ourian Plastic Surgery is proud to announce new content on liposuction and body sculpting options. The Beverly Hills clinic offers help for women and men seeking to improve their appearance.

Power Hero is a pioneering EV charging solutions company with a portfolio of 13 granted patents and many more pending. With more than 20+ years of expertise in capital markets, strategy, and technology,Gastwirth is a perfect choice as a Board Advisor

Los compradores que pasan la criba de las entidades se apresuran a cerrar las negociaciones para evitar el endurecimiento de las condiciones y el encarecimiento de precios que vendrá Leer

Esta incursión militar se produce solo cuatro días después de que la Oficina de Prensa del Gobierno israelí (GPO) revocara los carnés de prensa de los periodistas de Al Jazeera en el paí Leer

Laura Gallego habla sobre los estereotipos de género

Diferentes tipos de cáncer y sus afectaciones.

Una historia de vida detrás de la epidermólisis bullosa o piel de mariposa.

Tipos, factores y causas de la trombosis.

Óscar López, quien se desempeñó como subsecretario de Ambiente de Bogotá durante la administración de Enrique Peñalosa, defendió en 10AM la pertinencia de este proyecto; Ambientalistas alertaron sobre el impacto que tendría este proyecto

En este episodio de El Alargue analizmos las virtudes del Atlético Nacional campeón (primer semestre) y la importancia del manejo que le dio Hernán Darío Herrera a la nómina.

En este episodio de El Alargue hablamos sobre la victoria de La Equidad ante Medellín y analizamos si algunos clubes se encuentran o no en crisis.

En este apisodio de El Alargue analizamos los empates de Millonarios e Independiente Medellín en Libertadores, así como la clasificación de Santa Fe en Copa Sudamericana.

Fabian Sambueza estuvo dialogando en los micrófonos de El Alargue de Caracol Radio, sobre cómo va la preparación de Independiente Santa Fe, qué tan fácil es adapatarse a la idea del técnico Hubert Bodhert y cómo se sienten de cara al encuentro con Deportivo Pasto, por la fecha 4 del fútbol colombiano.

Es una semana clave para el Deportivo Independiente Medellín, deportivamente hablando, a nivel local e internacional. El cuadro antioqueño recibirá a Defensa y Justicia por Copa Sudamericana, y el fin de semana se juega su clasificación a los cuadrangulares finales, dependiendo de resultados ajenos.

En el programa 6AM de Caracol Radio, habló Billy Escobar, Superintendente de Sociedades, de como se ven reflejadas las mejoras en el manejo financiero de los equipos de fútbol en Colombia. 

En 6AM Hoy por Hoy de Caracol Radio estuvo el capitán Álvaro Farfán, delegado del Cuerpo Oficial de Bomberos de Cundinamarca, para hablar sobre algunos equipos que estarían “arrumados” en medio de las emergencias por incendios forestales en Colombia.

Después de una larga investigación, el documentalista David Baute llega a una conclusión. “A estas alturas ya no podemos ir con muchos paños calientes”, dice. via Pocket

DL Brasaemle
Nov 1, 1997; 38:2249-2263
Articles

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles

The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. The adipose tissue microenvironment drives specific metabolic reprogramming of adipose tissue macrophages, contributing to the induction of tissue inflammation. Uncoupling protein 2 (UCP2), a mitochondrial anion carrier, is thought to separately modulate inflammatory and metabolic processes in macrophages and is up-regulated in macrophages in the context of obesity and diabetes. Here, we investigate the role of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance. Using a myeloid-specific knockout of UCP2 (Ucp2ΔLysM), we found that UCP2 deficiency significantly increases glycolysis and oxidative respiration, both unstimulated and after inflammatory conditions. Strikingly, fatty acid loading abolished the metabolic differences between Ucp2ΔLysM macrophages and their floxed controls. Furthermore, Ucp2ΔLysM macrophages show attenuated pro-inflammatory responses toward Toll-like receptor-2 and -4 stimulation. To test the relevance of macrophage-specific Ucp2 deletion in vivo, Ucp2ΔLysM and Ucp2fl/fl mice were rendered obese and insulin resistant through high-fat feeding. Although no differences in adipose tissue inflammation or insulin resistance was found between the two genotypes, adipose tissue macrophages isolated from diet-induced obese Ucp2ΔLysM mice showed decreased TNFα secretion after ex vivo lipopolysaccharide stimulation compared with their Ucp2fl/fl littermates. Together, these results demonstrate that although UCP2 regulates both metabolism and the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the adipose tissue during obesity-induced insulin resistance.

Ying Zou
Dec 1, 2020; 61:1589-1604
Research Articles

Amanda D.V. MacCannell
Nov 18, 2020; 0:jlr.ILR120001204v1-jlr.ILR120001204
Images in Lipid Research

Adaptive thermogenesis is highly dependent on uncoupling protein 1 (UCP1), a protein expressed by thermogenic adipocytes present in brown adipose tissue (BAT) and white adipose tissue (WAT). Thermogenic capacity of human and mouse BAT can be measured by positron emission tomography-computed tomography quantifying the uptake of ¹⁸F-fluodeoxyglucose or lipid tracers. BAT activation is typically studied in response to cold exposure or treatment with β-3-adrenergic receptor agonists such as CL316,243 (CL). Currently, it is unknown whether cold-stimulated uptake of glucose or lipid tracers is a good surrogate marker of UCP1-mediated thermogenesis. In metabolic studies using radiolabeled tracers, we found that glucose uptake is increased in mildly cold-activated BAT of Ucp1^–/– versus WT mice kept at subthermoneutral temperature. Conversely, lower glucose disposal was detected after full thermogenic activation achieved by sustained cold exposure or CL treatment. In contrast, uptake of lipoprotein-derived fatty acids into chronically activated thermogenic adipose tissues was substantially increased in UCP1-deficient mice. This effect is linked to higher sympathetic tone in adipose tissues of Ucp1^–/– mice, as indicated by elevated levels of thermogenic genes in BAT and WAT. Thus, glucose and lipoprotein handling does not necessarily reflect UCP1-dependent thermogenic activity, but especially lipid uptake rather mirrors sympathetic activation of adipose tissues.

Beiging of white adipose tissue (WAT) has beneficial effects on metabolism. Although it is known that beige adipocytes are active in lipid catabolism and thermogenesis, how they are regulated deserves more explorations. In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous WAT (scWAT) responded to cold stimulation and was able to promote mobilization of triacylglycerol [TAG (triglyceride)]. In vitro studies showed that SCD1 promoted lipolysis in C3H10T1/2 white adipocytes. The lipolytic effect was contributed by one of SCD1’s products, oleic acid (OA). OA upregulated adipose TAG lipase and hormone-sensitive lipase expression. When SCD1 was overexpressed in the scWAT of mice, lipolysis was enhanced, and oxygen consumption and heat generation were increased. These effects were also demonstrated by the SCD1 knockdown experiments in mice. In conclusion, our study suggests that SCD1, known as an enzyme for lipid synthesis, plays a role in upregulating lipid mobilization through its desaturation product, OA.

An EY report released on Sunday showed that proceeds from initial public offerings (IPOs) in the country surged 61% last year to over $4.09 billion. The 'EY India IPO Trends Report: Q4 2020' showed that the increase in IPO proceeds came