Nigel Bradley has been the Web Services Manager at Northumbria University for the past 6 years. Although not (web) technical he has led the way for Northumbria to always be amongst first to implement new technologies whether it be their CMS, their SITS integration, their Web stats or more recently their adaptation of the Google maps API for various projects. Nigel facilitated a workshop session on "Geolinked Institutional Web Content" with Patrick Lauke and Sebastian Rahtz.

Bigelow Tea continues to transform its offerings with Peak Energy™ Black Tea plus extra L-Theanine and Caffeine, Whispering Wildflowers™ Herbal Tea plus L-Theanine, and Ginger Honey Herbal Tea plus Zinc where each blend provides flavor while featuring ingredients and nutrients with functional benefits.

Dr. Cavey is One of Five U.S. Doctors who have Received this Honor

Dr. Nigel Anthony Sellars is an expert in American Labor History and American Popular Culture with 30 years of experience in his profession.

Ben Sigelman CEO of LightStep and co-author of the OpenTracing standard discusses distributed tracing, a form of event-driven observability for debugging distributed systems, understanding latency outlyers, and delivering "white box" analytics.

Nigel Poulton, author of The Kubernetes Book and Docker Deep Dive, discusses Kubernetes fundamentals, why Kubernetes is gaining so much momentum, deploying an example app, and why Kubernetes is considered "the" Cloud OS.

Stephen Pennell looks over a photographic record of the coolest neighbourhood in Britain.

Seattle : University of Washington Press, 2023.

Saeed, Aisha, author

London : Pan Books Ltd : William Heinemann Ltd, 1986.

Nigel Ng and Uncle Roger take the WIRED Autocomplete Interview and answer the internet's most searched questions about themselves. Why does Uncle Roger say, 'hiya'? Where is Uncle Roger from? When did Nigel Ng start comedy? Does Nigel have an accent? Does he speak Chinese? Nigel and Uncle Roger answer all these questions and much more! Director: Alexandra Coccia Director of Photography: Bradley Wickham Editor: Paul Tael Talent: Nigel Ng Line Producer: Joseph Buscemi Associate Producer: Brandon White Production Manager: Eric Martinez Production Coordinator: Fernando Davila Camera Operator: Rahil Ashruff Audio: Brett Van Deusen Production Assistant: Ralphy Vasquez Groomer / Hair & Make-Up: Yev Write-Mason Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Ben Harowitz

New York : Springer, 2005

All it took was a flick of her whisk and we were hooked, remembers writer Stuart Heritage   

It's Hot or Not time again as Sportsmail's Riath Al-Samarrai reveals what's been making him feel warm and what's been leaving him cold this week.

Archives, Room Use Only - CT275.V16.P3 1929

Will Hughes has explained how Nigel Pearson has helped him become a new player at Watford and how he feels he has changed under the head coach.

Stephen Pennell looks over a photographic record of the coolest neighbourhood in Britain.

Nigel Lazenby always dreamed of owning a house with river frontage, but that turned into a nightmare when a landslip wrecked his and other homes along the Tamar River in 2016. Now, Nigel is one of a group of owners who just want "fair" compensation.

On this week's show we have two guests called Nigel. First, Nigel Phillips of the Arsenal Supporter's Trust to discuss a report they issued this week about the potential financial implications of Covid-19 and the shutdown of football on Arsenal. We talk about revenue streams drying up, playing behind closed doors, the money that the club spend each month without any income, the famous cash reserves, the reported 'cash injection' from KSE and what to expect when football does eventually return.

Then I'm joined by Nigel Mitchell, who many of you know as the man at pitch-side during Arsenal home games. We chat about getting the radio bug, what a typical match day is like for him, interviewing legends, doing a dream job for any Arsenal fan and loads more.

Follow Nigel Mitchell @MrNigelMitchell

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If you google "The NHS" you'll see screaming headlines from the Daily Mail about cost and waste - debate in parliament is about how much of our GDP we should be spending - and each year, hospital trusts go cap in hand to ask for more funding. Against this backdrop, a new analysis, and a first in a series, published on bmj.com, looks at what it...

Erlangen : F. Enke, 1874-1875.

Boston : Nathan Hale, 1835.

Norwich : University of East Anglia : Social Work Today, 1984.

Blockchain technology offers great promise and great risk. We need to better understand how it works and how to use it safely and effectively.

We have been exploring the use of the live attenuated Salmonella enterica serovar Typhi Ty21a vaccine strain as a versatile oral vaccine vector for the expression and delivery of multiple foreign antigens, including Shigella O-antigens. In this study, we separately cloned genes necessary for the biosynthesis of the Shigella flexneri serotype 2a and 3a O-antigens, which have been shown to provide broad cross-protection to multiple disease-predominant S. flexneri serotypes. The cloned S. flexneri 2a rfb operon, along with bgt and gtrII, contained on the SfII bacteriophage, was sufficient in Ty21a to express the heterologous S. flexneri 2a O-antigen containing the 3,4 antigenic determinants. Further, this rfb operon, along with gtrA, gtrB, and gtrX contained on the Sfx bacteriophage and oac contained on the Sf6 bacteriophage, was sufficient to express S. flexneri 3a O-antigen containing the 6, 7, and 8 antigenic determinants. Ty21a, with these plasmid-carried or chromosomally inserted genes, demonstrated simultaneous and stable expression of homologous S. Typhi O-antigen plus the heterologous S. flexneri O-antigen. Candidate Ty21a vaccine strains expressing heterologous S. flexneri 2a or 3a lipopolysaccharide (LPS) elicited significant serum antibody responses against both homologous S. Typhi and heterologous Shigella LPS and protected mice against virulent S. flexneri 2a or 3a challenges. These new S. flexneri 2a and 3a O-antigen-expressing Ty21a vaccine strains, together with our previously constructed Ty21a strains expressing Shigella sonnei or Shigella dysenteriae 1 O-antigens, have the potential to be used together for simultaneous protection against the predominant causes of shigellosis worldwide as well as against typhoid fever.

Shigella species, the causal agents of bacillary dysentery, use a type III secretion system (T3SS) to inject two waves of virulence proteins, known as effectors, into the colonic epithelium to subvert host cell machinery. Prior to host cell contact and secretion of the first wave of T3SS effectors, OspD1, an effector and antiactivator protein, prevents premature production of the second wave of effectors. Despite this important role, regulation of the ospD1 gene is not well understood. While ospD1 belongs to the large regulon of VirB, a transcriptional antisilencing protein that counters silencing mediated by the histone-like nucleoid structuring protein H-NS, it remains unclear if VirB directly or indirectly regulates ospD1. Additionally, it is not known if ospD1 is regulated by H-NS. Here, we identify the primary ospD1 transcription start site (+1) and show that the ospD1 promoter is remotely regulated by both VirB and H-NS. Our findings demonstrate that VirB regulation of ospD1 requires at least one of the two newly identified VirB regulatory sites, centered at –978 and –1270 relative to the ospD1 +1. Intriguingly, one of these sites lies on a 193-bp sequence found in three conserved locations on the large virulence plasmids of Shigella. The region required for H-NS-dependent silencing of ospD1 lies between –1120 and –820 relative to the ospD1 +1. Thus, our study provides further evidence that cis-acting regulatory sequences for transcriptional antisilencers and silencers, such as VirB and H-NS, can lie far upstream of the canonical bacterial promoter region (i.e., –250 to +1).

IMPORTANCE Transcriptional silencing and antisilencing mechanisms regulate virulence gene expression in many important bacterial pathogens. In Shigella species, plasmid-borne virulence genes, such as those encoding the type III secretion system (T3SS), are silenced by the histone-like nucleoid structuring protein H-NS and antisilenced by VirB. Previous work at the plasmid-borne icsP locus revealed that VirB binds to a remotely located cis-acting regulatory site to relieve transcriptional silencing mediated by H-NS. Here, we characterize a second example of remote VirB antisilencing at ospD1, which encodes a T3SS antiactivator and effector. Our study highlights that remote transcriptional silencing and antisilencing occur more frequently in Shigella than previously thought, and it raises the possibility that long-range transcriptional regulation in bacteria is commonplace.

Nigel Farage has been visited by police officers who advised him not to breach lockdown restrictions after he travelled to Dover to report on migrants.

Nigel Farage has become the butt of mocking jokes online after sharing his Clap for Carers effort.

From ‘Raging Bull’ to ‘Spirited Away’, the FT’s outgoing film critic picks his top movies

The Brexit party and the Welsh Plaid Cymru reveal their policies; Corbyn and McDonnell defend tax plans; Tories propose stamp duty rise for foreign buyers; while UK figures show more gloomy outlook

While MasterChef is supposed to be about spotting the rising star amongst amateur cooks, it seems that fans are more preoccupied with watching the judges eat.

It's Nigella Lawson week on MasterChef and on Monday's episode the cook had audiences swooning. 

Speaking to The Herald Sun , Matt gushed about the brunette beauty, praising her intellect and wit.

It's Nigella Lawson week on MasterChef and on Tuesday's episode the food journalist gave a shock result that saw an amateur contestant beat a professional chef. 

Brendan Pang suffered a shocking accident on Wednesday's episode of MasterChef when a fall left him with a bloody gash on his hand. 

It's Nigella Lawson week on MasterChef and viewers have taken to Twitter to comment on the chef's suddenly slight figure.

The former culinary hopeful has revealed what the 58-year-old British chef is really like behind the scenes after sharing the screen with her on the cooking reality show last week.

British celebrity chef Nigella Lawson was given her own dedicated week on Australia's MasterChef this month. 

The MasterChef Australia evictee, 28, enthused the curvy chef had given her a new lease of life in the kitchen before she was evicted during South African week.

Nigel Farage today unveiled his party's plans to allow voters to hold a Brexit referendum every ten years.

This show's USP appeared promising as it was a Willy Wonka-ish 'completely edible set', from which the three competitors must 'forage' their ingredient

The Brexit Party and former UKIP leader, 55, branded Year Of The Rabbit 'totally sick and frankly irresponsible' after it emerged they will kill off 'Neil Fromage' on tomorrow night's show.

Liverpool are striving to become only the second team in Premier League history to go a season unbeaten, but their next opponents Watford are focussed on fighting for their lives at the bottom.

Brexit Party leader Nigel Farage insisted 'No Deal is the best deal' and told the Boris Johnson it would be a 'historic mistake' to rehash Mrs May's Withdrawal Agreement - minus the backstop.